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1. 发明授权

US06221066B1 Shape memory segmented detachable coil 有权
公开(公告)号：US06221066B1
公开(公告)日：2001-04-24
申请号：US09264927
申请日：1999-03-09
申请人： David A. Ferrera , Daniel R. Kurz , Peter Wilson
发明人： David A. Ferrera , Daniel R. Kurz , Peter Wilson
IPC分类号： A61B1700
CPC分类号： A61B17/12163 , A61B17/12022 , A61B17/1214 , A61B2017/12072 , A61B2017/12077
摘要： The shape memory segmented detachable coil assembly includes a plurality of hollow, tubular coil segments, and a plurality of connector members, with adjacent coil segments connected together by the connector members. The connector members are currently preferably hollow, tubular connector members that are advantageously detachable from selected portions of the coil segments by application of energy to one or more selected connector members. A heat activation member is used for heating one or more selected connector members to disconnect selected portions of the coil assembly. The heat activation member typically can be advanced axially through or over the coil assembly, and currently preferably comprises a fiber optic, although the heat activation member can also comprise a heat pipe, or a device for generating heat by RF energy or electrical resistance.

2. 发明授权

US06171326B2 Three dimensional, low friction vasoocclusive coil, and method of manufacture 有权
标题翻译：三维，低摩擦血管闭塞线圈及其制造方法
公开(公告)号：US06171326B2
公开(公告)日：2001-01-09
申请号：US09140495
申请日：1998-08-27
申请人： David A. Ferrera , Daniel R. Kurz , Peter Wilson , Crystal K. Sein-Lwyn , Lok A. Lei
发明人： David A. Ferrera , Daniel R. Kurz , Peter Wilson , Crystal K. Sein-Lwyn , Lok A. Lei
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145
摘要： The three dimensional, low friction vasoocclusive coil has a distal portion that is three dimensionally shaped, and a proximal portion that is linear or helically shaped. The distal three dimensional portion will form a basket for filling the anatomical cavity at the site in the vasculature to be treated, while the proximal portion will fill and reinforce the basket. The vasoocclusive device is formed from at least one strand of a flexible material formed to have an a first inoperable, substantially linear configuration for insertion into and through a catheter or cannula to a desired portion of the vasculature to be treated, and a second operable, three dimensional configuration for occluding the desired portion of the vasculature to be treated. The vasoocclusive device has a distal portion having a second operable, three dimensional shape for filing the anatomical cavity at the site in the vasculature to be treated, and a proximal portion having a second operable, substantially linear shape for filling and reinforcing the distal, three dimensional shaped portion when it is implanted at the site in the vasculature to be treated. Mandrels are provided for use in the method of making the vasoocclusive device.
摘要翻译：三维低摩擦血管收缩性线圈具有三维形状的远侧部分，以及线性或螺旋状的近端部分。远端三维部分将形成一个篮，用于在待治疗的脉管系统中的位置处填充解剖腔，而近端部分将填充并加强篮。血管闭塞装置由柔性材料的至少一根股形成，以形成为具有用于插入导管或插管并穿过导管或插管到待治疗的脉管系统的期望部分的第一不可操作的基本上线性的构型，以及第二可操作的，用于封闭待治疗的脉管系统的期望部分的三维构型。血管收缩装置具有远端部分，其具有第二可操作的三维形状，用于在待治疗的脉管系统中的位置处填充解剖腔，以及具有第二可操作的基本线性形状的近端部分，用于填充和加强远端，三当植入在待治疗的脉管系统中的位置处时，其尺寸形状部分。心轴被提供用于制造血管收缩装置的方法。

3. 发明授权

US07070608B2 Vasoocclusive coil 失效
公开(公告)号：US07070608B2
公开(公告)日：2006-07-04
申请号：US09970390
申请日：2001-10-02
申请人： Daniel R. Kurz , David A. Ferrera , Peter Wilson
发明人： Daniel R. Kurz , David A. Ferrera , Peter Wilson
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B90/39
摘要： The vasoocclusive coil has a primary coil configuration with a helical loop at at least one end. The terminal helical loop can have a J-shaped configuration, preferably with a loop diameter of about 2 mm. The coil is preferably provided with helical loops at both ends, with helical loop at the proximal and distal ends of the coil acting as an anchor to prevent the coil from coming free from the location being treated and escaping into the vasculature. In a presently preferred embodiment both ends of the coil have a J-shape. In another presently preferred aspect, the vasoocclusive coil includes one or more loops intermediate the ends of the coil. The device is formed from a multi-stranded micro-cable having a plurality of flexible strands of a shape memory material and at least one radiopaque strand. The strands can be made of a shape memory nickel titanium alloy, that is highly flexible at a temperature appropriate for introduction into the body via a catheter, and that after placement will take on the therapeutic shape.

4. 发明授权

US06551305B2 Shape memory segmented detachable coil 有权
标题翻译：形状记忆分段可拆卸线圈
公开(公告)号：US06551305B2
公开(公告)日：2003-04-22
申请号：US09812867
申请日：2001-03-19
申请人： David A. Ferrera , Daniel R. Kurz , Peter Wilson
发明人： David A. Ferrera , Daniel R. Kurz , Peter Wilson
IPC分类号： A61B1700
CPC分类号： A61B17/12163 , A61B17/12022 , A61B17/1214 , A61B2017/12072 , A61B2017/12077
摘要： The shape memory segmented detachable coil assembly includes a plurality of hollow, tubular coil segments, and a plurality of connector members, with adjacent coil segments connected together by the connector members. The connector members are currently preferably hollow, tubular connector members that are advantageously detachable from selected portions of the coil segments by application of energy to one or more selected connector members. A heat activation member is used for heating one or more selected connector members to disconnect selected portions of the coil assembly. The heat activation member typically can be advanced axially through or over the coil assembly, and currently preferably comprises a fiber optic, although the heat activation member can also comprise a heat pipe, or a device for generating heat by RF energy or electrical resistance.
摘要翻译：形状记忆分割的可拆卸线圈组件包括多个中空的管状线圈段和多个连接器构件，其中相邻的线圈段由连接器构件连接在一起。连接器构件目前优选是中空的管状连接器构件，其通过将能量施加到一个或多个所选择的连接器构件而有利地可从线圈段的选定部分拆卸。热激活构件用于加热一个或多个所选择的连接器构件以断开线圈组件的选定部分。热激活构件通常可以轴向地前进通过线圈组件，并且目前优选地包括光纤，尽管热激活构件还可以包括热管或用于通过RF能量或电阻产生热的装置。

5. 发明授权

US6136015A Vasoocclusive coil 有权
公开(公告)号：US6136015A
公开(公告)日：2000-10-24
申请号：US139258
申请日：1998-08-25
申请人： Daniel R. Kurz , David A. Ferrera , Peter Wilson
发明人： Daniel R. Kurz , David A. Ferrera , Peter Wilson
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B90/39
摘要： The vasoocclusive coil has a primary coil configuration with a helical loop at at least one end. The terminal helical loop can have a J-shaped configuration, preferably with a loop diameter of about 2 mm. The coil is preferably provided with helical loops at both ends, with helical loop at the proximal and distal ends of the coil acting as an anchor to prevent the coil from coming free from the location being treated and escaping into the vasculature. In a presently preferred embodiment both ends of the coil have a J-shape. In another presently preferred aspect, the vasoocclusive coil includes one or more loops intermediate the ends of the coil. The device is formed from a multi-stranded micro-cable having a plurality of flexible strands of a shape memory material and at least one radiopaque strand. The strands can be made of a shape memory nickel titanium alloy, that is highly flexible at a temperature appropriate for introduction into the body via a catheter, and that after placement will take on the therapeutic shape.

6. 发明授权

US06306153B1 Vasoocclusive coil 有权
标题翻译：血管收缩线圈
公开(公告)号：US06306153B1
公开(公告)日：2001-10-23
申请号：US09557127
申请日：2000-04-25
申请人： Daniel R. Kurz , David A. Ferrera , Peter Wilson
发明人： Daniel R. Kurz , David A. Ferrera , Peter Wilson
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B90/39
摘要： The vasoocclusive coil has a primary coil configuration with a helical loop at at least one end. The terminal helical loop can have a J-shaped configuration, preferably with a loop diameter of about 2 mm. The coil is preferably provided with helical loops at both ends, with helical loop at the proximal and distal ends of the coil acting as an anchor to prevent the coil from coming free from the location being treated and escaping into the vasculature. In a presently preferred embodiment both ends of the coil have a J-shape. In another presently preferred aspect, the vasoocclusive coil includes one or more loops intermediate the ends of the coil. The device is formed from a multi-stranded micro-cable having a plurality of flexible strands of a shape memory material and at least one radiopaque strand. The strands can be made of a shape memory nickel titanium alloy, that is highly flexible at a temperature appropriate for introduction into the body via a catheter, and that after placement will take on the therapeutic shape.
摘要翻译：血管收缩线圈具有在至少一端具有螺旋环的初级线圈构型。端子螺旋环可以具有J形构造，优选具有约2mm的环直径。线圈优选地在两端设置有螺旋环，线圈的近端和远端处的螺旋环用作锚，以防止线圈从被处理的位置释放出来并逃逸到脉管系统中。在目前优选的实施例中，线圈的两端具有J形。在另一个目前优选的方面中，血管闭塞线圈包括在线圈末端之间的一个或多个环。该装置由具有形状记忆材料的多个柔性股线和至少一个不透射线的多股微电缆形成。线可以由形状记忆镍钛合金制成，其在适于通过导管引入身体的温度下是高度柔性的，并且在放置之后将呈现治疗形状。

7. 发明授权

US07008434B2 Clot retrieval device 有权
公开(公告)号：US07008434B2
公开(公告)日：2006-03-07
申请号：US10754660
申请日：2004-01-08
申请人： Daniel R. Kurz , David A. Ferrera
发明人： Daniel R. Kurz , David A. Ferrera
IPC分类号： A61B17/22
CPC分类号： A61B17/22031 , A61B17/221 , A61B2017/00867 , A61B2017/00871 , A61B2017/22034 , A61B2017/2217
摘要： The shape memory clot retrieval device can be placed in the vasculature of a patient for retrieving and removing distal clots. The clot retrieval device has an elongated catheter member that can be inserted in the vasculature, with one or more clot retrieval members on the elongated catheter member that are movable between an initial compressed configuration in which the clot retrieval device is inserted into the vasculature and an expanded configuration extending outwardly from the elongated catheter member to trap and hold clots within the vessel. The clot retrieval device typically can be introduced to the desired treatment site in the vasculature through a guiding catheter.

8. 发明授权

US06616617B1 Vasoocclusive device for treatment of aneurysms 失效
标题翻译：用于治疗动脉瘤的血管收缩装置
公开(公告)号：US06616617B1
公开(公告)日：2003-09-09
申请号：US09762539
申请日：2001-02-08
申请人： David A. Ferrera , Daniel R. Kurz , Lok A. Lei , Julia A. Larsen
发明人： David A. Ferrera , Daniel R. Kurz , Lok A. Lei , Julia A. Larsen
IPC分类号： A61B500
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B17/12163 , A61B17/1219 , A61B90/39 , A61B2017/00526 , A61B2017/00867 , A61B2017/00884 , A61B2017/00893 , A61B2017/1205 , A61B2017/12072 , A61M2025/09191
摘要： The three dimensional device is adapted to be inserted into a portion of a vasculature for occluding the portion of the vasculature for use in interventional therapy and vascular surgery. The device is formed from a multi-stranded microcable having a plurality of flexible strands of a shape memory material and at least one radiopaque strand. The device can be bundled by an outer cover to constrain the strands of the micro-cable about a longitudinal axis to produce a composite banded cable. The radiopaque strand can have a core strand with a plurality of intermittently spaced apart enlarged radiopaque portions that may be a plurality of beads of radiopaque material spaced apart and mounted on the core strand, or a plurality of coils intermittently wound about and spaced apart on the core strand.
摘要翻译：三维装置适于插入脉管系统的一部分中以封闭脉管系统的一部分用于介入治疗和血管手术。该装置由具有多个形状记忆材料的柔性股线和至少一个不透射线的多股微型显示器形成。该装置可以通过外盖捆绑，以围绕纵向轴线约束微缆线，以产生复合带状电缆。不透射线可以具有具有多个间歇间隔开的放大不透射线部分的芯线，该部分可以是间隔开并安装在芯股线上的多个不透射线材料珠，或者多个线圈间歇地缠绕在其上并间隔开芯链。

9. 发明授权

US06656201B2 Variable stiffness coil for vasoocclusive devices 有权
公开(公告)号：US06656201B2
公开(公告)日：2003-12-02
申请号：US09991021
申请日：2001-11-15
申请人： David A. Ferrera , Daniel R. Kurz
发明人： David A. Ferrera , Daniel R. Kurz
IPC分类号： A61M2900
CPC分类号： A61B17/12145 , A61B17/12022 , A61B90/39 , A61B2017/00867
摘要： The variable stiffness vasoocclusive coil is given variable stiffness along the length of the coil by selectively heat treating certain segments of a primary or secondary coil. The primary coil can be selectively heat treated to form soft or deformable segments along the length of the coil, and can then be shaped into a secondary shape that is set by a heat treatment process. Distal regions of the coil can also be heat treated to make the distal ends of the coil softer, more deformable, or less traumatic.

10. 发明授权

US06692504B2 Clot retrieval device 有权
标题翻译：凝块检索装置
公开(公告)号：US06692504B2
公开(公告)日：2004-02-17
申请号：US10023028
申请日：2001-12-17
申请人： Daniel R. Kurz , David A. Ferrera
发明人： Daniel R. Kurz , David A. Ferrera
IPC分类号： A61B1722
CPC分类号： A61B17/22031 , A61B17/221 , A61B2017/00867 , A61B2017/00871 , A61B2017/22034 , A61B2017/2217
摘要： A shape memory clot retrieval device which can be placed in the vasculature of a patient for retrieving and removing distal clots. The clot retrieval device has an elongated catheter member that can be inserted in the vasculature, with one or more clot retrieval members on the elongated catheter member that are movable between an initial compressed configuration in which the clot retrieval device is inserted into the vasculature and an expanded configuration extending outwardly from the elongated catheter member to trap and hold clots within the vessel. The clot retrieval device typically can be introduced to the desired treatment site in the vasculature through a guiding catheter.
摘要翻译：形状记忆凝块取出装置，其可以放置在患者的脉管系统中，用于检索和去除远端血块。凝块取出装置具有细长的导管构件，该导管构件可以插入脉管系统中，细长的导管构件上的一个或多个凝块取回构件可以在其中凝块取出装置插入脉管系统的初始压缩构型和扩张构型从细长的导管构件向外延伸以将血块捕获并保持在血管内。凝块回收装置通常可以通过引导导管引入脉管系统中的期望的治疗部位。

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