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1. 发明授权

US6057105A Detection of melanoma or breast metastasis with a multiple marker assay 失效
标题翻译：用多标记检测法检测黑素瘤或乳腺癌转移
公开(公告)号：US6057105A
公开(公告)日：2000-05-02
申请号：US987326
申请日：1997-12-09
申请人： Dave S. B. Hoon , Andrew J. Conrad , Peter Schmid
发明人： Dave S. B. Hoon , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Methods for detecting metastasis of melanoma and breast cancer cells, detecting subclinical metastasis, and monitoring treatment are disclosed. Kits for use in such methods also are disclosed. The methods provide for the detection of nucleic acids corresponding to multiple melanoma or breast cancer specific markers using template dependent amplification processes. Methods using multiple markers provide increased sensitivity over existing methods.
摘要翻译：公开了检测黑素瘤和乳腺癌细胞转移的方法，检测亚临床转移和监测治疗方法。用于这些方法的试剂盒也被公开。该方法提供使用模板依赖性扩增方法检测对应于多种黑素瘤或乳腺癌特异性标志物的核酸。使用多个标记的方法比现有方法提高了灵敏度。

2. 发明申请

US20090263788A1 EFFICIENT ALGORITHM FOR PCR TESTING OF BLOOD SAMPLES 审中-公开
标题翻译：用于血液样品PCR检测的有效算法
公开(公告)号：US20090263788A1
公开(公告)日：2009-10-22
申请号：US12493622
申请日：2009-06-29
申请人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
发明人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q1/70
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701 , C12Q2537/165
摘要： Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. Samples are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, Xrcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle. The dimensional indicia of each positive subpool is evaluated mathematically in accordance with a reduction by the method of minors, thereby unambiguously identifying a unique element in the grid, thereby unambiguously identifying a uniquely positive blood or plasma donation.
摘要翻译：提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。将样品形成池，随后通过高灵敏度测试（例如PCR）测试病毒污染。根据每个捐赠的样本被映射到N维矩阵或网格的每个元素的算法来测试池。矩阵的每个元素由矩阵标识符Xrcs来标识，其中rcs定义维度索引。从每个样品获取等分试样，并形成子池，每个子池包含其中一维索引固定的样品的等分试样。所有的子项目在一个PCR测试周期中进行测试。根据通过未成年人的方法的减少，数学地评估每个阳性子宫的维度标记，从而明确地识别网格中的唯一元素，从而明确地识别唯一的阳性血液或血浆捐赠。

3. 发明授权

US08158341B2 Efficient algorithm for PCR testing of blood samples 有权
标题翻译：血液样品PCR检测的有效算法
公开(公告)号：US08158341B2
公开(公告)日：2012-04-17
申请号：US11374484
申请日：2006-03-09
申请人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
发明人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701 , C12Q2537/165
摘要： A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an n-dimensional matrix comprising a multiplicity of elements, each element being identified by a matrix notation comprising an index for each dimension of the array. Samples are taken from each fluid donation and mapped to a matrix element with each sample identified by its corresponding element's notation; n aliquots being taken from each sample and subpools formed from the aliquots with each subpool containing an aliquot from all samples mapped to elements in which one of the dimensional indices is fixed. Subpools are tested for viral indication and the dimensional index of each subpool that returns a positive viral indication is determined. The dimensional indices are combined to identify a subset of matrix elements that contain a viral positive sample.
摘要翻译：提供了用于在最少数量的测试周期中鉴定病毒阳性生物流体捐赠的方法。该方法包括提供生物流体捐赠并且定义包括多个元素的n维矩阵，每个元素由包括阵列的每个维度的索引的矩阵符号标识。从每个流体捐赠取样，并将其映射到矩阵元素，每个样本由其对应元素的符号识别; 从每个样品取出等分试样，并从等分试样形成的子泳池，每个子泳池含有来自所有样品的等分试样，其映射到其中一个维度指数是固定的元素。测试子池的病毒指示，并确定返回阳性病毒指示的每个子池的维度指数。组合尺寸指数以识别含有病毒阳性样品的矩阵元素的子集。

4. 发明授权

US06566052B1 Efficient algorithm for PCR testing of blood samples 有权
标题翻译：血液样品PCR检测的有效算法
公开(公告)号：US06566052B1
公开(公告)日：2003-05-20
申请号：US09549477
申请日：2000-04-14
申请人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
发明人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q170
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701 , C12Q2537/165
摘要： Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. An apparatus and process is described which forms individual, separately sealed and connected sample containers from a flexible hollow tubing segment connected to a fluid donation container. The tubing segment is sealed at spaced-apart intervals along its length, with tubing segment portions in the intervals between the seals defining containers, each of which holds a portion of a plasma sample. The contents of the containers are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, Xrcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle. The dimensional indicia of each positive subpool is evaluated mathematically in accordance with a reduction by the method of minors, thereby unambiguously identifying a unique element in the grid, thereby unambiguously identifying a uniquely positive blood or plasma donation.
摘要翻译：提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。描述了一种从与流体供给容器连接的柔性中空管段形成单独的，分开的密封和连接的样品容器的装置和方法。管段沿着其长度以间隔间隔密封，密封件之间的间隔中的管段部分限定容器，每个容器保持一部分等离子体样品。将容器的内容物形成池，随后通过诸如PCR的高灵敏度试验来测试病毒污染。根据每个捐赠的样本被映射到N维矩阵或网格的每个元素的算法来测试池。矩阵的每个元素由矩阵标识符Xrcs来标识，其中rcs定义维度索引。从每个样品获取等分试样，并形成子池，每个子池包含其中一维索引固定的样品的等分试样。所有的子项目在一个PCR测试周期中进行测试。根据通过未成年人的方法的减少，数学地评估每个阳性子宫的维度标记，从而明确地识别网格中的唯一元素，从而明确地识别唯一的阳性血液或血浆捐赠。

5. 发明授权

US08037039B2 Runtime class database operation 有权
标题翻译：运行时类数据库操作
公开(公告)号：US08037039B2
公开(公告)日：2011-10-11
申请号：US11838705
申请日：2007-08-14
申请人： Carl Yates Perry , Jeffrey Michael Derstadt , Andrew J. Conrad , Jeffrey E. Reed , Shyamalan Pather
发明人： Carl Yates Perry , Jeffrey Michael Derstadt , Andrew J. Conrad , Jeffrey E. Reed , Shyamalan Pather
IPC分类号： G06F17/00 , G06F17/30
CPC分类号： G06F17/30979
摘要： Programmers typically like operating with databases through use of classes. Classes allow a user to function with a database through use of a non-database programming language. To ease use of the classes, a class context is generated at runtime that does not force a programmer to handle various source files that are a product of class generation. Therefore, the user can have the ease of using classes without having to perform extra actions.
摘要翻译：程序员通常喜欢通过使用类操作数据库。类允许用户通过使用非数据库编程语言与数据库一起工作。为了简化类的使用，在运行时生成类上下文，不会强制程序员处理作为类生成的产物的各种源文件。因此，用户可以轻松地使用类，而不必执行额外的操作。

6. 发明授权

US07685155B2 System and method of providing and utilizing an object schema to facilitate mapping between disparate domains 有权
标题翻译：提供和利用对象模式以促进不同域之间的映射的系统和方法
公开(公告)号：US07685155B2
公开(公告)日：2010-03-23
申请号：US10806526
申请日：2004-03-23
申请人： Ilker Cengiz , Luca Bolognese , Jason Z. Zhu , Dempsey R. Swan , David E. Sceppa , Andrew J. Conrad
发明人： Ilker Cengiz , Luca Bolognese , Jason Z. Zhu , Dempsey R. Swan , David E. Sceppa , Andrew J. Conrad
IPC分类号： G06F7/00 , G06F17/00 , G06F17/30
CPC分类号： G06F17/30607 , Y10S707/99944
摘要： The present invention relates to a system and methodology to facilitated data object persistence. An object schema is utilized to provide metadata for types in addition to what is provided by the type system for an underlying programming language. This metadata is then utilized by the system to translate data to and from user objects during a materialization or persistence process. The object schema provides information external to programming logic and type definitions. Consequently, the object schema can be deployed independent of an application thereby allowing the persistence storage of user objects to change without force the user to recompile and deploy application code.
摘要翻译：本发明涉及一种便于数据对象持久化的系统和方法。使用对象模式来提供除类型系统为底层编程语言提供的类型之外的类型的元数据。该元数据随后由系统用于在实现或持久化过程期间将数据与用户对象进行翻译。对象模式提供了编程逻辑和类型定义外的信息。因此，可以独立于应用程序部署对象模式，从而允许用户对象的持久存储更改，而不强制用户重新编译和部署应用程序代码。

7. 发明授权

US06348336B1 Process for purification of PCR test samples 失效
标题翻译：纯化PCR检测样品的方法
公开(公告)号：US06348336B1
公开(公告)日：2002-02-19
申请号：US08886330
申请日：1997-07-01
申请人： H. Edward Matveld , Lorraine B. Peddada , Andrew J. Conrad , Charles M. Heldebrant
发明人： H. Edward Matveld , Lorraine B. Peddada , Andrew J. Conrad , Charles M. Heldebrant
IPC分类号： C12P1934
CPC分类号： C12Q1/6806
摘要： A process is provided for preparing samples of blood, blood plasma, blood serum, or plasma proteins, including blood factor products, for PCR testing which minimizes contaminants which may interfere with the analysis. The process includes centrifugation of the initial sample to form a sample pellet, removing at least a portion of the supernatant from the pellet, and washing the pellet with an aqueous buffer. The buffer and washed pellet are then centrifuged, and a portion of the remaining supernatant is removed along with any contaminants contained therein. The clean, substantially contaminant-free pellet is then processed for PCR analysis.
摘要翻译：提供了用于制备血液，血浆，血清或血浆蛋白质（包括血液因子产品）的样品用于PCR测试的方法，其最小化可能干扰分析的污染物。该方法包括离心初始样品以形成样品沉淀，从沉淀中除去至少一部分上清液，并用水性缓冲液洗涤沉淀。然后将缓冲液和洗涤的沉淀物离心，并将其余上清液的一部分与其中所含的任何污染物一起除去。然后将干净，基本上无污染的颗粒处理用于PCR分析。

8. 发明申请

US20080263531A1 AUTOMATIC RUNTIME CONTROL BINDING 审中-公开
标题翻译：自动运行控制绑定
公开(公告)号：US20080263531A1
公开(公告)日：2008-10-23
申请号：US11847140
申请日：2007-08-29
申请人： Carl Yates Perry , Jeffrey Michael Derstadt , Andrew J. Conrad , Amanda K. Silver , Paul A. Vick , Shyamalan Pather , David E. Sceppa
发明人： Carl Yates Perry , Jeffrey Michael Derstadt , Andrew J. Conrad , Amanda K. Silver , Paul A. Vick , Shyamalan Pather , David E. Sceppa
IPC分类号： G06F9/44
CPC分类号： G06F16/90335
摘要： Binding can automatically take place between controls and information sources at runtime. This minimizes an amount of code that is to be generated by a user and thus can lower errors from the code. In addition, some wizards that allow binding without code writing can become problematic since some information is not available at runtime (e.g., when the wizard operates prior to runtime.) Relevant information is received and at least one binding is created based off received information.
摘要翻译：绑定可以在运行时自动发生在控件和信息源之间。这最小化了由用户生成的代码量，从而可以降低代码中的错误。另外，一些允许没有代码写入的绑定的向导可能会成为问题，因为一些信息在运行时不可用（例如，当向导在运行时之前运行时）。接收到相关信息，并且基于所接收的信息创建至少一个绑定。

9. 发明申请

US20080263063A1 TRANSLATING LATE BOUND LINQ EXPRESSIONS INTO DATABASE QUERIES 有权
标题翻译：将LINQ表达式转化为数据库查询
公开(公告)号：US20080263063A1
公开(公告)日：2008-10-23
申请号：US11940029
申请日：2007-11-14
申请人： David E. Sceppa , Carl Y. Perry , Jeffrey M. Derstadt , Andrew J. Conrad , Amanda K. Silver , Paul A. Vick , Shyamalan Pather , Colin Joseph Meek
发明人： David E. Sceppa , Carl Y. Perry , Jeffrey M. Derstadt , Andrew J. Conrad , Amanda K. Silver , Paul A. Vick , Shyamalan Pather , Colin Joseph Meek
IPC分类号： G06F17/30
CPC分类号： G06F9/45516
摘要： There is alteration of a late-bound expression produced by a compiler into an early-bound structure. Alteration of the late-bound expression can occur at runtime and a visitor pattern can be used to create the alteration. In one instance, a conversion from late-bound to early-bound takes place through replacing a late-bound property with a statically typed call. The early-bound structure can translate into an expression tree to enable an implementation of a store specific query operated upon storage.
摘要翻译：将编译器产生的后期界定表达式更改为早期绑定的结构。晚期绑定表达式的更改可能在运行时发生，访问者模式可用于创建更改。在一种情况下，通过使用静态类型调用替换后期绑定属性来实现从后期到早期的转换。早期绑定的结构可以转换为表达式树，以使得能够实现在存储时操作的商店特定查询。

10. 发明授权

US07739223B2 Mapping architecture for arbitrary data models 失效
标题翻译：任意数据模型的映射架构
公开(公告)号：US07739223B2
公开(公告)日：2010-06-15
申请号：US10652214
申请日：2003-08-29
申请人： Alexander Vaschillo , Ilker Cengiz , Bertan Ari , Srinivasa R. Burugapalli , Luca Bolognese , Avner Y. Aharoni , Steven D. White , Alex Laskos , Andrew J. Conrad , Todd F. Pfleiger , Jason Z. Zhu , Chris Suver , David Schach , Adam J. Wiener
发明人： Alexander Vaschillo , Ilker Cengiz , Bertan Ari , Srinivasa R. Burugapalli , Luca Bolognese , Avner Y. Aharoni , Steven D. White , Alex Laskos , Andrew J. Conrad , Todd F. Pfleiger , Jason Z. Zhu , Chris Suver , David Schach , Adam J. Wiener
IPC分类号： G06F17/30
CPC分类号： G06F17/30914 , G06F17/30557 , G06F17/30569 , Y10S707/99942
摘要： A data mapping architecture for mapping between two or more data sources without modifying the metadata or structure of the data sources themselves. Data mapping also supports updates. The architecture also supports at least the case where data sources that are being mapped, are given, their schemas predefined, and cannot be changed. The architecture includes a mapping component that receives respective metadata from at least two arbitrary data models, and maps expressions between the data models.
摘要翻译：用于在两个或多个数据源之间映射而不修改数据源本身的元数据或结构的数据映射架构。数据映射还支持更新。该架构还至少支持要映射的数据源，给定的模式，并且不能更改的情况。架构包括从至少两个任意数据模型接收相应元数据的映射组件，并且在数据模型之间映射表达式。

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