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1. 发明授权

US06566052B1 Efficient algorithm for PCR testing of blood samples 有权
标题翻译：血液样品PCR检测的有效算法
公开(公告)号：US06566052B1
公开(公告)日：2003-05-20
申请号：US09549477
申请日：2000-04-14
申请人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
发明人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q170
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701 , C12Q2537/165
摘要： Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. An apparatus and process is described which forms individual, separately sealed and connected sample containers from a flexible hollow tubing segment connected to a fluid donation container. The tubing segment is sealed at spaced-apart intervals along its length, with tubing segment portions in the intervals between the seals defining containers, each of which holds a portion of a plasma sample. The contents of the containers are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, Xrcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle. The dimensional indicia of each positive subpool is evaluated mathematically in accordance with a reduction by the method of minors, thereby unambiguously identifying a unique element in the grid, thereby unambiguously identifying a uniquely positive blood or plasma donation.
摘要翻译：提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。描述了一种从与流体供给容器连接的柔性中空管段形成单独的，分开的密封和连接的样品容器的装置和方法。管段沿着其长度以间隔间隔密封，密封件之间的间隔中的管段部分限定容器，每个容器保持一部分等离子体样品。将容器的内容物形成池，随后通过诸如PCR的高灵敏度试验来测试病毒污染。根据每个捐赠的样本被映射到N维矩阵或网格的每个元素的算法来测试池。矩阵的每个元素由矩阵标识符Xrcs来标识，其中rcs定义维度索引。从每个样品获取等分试样，并形成子池，每个子池包含其中一维索引固定的样品的等分试样。所有的子项目在一个PCR测试周期中进行测试。根据通过未成年人的方法的减少，数学地评估每个阳性子宫的维度标记，从而明确地识别网格中的唯一元素，从而明确地识别唯一的阳性血液或血浆捐赠。

2. 发明申请

US20090263788A1 EFFICIENT ALGORITHM FOR PCR TESTING OF BLOOD SAMPLES 审中-公开
标题翻译：用于血液样品PCR检测的有效算法
公开(公告)号：US20090263788A1
公开(公告)日：2009-10-22
申请号：US12493622
申请日：2009-06-29
申请人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
发明人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q1/70
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701 , C12Q2537/165
摘要： Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. Samples are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, Xrcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle. The dimensional indicia of each positive subpool is evaluated mathematically in accordance with a reduction by the method of minors, thereby unambiguously identifying a unique element in the grid, thereby unambiguously identifying a uniquely positive blood or plasma donation.
摘要翻译：提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。将样品形成池，随后通过高灵敏度测试（例如PCR）测试病毒污染。根据每个捐赠的样本被映射到N维矩阵或网格的每个元素的算法来测试池。矩阵的每个元素由矩阵标识符Xrcs来标识，其中rcs定义维度索引。从每个样品获取等分试样，并形成子池，每个子池包含其中一维索引固定的样品的等分试样。所有的子项目在一个PCR测试周期中进行测试。根据通过未成年人的方法的减少，数学地评估每个阳性子宫的维度标记，从而明确地识别网格中的唯一元素，从而明确地识别唯一的阳性血液或血浆捐赠。

3. 发明授权

US08158341B2 Efficient algorithm for PCR testing of blood samples 有权
标题翻译：血液样品PCR检测的有效算法
公开(公告)号：US08158341B2
公开(公告)日：2012-04-17
申请号：US11374484
申请日：2006-03-09
申请人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
发明人： Lorraine B. Peddada , Charles M. Heldebrant , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： B01L3/505 , B01L3/0296 , C12Q1/686 , C12Q1/701 , C12Q2537/165
摘要： A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an n-dimensional matrix comprising a multiplicity of elements, each element being identified by a matrix notation comprising an index for each dimension of the array. Samples are taken from each fluid donation and mapped to a matrix element with each sample identified by its corresponding element's notation; n aliquots being taken from each sample and subpools formed from the aliquots with each subpool containing an aliquot from all samples mapped to elements in which one of the dimensional indices is fixed. Subpools are tested for viral indication and the dimensional index of each subpool that returns a positive viral indication is determined. The dimensional indices are combined to identify a subset of matrix elements that contain a viral positive sample.
摘要翻译：提供了用于在最少数量的测试周期中鉴定病毒阳性生物流体捐赠的方法。该方法包括提供生物流体捐赠并且定义包括多个元素的n维矩阵，每个元素由包括阵列的每个维度的索引的矩阵符号标识。从每个流体捐赠取样，并将其映射到矩阵元素，每个样本由其对应元素的符号识别; 从每个样品取出等分试样，并从等分试样形成的子泳池，每个子泳池含有来自所有样品的等分试样，其映射到其中一个维度指数是固定的元素。测试子池的病毒指示，并确定返回阳性病毒指示的每个子池的维度指数。组合尺寸指数以识别含有病毒阳性样品的矩阵元素的子集。

4. 发明授权

US6057105A Detection of melanoma or breast metastasis with a multiple marker assay 失效
标题翻译：用多标记检测法检测黑素瘤或乳腺癌转移
公开(公告)号：US6057105A
公开(公告)日：2000-05-02
申请号：US987326
申请日：1997-12-09
申请人： Dave S. B. Hoon , Andrew J. Conrad , Peter Schmid
发明人： Dave S. B. Hoon , Andrew J. Conrad , Peter Schmid
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Methods for detecting metastasis of melanoma and breast cancer cells, detecting subclinical metastasis, and monitoring treatment are disclosed. Kits for use in such methods also are disclosed. The methods provide for the detection of nucleic acids corresponding to multiple melanoma or breast cancer specific markers using template dependent amplification processes. Methods using multiple markers provide increased sensitivity over existing methods.
摘要翻译：公开了检测黑素瘤和乳腺癌细胞转移的方法，检测亚临床转移和监测治疗方法。用于这些方法的试剂盒也被公开。该方法提供使用模板依赖性扩增方法检测对应于多种黑素瘤或乳腺癌特异性标志物的核酸。使用多个标记的方法比现有方法提高了灵敏度。

5. 发明授权

US08959002B2 Characterizing an elongate textile product 有权
标题翻译：表征细长的纺织品
公开(公告)号：US08959002B2
公开(公告)日：2015-02-17
申请号：US13141411
申请日：2009-12-08
申请人： Beat Keller , Stefan Gehrig , Peter Schmid , Loris De Vries
发明人： Beat Keller , Stefan Gehrig , Peter Schmid , Loris De Vries
IPC分类号： B65H63/06
CPC分类号： B65H63/062 , B65H2701/31 , G01N33/365
摘要： Readings of a characteristic of the yarn along the longitudinal direction of the yarn are detected. Values of a yarn parameter are determined from the readings. An event field contains a quadrant of a two-dimensional Cartesian coordinate system, whose abscissa defines an extension of yarn parameter values in the longitudinal direction and whose ordinate defines a deviation of the yarn parameter from a desired value. Densities of events in the event field are determined from the values of the yarn parameter and their extensions in the longitudinal direction. A yarn body is represented as an area in the event field. The area on the one hand is delimited by the abscissa, on the other hand by the ordinate and further by a line in the event field that substantially follows a constant event density. The representation of the yarn body permits a clearing limit to be defined in a rapid and rational manner.
摘要翻译：检测纱线沿纱线长度方向的特性的读数。纱线参数的值由读数确定。事件字段包含二维笛卡尔坐标系的象限，其横坐标定义了纵向上纱线参数值的延伸，纵坐标定义了纱线参数与期望值的偏差。事件场中事件的密度根据纱线参数的值和其在纵向方向上的延伸度来确定。纱线体表示为事件场中的区域。一方面的区域由横坐标限定，另一方面由纵坐标限定，并且进一步通过事件场中的一条直线大致遵循恒定的事件密度。纱线体的表示允许以快速和合理的方式定义清除限度。

6. 发明授权

US06911441B2 Prolonged release pharmaceutical composition 失效
标题翻译：长效释放药物组合物
公开(公告)号：US06911441B2
公开(公告)日：2005-06-28
申请号：US10320250
申请日：2002-12-16
申请人： Peter Schmid , Alexander Boettner , Carsten Schmidt , Mark Allan , Carole Barbot
发明人： Peter Schmid , Alexander Boettner , Carsten Schmidt , Mark Allan , Carole Barbot
IPC分类号： A61K9/22 , A61K31/545 , A61K47/14 , A61K47/24 , A61K31/546
CPC分类号： A61K31/545 , A61K9/0019 , A61K47/14 , A61K47/24
摘要： Novel pharmaceutical compositions of a cephalosporin in a prolonged release vehicle, comprising an oil and aluminium distearate, provide a prolonged duration of effective blood-plasma concentration of the cephalosporin after injection to animals.
摘要翻译：包含油和铝二硬脂酸酯的延长释放载体中的头孢菌素的新型药物组合物在注射到动物之后提供长时间的头孢菌素的有效血浆浓度。

7. 发明授权

US5586452A Jewelry with an integral hinge 失效
标题翻译：珠宝与整体铰链
公开(公告)号：US5586452A
公开(公告)日：1996-12-24
申请号：US192303
申请日：1994-02-04
申请人： Peter Schmid
发明人： Peter Schmid
IPC分类号： A44C3/00 , A44C25/00 , A44C15/00
CPC分类号： A44C25/004 , Y10T29/4959
摘要： An item of jewelry, specifically a locket, is made from stamped rings or rims (36, 38) of which one has an integral pivot pin (40) and the other has a hinge tongue (52) which are formed during the stamping. To connect the rings (36, 38) the tongue 40 is simply passed behind the pin (40) and then wrapped round it. The rings (36, 38) are soldered to respective locket shells (30, 32) to complete the locket.
摘要翻译：一件珠宝，特别是一个小盒子，由冲压的环或边缘（36,38）制成，其中一个具有一体的枢轴销（40），另一个具有在冲压期间形成的铰链舌片（52）。为了连接环（36,38），舌片40简单地通过销钉（40）后面，然后缠绕在其上。环（36,38）被焊接到相应的小盒壳（30,32）以完成小盒。

8. 发明授权

US5425917A Apparatus for attaching a labeled probe and/or antibody to macromolecules 失效
标题翻译：用于将标记的探针和/或抗体连接到大分子的装置
公开(公告)号：US5425917A
公开(公告)日：1995-06-20
申请号：US242148
申请日：1994-05-13
申请人： Peter Schmid
发明人： Peter Schmid
IPC分类号： C12Q1/68 , G01N27/447 , G01N33/00 , G01N27/28
CPC分类号： C12Q1/6813 , G01N27/44717
摘要： An apparatus and method for attaching a labeled probe to macromolecules such as DNA/RNA fragments or proteins attached to a membrane utilizes a flexible bag having an inlet and an outlet port. Reagents including the probe to which the membrane is to be exposed during the labeling process are stored in reservoirs. Pumps are provided to selectively transfer reagents from reservoirs to the inlet port and for selectively evacuating the bag via the outlet port so that reagents from the individual reservoirs can be sequentially supplied to or removed from the bag while the membrane is positioned therein. One or more rollers are arranged to roll back and forth over the top of the bag to uniformly expose the membrane to the reagent within the bag.
摘要翻译：将标记的探针附着到大分子如连接到膜上的DNA / RNA片段或蛋白质的装置和方法利用具有入口和出口的柔性袋。在标签过程中包括膜暴露的探针的试剂储存在储存器中。提供泵以选择性地将试剂从储存器转移到入口端口并且用于通过出口端口选择性地排空袋，使得来自各个储存器的试剂可以在膜定位在其中的过程中顺序地供应到袋或从袋中移除。一个或多个辊布置成在袋的顶部上来回滚动以将膜均匀地暴露于袋内的试剂。

9. 发明授权

US5249359A Process for manufacturing finely structured bodies such as heat exchangers 失效
标题翻译：用于制造诸如热交换器的精细结构体的方法
公开(公告)号：US5249359A
公开(公告)日：1993-10-05
申请号：US854065
申请日：1992-03-19
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
IPC分类号： B01D25/00 , B01J19/00 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , C02F3/10 , F28D9/00 , G02B5/18 , B23D15/00
CPC分类号： G02B5/1852 , B01D25/001 , B01J19/0093 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , F28D9/00 , F28D9/0037 , F28F13/185 , B01D2201/46 , C02F3/101 , F28F2260/00 , Y02W10/15 , Y10T29/301 , Y10T29/307 , Y10T29/4935 , Y10T29/49366 , Y10T29/49826
摘要： A method of producing a finely structured body which includes a plurality of stacked, cut sections of foil at least one of which is provided with grooves in a selected groove direction on at least one surface thereof, and which has a plurality of closely juxtaposed, channel-like perforations with high shape accuracy, true dimensions and high surface quality. The method includes: a. providing a vacuum clamping means comprised of a ground, sintered metal plate which is connected to a vacuum source and which is positioned on a work table which is movable in two mutually perpendicular directions X and Y; b. positioning a machinable foil on the ground, sintered metal plate and clamping the machinable foil thereto by applying an effective amount of vacuum; c. cutting a plurality of parallel grooves into the surface of the machinable foil by means of at least one shaping diamond positioned on a cutting spindle and adjustable in a direction Z, each groove of the plurality of grooves having a groove length, a groove width, and a cross-sectional shape that is constant over the groove length and freely selectable; d. cutting the grooved machinable foil into cut sections having selected lengths and widths; and e. stacking the cut sections, wherein the plurality of grooves have a form precision such that, for groove lengths of more than 1000 .mu.m, the groove width has an accuracy of about +1 .mu.m for land widths which equal or exceed about 15 .mu.m.
摘要翻译：一种制造精细结构体的方法，其包括多个层叠的切割部分的箔，其至少一个在其至少一个表面上沿选定的凹槽方向设置有凹槽，并且具有多个紧密并置的通道类似的穿孔具有高的形状精度，真实的尺寸和高的表面质量。该方法包括：a。提供真空夹紧装置，其包括接地的烧结金属板，该金属板连接到真空源并且位于可在两个相互垂直的方向X和Y上移动的工作台上; b。将可机加工的箔定位在地面上，烧结金属板，并通过施加有效量的真空将可机加工的箔夹紧在其上; C。通过位于切割轴上的至少一个成形金刚石将多个平行凹槽切割成可加工箔的表面，并且可沿方向Z调节，多个凹槽中的每个凹槽具有凹槽长度，凹槽宽度和在槽长度上恒定的横截面形状并且可自由选择; d。将切槽的可加工箔切割成具有选定长度和宽度的切割部分; 和e。堆叠切割部分，其中多个凹槽具有形状精度，使得对于大于1000μm的凹槽长度，对于等于或超过约15μm的凹槽宽度，凹槽宽度具有约+1μm的精度。

10. 发明授权

US3933211A Buoyancy balance 失效
标题翻译：浮力平衡
公开(公告)号：US3933211A
公开(公告)日：1976-01-20
申请号：US497618
申请日：1974-08-15
申请人： Peter Schmid
发明人： Peter Schmid
IPC分类号： G01G5/02
CPC分类号： G01G5/02
摘要： A buoyancy balance incorporating a buoyant body floating in a fluid and a load bowl or scale operatively coupled with the buoyant body. The invention contemplates the provision of means for partially compensating the change in buoyancy brought about by the movement of the load bowl.
摘要翻译：浮力平衡结合了漂浮在流体中的浮体和与浮力体可操作耦合的载荷碗或秤。本发明设想提供用于部分地补偿由负载碗的运动引起的浮力变化的装置。

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