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1. 发明申请

US20080076836A1 METHOD AND APPARATUS FOR USING LIGHT TO ENHANCE CELL GROWTH AND SURVIVAL 审中-公开
标题翻译：使用光提高细胞生长和存活的方法和装置
公开(公告)号：US20080076836A1
公开(公告)日：2008-03-27
申请号：US11843573
申请日：2007-08-22
申请人： Darrell Wagner , Haris Sih , Steven Girouard
发明人： Darrell Wagner , Haris Sih , Steven Girouard
IPC分类号： A61K31/00 , A61P43/00 , C12P1/00 , C12Q1/02
CPC分类号： G01N33/5017 , G01N2500/10
摘要： A biologic agent preparation system is provided for producing one or more biologic agents in vitro including pro-growth factors and/or pro-survival factors from cells. The one or more biologic agents are produced in response to exposure of mammalian cells to light. A biologic agent delivery system is also provided that delivers the pro-growth factors and/or pro-survival factors to an injured tissue region, or delivers cells treated with the pro-growth factors and/or pro-survival factors to the injured tissue region.
摘要翻译：提供生物制剂制备系统用于在体外制备一种或多种生物制剂，包括来自细胞的促生长因子和/或促生存因子。响应于哺乳动物细胞暴露于光而产生一种或多种生物制剂。还提供生物剂递送系统，其将促生长因子和/或促生存因子递送至损伤的组织区域，或将用促生长因子和/或促生存因子处理的细胞递送至受损组织区域。

2. 发明申请

US20070036770A1 Biologic device for regulation of gene expression and method therefor 审中-公开
标题翻译：用于调节基因表达的生物装置及其方法
公开(公告)号：US20070036770A1
公开(公告)日：2007-02-15
申请号：US11272432
申请日：2005-11-10
申请人： Darrell Wagner , Haris Sih , Jihong Ou , Jeffrey Ross , Steven Girouard , Ronald Heil
发明人： Darrell Wagner , Haris Sih , Jihong Ou , Jeffrey Ross , Steven Girouard , Ronald Heil
IPC分类号： A61K48/00 , G06F19/00 , C12N15/86
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

3. 发明申请

US20070036771A1 BIOLOGIC DEVICE FOR REGULATION OF GENE EXPRESSION AND METHOD THEREFOR 审中-公开
标题翻译：用于调节基因表达的生物学设备及其方法
公开(公告)号：US20070036771A1
公开(公告)日：2007-02-15
申请号：US11277552
申请日：2006-03-27
申请人： Darrell Wagner , Haris Sih , Jihong Qu , Jeffrey Ross , Steven Girouard , Ronald Heil
发明人： Darrell Wagner , Haris Sih , Jihong Qu , Jeffrey Ross , Steven Girouard , Ronald Heil
IPC分类号： A61K48/00 , G06F19/00 , A61N1/00
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

4. 发明申请

US20070150005A1 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US20070150005A1
公开(公告)日：2007-06-28
申请号：US11318263
申请日：2005-12-23
申请人： Haris Sih , Tamara Baynham , Darrell Wagner
发明人： Haris Sih , Tamara Baynham , Darrell Wagner
IPC分类号： A61N1/36
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

5. 发明申请

US20080091242A1 Subcutaneous cardiac sensing and stimulation system employing blood sensor 有权
标题翻译：使用血液传感器的皮下心脏感知和刺激系统
公开(公告)号：US20080091242A1
公开(公告)日：2008-04-17
申请号：US11975040
申请日：2007-10-17
申请人： Apurv Kamath , Paul Haefner , Darrell Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell Wagner , Marina Brockway
IPC分类号： A61N1/05
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸内放置并且设置在壳体中或外壳上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

6. 发明申请

US20080058905A1 METHOD AND APPARATUS UTILIZING LIGHT AS THERAPY FOR FUNGAL INFECTION 审中-公开
标题翻译：方法和装置利用光作为治疗真菌感染
公开(公告)号：US20080058905A1
公开(公告)日：2008-03-06
申请号：US11847539
申请日：2007-08-30
申请人： Darrell Wagner
发明人： Darrell Wagner
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61N2005/0645 , A61N2005/0652 , A61N2005/0662
摘要： Described herein are methods and apparatus for treating fungal nail infections and similar diseases with light therapy. In one embodiment, an apparatus that utilizes one or more blue light emitting diodes (LED) to irradiate fungus residing under and around the nail is applied externally to a toe or finger in order to kill the fungus and restore normal nail growth. Light therapy may applied in this manner periodically at scheduled times. Another embodiment involves the use of a bootie-like structure having blue light emitting diodes for irradiating the toes, heal, and foot bottom.
摘要翻译：本文描述了用光疗法治疗真菌指甲感染和类似疾病的方法和装置。在一个实施例中，利用一个或多个蓝色发光二极管（LED）照射驻留在指甲下方和周围的真菌的装置在外部施加到脚趾或手指以杀死真菌并恢复正常的指甲生长。定期施用光疗法。另一实施例涉及使用具有蓝色发光二极管的靴状结构来照射脚趾，愈合和脚底。

7. 发明授权

US06957104B2 Ventricular pacing for prevention of atrial fibrillation 失效
标题翻译：心室起搏预防心房颤动
公开(公告)号：US06957104B2
公开(公告)日：2005-10-18
申请号：US10038498
申请日：2002-01-03
申请人： Darrell Wagner
发明人： Darrell Wagner
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/395
摘要： A method and apparatus for preventing atrial fibrillation arising from a premature atrial contraction. Upon detection of a premature atrial contraction, a pace is delivered to a ventricle at a specified AV interval selected as either a late-pace or early-pace value. The resulting ventricular depolarization then occurs during a time when the atria are not vulnerable to the triggering of fibrillation.
摘要翻译：一种用于预防心房颤动的方法和装置，其由过早的心房收缩引起。在检测到过早的心房收缩时，以指定的AV间隔将步调递送到心室，其被选择为晚期或早期值。因此，心房去极化随后发生在心房不易触发原纤化的时期。

8. 发明申请

US20070123923A1 Implantable medical device minimizing rotation and dislocation 审中-公开
标题翻译：植入式医疗器械减少旋转和脱位
公开(公告)号：US20070123923A1
公开(公告)日：2007-05-31
申请号：US11290355
申请日：2005-11-30
申请人： Curtis Lindstrom , Ronald Heil , Jason Shiroff , Paul Haefner , Adam Cates , Darrell Wagner
发明人： Curtis Lindstrom , Ronald Heil , Jason Shiroff , Paul Haefner , Adam Cates , Darrell Wagner
IPC分类号： A61N1/375 , A61F2/04
CPC分类号： A61F2/0095 , A61N1/375
摘要： Housings for implantable medical devices are configured so as to engage with surrounding tissues inside of a body and resist both rotation in place and movement through the body. Device housings include shapes, surface features, and/or standard surfaces and may include attached implements that engage the surrounding tissue. Shapes include elongated members, flared ends, and so forth. Surface features include pores, grooves, through-holes, and so forth. Attached implements include needles, barbs, tension springs, and so forth. Also provided are methods for engaging an implantable medical device with surrounding tissues.
摘要翻译：用于可植入医疗装置的壳体构造成与身体内的周围组织接合并抵抗适当位置的旋转和穿过身体的运动。设备外壳包括形状，表面特征和/或标准表面，并且可以包括接合周围组织的附接工具。形状包括细长构件，扩口端等。表面特征包括孔，槽，通孔等。附件包括针，倒钩，拉伸弹簧等。还提供了用于使可植入医疗装置与周围组织接合的方法。

9. 发明申请

US20050038350A1 Biopotential signal source separation using source impedances 有权
标题翻译：使用源阻抗的生物电位信号源分离
公开(公告)号：US20050038350A1
公开(公告)日：2005-02-17
申请号：US10821206
申请日：2004-04-08
申请人： Apurv Kamath , Darrell Wagner , Paul Haefner , Marina Brockway
发明人： Apurv Kamath , Darrell Wagner , Paul Haefner , Marina Brockway
IPC分类号： A61B5/042 , A61B5/0428 , A61B5/0464 , A61N1/365 , A61N1/39 , A61B5/0402
CPC分类号： A61B5/0464 , A61B5/042 , A61B5/0428 , A61N1/36585 , A61N1/3956
摘要： Cardiac methods and devices that separate signals using at least two composite signals acquired at least at two input impedances. A target source impedance may be selected, and a cardiac signal may be separated from composite signals using the selected target source impedance. Medical systems include a cardiac device having a housing that provides amplification circuitry configured to have a first amplifier input impedance and a second amplifier input impedance, such as using two separate circuits or switching between two input impedances. One or more electrode assemblies are coupled to the amplification circuitry. A signal processor is provided in the housing configured to separate a source signal using a first composite signal detected at the first input impedance and a second composite signal detected at the second input impedance. The phase response of the first input amplifier circuit is about equal to that of the second input amplifier circuit.
摘要翻译：使用至少两个输入阻抗获取的至少两个复合信号分离信号的心脏方法和装置。可以选择目标源阻抗，并且可以使用所选择的目标源阻抗将心脏信号与复合信号分离。医疗系统包括具有壳体的心脏装置，其提供被配置为具有第一放大器输入阻抗和第二放大器输入阻抗的放大电路，例如使用两个分离的电路或在两个输入阻抗之间切换。一个或多个电极组件耦合到放大电路。信号处理器设置在壳体中，配置成使用在第一输入阻抗处检测到的第一复合信号和在第二输入阻抗处检测到的第二复合信号来分离源信号。第一输入放大器电路的相位响应大约等于第二输入放大器电路的相位响应。

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