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1. 发明申请

US20080004479A1 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US20080004479A1
公开(公告)日：2008-01-03
申请号：US11820238
申请日：2007-06-18
申请人： Daren Stewart , Paul Lovoi , Thomas Rusch , Alex Lim , Darius Francescatti
发明人： Daren Stewart , Paul Lovoi , Thomas Rusch , Alex Lim , Darius Francescatti
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

2. 发明申请

US20050080313A1 Applicator for radiation treatment of a cavity 审中-公开
标题翻译：辐射治疗腔的施放器
公开(公告)号：US20050080313A1
公开(公告)日：2005-04-14
申请号：US10683885
申请日：2003-10-10
申请人： Daren Stewart , Paul Lovoi , Thomas Rusch , Alex Lim , Darius Francescatti
发明人： Daren Stewart , Paul Lovoi , Thomas Rusch , Alex Lim , Darius Francescatti
IPC分类号： A61B5/00 , A61B6/00 , A61M25/00 , A61M36/00 , A61N20060101 , A61N5/10
CPC分类号： A61N5/1015 , A61M25/1002 , A61M2025/0008 , A61M2025/1086 , A61M2210/1007 , A61N2005/1018
摘要： An applicator for facilitating radiation treatment in a body cavity, particularly post resection, provides for superior wound closure management, with an integrated drain and a flexible main shaft that permits further treatments at intervals without disturbing the wound closure. The drain includes channels in the shaft, and the surface of an expandable balloon of the applicator may have features that help channel the flow of drain liquids toward the cavity entrance. Non-spherical, irregular geometries of balloons are achieved in several different ways. In some embodiments multiple balloons are included, either an inner and outer balloon or a series of balloons extending outwardly from the main shaft. Non-balloon applicators are also disclosed.
摘要翻译：用于促进体腔中辐射治疗，特别是后切除术的施用器提供了优异的创伤闭合管理，具有集成的排水管和柔性主轴，其允许间隔进一步的治疗而不干扰伤口闭合。排水口包括轴中的通道，并且施加器的可膨胀气囊的表面可以具有帮助将排出液体流向空腔入口的特征。气球的非球形，不规则几何形状以几种不同的方式实现。在一些实施例中，包括多个气囊，内球囊和外球囊或从主轴向外延伸的一系列气球。还公开了无气球涂抹器。

3. 发明申请

US20050080340A1 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US20050080340A1
公开(公告)日：2005-04-14
申请号：US10962247
申请日：2004-10-08
申请人： Daren Stewart , Paul Lovoi , Thomas Rusch , Alex Lim , Darius Francescatti
发明人： Daren Stewart , Paul Lovoi , Thomas Rusch , Alex Lim , Darius Francescatti
IPC分类号： A61B5/00 , A61B6/00 , A61B17/22 , A61B19/00 , A61M25/00 , A61M36/00 , A61N20060101 , A61N5/10
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

4. 发明申请

US20060173235A1 Gynecological brachytherapy applicator and system 失效
标题翻译：妇科近距离放射治疗仪和系统
公开(公告)号：US20060173235A1
公开(公告)日：2006-08-03
申请号：US11323346
申请日：2005-12-30
申请人： Alex Lim , Paul Lovoi , Heike Hausen , Daren Stewart
发明人： Alex Lim , Paul Lovoi , Heike Hausen , Daren Stewart
IPC分类号： A61N5/00
CPC分类号： A61N5/1016 , A61N5/1048 , A61N2005/1005
摘要： A vaginal brachytherapy applicator is versatile to different anatomies and more comfortable to the patient than prior applicators. An inflatable balloon on a shaft may be inelastic or elastic. In one embodiment the shaft is rotatable relative to the balloon for enabling a ring or band of dose delivery, for versatility in radiation placement. Alternatively, the source can be rotated and pulled back within a stationary shaft. An adjustment is provided for reducing the length of balloon that inflates, to accommodate different anatomies and positions. Although isotope radiation sources can be used in the applicator, an electronic source is preferred, and the system and method include procedures for using the applicator with an electronic source.
摘要翻译：阴道近距离放射治疗仪对于不同的解剖结构是多功能的，对于患者而言比以前的给药者更舒适。轴上的可膨胀气球可能是无弹性的或弹性的。在一个实施例中，轴可相对于球囊旋转，以实现用于辐射放置的多功能性的剂量递送环或带。或者，源可以在固定轴内旋转和拉回。提供了一种减小气囊膨胀长度的调整，以适应不同的解剖结构和位置。虽然同位素辐射源可以用于施用器中，但是电子源是优选的，并且该系统和方法包括使用具有电子源的施加器的程序。

5. 发明申请

US20060171506A1 MINIATURE X-RAY TUBE COOLING SYSTEM 有权
标题翻译：微型X射线管冷却系统
公开(公告)号：US20060171506A1
公开(公告)日：2006-08-03
申请号：US10789653
申请日：2004-02-28
申请人： Paul Lovoi , John Rieke , Alex Lim , Peter Smith , Thomas Rusch
发明人： Paul Lovoi , John Rieke , Alex Lim , Peter Smith , Thomas Rusch
IPC分类号： H01J35/10 , H01J35/26 , H01J35/24 , H01J35/28 , H01J35/12
CPC分类号： A61N5/1002 , A61M25/003 , A61M25/10 , A61M2025/0004 , A61M2025/0034 , A61M2025/0036 , A61M2025/0039 , A61N2005/005 , A61N2005/1022 , H01J35/32 , H01J2235/1216 , H01J2235/122 , H01J2235/1262 , H05G1/025
摘要： A miniature x-ray tube is cooled using a catheter preferably having multiple small lumens for inflow and outflow of coolant. Inflow may be through an outer lumen(s) in a concentric-extrusion catheter, the liquid turning back at the distal end of the catheter to a proximal flow over the anode end of the x-ray tube and through an inner lumen within which the x-ray tube is positioned. A coolant distribution head may engage with the anode end of the x-ray tube, with small orifices so as to distribute coolant essentially evenly over the anode surface. Temperature and flow rate of the inflowing coolant liquid are balanced so as to optimize heat transfer while efficiently carrying coolant through small lumens without the need for high pressures. Some embodiments use the inflation liquid in an applicator balloon as the coolant, with the liquid actively flowing or, in a simplified system, with the liquid static.
摘要翻译：使用优选具有用于冷却剂的流入和流出的多个小流明的导管来冷却微型X射线管。流入可以穿过同心挤出导管中的外腔，液体在导管的远端处返回到X射线管的阳极端上的近端流动并且穿过内腔，在内腔内 x射线管被定位。冷却剂分配头可以与X射线管的阳极端接合，具有小孔，以便将冷却剂基本均匀地分布在阳极表面上。流入的冷却剂液体的温度和流速是平衡的，以便优化热传递，同时有效地将冷却剂携带在小流明中，而不需要高压。一些实施例使用施用器气囊中的充气液体作为冷却剂，其中液体主动地流动，或者在简化的系统中使液体静止。

6. 发明授权

US07783006B2 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US07783006B2
公开(公告)日：2010-08-24
申请号：US10962247
申请日：2004-10-08
申请人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
发明人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

7. 发明授权

US07885382B2 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US07885382B2
公开(公告)日：2011-02-08
申请号：US11820238
申请日：2007-06-18
申请人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
发明人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

8. 发明申请

US20060173232A1 HDR adapter for electronic radiation source applicator 审中-公开
标题翻译：用于电子辐射源的HDR适配器
公开(公告)号：US20060173232A1
公开(公告)日：2006-08-03
申请号：US11323347
申请日：2005-12-30
申请人： Paul Lovoi , Alex Lim
发明人： Paul Lovoi , Alex Lim
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N2005/1008
摘要： An applicator designed for use with a miniature electronic x-ray source, having a relatively large guide for the electronic source, is modified by an adapter inserted into the source guide to produce a narrower-diameter guide that will receive a standard afterloader that irradiates with isotopes.
摘要翻译：设计用于具有用于电子源的相对较大的引导件的微型电子X射线源的施加器被插入到源引导件中的适配器改变以产生更窄直径的引导件，其将接收标准的后加载器，该引导器照射同位素

9. 发明申请

US20050061533A1 High voltage cable for a miniature x-ray tube 有权
标题翻译：用于微型X射线管的高压电缆
公开(公告)号：US20050061533A1
公开(公告)日：2005-03-24
申请号：US10961962
申请日：2004-10-08
申请人： Paul Lovoi , Peter Smith , Alex Lim
发明人： Paul Lovoi , Peter Smith , Alex Lim
IPC分类号： A61N5/10 , H01J9/04 , H01J9/24 , H01J35/06 , H01J35/32 , H01B1/00 , H01J35/00 , H01J35/22 , H02G1/00
CPC分类号： A61N5/1001 , A61N5/1002 , H01J9/04 , H01J9/24 , H01J35/06 , H01J35/32 , H01J2235/02 , H01J2235/164
摘要： In a miniature x-ray tube, which may be on the order of approximately 1 mm in diameter or even less, a high voltage cable is provided in various embodiments for conducting current to the cathode of the x-ray tube and for conducting high voltage to the cathode and anode of the tube. In various embodiments of the cable, two conductors occupy a center region of the cable, packed as closely together as possible, in various shapes that are compact and present as smooth as possible an external shape for maximizing dielectric properties against the exterior high voltage ground, surrounding and generally concentric with the inner conductors. The inner conductors, which carry high voltage in opposition to the outer ground, can be in opposed D shapes, coaxial, two flattened conductors side by side, or simply a pair of cylindrical wires positioned as closely as possible. The space between the inner conductors and the outer ground can be occupied by a glass insulator, polymer, successive layers of polymers and adhesive, air, gas, vacuum or other dielectrics. A partially conductive region can surround the inner conductors.
摘要翻译：在可以在大约1mm直径甚至更小的数量级的微型x射线管中，在各种实施例中提供高压电缆，用于将电流传导到x射线管的阴极和用于传导高电压到管的阴极和阳极。在电缆的各种实施例中，两个导体占据电缆的中心区域，尽可能紧密地包装在各种形状中，其紧凑并呈现尽可能平滑的外部形状，用于使外部高压地面的介电特性最大化，围绕并且与内部导体大致同心。承载与外部地面相对的高电压的内部导体可以彼此相对的D形状，同轴的，两个扁平的导体，或简单的一对圆柱形的电线尽可能靠近。内部导体和外部地面之间的空间可以由玻璃绝缘体，聚合物，连续的聚合物层和粘合剂，空气，气体，真空或其它电介质占据。部分导电区域可以围绕内部导体。

10. 发明申请

US20080167514A1 Gynecological brachytherapy applicator and system 有权
标题翻译：妇科近距离放射治疗仪和系统
公开(公告)号：US20080167514A1
公开(公告)日：2008-07-10
申请号：US12074468
申请日：2008-03-03
申请人： Alex Lim , Paul A. Lovoi , Heike Hausen , Daren L. Stewart
发明人： Alex Lim , Paul A. Lovoi , Heike Hausen , Daren L. Stewart
IPC分类号： A61M36/10
CPC分类号： A61N5/1016 , A61N5/1048 , A61N2005/1005
摘要： A vaginal brachytherapy applicator is versatile to different anatomies and more comfortable to the patient than prior applicators. An inflatable balloon on a shaft may be inelastic or elastic. In one embodiment the shaft is rotatable relative to the balloon for enabling a ring or band of dose delivery, for versatility in radiation placement. Alternatively, the source can be rotated and pulled back within a stationary shaft. An adjustment is provided for reducing the length of balloon that inflates, to accommodate different anatomies and positions. Although isotope radiation sources can be used in the applicator, an electronic source is preferred, and the system and method include procedures for using the applicator with an electronic source.
摘要翻译：阴道近距离放射治疗仪对于不同的解剖结构是多功能的，对于患者而言比以前的给药者更舒适。轴上的可膨胀气球可能是无弹性的或弹性的。在一个实施例中，轴可相对于球囊旋转，以实现用于辐射放置的多功能性的剂量递送环或带。或者，源可以在固定轴内旋转和拉回。提供了一种减小气囊膨胀长度的调整，以适应不同的解剖结构和位置。虽然同位素辐射源可以用于施用器中，但是电子源是优选的，并且该系统和方法包括使用具有电子源的施加器的程序。

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