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1. 发明授权

US07783006B2 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US07783006B2
公开(公告)日：2010-08-24
申请号：US10962247
申请日：2004-10-08
申请人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
发明人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

2. 发明授权

US07885382B2 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US07885382B2
公开(公告)日：2011-02-08
申请号：US11820238
申请日：2007-06-18
申请人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
发明人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

3. 发明授权

US07127033B2 Miniature x-ray tube cooling system 有权
标题翻译：微型X射线管冷却系统
公开(公告)号：US07127033B2
公开(公告)日：2006-10-24
申请号：US10789653
申请日：2004-02-28
申请人： Paul A. Lovoi , John Rieke , Alex Lim , Peter C. Smith , Thomas W. Rusch
发明人： Paul A. Lovoi , John Rieke , Alex Lim , Peter C. Smith , Thomas W. Rusch
IPC分类号： H01J35/32
CPC分类号： A61N5/1002 , A61M25/003 , A61M25/10 , A61M2025/0004 , A61M2025/0034 , A61M2025/0036 , A61M2025/0039 , A61N2005/005 , A61N2005/1022 , H01J35/32 , H01J2235/1216 , H01J2235/122 , H01J2235/1262 , H05G1/025
摘要： A miniature x-ray tube is cooled using a catheter preferably having multiple small lumens for inflow and outflow of coolant. Inflow may be through an outer lumen(s) in a concentric-extrusion catheter, the liquid turning back at the distal end of the catheter to a proximal flow over the anode end of the x-ray tube and through an inner lumen within which the x-ray tube is positioned. A coolant distribution head may engage with the anode end of the x-ray tube, with small orifices so as to distribute coolant essentially evenly over the anode surface. Temperature and flow rate of the inflowing coolant liquid are balanced so as to optimize heat transfer while efficiently carrying coolant through small lumens without the need for high pressures. Some embodiments use the inflation liquid in an applicator balloon as the coolant, with the liquid actively flowing or, in a simplified system, with the liquid static.
摘要翻译：使用优选具有用于冷却剂的流入和流出的多个小流明的导管来冷却微型X射线管。流入可以穿过同心挤出导管中的外腔，液体在导管的远端处返回到X射线管的阳极端上的近端流动并且穿过内腔，在内腔内 x射线管被定位。冷却剂分配头可以与X射线管的阳极端接合，具有小孔，以便将冷却剂基本均匀地分布在阳极表面上。流入的冷却剂液体的温度和流速是平衡的，以便优化热传递，同时有效地将冷却剂携带在小流明中，而不需要高压。一些实施例使用施用器气囊中的充气液体作为冷却剂，其中液体主动地流动，或者在简化的系统中使液体静止。

4. 发明申请

US20100074407A1 Treatment of lesions or imperfections in skin, near-skin or in other anatomic tissues, including under direct visualization 审中-公开
标题翻译：治疗皮肤，近皮肤或其他解剖组织中的损伤或缺陷，包括直接观察
公开(公告)号：US20100074407A1
公开(公告)日：2010-03-25
申请号：US12284289
申请日：2008-09-19
申请人： Steve Axelrod , Thomas W. Rusch , Paul A. Lovoi , Anuradha Walawalkar , Sara Z. Yao
发明人： Steve Axelrod , Thomas W. Rusch , Paul A. Lovoi , Anuradha Walawalkar , Sara Z. Yao
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1001 , A61N2005/1091 , A61N2005/1094 , A61N2005/1095
摘要： An apparatus and method for treatment of lesions or imperfections in or near exposed anatomic surfaces using low-level ionizing radiation includes a substantially transparent applicator to administer radiation from an energy source to a surface area with the lesion. The applicator is positioned over the lesion to be treated, a treatment plan is created to achieve the desired therapeutic effect to the lesion, and execution of the treatment plan is executed by the energy source. Verification of the treatment to plan and safety methods are disclosed.
摘要翻译：用于使用低级电离辐射治疗暴露的解剖表面内或附近的损伤或缺陷的装置和方法包括基本上透明的施用器，以将能量源的辐射施加到具有损伤的表面区域。施用器位于要治疗的病变上，创建治疗计划以实现对病变的期望的治疗效果，并且由能量源执行治疗计划的执行。公开了对计划和安全方法的处理的验证。

5. 发明授权

US07158612B2 Anode assembly for an x-ray tube 有权
标题翻译：用于X射线管的阳极组件
公开(公告)号：US07158612B2
公开(公告)日：2007-01-02
申请号：US10371401
申请日：2003-02-21
申请人： Thomas W. Rusch , Peter C. Smith , Steven D. Hansen , Paul A. Lovoi , Donald G. Pellinen
发明人： Thomas W. Rusch , Peter C. Smith , Steven D. Hansen , Paul A. Lovoi , Donald G. Pellinen
IPC分类号： H01J35/32 , H01J35/20
CPC分类号： H01J35/08 , H01J35/32 , H01J2235/081 , H01J2235/087 , H01J2235/164
摘要： A miniature x-ray tube has an anode assembly capable of transmitting x-rays through the anode and over a wide angular range. The anode is in the shape of a cone or truncated cone with an axis on the x-ray tube frame axis, formed of low-Z material with high thermal conductivity for heat dissipation. A target material on the anode body is in a thin layer, which may be approximately 0.5 to 5 microns thick. In one embodiment a tube evacuation exhaust port at the tail end of the anode assembly forms a cavity for a getter, with a pinched-off tubulation at the end of the cavity.
摘要翻译：微型x射线管具有能够通过阳极透射x射线并且在宽角度范围内的阳极组件。阳极呈圆锥形或截锥形，X射线管框架轴上具有轴，由具有高导热性的低Z材料形成，用于散热。阳极体上的目标材料为薄层，其厚度可为约0.5至5微米。在一个实施例中，在阳极组件的尾端处的排气排气口形成用于吸气剂的空腔，在空腔的端部处具有夹断的管道。

6. 发明授权

US3937958A Charged particle beam apparatus 失效
标题翻译：带电粒子束装置
公开(公告)号：US3937958A
公开(公告)日：1976-02-10
申请号：US563330
申请日：1975-03-31
申请人： Thomas W. Rusch , Jerry A. Sievers
发明人： Thomas W. Rusch , Jerry A. Sievers
IPC分类号： G01N23/225 , G21K1/087 , H01J37/063 , H01J37/08 , H01J37/26 , H05H7/08
CPC分类号： H01J37/08 , G21K1/087 , H01J37/063
摘要： A charged particle beam (e.g., ions or electrons) apparatus including two electrostatic focusing lenses and an electrode having a diameter limiting aperture positioned between the lenses is further provided with two electrode assemblies which interact with an extractor electrode and with a source of charged particles such that the trajectories of the particles in the beam passing through the second of the two assemblies are substantially parallel. This feature and other disclosed improvements facilitate the production of a substantially monoenergetic beam which under a first set of conditions can be focused to provide a small-diameter, spherical-aberration limited beam and which under another set of conditions, can be focused to provide a high current beam.
摘要翻译：包括两个静电聚焦透镜和位于透镜之间的具有直径限制孔的电极的带电粒子束（例如，离子或电子）装置还设置有两个电极组件，其与提取器电极和带电粒子源通过两个组件中的第二个组件的束中的颗粒的轨迹基本上平行。该特征和其他公开的改进有助于生产基本单能束，其在第一组条件下可以被聚焦以提供小直径的球面像差受限束，并且在另一组条件下可以聚焦以提供高电流束。

7. 发明申请

US20130030238A1 BRACHYTHERAPY DEVICES, KITS AND METHODS OF USE 审中-公开
标题翻译： BRACHYTHERAPY DEVICES，KITTS AND METHODS OF USE
公开(公告)号：US20130030238A1
公开(公告)日：2013-01-31
申请号：US13192426
申请日：2011-07-27
申请人： Linda A. Kelley , Randall W. Holt , Aileen Lum , Anuradha Walawalkar , Thomas W. Rusch
发明人： Linda A. Kelley , Randall W. Holt , Aileen Lum , Anuradha Walawalkar , Thomas W. Rusch
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1016 , A61N5/1027 , A61N2005/1022 , A61N2005/1095
摘要： The radial dose function of an electronic x-ray brachytherapy source is flattened by filtering with transition metals in the fourth row of the periodic table, i.e. titanium through nickel. Titanium-walled applicator devices of small diameter, under 10 mm, and with wall thicknesses of about 0.2 mm to 0.6 mm, are disclosed. The walls can be of titanium or alloys thereof, providing adequate strength and flattening the radial dose function curve particularly for x-rays in an energy range of about 45 kV to 55 kV.
摘要翻译：电子X射线近距离放射治疗源的径向剂量功能通过用周期表第四行中的过渡金属（即钛通过镍）过滤而变平。公开了直径小于10毫米，壁厚约0.2毫米至0.6毫米的钛壁施用装置。壁可以是钛或其合金，提供足够的强度并使径向剂量函数曲线变平，特别是对于在约45kV至55kV的能量范围内的X射线。

8. 发明申请

US20110305316A1 Apparatus and methods for radiation treatment of tissue surfaces 有权
标题翻译：组织表面放射治疗的装置和方法
公开(公告)号：US20110305316A1
公开(公告)日：2011-12-15
申请号：US12802744
申请日：2010-06-11
申请人： Randall W. Holt , Steve Axelrod , Robert Burnside , Robert G. Neimeyer , Thomas W. Rusch
发明人： Randall W. Holt , Steve Axelrod , Robert Burnside , Robert G. Neimeyer , Thomas W. Rusch
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/103 , A61N5/1043 , A61N2005/1091
摘要： A device, system and method for administering radiation therapy to a tissue surface of a patient utilizes an applicator capable of controlled movement and repositioning over a selected area of tissue, under the control of a computer or controller. A servo-controlled manipulator can effect a raster scan of the desired area, such as an area of the skin, and this can be in any desired pattern such as serpentine, spiral, parallel but unidirectional, or irregular patterns. Preferably a third direction of control is included, i.e. a depth direction, with an appropriate form of depth sensor, a signal from which can be used to adjust the radiation source so that radiation of the tissue surface is consistent over varied contoured.
摘要翻译：用于向患者的组织表面施用放射治疗的装置，系统和方法利用在计算机或控制器的控制下能够受控地移动和重新定位在组织的选定区域上的施加器。伺服控制的机械手可以对期望的区域（例如皮肤区域）进行光栅扫描，并且这可以是任何期望的图案，例如蛇形，螺旋，平行但单向或不规则图案。优选地，包括第三控制方向，即具有适当形式的深度传感器的深度方向，可以使用信号来调整辐射源，使得组织表面的辐射在多种轮廓上是一致的。

9. 发明申请

US20100022818A1 Applicators for brachytherapy treatment 审中-公开
标题翻译：近距离放射治疗的施放者
公开(公告)号：US20100022818A1
公开(公告)日：2010-01-28
申请号：US12220717
申请日：2008-07-25
申请人： Steve Axelrod , Thomas W. Rusch , Linda Kelley , Lucymarie Mantese
发明人： Steve Axelrod , Thomas W. Rusch , Linda Kelley , Lucymarie Mantese
IPC分类号： A61M36/04
CPC分类号： A61N5/1015 , A61M25/10 , A61N2005/1094
摘要： An applicator for brachytherapy radiation avoids over-radiation in the distal axial direction from a source positioned in the applicator, by attenuating distal axial radiation which tends to over-radiate, causing a “hot spot” in tissue in the axial direction, when the radiation travels through air space in the lumen.
摘要翻译：用于近距离放射线辐射的施加器避免了远离轴向方向的过度辐射，该辐射通过减弱趋向于过度辐射的远端轴向辐射，从而使得在轴向方向上的组织中产生“热点” 穿过管腔中的空气空间。

10. 发明申请

US20090227827A1 Vaginal applicator for brachytherapy treatment of vaginal and endometrial disease 审中-公开
标题翻译：用于近距离放射治疗阴道和子宫内膜疾病的阴道涂抹器
公开(公告)号：US20090227827A1
公开(公告)日：2009-09-10
申请号：US12075120
申请日：2008-03-05
申请人： Heike Hausen , Thomas W. Rusch , James E. Jervis
发明人： Heike Hausen , Thomas W. Rusch , James E. Jervis
IPC分类号： A61M36/10
CPC分类号： A61N5/1016
摘要： A vaginal brachytherapy applicator has an insertable tip section, preferably rigid or at least firm enough to retain its shape when inserted, and a tubular handle section extending proximally from the tip section. A common lumen extends from the handle into and through most of the length of the tip section. In one embodiment the tip section is made of a flexible open-celled foam material with a substantially impermeable outer skin, and in this case the tip section can be contracted, or stretched lengthwise to reduce its diameter, for ease of insertion, then re-expanded to its nominal and working configuration prior to insertion of a radiation source into the lumen and irradiation of tissue surrounding the tip section.
摘要翻译：阴道近距离放射治疗器具有可插入的尖端部分，优选刚性或至少足够坚固以在插入时保持其形状，以及从尖端部分向近侧延伸的管状手柄部分。共同的内腔从手柄延伸并穿过尖端部分的大部分长度。在一个实施例中，尖端部分由具有基本上不可渗透的外皮的柔性开孔泡沫材料制成，并且在这种情况下，尖端部分可以收缩或纵向拉伸以减小其直径，以便于插入，在将辐射源插入管腔中并且在末梢部分周围的组织的照射之前扩展到其标称和工作配置。

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