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1. 发明申请

US20090098148A1 HIGH EFFICIENCY TISSUE-SPECIFIC COMPOUND DELIVERY SYSTEM USING STREPTAVADIN-PROTEIN A FUSION PROTEIN 审中-公开
标题翻译：使用STREPTAVADIN蛋白质融合蛋白的高效组织特异性化合物递送系统
公开(公告)号：US20090098148A1
公开(公告)日：2009-04-16
申请号：US12335010
申请日：2008-12-15
申请人： Daniel Meruelo , Kouichi Ohno , Brandi A. Levin
发明人： Daniel Meruelo , Kouichi Ohno , Brandi A. Levin
IPC分类号： A61K39/395 , C07K16/18 , C12N9/96
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/6817 , A61K47/6898 , C07K16/2833 , C07K16/2863 , C07K16/2896 , C07K2319/00
摘要： The present invention relates to methods and compositions that can be employed to introduce toxins and nucleic acids into the cytoplasm or nucleus of a eukaryotic cell, particularly a cell of a higher vertebrate. The invention particularly concerns the use of a fusion protein of streptavidin and protein A sequences to form a non-covalent complex of a toxin or nucleic acid and an antibody.
摘要翻译：本发明涉及可用于将毒素和核酸引入真核细胞，特别是较高脊椎动物细胞的细胞质或细胞核的方法和组合物。本发明特别涉及使用链霉亲和素和蛋白A序列的融合蛋白来形成毒素或核酸和抗体的非共价复合物。

2. 发明授权

US06497881B1 High efficiency tissue specific compound delivery system using streptavidin-protein a fusion protein 失效
标题翻译：使用链霉抗生物素蛋白 - 融合蛋白的高效组织特异性化合物递送系统
公开(公告)号：US06497881B1
公开(公告)日：2002-12-24
申请号：US08566421
申请日：1995-11-30
申请人： Daniel Meruelo , Kouichi Ohno , Brandi A. Levin
发明人： Daniel Meruelo , Kouichi Ohno , Brandi A. Levin
IPC分类号： A61K39385
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/6817 , A61K47/6898 , C07K16/2833 , C07K16/2863 , C07K16/2896 , C07K2319/00
摘要： The present invention relates to methods and compositions that can be employed to introduce toxins and nucleic acids into the cytoplasm or nucleus of a eukaryotic cell, particularly a cell of a higher vertebate. The invention particularly concerns the use of a fusion protein of streptavidin and protein A sequences to form a non-covalent complex of a toxin or nucleic acid and an antibody.
摘要翻译：本发明涉及可用于将毒素和核酸引入真核细胞的细胞质或细胞核中的方法和组合物，特别是高级石鳖子的细胞。本发明特别涉及使用链霉亲和素和蛋白A序列的融合蛋白来形成毒素或核酸和抗体的非共价复合物。

3. 发明授权

US06432699B1 Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A 失效
标题翻译：具有含有蛋白A的IgG结合结构域的嵌合包膜蛋白的病毒载体
公开(公告)号：US06432699B1
公开(公告)日：2002-08-13
申请号：US08829558
申请日：1997-03-28
申请人： Daniel Meruelo , Kouichi Ohno
发明人： Daniel Meruelo , Kouichi Ohno
IPC分类号： C12N1513
CPC分类号： C12N7/00 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2740/13022 , C12N2770/36122 , C12N2770/36143 , C12N2770/36145 , C12N2770/36152 , C12N2810/6018 , C12N2810/609
摘要： The invention involves viral vectors that can be used to transduce a target cell, i.e., to introduce genetic material into the cell. The targets of interest are eukaryotic cells and particularly human cells. The transduction can be done in vivo or in vitro. More particularly the invention concerns viral vectors that have chimeric envelope proteins and contain the IgG-binding domain of protein A. These vectors when used in conjunction with antibodies targeting a particular cell are particularly useful for gene therapy.
摘要翻译：本发明涉及可用于转导靶细胞的病毒载体，即将遗传物质引入细胞。感兴趣的目标是真核细胞，特别是人类细胞。转导可以在体内或体外进行。更具体地，本发明涉及具有嵌合包膜蛋白并含有蛋白A的IgG结合结构域的病毒载体。当与针对特定细胞的抗体结合使用时，这些载体特别可用于基因治疗。

4. 发明申请

US20110077127A1 TRAINING SUPPORT SYSTEM AND TRAINING SUPPORT METHOD 有权
标题翻译：培训支持系统和培训支持方法
公开(公告)号：US20110077127A1
公开(公告)日：2011-03-31
申请号：US12735859
申请日：2009-03-03
申请人： Hiroshi Ishii , Kouichi Ohno , Kazuo Yuge , Masahiro Katou , Sachihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
发明人： Hiroshi Ishii , Kouichi Ohno , Kazuo Yuge , Masahiro Katou , Sachihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
IPC分类号： A63B71/00
CPC分类号： A63B24/0006 , A63B21/0058 , A63B21/0084 , A63B21/0088 , A63B21/023 , A63B21/06 , A63B21/154 , A63B21/4034 , A63B21/4045 , A63B23/0205 , A63B23/0233 , A63B23/03525 , A63B23/0405 , A63B23/1209 , A63B24/0084 , A63B69/06 , A63B71/0622 , A63B2024/0012 , A63B2071/0625 , A63B2071/0647 , A63B2208/0238 , A63B2220/13 , A63B2220/30 , A63B2220/803 , G06F19/00 , G06F19/3481
摘要： A training support system (S) allows an exerciser to practice training exercises safely and effectively with high motivation. The training support system (S) comprises a display means (4) which conducts display relating to training for the exerciser who uses a training machine (1) for muscle training, and a controller (3). The controller (3) allows dynamic display of reference motion and training motion on the display means (4) and variation of the display on the display means (4) according to the difference between the reference motion and the training motion.
摘要翻译：培训支持系统（S）允许锻炼者以高动机安全有效地练习训练。所述训练支援系统（S）包括显示装置（4），所述显示装置（4）对使用训练机（1）进行肌肉训练的运动员的培训进行显示，以及控制器（3）。控制器（3）允许根据参考运动和训练运动之间的差异，在显示装置（4）上动态地显示参考运动和训练运动以及显示装置（4）上显示的变化。

5. 发明授权

US08337364B2 Training support system and training support method 有权
标题翻译：培训支持体系和培训支持方式
公开(公告)号：US08337364B2
公开(公告)日：2012-12-25
申请号：US12735859
申请日：2009-03-03
申请人： Hiroshi Ishii , Kouichi Ohno , Kazuo Yuge , Masahiro Katou , Sachihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
发明人： Hiroshi Ishii , Kouichi Ohno , Kazuo Yuge , Masahiro Katou , Sachihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
IPC分类号： A63B71/00
CPC分类号： A63B24/0006 , A63B21/0058 , A63B21/0084 , A63B21/0088 , A63B21/023 , A63B21/06 , A63B21/154 , A63B21/4034 , A63B21/4045 , A63B23/0205 , A63B23/0233 , A63B23/03525 , A63B23/0405 , A63B23/1209 , A63B24/0084 , A63B69/06 , A63B71/0622 , A63B2024/0012 , A63B2071/0625 , A63B2071/0647 , A63B2208/0238 , A63B2220/13 , A63B2220/30 , A63B2220/803 , G06F19/00 , G06F19/3481
摘要： A training support system (S) allows an exerciser to practice training exercises safely and effectively with high motivation. The training support system (S) comprises a display means (4) which conducts display relating to training for the exerciser who uses a training machine (1) for muscle training, and a controller (3). The controller (3) allows dynamic display of reference motion and training motion on the display means (4) and variation of the display on the display means (4) according to the difference between the reference motion and the training motion.
摘要翻译：培训支持系统（S）允许锻炼者以高动机安全有效地练习训练。所述训练支援系统（S）包括显示装置（4），所述显示装置（4）对使用训练机（1）进行肌肉训练的运动员的培训进行显示，以及控制器（3）。控制器（3）允许根据参考运动和训练运动之间的差异，在显示装置（4）上动态地显示参考运动和训练运动以及显示装置（4）上显示的变化。

6. 发明授权

US08858397B2 Training device and a control method of the same 有权
标题翻译：训练装置及其控制方法相同
公开(公告)号：US08858397B2
公开(公告)日：2014-10-14
申请号：US12921631
申请日：2009-03-19
申请人： Hiroshi Ishii , Kouichi Ohno , Hiroshi Yaegashi , Kazuo Yuge , Masahiro Katou , Yukihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
发明人： Hiroshi Ishii , Kouichi Ohno , Hiroshi Yaegashi , Kazuo Yuge , Masahiro Katou , Yukihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
IPC分类号： A63B21/005 , A63B24/00 , A63B21/00 , A63B23/035 , A63B23/04 , A63B21/002
CPC分类号： A63B23/0405 , A63B21/00069 , A63B21/002 , A63B21/0058 , A63B21/4045 , A63B23/03525 , A63B24/0087 , A63B2208/0238 , A63B2220/13 , A63B2220/30 , A63B2220/40
摘要： A training machine for enabling the exerciser to exercise under a load appropriate for the individual exercise capability and physical function of the exerciser. The exerciser (E) enters a desired velocity-load characteristic into a load characteristic input device (7), and the velocity-load characteristic is stored in the load characteristic memory device (8). A load instruction value is determined according to the velocity-load characteristic and to the velocity inputted from a velocity calculation means (6) into the load characteristic memory device (8) and transmitted to a control means (1). The control means (1) rotates a servomotor (2) with a torque instruction value corresponding to the load instruction value. A movement mechanism (3) converts the rotation into linear movement to move a movable unit (4). With this, the exerciser can carry out training of reciprocal movement.
摘要翻译：一种培训机器，用于使训练者能够在适合于锻炼者的个人运动能力和身体功能的负荷下运动。训练器（E）将期望的速度 - 负载特性输入到负载特性输入装置（7）中，速度 - 负载特性被存储在负载特性存储装置（8）中。根据速度 - 负载特性和从速度计算装置（6）输入到负载特性存储装置（8）中的速度来确定装载指令值，并将其传送到控制装置（1）。控制装置（1）利用与加载指令值相对应的转矩指令值使伺服电动机（2）旋转。移动机构（3）将旋转转换为线性运动以移动可移动单元（4）。运动员可以进行互动训练。

7. 发明授权

US07143857B2 Vehicle drive system operation apparatus and vehicle drive control system 有权
标题翻译：车辆驱动系统运行装置和车辆驱动控制系统
公开(公告)号：US07143857B2
公开(公告)日：2006-12-05
申请号：US10723005
申请日：2003-11-26
申请人： Takashi Ichikawa , Terumasa Suyama , Kouichi Ohno , Ichiro Aoki
发明人： Takashi Ichikawa , Terumasa Suyama , Kouichi Ohno , Ichiro Aoki
IPC分类号： B60R25/10
CPC分类号： B60R25/24
摘要： A drive system operation apparatus that is easy to operate and improves the level of security in a vehicle. A gearshift operator and an engine switch are located near each other. A cover covers the gearshift operator and the engine switch. The cover is opened when predetermined conditions, including establishment of wireless communication with an authorized key, are satisfied.
摘要翻译：一种易于操作并提高车辆安全性的驱动系统操作装置。换档操作员和发动机开关位于彼此附近。盖子覆盖换挡操作员和发动机开关。当满足包括建立与授权密钥的无线通信的预定条件时，盖被打开。

8. 发明申请

US20110082006A1 TRAINING MACHINE AND METHOD FOR CONTROLLING TRAINING MACHINE 有权
标题翻译：培训机和控制培训机的方法
公开(公告)号：US20110082006A1
公开(公告)日：2011-04-07
申请号：US12921631
申请日：2009-03-19
申请人： Hiroshi Ishii , Kouichi Ohno , Hiroshi Yaegashi , Kazuo Yuge , Masahiro Katou , Yukihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
发明人： Hiroshi Ishii , Kouichi Ohno , Hiroshi Yaegashi , Kazuo Yuge , Masahiro Katou , Yukihide Iwamoto , Makoto Hashizume , Hajime Kenmotsu , Shinichiro Takasugi
IPC分类号： A63B21/00
CPC分类号： A63B23/0405 , A63B21/00069 , A63B21/002 , A63B21/0058 , A63B21/4045 , A63B23/03525 , A63B24/0087 , A63B2208/0238 , A63B2220/13 , A63B2220/30 , A63B2220/40
摘要： A training machine for enabling the exerciser to exercise under a load appropriate for the individual exercise capability and physical function of the exerciser. The exerciser (E) enters a desired velocity-load characteristic into a load characteristic input device (7), and the velocity-load characteristic is stored in the load characteristic memory device (8). A load instruction value is determined according to the velocity-load characteristic and to the velocity inputted from a velocity calculation means (6) into the load characteristic memory device (8) and transmitted to a control means (1). The control means (1) rotates a servomotor (2) with a torque instruction value corresponding to the load instruction value. A movement mechanism (3) converts the rotation into linear movement to move a movable unit (4). With this, the exerciser can carry out training of reciprocal movement.
摘要翻译：一种培训机器，用于使训练者能够在适合于锻炼者的个人运动能力和身体功能的负荷下运动。训练器（E）将期望的速度 - 负载特性输入到负载特性输入装置（7）中，速度 - 负载特性被存储在负载特性存储装置（8）中。根据速度 - 负载特性和从速度计算装置（6）输入到负载特性存储装置（8）中的速度来确定装载指令值，并将其传送到控制装置（1）。控制装置（1）利用与加载指令值相对应的转矩指令值使伺服电动机（2）旋转。移动机构（3）将旋转转换为线性运动以移动可移动单元（4）。运动员可以进行互动训练。

9. 发明授权

US06555808B2 Apparatus for detecting rotational angle 失效
公开(公告)号：US06555808B2
公开(公告)日：2003-04-29
申请号：US09906242
申请日：2001-07-16
申请人： Shuichi Takeuchi , Kouichi Ohno
发明人： Shuichi Takeuchi , Kouichi Ohno
IPC分类号： G01D534
CPC分类号： G01D5/36
摘要： A relative rotational angle of a rotary body is measured with respect to a reference angle. First openings are arranged about the circumference of a disk, which rotates integrally with the rotary body, at predetermined pitches. A first detecting element detects the first openings and generates a first binary code. The relative rotational angle of the rotary body is computed in accordance with the first binary code. A second detecting element detects the second openings and generates a second binary code. The reference angle of the rotary body is computed and reset in accordance with the second binary code. Third openings are concentrical with the first and second openings. A third detecting element detects the third openings and generates a third binary code. The reference angle is determined based on the combination of the first and third binary codes.

10. 发明授权

US5469296A Control device for antiglare mirror 失效
标题翻译：防眩光镜控制装置
公开(公告)号：US5469296A
公开(公告)日：1995-11-21
申请号：US218640
申请日：1994-03-28
申请人： Kouichi Ohno , Hideki Miyatake , Yutaka Yoshida
发明人： Kouichi Ohno , Hideki Miyatake , Yutaka Yoshida
IPC分类号： B60R1/04 , B60R1/08 , G02F1/15 , G02F1/163 , G02B5/08
CPC分类号： B60R1/088
摘要： A control device for controlling an antiglare mirror in vehicles. The inner mirror, which has a gel-type EC cell, reduces its mirror reflectivity as the positive voltage applied thereto increases. A rear light sensor receives the light from behind through the inner mirror. A comparison decision circuit detects the intensity of the light from behind in accordance with the light receiving state of the rear light sensor and an ambient light sensor. A driving circuit applies a positive voltage to the EC cell of the inner mirror so that the light from behind has a predetermined intensity level. A control circuit supplies a negative or positive voltage to outer mirrors in accordance with the positive voltage applied to the inner mirror. The outer mirrors enhances their mirror reflectivity as the negative voltage level applied becomes high and reduces their mirror reflectivity as the positive voltage level applied becomes high.
摘要翻译：一种用于控制车辆中防眩光镜的控制装置。具有凝胶型EC电池的内反射镜随着施加于其上的正电压而降低其镜面反射率。后灯传感器通过内镜从后面接收光。比较判定电路根据后方光传感器和环境光传感器的受光状态来检测来自后面的光的强度。驱动电路向内反射镜的EC单元施加正电压，使得来自后面的光具有预定的强度水平。控制电路根据施加到内镜的正电压向外反射镜提供负电压或正电压。随着施加的负电压电平变高，外反射镜增强了其反射率，因为施加的负电压电平变高，并降低了其反射率。

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