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1. 发明专利

JP2006231070A Devices and methods for pain treatment 有权
标题翻译：用于疼痛治疗的装置和方法
公开(公告)号：JP2006231070A
公开(公告)日：2006-09-07
申请号：JP2006104033
申请日：2006-04-05
申请人： Durect Corp , ダレクトコーポレーション
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04
CPC分类号： A61M37/0069 , A61K9/0004 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26
摘要： PROBLEM TO BE SOLVED: To provide devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. SOLUTION: A drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device 10. The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures during a treatment period. The drug delivery devices 10 store the drug formulation safely to provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use, the drug delivery device is implanted in the subject's body at an implantation site to release the drug formulation. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于系统递送芬太尼或芬太尼（例如舒芬太尼）以治疗疼痛的装置和方法。解决方案：包含芬太尼或芬太尼同系物的药物制剂储存在药物递送装置10内。药物制剂包含一定量的足以治疗的药物，并且在治疗期间在体温下是稳定的。药物递送装置10安全地储存药物制剂以提供足够的保护以防止身体过程以防止制剂的不可接受的降解，并且以治疗有效的速率以受控的方式释放药物制剂以治疗疼痛。在使用中，将药物递送装置植入到受试者的身体中的植入部位以释放药物制剂。一旦在分娩位置被释放，药物制剂进入体循环并被运送到体内的作用部位以调节疼痛反应。版权所有（C）2006，JPO＆NCIPI

2. 发明申请

WO0054745A3 DEVICES AND METHODS FOR PAIN MANAGEMENT 审中-公开
标题翻译：用于疼痛管理的装置和方法
公开(公告)号：WO0054745A3
公开(公告)日：2000-11-30
申请号：PCT/US0007068
申请日：2000-03-16
申请人： DURECT CORP , JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04 , A61F13/02 , A61K9/70 , A61M5/00
CPC分类号： A61M37/0069 , A61K9/0004 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device (e.g., contained in a reservoir or impregnated within a matrix within the controlled drug delivery device). The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures (i.e., no unacceptable degradation) for the entire pre-selected treatment period. The drug delivery devices store the drug formulation safely (e.g., without dose dumping), provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use, the drug delivery device is implanted in the subject's body at an implantation site, and the drug formulation is released from the drug delivery device to a delivery site. The delivery site may be the same as, near, or distant from the implantation site. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response (e.g., the brain or other pain sensory location).
摘要翻译：本发明的特征在于全身递送芬太尼或芬太尼同源物（例如舒芬太尼）以治疗疼痛的装置和方法。在本发明中，包含芬太尼或芬太尼同源物的药物制剂储存在药物递送装置（例如容纳在储库中或浸渍在受控药物递送装置内的基质内）内。药物制剂包含足以治疗的量的药物，并且在整个预选治疗期间在体温下稳定（即没有不可接受的降解）。药物输送装置安全地储存药物制剂（例如，无剂量倾倒），提供对身体过程的充分保护以防止制剂不可接受的降解，并且以受控的方式以治疗有效的速率释放药物制剂以治疗疼痛。在使用中，药物递送装置在植入部位植入受治疗者体内，药物制剂从药物递送装置释放到递送部位。输送部位可以与植入部位相同，接近或远离。一旦在递送部位释放，药物制剂进入全身循环并被运送到体内作用部位以调节疼痛反应（例如，大脑或其他疼痛感觉部位）。

3. 发明公开

EP1435874A4 IMPLANTABLE DEVICES AND METHODS FOR TREATMENT OF PAIN BY DELIVERY OF FENTANYL AND FENTANYL CONGENERS 有权
标题翻译：植入的装置和用于治疗疼痛BY和芬太尼芬太尼相关的配送方式
公开(公告)号：EP1435874A4
公开(公告)日：2007-05-09
申请号：EP02757559
申请日：2002-08-29
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , WICKMAN PETER , YUM SU IL , POUTIATINE ANDREW , DINKA JOHN
IPC分类号： A61J1/10 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04
CPC分类号： A61F2/02 , A61F2250/0067 , A61K9/0004 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/168 , A61M5/16804 , A61M5/16881 , A61M31/002 , A61M2005/14264
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element that defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

4. 发明专利

DE60228293D1 未知
公开(公告)号：DE60228293D1
公开(公告)日：2008-09-25
申请号：DE60228293
申请日：2002-08-29
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , WICKMAN PETER , YUM SU IL , POUTIATINE ANDREW , DINKA JOHN
IPC分类号： A61F2/02 , A61J1/10 , A61F2/00 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

5. 发明专利

ES2312606T3 DISPOSITIVOS IMPLANTABLES PARA EL TRATAMIENTO DEL DOLOR MEDIANTE LA LIBERACION DE FENTALINO Y CONGENERES DE FENTALINO. 未知
公开(公告)号：ES2312606T3
公开(公告)日：2009-03-01
申请号：ES02757559
申请日：2002-08-29
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M
IPC分类号： A61F2/02 , A61J1/10 , A61F2/00 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04
摘要： Dispositivo de liberación controlada de fármacos, adaptado para una implantación completa, que comprende: una carcasa que define un depósito, conteniendo el depósito una formulación que comprende un fármaco seleccionado del grupo que consiste en fentanilo o un congénere de fentanilo, donde el fármaco está presente en una cantidad suficiente para el tratamiento del dolor en un sujeto durante un periodo de por los menos aproximadamente 3 días; una bomba conectada operativamente a la carcasa; y un elemento de dilatación térmica que comprende una entrada, un canal de dilatación térmica adaptado para contener un volumen de formulación asociado con la dilatación térmica, y una salida; en el que en su uso, la entrada, el canal de dilatación térmica y la salida definen una vía de paso de flujo desde el depósito y fuera del dispositivo, de manera que el accionamiento de la bomba impulsa un movimiento de la formulación a través de la vía de paso de flujo.

6. 发明专利

AU2002323569B2 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners 未知
公开(公告)号：AU2002323569B2
公开(公告)日：2008-05-29
申请号：AU2002323569
申请日：2002-08-29
申请人： DURECT CORP
发明人： THEEUWES FELIX , CULWELL JOHN , POUTIATINE ANDREW , WICKMAN PETER , JOHNSON RANDOLPH MELLUS , GILLIS EDWARD M , FILICE JAMES A , BROWN JAMES E , DINKA JOHN , YUM SU IL
IPC分类号： A61J1/10 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

7. 发明专利

AU769314B2 Devices and methods for pain management 未知
公开(公告)号：AU769314B2
公开(公告)日：2004-01-22
申请号：AU3756100
申请日：2000-03-16
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04

8. 发明专利

CA2363705C DEVICES AND METHODS FOR PAIN MANAGEMENT 未知
公开(公告)号：CA2363705C
公开(公告)日：2013-06-11
申请号：CA2363705
申请日：2000-03-16
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61K31/4468 , A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K9/70 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/00 , A61P25/04
摘要： The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device (e.g., contained in a reservoir or impregnated within a matrix within the controlled drug delivery device). The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures (i.e., no unacceptable degradation) for the entire pre-selected treatment period. The drug delivery devices store the drug formulation safely (e.g., without dose dumping), provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use, the drug delivery device is implanted in the subject's body at an implantation site, and the drug formulation is released from the drug delivery device to a delivery site. The delivery site may be the same as, near, or distant from the implantation site. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response (e.g., the brain or other pain sensory location).

9. 发明专利

AU3756100A Devices and methods for pain management 未知
公开(公告)号：AU3756100A
公开(公告)日：2000-10-04
申请号：AU3756100
申请日：2000-03-16
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04

10. 发明专利

CA2363705A1 DEVICES AND METHODS FOR PAIN MANAGEMENT 未知
公开(公告)号：CA2363705A1
公开(公告)日：2000-09-21
申请号：CA2363705
申请日：2000-03-16
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04 , A61F13/02 , A61K9/70 , A61M5/00
摘要： The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device (e.g., contained in a reservoir or impregnated within a matrix within the controlled drug delivery device). The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures (i.e., no unacceptable degradation) for the entire pre-selected treatment period. The drug delivery devices store the drug formulation safely (e.g., without dose dumping), provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use , the drug delivery device is implanted in the subject's body at an implantati on site, and the drug formulation is released from the drug delivery device to a delivery site. The delivery site may be the same as, near, or distant from t he implantation site. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response (e.g., the brain or other pain sensor y location).

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