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1. 发明专利

JP2013079281A Transdermal delivery system 有权
标题翻译：超传送系统
公开(公告)号：JP2013079281A
公开(公告)日：2013-05-02
申请号：JP2013002422
申请日：2013-01-10
申请人： Durect Corp , デュレクトコーポレーション
发明人： YUM SU IL , THEEUWES FELIX
IPC分类号： A61K31/4535 , A61K9/70 , A61P25/04
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： PROBLEM TO BE SOLVED: To provide transdermal delivery systems for administering sufentanil through the skin.SOLUTION: The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer as an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：要解决的问题：提供用于通过皮肤施用舒芬太尼的透皮递送系统。解决方案：当施用于受试者时，系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，包括对来自系统的舒芬太尼的通量的高度剂型速率控制，来自系统通过皮肤的高净通量的舒芬太尼，缺乏作为粘合剂的渗透促进剂优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。版权所有（C）2013，JPO＆INPIT

2. 发明申请

WO2006047362A2 TRANSDERMAL DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2006047362A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038086
申请日：2005-10-21
申请人： DURECT CORP , YUM SU II , THEEUWES FELIX
发明人： YUM SU II , THEEUWES FELIX
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。该系统含有足够量的舒芬太尼，以在应用于受试者时诱导和维持恒定的止痛状态。该系统的特征在于具有一个或多个特征，包括对来自系统的舒芬太尼通量的高度剂量率控制，来自系统通过皮肤的高舒芬太尼净通量，缺乏渗透促进剂，展示粘合剂构件优越的剪切时间，来自系统的舒芬太尼的净通量的低变化系数，高的递送效率以及来自系统的舒芬太尼的基本恒定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时长时间诱导和维持镇痛的方法。

3. 发明申请

WO0243800A2 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于从药物递送装置进行控制的装置和方法
公开(公告)号：WO0243800A2
公开(公告)日：2002-06-06
申请号：PCT/US0143143
申请日：2001-11-21
申请人： DURECT CORP , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
发明人： BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00 , A61M39/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

4. 发明专利

JP2006231070A Devices and methods for pain treatment 有权
标题翻译：用于疼痛治疗的装置和方法
公开(公告)号：JP2006231070A
公开(公告)日：2006-09-07
申请号：JP2006104033
申请日：2006-04-05
申请人： Durect Corp , ダレクトコーポレーション
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04
CPC分类号： A61M37/0069 , A61K9/0004 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26
摘要： PROBLEM TO BE SOLVED: To provide devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. SOLUTION: A drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device 10. The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures during a treatment period. The drug delivery devices 10 store the drug formulation safely to provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use, the drug delivery device is implanted in the subject's body at an implantation site to release the drug formulation. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于系统递送芬太尼或芬太尼（例如舒芬太尼）以治疗疼痛的装置和方法。解决方案：包含芬太尼或芬太尼同系物的药物制剂储存在药物递送装置10内。药物制剂包含一定量的足以治疗的药物，并且在治疗期间在体温下是稳定的。药物递送装置10安全地储存药物制剂以提供足够的保护以防止身体过程以防止制剂的不可接受的降解，并且以治疗有效的速率以受控的方式释放药物制剂以治疗疼痛。在使用中，将药物递送装置植入到受试者的身体中的植入部位以释放药物制剂。一旦在分娩位置被释放，药物制剂进入体循环并被运送到体内的作用部位以调节疼痛反应。版权所有（C）2006，JPO＆NCIPI

5. 发明申请

WO0054745A3 DEVICES AND METHODS FOR PAIN MANAGEMENT 审中-公开
标题翻译：用于疼痛管理的装置和方法
公开(公告)号：WO0054745A3
公开(公告)日：2000-11-30
申请号：PCT/US0007068
申请日：2000-03-16
申请人： DURECT CORP , JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61P25/04 , A61F13/02 , A61K9/70 , A61M5/00
CPC分类号： A61M37/0069 , A61K9/0004 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising fentanyl or a fentanyl congener is stored within a drug delivery device (e.g., contained in a reservoir or impregnated within a matrix within the controlled drug delivery device). The drug formulation comprises an amount of drug sufficient for treatment and is stable at body temperatures (i.e., no unacceptable degradation) for the entire pre-selected treatment period. The drug delivery devices store the drug formulation safely (e.g., without dose dumping), provide sufficient protection from bodily processes to prevent unacceptable degradation of the formulation, and release the drug formulation in a controlled fashion at a therapeutically effective rate to treat pain. In use, the drug delivery device is implanted in the subject's body at an implantation site, and the drug formulation is released from the drug delivery device to a delivery site. The delivery site may be the same as, near, or distant from the implantation site. Once released at the delivery site, the drug formulation enters the systemic circulation and is transported to the site of action in the body to modulate the pain response (e.g., the brain or other pain sensory location).
摘要翻译：本发明的特征在于全身递送芬太尼或芬太尼同源物（例如舒芬太尼）以治疗疼痛的装置和方法。在本发明中，包含芬太尼或芬太尼同源物的药物制剂储存在药物递送装置（例如容纳在储库中或浸渍在受控药物递送装置内的基质内）内。药物制剂包含足以治疗的量的药物，并且在整个预选治疗期间在体温下稳定（即没有不可接受的降解）。药物输送装置安全地储存药物制剂（例如，无剂量倾倒），提供对身体过程的充分保护以防止制剂不可接受的降解，并且以受控的方式以治疗有效的速率释放药物制剂以治疗疼痛。在使用中，药物递送装置在植入部位植入受治疗者体内，药物制剂从药物递送装置释放到递送部位。输送部位可以与植入部位相同，接近或远离。一旦在递送部位释放，药物制剂进入全身循环并被运送到体内作用部位以调节疼痛反应（例如，大脑或其他疼痛感觉部位）。

6. 发明申请

WO2013078396A3 RADIATION-STERILIZED BIODEGRADABLE DRUG DELIVERY COMPOSITIONS 审中-公开
标题翻译：辐射灭菌生物可降解药物组合物
公开(公告)号：WO2013078396A3
公开(公告)日：2015-06-11
申请号：PCT/US2012066375
申请日：2012-11-21
申请人： DURECT CORP
发明人： SEKAR MICHAEL , YUM SU IL , THEEUWES FELIX , VAN OSDOL WILLIAM W
IPC分类号： A61K47/00
CPC分类号： A61K47/48246 , A61K9/0019 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1647 , A61K9/19 , A61K31/198 , A61K31/7052 , A61K38/17 , A61K38/22 , A61K38/26 , A61K38/27 , A61K41/0019 , A61K45/06 , A61K47/48015 , A61K47/52 , A61K47/64 , A61L2/0035 , A61L2/0041 , A61L2/007 , A61L2202/21 , C07K14/575 , C07K14/61 , A61K2300/00
摘要： The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided.
摘要翻译：本公开涉及通过组合车辆（例如单相载体）和包含有益剂的不溶性组分制备组合物的方法，并且在使用之前使用电离辐射对组合物进行灭菌，其中有益剂是稳定的在暴露于灭菌剂量的电离辐射之后。提供了相关的组合物和方法。

7. 发明申请

WO2006047362A9 TRANSDERMAL DELIVERY SYSTEMS 审中-公开
标题翻译：变送器系统
公开(公告)号：WO2006047362A9
公开(公告)日：2006-08-17
申请号：PCT/US2005038086
申请日：2005-10-21
申请人： DURECT CORP , YUM SU II , THEEUWES FELIX
发明人： YUM SU II , THEEUWES FELIX
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高递送效率以及来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

8. 发明申请

WO03009882B1 LOCAL CONCENTRATION MANAGEMENT SYSTEM 审中-公开
标题翻译：本地集中管理系统
公开(公告)号：WO03009882B1
公开(公告)日：2003-11-20
申请号：PCT/US0222813
申请日：2002-07-16
申请人： DURECT CORP , THEEUWES FELIX , YUM SU IL
发明人： THEEUWES FELIX , YUM SU IL
IPC分类号： A61M25/00 , A61M25/14 , A61M25/16 , A61M29/00
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body (20) defining a lumen (26) between its proximal (21) and distal (23) ends, and a diffuser element (30), a dilutor element (60), or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body (20) so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译：本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括一个装置，该装置包括在其近端（21）和远端（23）端部之间限定内腔（26）的细长体（20）和扩散器元件（30），稀释元件（60）或两者。可选择性地渗透该试剂的扩散器元件与细长体（20）可操作地相关联，使得试剂流过细长体并进入并穿过扩散器元件以离开系统。稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。

9. 发明申请

WO02102278A2 DEVICE AND METHOD FOR DELIVERING MICRODOSES OF AGENT TO THE EAR 审中-公开
标题翻译：用于将药剂微粒体递送至耳朵的装置和方法
公开(公告)号：WO02102278A2
公开(公告)日：2002-12-27
申请号：PCT/US0219290
申请日：2002-06-17
申请人： DURECT CORP , ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
发明人： ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
IPC分类号： A61F11/00 , A61F
CPC分类号： A61F11/00
摘要： The present invention provides devices and methods for delivery of very low dosages to the inner ear. The device is a self-contained unit that reproducibly and consistently delivers a dose of therapeutic agent that is effective, yet below the ototoxic threshold for that agent. The invention further provides therapeutic methods using the device of the invention.
摘要翻译：本发明提供了用于将非常低剂量递送到内耳的装置和方法。该装置是一种独立的单元，其可重复地和一致地递送有效剂量的治疗剂，但低于该药剂的耳毒性阈值。本发明还提供了使用本发明的装置的治疗方法。

10. 发明申请

WO0141858A3 CATHETER WITH STYLET LUMEN 审中-公开
标题翻译：带有白炽灯的导管
公开(公告)号：WO0141858A3
公开(公告)日：2002-01-31
申请号：PCT/US0033476
申请日：2000-12-07
申请人： DURECT CORP , GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
发明人： GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
IPC分类号： A61M25/00 , A61M25/01 , A61M25/14
CPC分类号： A61M25/0102 , A61M2025/0034 , A61M2025/0037 , A61M2025/0039
摘要： The present invention features a catheter suitable for drug delivery. The catheter comprises a catheter body comprising a proximal and a distal end, and defining a drug delivery lumen and a stylet lumen. The stylet lumen comprises a distal end configured to permit a stylet to abut the stylet lumen distal end, and a proximal aperture which is distal to the proximal end of the catheter, providing entry of the stylet into the side of the catheter. The stylet lumen is adapted for slidably receiving a stylet which can be used to guide the catheter to the intended site in the body of a subject and thus to facilitate implantation of the catheter.
摘要翻译：本发明的特征在于适于药物递送的导管。导管包括导管主体，其包括近端和远端，并且限定药物输送腔和探针管腔。探针管腔包括构造成允许探针邻接探针管腔远端的远端，以及远离导管近端的近端孔，提供探针进入导管侧。探针腔适于可滑动地容纳可用于将导管引导到受试者身体中预期部位的探针，并因此便于植入导管。

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