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1. 发明申请

WO2004050141A3 CATHETER FEED THROUGH GUIDE 审中-公开
标题翻译：导管通过指南进给
公开(公告)号：WO2004050141A3
公开(公告)日：2005-03-24
申请号：PCT/US0338448
申请日：2003-12-04
申请人： DURECT CORP , POUTIATINE ANDREW I , FILICE JAMES A
发明人： POUTIATINE ANDREW I , FILICE JAMES A
IPC分类号： A61B17/34 , A61M20060101 , A61M25/01 , A61M25/09
CPC分类号： A61M25/0194 , A61B17/3415 , A61B2017/320056 , A61M25/0662 , A61M2025/09175
摘要： A catheter feed through guide apparatus and method which facilitates the feeding of a catheter through a tunneler during implant procedures and avoids damage to the catheter and catheter tip during the catheter feed through procedure. The apparatus comprises a guide element (20) configured to fit through a tunneler (34) and to releasibly engage a catheter or catheter end.
摘要翻译：导管通过引导装置和方法，其有助于在植入过程期间通过隧道器进给导管，并且避免在导管进料过程期间损伤导管和导管尖端。该装置包括构造成通过隧道器（34）配合并可释放地接合导管或导管端的引导元件（20）。

2. 发明申请

WO2004067062A3 EXPANDABLE BORE INJECTION NEEDLE 审中-公开
标题翻译：可膨胀的注射针
公开(公告)号：WO2004067062A3
公开(公告)日：2006-05-04
申请号：PCT/US2004002447
申请日：2004-01-28
申请人： DURECT CORP
发明人： GILLIS EDWARD M , FILICE JAMES A , BROWN JIM , RAMPERSAUD CHARLES , POUTIATINE ANDREW , ARGONZA DANNY
IPC分类号： A61B17/34 , A61M20060101 , A61M5/178
CPC分类号： A61B17/3468 , A61B17/3439
摘要： The present invention is a trocar/cannula assembly that is capable of delivering large-diameter objects/fluids into a body cavity interior, while minimizing the puncture footprint left after insertion. Generally, the invention could be a composite needle (12) having a composite wall (18) forming a trocar shaft (18) with at least two rigid elements (20), and flexible material (26) therebetween, which together at least partially define a trocar bore having a diameter, and a puncture tip (30). Together these elements enable the composite wall to flex outward so as to increase the diameter of the trocar bore. Additionally, the present invention could also be described as an expandable bore trocar/cannula that is made up of an expandable cannula body (40) having an interior channel that is capable of flexing radially outward, and a trocar tip associated with the cannula body to facilitate the insertion of the trocar/cannula into a patient.
摘要翻译：本发明是一种套管针/套管组件，其能够将大直径物体/流体输送到体腔内部，同时最小化插入后留下的穿刺足迹。通常，本发明可以是具有形成具有至少两个刚性元件（20）的套管针轴（18）的复合壁（18）和其间的柔性材料（26）的复合针（12），其一起至少部分地限定具有直径的套管针孔和穿刺尖端（30）。这些元件一起使得复合壁向外弯曲，从而增加套管针孔的直径。另外，本发明还可以被描述为由可扩张的套管主体（40）构成的可扩展的套管针/套管，其具有能够径向向外弯曲的内部通道，以及与插管主体相关联的套针针头有助于套管针/套管插入患者体内。

3. 发明申请

WO0243800A2 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于从药物递送装置进行控制的装置和方法
公开(公告)号：WO0243800A2
公开(公告)日：2002-06-06
申请号：PCT/US0143143
申请日：2001-11-21
申请人： DURECT CORP , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
发明人： BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00 , A61M39/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

4. 发明申请

WO2004050142A3 CATHETER LOOP MANAGER 审中-公开
公开(公告)号：WO2004050142A3
公开(公告)日：2007-05-03
申请号：PCT/US0338548
申请日：2003-12-04
申请人： DURECT CORP , POUTIATINE ANDREW I , GILLIS EDWARD M , PARIKH RITEN , FILICE JAMES A
发明人： POUTIATINE ANDREW I , GILLIS EDWARD M , PARIKH RITEN , FILICE JAMES A
IPC分类号： A61M5/32 , A61M20060101 , A61M5/142 , A61M25/00 , A61M25/01 , A61M39/12
CPC分类号： A61M5/14276 , A61M25/0097 , A61M25/0113 , A61M39/12
摘要： A catheter loop manager (10) which controls the slack portion of a catheter located adjacent to an implanted pump (12) and prevents fibrotic encapsulation of the slack catheter portion. The catheter loop manager comprises a retainer element (18) configured to associate with an implantable pump and to releasibly hold or retain a loop or section of catheter adjacent to the pump. A pull tool (20) is used to releasibly engage a catheter section and pull the catheter section into a loop within a retention channel in the retainer element.
摘要翻译：导管回路管理器（10），其控制位于植入泵（12）附近的导管的松弛部分并防止松弛导管部分的纤维化封装。导管回路管理器包括被配置为与可植入泵相关联并且可释放地保持或保持与泵相邻的导管的环或部分的保持器元件（18）。拉动工具（20）用于可释放地接合导管部分并将导管部分拉入保持器元件中的保持通道内的环中。

5. 发明申请

WO0141858A3 CATHETER WITH STYLET LUMEN 审中-公开
标题翻译：带有白炽灯的导管
公开(公告)号：WO0141858A3
公开(公告)日：2002-01-31
申请号：PCT/US0033476
申请日：2000-12-07
申请人： DURECT CORP , GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
发明人： GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
IPC分类号： A61M25/00 , A61M25/01 , A61M25/14
CPC分类号： A61M25/0102 , A61M2025/0034 , A61M2025/0037 , A61M2025/0039
摘要： The present invention features a catheter suitable for drug delivery. The catheter comprises a catheter body comprising a proximal and a distal end, and defining a drug delivery lumen and a stylet lumen. The stylet lumen comprises a distal end configured to permit a stylet to abut the stylet lumen distal end, and a proximal aperture which is distal to the proximal end of the catheter, providing entry of the stylet into the side of the catheter. The stylet lumen is adapted for slidably receiving a stylet which can be used to guide the catheter to the intended site in the body of a subject and thus to facilitate implantation of the catheter.
摘要翻译：本发明的特征在于适于药物递送的导管。导管包括导管主体，其包括近端和远端，并且限定药物输送腔和探针管腔。探针管腔包括构造成允许探针邻接探针管腔远端的远端，以及远离导管近端的近端孔，提供探针进入导管侧。探针腔适于可滑动地容纳可用于将导管引导到受试者身体中预期部位的探针，并因此便于植入导管。

6. 发明公开

EP1435874A4 IMPLANTABLE DEVICES AND METHODS FOR TREATMENT OF PAIN BY DELIVERY OF FENTANYL AND FENTANYL CONGENERS 有权
标题翻译：植入的装置和用于治疗疼痛BY和芬太尼芬太尼相关的配送方式
公开(公告)号：EP1435874A4
公开(公告)日：2007-05-09
申请号：EP02757559
申请日：2002-08-29
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , WICKMAN PETER , YUM SU IL , POUTIATINE ANDREW , DINKA JOHN
IPC分类号： A61J1/10 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04
CPC分类号： A61F2/02 , A61F2250/0067 , A61K9/0004 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/168 , A61M5/16804 , A61M5/16881 , A61M31/002 , A61M2005/14264
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element that defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

7. 发明公开

EP1435919A4 DEVICE AND METHOD FOR ACCURATE DELIVERY OF AN ACTIVE AGENT 有权
标题翻译：设备和方法，实际费用的积极
公开(公告)号：EP1435919A4
公开(公告)日：2007-05-09
申请号：EP02763595
申请日：2002-08-29
申请人： DURECT CORP
发明人： GILLIS EDWARD M , POUTIATINE ANDREW I , DINKA JOHN , FILICE JAMES A , WICKMAN PETER , CULWELL JOHN
IPC分类号： A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/168
CPC分类号： A61K9/0024 , A61F2/02 , A61F2250/0067 , A61K9/0004 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/16881 , A61M2005/14264
摘要： Implantable delivery devices (1) for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir (3) for storing the agent, a driving means for driving the agent from the reservoir (3) and a valving and control mechanism (10) which is positively actuatable between a closed configuration and an open configuration.

8. 发明专利

AU2003298853A8 Catheter feed through guide 未知
公开(公告)号：AU2003298853A8
公开(公告)日：2004-06-23
申请号：AU2003298853
申请日：2003-12-04
申请人： DURECT CORP
发明人： FILICE JAMES A , POUTIATINE ANDREW I
IPC分类号： A61B17/34 , A61M20060101 , A61M25/01 , A61M25/09
摘要： A catheter feed through guide apparatus and method which facilitates the feeding of a catheter through a tunneler during implant procedures and avoids damage to the catheter and catheter tip during the catheter feed through procedure. The apparatus comprises a guide element configured to fit through a tunneler and to releasibly engage a catheter or catheter end.

9. 发明专利

AU2002327596A1 Device and method for accurate delivery of an active agent 未知
公开(公告)号：AU2002327596A1
公开(公告)日：2003-04-01
申请号：AU2002327596
申请日：2002-08-29
申请人： DURECT CORP
发明人： FILICE JAMES A , WICKMAN PETER , DINKA JOHN , GILLIS EDWARD M , CULWELL JOHN , POUTIATINE ANDREW
IPC分类号： A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/168

10. 发明专利

AT404132T 未知
公开(公告)号：AT404132T
公开(公告)日：2008-08-15
申请号：AT02757559
申请日：2002-08-29
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH , THEEUWES FELIX , BROWN JAMES , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD , WICKMAN PETER , YUM SU , POUTIATINE ANDREW , DINKA JOHN
IPC分类号： A61F2/02 , A61J1/10 , A61F2/00 , A61K9/00 , A61K9/22 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61P25/04
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

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