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1. 发明申请

WO2009109631A1 A PENTOSE SUGAR FERMENTING CELL 审中-公开
标题翻译：雄性糖酵母细胞
公开(公告)号：WO2009109631A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009052621
申请日：2009-03-05
申请人： DSM IP ASSETS BV , KLAASSEN PAUL , LAAN VAN DER JAN METSKE , GIELESEN BIANCA ELISBETH MARIA , SUYLEKOM VAN GIJSBERDINA PIETERNELLA
发明人： KLAASSEN PAUL , LAAN VAN DER JAN METSKE , GIELESEN BIANCA ELISBETH MARIA , SUYLEKOM VAN GIJSBERDINA PIETERNELLA
IPC分类号： C12N9/92 , C12N15/52 , C12P7/10
CPC分类号： C12N9/92 , C12P7/10 , Y02E50/16
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
摘要翻译：本发明涉及包含编码木糖异构酶的核苷酸序列的细胞，其中木糖异构酶的氨基酸序列与SEQ ID NO：3所示的氨基酸序列具有至少约70％的序列同一性，其中所述核苷酸序列与宿主异源。本发明的细胞可用于生产发酵产物如乙醇的方法中。这样的方法可以包括用本发明的细胞发酵含有木糖来源的培养基，使得细胞向发酵产物发酵木糖。

2. 发明申请

WO2008040731A3 PRODUCTION OF BETA-LACTAM ANTIBIOTICS 审中-公开
标题翻译：生产β-LACTAM抗生素
公开(公告)号：WO2008040731A3
公开(公告)日：2008-05-22
申请号：PCT/EP2007060460
申请日：2007-10-02
申请人： DSM IP ASSETS BV , BOER REMON , HANS MARCUS , BOVENBERG ROELOF ARY LANS , KLAASSEN PAUL , LAAN VAN DER JAN METSKE
发明人： HANS MARCUS , BOVENBERG ROELOF ARY LANS , KLAASSEN PAUL , LAAN VAN DER JAN METSKE
IPC分类号： C12N9/02 , C12P37/00
CPC分类号： C12N9/0004
摘要： The present invention describes a process for the production of an N-a-amino-hydroxyphenylacetyl or an N-a-aminophenylacetyl ß-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl- valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N- hydroxyphenylglycyl or the N-phenylglycyl ß-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V. An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing ß-lactam antibiotics with N-a-amino-hydroxyphenylacetyl or an N-a-aminophenylacetyl side chains.
摘要翻译：本发明描述了一种生产Na-氨基 - 羟基苯基乙酰基或一种氨基苯乙酰基β-内酰胺抗生素的方法，其包括前体三肽羟基苯基甘氨酰 - 半胱氨酰缬氨酸（HpgCV）或苯基甘氨酰 - 半胱氨酰缬氨酸（HpgCV） PgCV）分别与N-羟基苯基甘氨酰或N-苯基甘氨酰ß-内酰胺抗生素反应。三肽HpgCV或三肽PgCV可以通过使氨基酸羟基苯基甘氨酸（Hpg）或苯基甘氨酸（Pg），半胱氨酸（C）和缬氨酸（V）与非核糖体肽合成酶（NRPS）接触来进一步制备，以形成三肽HpgCV或三肽PgCV，NRPS包括对于Hpg或Pg特有的第一模块M1，对C特异的第二模块M2和对于V特定的第三模块M3。进一步提供IPNS，其在该转换中具有改善的活性，如以及催化三肽形成的NRPS。还提供了能够用N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯乙酰侧链发酵生产β-内酰胺抗生素的宿主细胞。

3. 发明申请

WO2012049179A2 POLYPEPTIDES WITH KINASE ACTIVITY 审中-公开
标题翻译：多激素与激酶活性
公开(公告)号：WO2012049179A2
公开(公告)日：2012-04-19
申请号：PCT/EP2011067738
申请日：2011-10-11
申请人： DSM IP ASSETS BV , WISSELINK HENDRIK WOUTER , MARIS VAN ANTONIUS JEROEN ADRIAAN , PRONK JACOBUS THOMAS , KLAASSEN PAUL , JONG DE RENE MARCEL
发明人： WISSELINK HENDRIK WOUTER , MARIS VAN ANTONIUS JEROEN ADRIAAN , PRONK JACOBUS THOMAS , KLAASSEN PAUL , JONG DE RENE MARCEL
IPC分类号： C12N1/18 , C12N9/12 , C12P7/08
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to Y274 and/or D376 of SEQ ID NO: 51, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 51, and wherein the polypeptide has kinase activity.
摘要翻译：本发明涉及在一个或多个对应于SEQ ID NO：51的Y274和/或D376的位置具有突变的多肽，其中所述多肽与SEQ ID NO：51具有至少50％的序列同一性，并且其中所述多肽具有激酶活性。

4. 发明申请

WO2010066743A3 FERMENTATION OF ISOMALTULOSE 审中-公开
标题翻译：异烟酸的发酵
公开(公告)号：WO2010066743A3
公开(公告)日：2010-10-21
申请号：PCT/EP2009066643
申请日：2009-12-08
申请人： DSM IP ASSETS BV , GIELESEN BIANCA , KLAASSEN PAUL , LAAT DE WILHELMUS THEODORUS ANTONIUS MARIA
发明人： GIELESEN BIANCA , KLAASSEN PAUL , LAAT DE WILHELMUS THEODORUS ANTONIUS MARIA
IPC分类号： C12P7/06 , C12N1/18 , C12R1/865
CPC分类号： C12N1/18 , C12P7/06 , C12R1/865 , Y02E50/17
摘要： The present invention relates to a process for the fermentation of isomaltulose. wherein isomaltulose obtained from plant material is contacted with cells of Saccharomyces. Preferably, the Saccharomyces is Saccharomyces cerevisiae. According to a preferred embodiment the specific growth rate on isomaltulose is 0.25 h-1 or more under anaerobic conditions. Preferably the fermentation has a yield of ethanol of 0.3 g ethanol/g sugar or more.
摘要翻译：本发明涉及异麦芽酮糖的发酵方法。其中从植物材料获得的异麦芽酮糖与酵母属细胞接触。优选地，酵母属是酿酒酵母（Saccharomyces cerevisiae）。根据优选实施方案，异麦芽酮糖的比生长速率在厌氧条件下为0.25h -1以上。优选地，发酵具有0.3g乙醇/ g糖或更多糖的乙醇产率。

5. 发明申请

WO2012143513A3 YEAST CELL CAPABLE OF CONVERTING SUGARS INCLUDING ARABINOSE AND XYLOSE 审中-公开
标题翻译：酵母细胞能够转化糖，包括阿拉伯糖和木糖
公开(公告)号：WO2012143513A3
公开(公告)日：2012-12-27
申请号：PCT/EP2012057273
申请日：2012-04-20
申请人： DSM IP ASSETS BV , KLAASSEN PAUL , GIELESEN BIANCA ELISABETH MARIA , VAN SUYLEKOM GIJSBERDINA PIETERNELLA , SARANTINOPOULOS PANAGIOTIS , HEIJNE WILBERT HERMAN MARIE , GREEVE ALDO
发明人： KLAASSEN PAUL , GIELESEN BIANCA ELISABETH MARIA , VAN SUYLEKOM GIJSBERDINA PIETERNELLA , SARANTINOPOULOS PANAGIOTIS , HEIJNE WILBERT HERMAN MARIE , GREEVE ALDO
IPC分类号： C07K14/395 , C12N1/36 , C12P7/10 , C12R1/865
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/1205 , C12N9/90 , C12N9/92 , C12P2203/00 , C12R1/865 , C12Y207/01016 , C12Y503/01 , C12Y503/01003 , C12Y503/01005 , Y02E50/16
摘要： Yeast cell belonging to the genus Saccharomyces having introduced into its genome at least one xylA gene and at least one of each of araA, araB and araD genes and that is capable of consuming a mixed sugar mixture comprising glucose, xylose and arabinose, wherein the cell co-consumes glucose and arabinose, has genetic variations obtained during adaptive evolution and has a specific xylose consumption rate in the presence of glucose that is 0.25 g xylose/h, g DM or more.
摘要翻译：属于酵母属的酵母细胞已经在其基因组中引入了至少一个xylA基因和araA，araB和araD基因各自中的至少一个并且能够消耗包含葡萄糖，木糖和阿拉伯糖的混合糖混合物，其中所述细胞共同消耗葡萄糖和阿拉伯糖，在适应性进化过程中获得遗传变异并且在葡萄糖存在下具有特定的木糖消耗速率，所述葡萄糖为0.25g木糖/ h，gDM或更高。

6. 发明申请

WO2009077523A3 IMPROVED STATIN PRODUCTION 审中-公开
标题翻译：改善生产力
公开(公告)号：WO2009077523A3
公开(公告)日：2009-08-13
申请号：PCT/EP2008067607
申请日：2008-12-16
申请人： DSM IP ASSETS BV , KLAASSEN PAUL , VOLLEBREGT ADRIANUS WILHELMUS , VAN DEN BERG MARCO ALEXANDER , MEIJRINK BERNARD
发明人： KLAASSEN PAUL , VOLLEBREGT ADRIANUS WILHELMUS , VAN DEN BERG MARCO ALEXANDER , MEIJRINK BERNARD
IPC分类号： C12P17/06 , C12N9/18 , C12N15/10 , C12P7/42 , C12P7/52
CPC分类号： C12N9/18 , C12P7/42 , C12P7/62 , C12P17/06
摘要： The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin and/or simvastatin comprising culturing a mutant host capable of producing said compound wherein esterase activity in said mutant host is more than 25% below the activity of said esterase in the parent host. Also, the present invention provides mutant hosts having 2-methylbutyric esterase and/or 2,2-dimethylbutyric esterase activity which is more than 25% below the activity of said esterase in the parent host.
摘要翻译：本发明提供了发酵生产贝伐菌素，洛伐他汀，普伐他汀和/或辛伐他汀的方法，其包括培养能够产生所述化合物的突变宿主，其中所述突变宿主中的酯酶活性低于所述酯酶活性的25％父主机。此外，本发明提供了具有2-甲基丁酸酯酶和/或2,2-二甲基丁酸酯酶活性的突变体宿主，其比母体宿主中所述酯酶的活性低25％以上。

7. 发明申请

WO2014195520A3 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195520A3
公开(公告)日：2015-02-26
申请号：PCT/EP2014063068
申请日：2014-06-20
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： KLAASSEN PAUL , DE WAAL PAULUS PETRUS , DE JONG RENÉ MARCEL , DRIESSEN ARNOLD JACOB MATTIEU , NIJLAND JEROEN GERBEN , SHIN HYUN YONG
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution corresponding to F85T/A/C/H/M/N, T89H/D/C/A/N, V187T/C/D/E/F/G/H/K/M/Q/R/S/W/Y, A191N/G/P/ C/D/F/H/I/K/Q/V/W/Y, Y214V/Q/G/L/M/N/P/R/S, Q215L/M/I/A/C/D/F/S, I218K/N/A/C/D/E/H/L, T219G/F/D/N, I222D/C/H/E/G/P/S/V/Y, Y226D/M/R/C/G/H/I/L/P/Q/T/W, Q338C/E/F/D/G/I/P/R/S/T/V/W/Y, M339N/V/D/E/H/K/P/Q/R/Y, Q341T/M/N/S/Y, Q342Y/S/C/A/D/F/G/H/I/K/L/N/P/R/T/V/W, L343K/R/P/C/D/E/G/H/I/M/N/Q/S/T/Y, N346W/Y/F/G/H/K/L/M/R/T, N347A/I/E/H/L, Y350R/L/T/D/K/M/N/V, G373L/E/N /F/K/M/R/V/W/Y, N376I/T/M/A/C/E/F/H/K/L/P/Q/R/V/W/Y, T380M/F/H/N/P/Q/R/S/V, S383Q/T/C/D/E/F/I/K/L/M/R/V/W/Y, F444Y/D/E/H/K/N/P/Q/R/W, F446Q/L/H/D/E/I/M/N, T448M/H/D/E/F/K/R/W/Y, T449F/M/N/S/D/E/G/H/I/K/L/P/Q/R/V/W/Y, T451I/E/C/D/F/H/K/L/M/N/Q/R/S/T/V/W/Y, W455T/N/A/C/E/L/P/Q/T, N478P/F/V/G/I/K/R/W, or W479T/S/Q/D/E/F/G/H/I/M/N/P/R/V/Y of SEQ ID NO:59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS).
摘要翻译：本发明涉及一种对F85T / A / C / H / M / N，T89H / D / C / A / N，V187T / C / D / E / F / G / H / K / M / Q / R / S / W / Y，A191N / G / P / C / D / F / H / I / K / Q / V / W / Y，Y214V / Q / G / L / M / N / P / R / S，Q215L / M / I / A / C / D / F / S，I218K / N / A / C / D / E / H / L，T219G / F / D / N，I222D / C / H / E / G / P / S / V / Y，Y226D / M / R / C / G / H / I / L / P / Q / T / W，Q338C / E / F / D / G / / P / R / S / T / V / W / Y，M339N / V / D / E / H / K / P / Q / R / Y，Q341T / M / N / S / Y，Q342Y / S / C / A / D / F / G / H / I / K / L / N / P / R / T / V / W，L343K / R / P / C / D / E / G / H / I / M / N / Q / S / T / Y，N346W / Y / F / G / H / K / L / M / R / T，N347A / I / E / H / L，Y350R / L / T / D / K / M / N / V，G373L / E / N / F / K / M / R / V / W / Y，N376I / T / M / A / C / E / F / H / K / L / P / Q / R / V / W / Y，T380M / F / H / N / P / Q / R / S / V，S383Q / T / C / D / E / F / I / K / L / M / R / V / W / Y，F444Y / D / E / H / K / N / P / Q / R / W，F446Q / L / H / D / E / I / M / N，T448M / H / D / E / F / K / R / W / Y，T449F / M / N / S / D / E / G / H / I / K / L / P / Q / R / V / W / Y，T451I / E / C / D / F / H / K / L / M / N / Q / R / S / T / V / W / Y，W455T / N / A / C / E / L / P / Q / T，N478P / F / V / G / I / K / R / W，或SEQ ID NO：59的W479T / S / Q / D / E / F / G / H / I / M / N / P / R / V / Y，主要辅导员超家庭成员（MFS）的成员。

8. 发明申请

WO2014195377A3 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有渗透酶活性的多肽
公开(公告)号：WO2014195377A3
公开(公告)日：2015-02-19
申请号：PCT/EP2014061635
申请日：2014-06-04
申请人： DSM IP ASSETS BV
发明人： KLAASSEN PAUL , DE WAAL PAULUS PETRUS , DE JONG RENÉ MARCEL , DRIESSEN ARNOLD JACOB MATTIEU , NIJLAND JEROEN GERBEN , SHIN HYUN YONG
IPC分类号： C07K14/395
CPC分类号： C07K14/395 , C12P19/02
摘要： The invention relates to a polypeptide having one or more substitution corresponding to T89C/Y, V187M/Q/C/G/Y, A191 l/K/D/C/E/N/W/R/P, Y214L/P, Q215D/E/S/M/L/C/F/A, 1218W, T219V/L/R/E, I222G/Y/M/P/S/W, Y226M/T/P/Q, Q338R/I/D/E/F/G/P, M339Y/E/N, Q341V/Y/S/H, Q342N/H/R/C/F/G/I/K/L/P/S/T/W, L343Y/Q/I/C/E/K/N/P/S, N346G/I, N347S/L/K/G/TA/, Y350E/S/Q, G373R/K/L/IWY, N376K/Q/A/C/D/E/I/M/P, T380Y/G/M/A/S/D/E/I/K/L/W, S383Y/WA//C/E/I/L/Q/R, F446H/D/I, T448/R/K/H/D/E/W, T449F/H/A/G/I/L/P/QA/, T451W/Y/S, W455D/K/E/P/Q, N478Q/I/F/G, or W479S/I/F/D/E/H/M/N/R/T/Y of SEQ ID NO:59 wherein the polypeptide is member of the Major Facilitator Superfamily (MFS).
摘要翻译：本发明涉及具有一个或多个对应于T89C / Y，V187M / Q / C / G / Y，A1911 / K / D / C / E / N / W / R / P，Y214L / P， Q215D / E / S / M / L / C / F / A，1218W，T219V / L / R / E，I222G / Y / M / P / S / W，Y226M / T / P / Q，Q338R / D / E / F / G / P，M339Y / E / N，Q341V / Y / S / H，Q342N / H / R / C / F / G / I / K / L / P / S / L343Y / Q / I / C / E / K / N / P / S，N346G / I，N347S / L / K / G / TA /，Y350E / S / Q，G373R / K / L / IWY，N376K / Q / A / C / D / E / I / M / P，T380Y / G / M / A / S / D / E / I / K / L / W，S383Y / Q / R，F446H / D / I，T448 / R / K / H / D / E / W，T449F / H / A / G / I / L / P / QA /，T451W / Y / S，W455D / K SEQ ID NO：59的/ E / P / Q，N478Q / I / F / G或W479S / I / F / D / E / H / M / N / R / T / Y，其中所述多肽是主要促进者超级家庭（MFS）。

9. 发明申请

WO2014180820A3 GPD-YEAST STRAINS WITH IMPROVED OSMOTOLERANCE 审中-公开
标题翻译： GPD-YEAST菌株具有改善的易感性
公开(公告)号：WO2014180820A3
公开(公告)日：2015-01-08
申请号：PCT/EP2014059193
申请日：2014-05-06
申请人： DSM IP ASSETS BV
发明人： GUADALUPE MEDINA VICTOR GABRIEL , METZ BENJAMIN , OUD BART , GRAAF VAN DER CHARLOTTE M , MANS ROBERT , PRONK JACOBUS THOMAS , MARIS VAN ANTONIUS JEROEN ADRIAAN , KLAASSEN PAUL
IPC分类号： C12N1/36 , C12N9/02 , C12N9/04 , C12N9/16 , C12N15/01 , C12P7/06 , C12R1/865
CPC分类号： C12N9/0006 , C12N1/36 , C12N9/0008 , C12N9/16 , C12N15/01 , C12P7/06 , C12R1/865 , C12Y101/01008 , C12Y102/0101 , C12Y301/03021 , Y02E50/16 , Y02E50/17
摘要： Yeast cell that is genetically modified comprising: a) a deletion or disruption of one or more nucleotide sequence selected from the group of GPD1, GPD2, GPP1 and GPP2 and b) presence of one or more heterologous nucleotide sequence encoding a NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10.), wherein the yeast cell has an osmotolerance of 0.5 OsM or more.
摘要翻译：经遗传修饰的酵母细胞包含：a）选自GPD1，GPD2，GPP1和GPP2的一个或多个核苷酸序列的缺失或破坏，以及b）存在一个或多个编码NAD +依赖性乙酰化乙醛的异源核苷酸序列脱氢酶（EC 1.2.1.10。），其中酵母细胞具有0.5 OsM以上的渗透性。

10. 发明申请

WO2014195521A3 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195521A3
公开(公告)日：2015-02-19
申请号：PCT/EP2014063069
申请日：2014-06-20
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： KLAASSEN PAUL , DE WAAL PAULUS PETRUS , DE JONG RENÉ MARCEL , DRIESSEN ARNOLD JACOB MATTIEU , NIJLAND JEROEN GERBEN , SHIN HYUN YONG
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 &Dgr;tR.
摘要翻译：本发明涉及在对应于SEQ ID NO：59的位置339或376的位置具有一个或多个取代的多肽，其中多肽是主要促进剂超家族（MFS）的成员。在一个实施方案中，取代位于对应于376的位置，并且其中该位置处的氨基酸被具有范德华体积为80至138埃的氨基酸和10至100重量％的侧链疏水性。

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