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    • 2. 发明申请
    • POLYPEPTIDES WITH PERMEASE ACTIVITY
    • 具有过氧化物酶活性的多糖
    • WO2014195522A3
    • 2015-03-05
    • PCT/EP2014063070
    • 2014-06-20
    • DSM IP ASSETS BVUNIV GRONINGEN
    • KLAASSEN PAULDE WAAL PAULUS PETRUSDE JONG RENÉ MARCELDRIESSEN ARNOLD JACOB MATTIEUNIJLAND JEROEN GERBENSHIN HYUN YONG
    • C07K14/395
    • C07K14/395
    • The invention relates to a polypeptide having one or more substitution corresponding to T89C/Y, V187M/Q/C/G/Y, A191 l/K/D/C/E/N/W/R/P, Y214L/P, Q215D/E/S/M/L/C/F/A, 1218W, T219V/L/R/E, I222G/Y/M/P/S/W, Y226M/T/P/Q, Q338R/I/D/E/F/G/P, M339Y/E/N, Q341V/Y/S/H, Q342N/H/R/C/F/G/I/K/L/P/S/T/W, L343Y/Q/I/C/E/K/N/P/S, N346G/I, N347S/L/K/G/TA/, Y350E/S/Q, G373R/K/L/IWY, N376K/Q/A/C/D/E/I/M/P, T380Y/G/M/A/S/D/E/I/K/L/W, S383Y/WA//C/E/I/L/Q/R, F446H/D/I, T448/R/K/H/D/E/W, T449F/H/A/G/I/L/P/QA/, T451W/Y/S, W455D/K/E/P/Q, N478Q/I/F/G, or W479S/I/F/D/E/H/M/N/R/T/Y of SEQ ID NO:59 wherein the polypeptide is member of the Major Facilitator Superfamily (MFS).
    • 本发明涉及对应于T89C / Y,V187M / Q / C / G / Y,A191I / K / D / C / E / N / W / R / P,Y214L / P, Q215D / E / S / M / L / C / F / A,1218W,T219V / L / R / E,I222G / Y / M / P / S / W,Y226M / T / P / Q,Q338R / I / D / E / F / G / P,M339Y / E / N,Q341V / Y / S / H,Q342N / H / R / C / F / G / I / K / L / P / S / T / L343Y / Q / I / C / E / K / N / P / S,N346G / I,N347S / L / K / G / TA /,Y350E / S / Q,G373R / K / L / IWY,N376K / Q / A / C / D / E / I / M / P,T380Y / G / M / A / S / D / E / I / K / L / W,S383Y / WA // C / E / I / Q / R,F446H / D / I,T448 / R / K / H / D / E / W,T449F / H / A / G / I / L / P / QA /,T451W / Y / S,W455D / K / E / P / Q,N478Q / I / F / G或SEQ ID NO:59的W479S / I / F / D / E / H / M / N / R / T / Y,其中多肽是 主要辅导员超家庭(MFS)。
    • 3. 发明申请
    • POLYPEPTIDES WITH PERMEASE ACTIVITY
    • 具有渗透酶活性的多肽
    • WO2014195377A3
    • 2015-02-19
    • PCT/EP2014061635
    • 2014-06-04
    • DSM IP ASSETS BV
    • KLAASSEN PAULDE WAAL PAULUS PETRUSDE JONG RENÉ MARCELDRIESSEN ARNOLD JACOB MATTIEUNIJLAND JEROEN GERBENSHIN HYUN YONG
    • C07K14/395
    • C07K14/395C12P19/02
    • The invention relates to a polypeptide having one or more substitution corresponding to T89C/Y, V187M/Q/C/G/Y, A191 l/K/D/C/E/N/W/R/P, Y214L/P, Q215D/E/S/M/L/C/F/A, 1218W, T219V/L/R/E, I222G/Y/M/P/S/W, Y226M/T/P/Q, Q338R/I/D/E/F/G/P, M339Y/E/N, Q341V/Y/S/H, Q342N/H/R/C/F/G/I/K/L/P/S/T/W, L343Y/Q/I/C/E/K/N/P/S, N346G/I, N347S/L/K/G/TA/, Y350E/S/Q, G373R/K/L/IWY, N376K/Q/A/C/D/E/I/M/P, T380Y/G/M/A/S/D/E/I/K/L/W, S383Y/WA//C/E/I/L/Q/R, F446H/D/I, T448/R/K/H/D/E/W, T449F/H/A/G/I/L/P/QA/, T451W/Y/S, W455D/K/E/P/Q, N478Q/I/F/G, or W479S/I/F/D/E/H/M/N/R/T/Y of SEQ ID NO:59 wherein the polypeptide is member of the Major Facilitator Superfamily (MFS).
    • 本发明涉及具有一个或多个对应于T89C / Y,V187M / Q / C / G / Y,A1911 / K / D / C / E / N / W / R / P,Y214L / P, Q215D / E / S / M / L / C / F / A,1218W,T219V / L / R / E,I222G / Y / M / P / S / W,Y226M / T / P / Q,Q338R / D / E / F / G / P,M339Y / E / N,Q341V / Y / S / H,Q342N / H / R / C / F / G / I / K / L / P / S / L343Y / Q / I / C / E / K / N / P / S,N346G / I,N347S / L / K / G / TA /,Y350E / S / Q,G373R / K / L / IWY,N376K / Q / A / C / D / E / I / M / P,T380Y / G / M / A / S / D / E / I / K / L / W,S383Y / Q / R,F446H / D / I,T448 / R / K / H / D / E / W,T449F / H / A / G / I / L / P / QA /,T451W / Y / S,W455D / K SEQ ID NO:59的/ E / P / Q,N478Q / I / F / G或W479S / I / F / D / E / H / M / N / R / T / Y,其中所述多肽是 主要促进者超级家庭(MFS)。
    • 4. 发明申请
    • POLYPEPTIDES WITH PERMEASE ACTIVITY
    • 具有过氧化物酶活性的多糖
    • WO2014195520A3
    • 2015-02-26
    • PCT/EP2014063068
    • 2014-06-20
    • DSM IP ASSETS BVUNIV GRONINGEN
    • KLAASSEN PAULDE WAAL PAULUS PETRUSDE JONG RENÉ MARCELDRIESSEN ARNOLD JACOB MATTIEUNIJLAND JEROEN GERBENSHIN HYUN YONG
    • C07K14/395
    • C07K14/395
    • The invention relates to a polypeptide having one or more substitution corresponding to F85T/A/C/H/M/N, T89H/D/C/A/N, V187T/C/D/E/F/G/H/K/M/Q/R/S/W/Y, A191N/G/P/ C/D/F/H/I/K/Q/V/W/Y, Y214V/Q/G/L/M/N/P/R/S, Q215L/M/I/A/C/D/F/S, I218K/N/A/C/D/E/H/L, T219G/F/D/N, I222D/C/H/E/G/P/S/V/Y, Y226D/M/R/C/G/H/I/L/P/Q/T/W, Q338C/E/F/D/G/I/P/R/S/T/V/W/Y, M339N/V/D/E/H/K/P/Q/R/Y, Q341T/M/N/S/Y, Q342Y/S/C/A/D/F/G/H/I/K/L/N/P/R/T/V/W, L343K/R/P/C/D/E/G/H/I/M/N/Q/S/T/Y, N346W/Y/F/G/H/K/L/M/R/T, N347A/I/E/H/L, Y350R/L/T/D/K/M/N/V, G373L/E/N /F/K/M/R/V/W/Y, N376I/T/M/A/C/E/F/H/K/L/P/Q/R/V/W/Y, T380M/F/H/N/P/Q/R/S/V, S383Q/T/C/D/E/F/I/K/L/M/R/V/W/Y, F444Y/D/E/H/K/N/P/Q/R/W, F446Q/L/H/D/E/I/M/N, T448M/H/D/E/F/K/R/W/Y, T449F/M/N/S/D/E/G/H/I/K/L/P/Q/R/V/W/Y, T451I/E/C/D/F/H/K/L/M/N/Q/R/S/T/V/W/Y, W455T/N/A/C/E/L/P/Q/T, N478P/F/V/G/I/K/R/W, or W479T/S/Q/D/E/F/G/H/I/M/N/P/R/V/Y of SEQ ID NO:59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS).
    • 本发明涉及一种对F85T / A / C / H / M / N,T89H / D / C / A / N,V187T / C / D / E / F / G / H / K / M / Q / R / S / W / Y,A191N / G / P / C / D / F / H / I / K / Q / V / W / Y,Y214V / Q / G / L / M / N / P / R / S,Q215L / M / I / A / C / D / F / S,I218K / N / A / C / D / E / H / L,T219G / F / D / N,I222D / C / H / E / G / P / S / V / Y,Y226D / M / R / C / G / H / I / L / P / Q / T / W,Q338C / E / F / D / G / / P / R / S / T / V / W / Y,M339N / V / D / E / H / K / P / Q / R / Y,Q341T / M / N / S / Y,Q342Y / S / C / A / D / F / G / H / I / K / L / N / P / R / T / V / W,L343K / R / P / C / D / E / G / H / I / M / N / Q / S / T / Y,N346W / Y / F / G / H / K / L / M / R / T,N347A / I / E / H / L,Y350R / L / T / D / K / M / N / V,G373L / E / N / F / K / M / R / V / W / Y,N376I / T / M / A / C / E / F / H / K / L / P / Q / R / V / W / Y,T380M / F / H / N / P / Q / R / S / V,S383Q / T / C / D / E / F / I / K / L / M / R / V / W / Y,F444Y / D / E / H / K / N / P / Q / R / W,F446Q / L / H / D / E / I / M / N,T448M / H / D / E / F / K / R / W / Y,T449F / M / N / S / D / E / G / H / I / K / L / P / Q / R / V / W / Y,T451I / E / C / D / F / H / K / L / M / N / Q / R / S / T / V / W / Y,W455T / N / A / C / E / L / P / Q / T,N478P / F / V / G / I / K / R / W,或SEQ ID NO:59的W479T / S / Q / D / E / F / G / H / I / M / N / P / R / V / Y, 主要辅导员超家庭成员(MFS)的成员。