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1. 发明申请

WO2010102976A1 PREGASTRIC ESTERASE AND DERIVATIVES THEREOF 审中-公开
标题翻译： PREGASTRIC ESTERASE及其衍生物
公开(公告)号：WO2010102976A1
公开(公告)日：2010-09-16
申请号：PCT/EP2010/052903
申请日：2010-03-08
申请人： DSM IP ASSETS B.V. , PARENICOVA, Lucie , BUSINK, Ronald , LAAN, VAN DER, Jan Metske
发明人： PARENICOVA, Lucie , BUSINK, Ronald , LAAN, VAN DER, Jan Metske
IPC分类号： C12N9/20 , A23C19/032 , C12N1/15 , C12N15/21 , C12H1/00 , C12P21/02
CPC分类号： A23C19/063 , A23C19/0328 , A23C19/072 , A23C19/082 , C12N9/20
摘要： The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.
摘要翻译：本发明涉及新的脂肪酶多核苷酸序列，其相应的蛋白质以及制备所述序列和所述蛋白质的方法以及蛋白质在制备食物组合物中的用途。本发明还涉及从宿主细胞外部释放蛋白质的方法以及杀死微生物的方法。

2. 发明申请

WO2010102982A1 METHOD FOR IMPROVING THE YIELD OF A POLYPEPTIDE 审中-公开
标题翻译：改善多肽的含量的方法
公开(公告)号：WO2010102982A1
公开(公告)日：2010-09-16
申请号：PCT/EP2010/052918
申请日：2010-03-08
申请人： DSM IP Assets B.V. , LAAN, VAN DER, Jan Metske , WU, Liang , ROUBOS, Johannes, Andries , PARENICOVA, Lucie , LOS, Alrik Pieter , PEIJ, VAN, Noël Nicolaas Maria Elisabeth , PEL, Herman Jan
发明人： LAAN, VAN DER, Jan Metske , WU, Liang , ROUBOS, Johannes, Andries , PARENICOVA, Lucie , LOS, Alrik Pieter , PEIJ, VAN, Noël Nicolaas Maria Elisabeth , PEL, Herman Jan
IPC分类号： C12P21/02 , C12N15/67
CPC分类号： C12P21/02
摘要： The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.
摘要翻译：本发明涉及提高蛋白质产量的方法。该方法包括将一组相关蛋白质特征的值修改为落入最佳范围内，或者变得更接近于真核宿主中的一种或多种蛋白质特征的最佳值。

3. 发明申请

WO2011134916A1 NOVEL ASPARAGINASE ENZYME 审中-公开
标题翻译：新颖的ASPARAGINASE ENZYME
公开(公告)号：WO2011134916A1
公开(公告)日：2011-11-03
申请号：PCT/EP2011/056503
申请日：2011-04-22
申请人： DSM IP Assets B.V. , LAAN, VAN DER, Jan Metske , LANGE, DE, Ilse , STOR, Mark, Cristiaan
发明人： LAAN, VAN DER, Jan Metske , LANGE, DE, Ilse , STOR, Mark, Cristiaan
IPC分类号： C12N9/82 , C07K14/38
CPC分类号： C12N9/82 , C07K14/38
摘要： The present invention relates to a protein which exhibits asparaginase activity and which has an amino acid sequence according to SEQ ID NO. 2 - SEQ ID NO.10. The advantage of the protein of the present invention is that it exhibits asparaginase activity (EC 3.5.1.1) with a specific activity at acidic, neutral and alkaline pH which is many times higher than the specific activity of wild-type asparaginase.
摘要翻译：本发明涉及显示天冬酰胺酶活性的蛋白质，其具有根据SEQ ID NO：1的氨基酸序列。 2 - SEQ ID NO.10。本发明的蛋白质的优点在于其表现出在酸性，中性和碱性pH下具有比野生型天冬酰胺酶比活性高出许多倍的比活性的天冬酰胺酶活性（EC 3.5.1.1）。

4. 发明申请

WO2010069914A1 STATIN TRANSCRIPTION REGULATORS 审中-公开
标题翻译： STATIN转录调节器
公开(公告)号：WO2010069914A1
公开(公告)日：2010-06-24
申请号：PCT/EP2009/067067
申请日：2009-12-14
申请人： DSM IP ASSETS B.V. , HANS, Marcus , BERG, VAN DEN, Marco Alexander , LAAN, VAN DER, Jan Metske
发明人： HANS, Marcus , BERG, VAN DEN, Marco Alexander , LAAN, VAN DER, Jan Metske
IPC分类号： C12N15/52 , C07K14/385 , C12P7/42
CPC分类号： C12P7/42 , C07K14/385
摘要： The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin or simvastatin comprising culturing a host, preferably a filamentous fungus, comprising one of the transcription regulator genes having SEQ ID NO 23, SEQ ID NO 26, SEQ ID NO 27 and SEQ ID NO 28. Furthermore, the invention provides a host for the production of above mentioned statins comprising one of said transcription regulators.
摘要翻译：本发明提供了发酵生产美伐他汀，洛伐他汀，普伐他汀或辛伐他汀的方法，其包括培养宿主，优选丝状真菌，其包含具有SEQ ID NO 23，SEQ ID NO 26，SEQ ID NO 27的转录调节基因之一此外，本发明提供了用于生产上述他汀类药物的宿主，其包含所述转录调节物之一。

5. 发明申请

WO2010072765A2 MUTANT PENICILLIN G ACYLASES 审中-公开
标题翻译：突变青霉素G酰基转移酶
公开(公告)号：WO2010072765A2
公开(公告)日：2010-07-01
申请号：PCT/EP2009/067752
申请日：2009-12-22
申请人： DSM IP ASSETS B.V. , LAAN, VAN DER, Jan Metske , MOODY, Harold, Monro , KERKMAN, Richard , DOES, VAN DER, Thomas
发明人： LAAN, VAN DER, Jan Metske , MOODY, Harold, Monro , KERKMAN, Richard , DOES, VAN DER, Thomas
IPC分类号： C12N15/55 , C12N9/84 , C12P35/04 , C12P37/04
CPC分类号： C12N9/84 , C12P35/04 , C12P37/04
摘要： The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acid positions A3, A77, A90, A144 A192, B24, B109, B148, B313, B460 and B488 according to the amino acid numbering of the Escherichia coli penicillin G acylase having the amino acid sequence depicted in SEQ ID No: 1.
摘要翻译：本发明涉及衍生自野生型青霉素G酰基转移酶的突变原核青霉素G酰基转移酶，其特征在于突变体在选自组的一个或多个氨基酸位置处具有氨基酸取代根据具有氨基酸序列的大肠杆菌青霉素G酰基转移酶的氨基酸编号由氨基酸位置A3，A77，A90，A144，A192，B24，B109，B148，B313，B460和B488组成如SEQ ID No：1所示。

6. 发明申请

WO2009109631A9 A PENTOSE SUGAR FERMENTING CELL 审中-公开
公开(公告)号：WO2009109631A9
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052621
申请日：2009-03-05
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisbeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
发明人： KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisbeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
IPC分类号： C12N9/92 , C12P7/10 , C12N15/52
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

7. 发明申请

WO2009109630A1 A PENTOSE SUGAR FERMENTING CELL 审中-公开
标题翻译：五香糖发酵细胞
公开(公告)号：WO2009109630A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052620
申请日：2009-03-05
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
发明人： KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
IPC分类号： C12N9/92 , C12P7/10 , C12N15/52
CPC分类号： C12N9/92 , C12P7/10 , Y02E50/16
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
摘要翻译：本发明涉及包含编码木糖异构酶的核苷酸序列的细胞，其中所述木糖异构酶的氨基酸序列与SEQ ID NO：1所示的氨基酸序列具有至少约70％的序列同一性 ID NO：3，并且其中所述核苷酸序列对于宿主而言是异源的。本发明的细胞可用于生产发酵产物如乙醇的方法中。这种方法可以包括用本发明的细胞发酵含有木糖来源的培养基，使得细胞将木糖发酵成发酵产物。

8. 发明申请

WO2008040731A2 PRODUCTION OF BETA-LACTAM ANTIBIOTICS 审中-公开
标题翻译： β-内酰胺抗生素的生产
公开(公告)号：WO2008040731A2
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060460
申请日：2007-10-02
申请人： DSM IP ASSETS B.V. , BOER, Rémon , HANS, Marcus , BOVENBERG, Roelof, Ary, Lans , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske
发明人： HANS, Marcus , BOVENBERG, Roelof, Ary, Lans , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske
IPC分类号： C12N9/02 , C12P37/00
CPC分类号： C12N9/0004
摘要： The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl- valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N- hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V. An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing β-lactam antibiotics with N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl side chains.
摘要翻译：本发明描述了用于生产N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯基乙酰基β-内酰胺抗生素的方法，其包含IPNS-催化的前体三肽羟基苯基甘氨酰 - 半胱氨酰 - 缬氨酸（HpgCV）或苯基甘氨酰 - 半胱氨酰 - 缬氨酸（PgCV）分别与N-羟基苯基甘氨酰基或N-苯基甘氨酰基β-内酰胺抗生素接触。三肽HpgCV或三肽PgCV还可以通过使氨基酸羟苯甘氨酸（Hpg）或苯基甘氨酸（Pg），半胱氨酸（C）和缬氨酸（V）与非核糖体肽合成酶（NRPS）接触以制备三肽HpgCV或三肽PgCV，NRPS包含特异于Hpg或Pg的第一模块M1，特异于C的第二模块M2和特异于V的第三模块M3。进一步提供具有改进的活性的IPNS，以及催化三肽形成的NRPS。还提供了能够用N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯基乙酰基侧链发酵产生β-内酰胺抗生素的宿主细胞。

9. 发明申请

WO2012104239A1 MUTANT CELLOBIOHYDROLASE 审中-公开
标题翻译：突变型细胞溶胶
公开(公告)号：WO2012104239A1
公开(公告)日：2012-08-09
申请号：PCT/EP2012/051416
申请日：2012-01-30
申请人： DSM IP ASSETS B.V. , LAAN, VAN DER, Jan Metske , SCHOONEVELD-BERGMANS, Margot, Elisabeth, Francoise , JACOBS, Denise, Ilse
发明人： LAAN, VAN DER, Jan Metske , SCHOONEVELD-BERGMANS, Margot, Elisabeth, Francoise , JACOBS, Denise, Ilse
IPC分类号： C12N9/42 , C12N9/24
CPC分类号： C12N9/2437 , C12P19/14 , C12Y302/01091
摘要： The invention relates to Mutant cellobiohydrolase, being a mutant of SEQ ID NO:1, having a substitution at position N247(I,F,H,W) of SEQ ID NO: 1, wherein the mutant cellobiohydrolase has at least 50% sequence identity with SEQ ID NO: 1, and wherein the mutant cellobiohydrolase has CBHI activity.
摘要翻译：本发明涉及作为SEQ ID NO：1的突变体的突变型纤维二糖水解酶，其在SEQ ID NO：1的N247位（I，F，H，W）处具有取代，其中突变纤维二糖水解酶具有至少50％的序列同一性具有SEQ ID NO：1，并且其中所述突变纤维二糖水解酶具有CBHI活性。

10. 发明申请

WO2008128975A1 NOVEL ASPARAGINASES AND USES THEREOF 审中-公开
标题翻译：新颖的雅加达及其用途
公开(公告)号：WO2008128975A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054693
申请日：2008-04-17
申请人： DSM IP ASSETS B.V. , LAAN, VAN DER, Jan Metske , STOR, Mark, Cristiaan , LANGE, DE, Ilse , MOHRMANN, Lisette
发明人： LAAN, VAN DER, Jan Metske , STOR, Mark, Cristiaan , LANGE, DE, Ilse , MOHRMANN, Lisette
IPC分类号： C12N9/82 , A23L1/03 , A23L1/30 , C07K14/38
CPC分类号： C12N9/82 , A23L5/25 , A23L29/06 , C12Y305/01001
摘要： The present invention relates to an asparaginase having the width of the pH activity profile which is at least 3.5. Furthermore the invention relates to newly identified asparaginase polypeptide according to any one of SEQ ID NO: 2 or SEQ ID NO: 4 and to variants thereof and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.
摘要翻译：本发明涉及具有至少3.5的pH活性分布宽度的天冬酰胺酶。此外，本发明涉及根据SEQ ID NO：2或SEQ ID NO：4中任一项的新鉴定的天冬酰胺酶多肽及其变体，以及编码这种新型天冬酰胺酶变体的多核苷酸序列。此外，本发明涉及这些新型天冬酰胺酶变体在工业过程中的用途。

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