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1. 发明申请

WO2009109631A9 A PENTOSE SUGAR FERMENTING CELL 审中-公开
公开(公告)号：WO2009109631A9
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052621
申请日：2009-03-05
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisbeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
发明人： KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisbeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
IPC分类号： C12N9/92 , C12P7/10 , C12N15/52
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

2. 发明申请

WO2009109634A1 A PENTOSE SUGAR FERMENTING CELL 审中-公开
公开(公告)号：WO2009109634A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052625
申请日：2009-03-05
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , LAAN, VAN DER,, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
发明人： KLAASSEN, Paul , LAAN, VAN DER,, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
IPC分类号： C12N9/92 , C12P7/10 , C12N15/52
CPC分类号： C12N9/92 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

3. 发明申请

WO2009109633A1 A PENTOSE SUGAR FERMENTING CELL 审中-公开
公开(公告)号：WO2009109633A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052623
申请日：2009-03-05
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , LAAN, VAN DER,, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
发明人： KLAASSEN, Paul , LAAN, VAN DER,, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
IPC分类号： C12N9/92 , C12P7/10 , C12N15/52
CPC分类号： C12N9/92 , C12P7/10 , Y02E50/16
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

4. 发明申请

WO2009109630A1 A PENTOSE SUGAR FERMENTING CELL 审中-公开
标题翻译：五香糖发酵细胞
公开(公告)号：WO2009109630A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052620
申请日：2009-03-05
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
发明人： KLAASSEN, Paul , LAAN, VAN DER, Jan Metske , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella
IPC分类号： C12N9/92 , C12P7/10 , C12N15/52
CPC分类号： C12N9/92 , C12P7/10 , Y02E50/16
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
摘要翻译：本发明涉及包含编码木糖异构酶的核苷酸序列的细胞，其中所述木糖异构酶的氨基酸序列与SEQ ID NO：1所示的氨基酸序列具有至少约70％的序列同一性 ID NO：3，并且其中所述核苷酸序列对于宿主而言是异源的。本发明的细胞可用于生产发酵产物如乙醇的方法中。这种方法可以包括用本发明的细胞发酵含有木糖来源的培养基，使得细胞将木糖发酵成发酵产物。

5. 发明申请

WO2011003893A1 FERMENTATIVE PRODUCTION OF ETHANOL FROM GLUCOSE, GALACTOSE AND ARABINOSE EMPLOYING A RECOMBINANT YEAST STRAIN 审中-公开
标题翻译：从采用重组酵母菌株的葡萄糖，糖苷和阿拉伯胶衍生乙醇的生产
公开(公告)号：WO2011003893A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059618
申请日：2010-07-06
申请人： DSM IP Assets B.V. , KLAASSEN, Paul , SUYLEKOM, VAN, Gijsberdina, Pieternella , GIELESEN, Bianca, Elisabeth, Maria , BROERS, Nicolette, Jasmijn , WIEDEMANN, Beate , LAAT, DE, Wilhelmus, Theodorus, Antonius, Maria
发明人： KLAASSEN, Paul , SUYLEKOM, VAN, Gijsberdina, Pieternella , GIELESEN, Bianca, Elisabeth, Maria , BROERS, Nicolette, Jasmijn , WIEDEMANN, Beate , LAAT, DE, Wilhelmus, Theodorus, Antonius, Maria
IPC分类号： C12P7/10
CPC分类号： C12P7/10 , C12P7/46 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia , and b) recovery of the fermentation product, wherein the yeast comprises the genes araA , araB and araD and the sugar composition comprises glucose, galactose and arabinose.
摘要翻译：本发明涉及从糖组合物生产一种或多种发酵产物的方法，包括以下步骤：a）在属于酵母属，克鲁维酵母属，假丝酵母属，毕赤酵母属的酵母存在下发酵糖组合物，粟酒裂殖酵母属（Schizosaccharomyces），汉逊酵母（Hansenula），克洛克氏菌属（Schwanniomyces）或耶氏酵母属（Yarrowia），以及b）回收发酵产物，其中酵母包含araA，araB和araD基因，糖组合物包含葡萄糖，半乳糖和阿拉伯糖。

6. 发明申请

WO2008040731A2 PRODUCTION OF BETA-LACTAM ANTIBIOTICS 审中-公开
标题翻译： β-内酰胺抗生素的生产
公开(公告)号：WO2008040731A2
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060460
申请日：2007-10-02
申请人： DSM IP ASSETS B.V. , BOER, Rémon , HANS, Marcus , BOVENBERG, Roelof, Ary, Lans , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske
发明人： HANS, Marcus , BOVENBERG, Roelof, Ary, Lans , KLAASSEN, Paul , LAAN, VAN DER, Jan Metske
IPC分类号： C12N9/02 , C12P37/00
CPC分类号： C12N9/0004
摘要： The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl- valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N- hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V. An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing β-lactam antibiotics with N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl side chains.
摘要翻译：本发明描述了用于生产N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯基乙酰基β-内酰胺抗生素的方法，其包含IPNS-催化的前体三肽羟基苯基甘氨酰 - 半胱氨酰 - 缬氨酸（HpgCV）或苯基甘氨酰 - 半胱氨酰 - 缬氨酸（PgCV）分别与N-羟基苯基甘氨酰基或N-苯基甘氨酰基β-内酰胺抗生素接触。三肽HpgCV或三肽PgCV还可以通过使氨基酸羟苯甘氨酸（Hpg）或苯基甘氨酸（Pg），半胱氨酸（C）和缬氨酸（V）与非核糖体肽合成酶（NRPS）接触以制备三肽HpgCV或三肽PgCV，NRPS包含特异于Hpg或Pg的第一模块M1，特异于C的第二模块M2和特异于V的第三模块M3。进一步提供具有改进的活性的IPNS，以及催化三肽形成的NRPS。还提供了能够用N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯基乙酰基侧链发酵产生β-内酰胺抗生素的宿主细胞。

7. 发明申请

WO2012049173A1 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2012049173A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/067726
申请日：2011-10-11
申请人： DSM IP ASSETS B.V. , WISSELINK, Hendrik Wouter , MARIS, VAN, Antonius Jeroen Adriaan , PRONK, Jacobus Thomas , KLAASSEN, Paul , JONG, DE, René Marcel
发明人： WISSELINK, Hendrik Wouter , MARIS, VAN, Antonius Jeroen Adriaan , PRONK, Jacobus Thomas , KLAASSEN, Paul , JONG, DE, René Marcel
IPC分类号： C12N9/12 , C12N1/18 , C12P7/08 , C07K14/395
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译：本发明涉及在一个或多个对应于SEQ ID NO：55的T219的位置具有突变的多肽，其中多肽与SEQ ID NO：55具有至少50％的序列同一性，并且其中多肽具有通透酶活性。

8. 发明申请

WO2011131667A1 CELL SUITABLE FOR FERMENTATION OF A MIXED SUGAR COMPOSITION 审中-公开
标题翻译：用于发酵混合糖成分的细胞
公开(公告)号：WO2011131667A1
公开(公告)日：2011-10-27
申请号：PCT/EP2011/056232
申请日：2011-04-19
申请人： DSM IP ASSETS B.V. , KLAASSEN, Paul , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternell , HEIJNE, Wilbert Herman Marie
发明人： KLAASSEN, Paul , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternell , HEIJNE, Wilbert Herman Marie
IPC分类号： C12N1/36 , C07K14/395
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol 10 dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.
摘要翻译：本发明涉及一种适用于从包含葡萄糖，半乳糖，阿拉伯糖和木糖的糖组合物生产一种或多种发酵产物的细胞，其中所述细胞包含两个至十五个拷贝的一个或多个木糖异构酶基因或二至十五个拷贝的一种或多种木糖还原酶和木糖醇10脱氢酶，以及两至十个拷贝的araA，araB和araD基因，其中这些基因整合到细胞基因组中。

9. 发明申请

WO2007122249A1 PRODUCTION OF COMPOUNDS IN A RECOMBINANT HOST 审中-公开
标题翻译：在重组生物中生产化合物
公开(公告)号：WO2007122249A1
公开(公告)日：2007-11-01
申请号：PCT/EP2007/054045
申请日：2007-04-25
申请人： DSM IP Assets B.V. , BOVENBERG, Roelof, Ary, Lans , VAN DEN BERG, Marco Alexander , HAGE, Suzanne , KLAASSEN, Paul , MEIJRINK, Bernard , RAAMSDONK, Lourina, Madeleine
发明人： BOVENBERG, Roelof, Ary, Lans , VAN DEN BERG, Marco Alexander , HAGE, Suzanne , KLAASSEN, Paul , MEIJRINK, Bernard , RAAMSDONK, Lourina, Madeleine
IPC分类号： C07K14/385 , C12N1/16
CPC分类号： C12N9/1029 , C12N9/0004 , C12N9/93 , C12P7/02 , C12P13/02 , C12P17/06 , C12P17/181 , C12P17/182 , C12P17/188
摘要： The present invention provides a recombinant Penicillium chrysogenum strain characterized in that a gene selected from the list consisting of penDE, pcbAB and pcbC is inactivated and the use of such a strain for the preparation of a compound of interest. Furthermore, it is an object of the present invention to provide a method for the production of a compound of interest in a eukaryotic recombinant microorganism comprising the steps of : (a) Reducing the level of secondary metabolite production in said microorganism with 50-100%; (b) Introducing a heterologous gene into said microorganism
摘要翻译：本发明提供重组产黄青霉菌株，其特征在于，从PenDE，pcbAB和pcbC列表中选出的基因被灭活，并且使用这样的菌株来制备感兴趣的化合物。此外，本发明的目的是提供一种在真核重组微生物中生产感兴趣的化合物的方法，包括以下步骤：（a）降低所述微生物中次级代谢产物的产生水平，其中50-100％ ; （b）将异源基因引入所述微生物

10. 发明申请

WO2011131674A1 PROCESS FOR THE PRODUCTION OF CELLS WHICH ARE CAPABLE OF CONVERTING ARABINOSE 审中-公开
标题翻译：生产可转化阿拉伯糖的细胞的方法
公开(公告)号：WO2011131674A1
公开(公告)日：2011-10-27
申请号：PCT/EP2011/056242
申请日：2011-04-19
申请人： DSM IP ASSETS B.V. , KLAASSEN, Paul , GIELESEN, Bianca Elisabeth Maria , HEIJNE, Wilbert Herman Marie , SUYLEKOM, VAN, Gijsberdina Pieternell
发明人： KLAASSEN, Paul , GIELESEN, Bianca Elisabeth Maria , HEIJNE, Wilbert Herman Marie , SUYLEKOM, VAN, Gijsberdina Pieternell
IPC分类号： C07K14/395 , C12N1/36
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention relates to a process for the production of cells which are capable of converting arabinose, comprising the following steps: a)Introducing into a host strain that cannot convert arabinose, the genes AraA, araB and araD, this cell is designated as constructed cell; b)Subjecting the constructed cell to adaptive evolution until a cell that converts arabinose is obtained, c)Optionally, subjecting the first arabinose converting cell to adaptive evolution to improve the arabinose conversion; the cell produced in step b) or c) is designated as first arabinose converting cell; d)Analysing the full genome or part of the genome of the first arabinose converting cell and that of the constructed cell; e)Identifying single nucleotide polymorphisms (SNP's) in the first arabinose converting cell; and f)Using the information of the SNP's in rational design of a cell capable of converting arabinose; g)Construction of the cell capable of converting arabinose designed in step f).
摘要翻译：本发明涉及生产能够转化阿拉伯糖的细胞的方法，包括以下步骤：a）引入不能转化阿拉伯糖的宿主菌株，AraA，araB和araD基因，该细胞被命名为构建的细胞 ; b）使构建的细胞进行自适应进化，直到获得转化阿拉伯糖的细胞，c）任选地，使第一阿拉伯糖转化细胞经受适应性进化以改善阿拉伯糖转化; 步骤b）或c）中产生的细胞被指定为第一阿拉伯糖转化细胞; d）分析第一个阿拉伯糖转化细胞和构建的细胞的全基因组或部分基因组; e）鉴定第一个阿拉伯糖转化细胞中的单核苷酸多态性（SNP）; 和f）使用SNP的信息来合理设计能够转化阿拉伯糖的细胞; g）能够转化步骤f）中设计的阿拉伯糖的细胞的构建。

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