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1. 发明申请

WO2014014753A1 COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A CELLULOSE ETHER OF VERY LOW VISCOSITY 审中-公开
标题翻译：包含有机液体稀释剂的组合物和非常低粘度的纤维素醚
公开(公告)号：WO2014014753A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050216
申请日：2013-07-12
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： BRACKHAGEN, Meinolf , GRASMAN, Nicholas, S. , HALL, Mark, J. , GUILLAUDEU, Steven, J. , SCHMITT, Robert, L. , KNARR, Matthias
IPC分类号： C08L1/28 , A61K9/08 , A61K47/38 , A61K9/28 , A61K9/16
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/2866 , A61K31/343 , A61K31/4166 , C08L1/284
摘要： A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa∙s, measured as a 2 wt.-% solution in water at 20°C, is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa»s and optionally one or more adjuvants.
摘要翻译：包含有机液体稀释剂和至少一种具有高达2.33mPa.s的非离子纤维素醚的非离子纤维素醚的液体组合物，其在20℃下以2重量％的水溶液测量，在延伸的时间段。液体组合物可用于通过喷雾干燥制备包含至少一种纤维素醚中的至少一种活性成分的固体分散体。或者，可以通过共混和挤出至少一种活性成分，至少一种粘度高达2.33mPa·s的纤维素醚和任选的一种或多种佐剂来制备固体分散体。

2. 发明申请

WO2013055668A1 INJECTION-MOLDED DOSAGE FORM 审中-公开
标题翻译：注射剂型剂型
公开(公告)号：WO2013055668A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059323
申请日：2012-10-09
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： READ, Michael, D. , COPPENS, Karen, A. , HALL, Mark, J. , ZHAO, Jin
IPC分类号： C08L1/28 , A61K9/48 , C08L5/00
CPC分类号： A61K9/4816 , A61K9/4833 , A61K9/4883 , C08K5/0016 , C08K5/05 , C08L1/28 , C08L1/286 , C08L5/00
摘要： An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection- molding the plasticized composition into a three-dimensional shell of a dosage form.
摘要翻译：具有良好质量的剂型的注射成型的外壳可以通过以下方式生产：a）提供组合物，其包含i）25至90重量％的乙基纤维素，ii）7.5至60重量％的不同于乙基纤维素的多糖或多糖衍生物，和iii）基于组合物的总重量，2.5至50重量％的至少一种与多糖和多糖衍生物不同的组分，条件是组合物包含零或不大于10重量％的明胶和 0或不超过10重量％的包含均聚或共聚的丙烯酸，均聚或共聚的甲基丙烯酸，均聚或共聚的丙烯酸酯或均聚或共聚的甲基丙烯酸酯的聚合物的聚合物，和b）使组合物经受剪切和加热塑化组合物并将增塑组合物注塑成剂型的三维壳。

3. 发明申请

WO2014014752A1 SOLID DISPERSION COMPRISING A HIGHLY SUBSTITUTED HYDROXYALKYL METHYLCELLULOSE 审中-公开
标题翻译：包含高取代羟基甲基甲基纤维素的固体分散体
公开(公告)号：WO2014014752A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050213
申请日：2013-07-12
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： GRASMAN, Nicholas S. , GUILLAUDEU, Steven J. , HALL, Mark, J. , SHRESTHA, Uma , ROSE, Maureen L. , PORTER, William W. , SPAULDING, Wesley J. , O'DONNELL, Kevin P. , ROGERS, True L.
IPC分类号： A61K9/14 , A61K9/16 , A61K31/343 , A61K31/415 , A61K31/58
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1652 , A61K9/4891 , A61K31/343 , A61K31/4166 , A61K31/58
摘要： A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.
摘要翻译：一种固体分散体，其包含至少一种具有1.0至2.7的DS和0.40至1.30的DS的羟烷基甲基纤维素中的至少一种活性成分，其中DS是甲氧基的取代度，MS是羟基烷氧基的摩尔取代组，可以通过挤出或喷雾干燥来生产。

4. 发明公开

EP2874607A1 SOLID DISPERSION COMPRISING A HIGHLY SUBSTITUTED HYDROXYALKYL METHYLCELLULOSE 有权转让
标题翻译：具有高固体分散体取代的羟甲基纤维素
公开(公告)号：EP2874607A1
公开(公告)日：2015-05-27
申请号：EP13740163.4
申请日：2013-07-12
申请人： Dow Global Technologies LLC
发明人： GRASMAN, Nicholas S. , GUILLAUDEU, Steven J. , HALL, Mark, J. , SHRESTHA, Uma , ROSE, Maureen L. , PORTER, William W. , SPAULDING, Wesley J. , O'DONNELL, Kevin P. , ROGERS, True L.
IPC分类号： A61K9/14 , A61K9/16 , A61K31/343 , A61K31/415 , A61K31/58
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1652 , A61K9/4891 , A61K31/343 , A61K31/4166 , A61K31/58
摘要： A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.

5. 发明授权

EP2874607B1 SOLID DISPERSION COMPRISING A HIGHLY SUBSTITUTED HYDROXYALKYL METHYLCELLULOSE 有权转让
标题翻译： FESTE散剂麻醉剂HOCHSUBSTITERERTER羟丙基甲基纤维素
公开(公告)号：EP2874607B1
公开(公告)日：2017-05-31
申请号：EP13740163.4
申请日：2013-07-12
申请人： Dow Global Technologies LLC
发明人： GRASMAN, Nicholas S. , GUILLAUDEU, Steven J. , HALL, Mark, J. , SHRESTHA, Uma , ROSE, Maureen L. , PORTER, William W. , SPAULDING, Wesley J. , O'DONNELL, Kevin P. , ROGERS, True L.
IPC分类号： A61K9/14 , A61K9/16 , A61K31/343 , A61K31/4166 , A61K31/58 , A61K9/48 , A61K47/38
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1652 , A61K9/4891 , A61K31/343 , A61K31/4166 , A61K31/58
摘要： A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.
摘要翻译：在至少一种羟烷基甲基纤维素中的至少一种羟烷基甲基纤维素中含有至少一种活性成分的固体分散体，DS为1.0至2.7，MS为0.40至1.30，其中DS为甲氧基的取代度，MS为羟基烷氧基组，可以通过挤出或喷雾干燥来生产。

6. 发明公开

EP2766423A1 INJECTION-MOLDED DOSAGE FORM 审中-公开
标题翻译： SPRITZGEGOSSENE DARREICHUNGSFORM
公开(公告)号：EP2766423A1
公开(公告)日：2014-08-20
申请号：EP12783442.2
申请日：2012-10-09
申请人： Dow Global Technologies LLC
发明人： READ, Michael, D. , COPPENS, Karen, A. , HALL, Mark, J. , ZHAO, Jin
IPC分类号： C08L1/28 , A61K9/48 , C08L5/00
CPC分类号： A61K9/4816 , A61K9/4833 , A61K9/4883 , C08K5/0016 , C08K5/05 , C08L1/28 , C08L1/286 , C08L5/00
摘要： An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.
摘要翻译：具有良好质量的剂型的注射成型的外壳可以通过以下方法生产：a）提供组合物，该组合物包含i）25至90重量％的乙基纤维素，ii）7.5至60重量％的不同于乙基纤维素的多糖或多糖衍生物，和iii）基于组合物的总重量，2.5至50重量％的至少一种与多糖和多糖衍生物不同的组分，条件是组合物包含零或不超过10重量％的明胶和 0或不超过10重量％的包含均聚或共聚的丙烯酸，均聚或共聚的甲基丙烯酸，均聚或共聚的丙烯酸酯或均聚或共聚的甲基丙烯酸酯的聚合物的聚合物，和b）使组合物经受剪切和加热塑化组合物并将增塑组合物注模成剂型的三维壳体。

7. 发明授权

EP2875072B1 COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A CELLULOSE ETHER OF VERY LOW VISCOSITY 有权转让
标题翻译：制备含有有机溶剂液体和低粘度的纤维素
公开(公告)号：EP2875072B1
公开(公告)日：2017-03-15
申请号：EP13741943.8
申请日：2013-07-12
申请人： Dow Global Technologies LLC
发明人： BRACKHAGEN, Meinolf , GRASMAN, Nicholas, S. , HALL, Mark, J. , GUILLAUDEU, Steven, J. , SCHMITT, Robert, L. , KNARR, Matthias
IPC分类号： C08L1/28 , A61K9/08 , A61K47/38 , A61K9/28 , A61K9/16
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/2866 , A61K31/343 , A61K31/4166 , C08L1/284

8. 发明公开

EP2875072A1 COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A CELLULOSE ETHER OF VERY LOW VISCOSITY 有权转让
标题翻译：制备含有有机溶剂液体和低粘度的纤维素
公开(公告)号：EP2875072A1
公开(公告)日：2015-05-27
申请号：EP13741943.8
申请日：2013-07-12
申请人： Dow Global Technologies LLC
发明人： BRACKHAGEN, Meinolf , GRASMAN, Nicholas, S. , HALL, Mark, J. , GUILLAUDEU, Steven, J. , SCHMITT, Robert, L. , KNARR, Matthias
IPC分类号： C08L1/28 , A61K9/08 , A61K47/38 , A61K9/28 , A61K9/16
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/2866 , A61K31/343 , A61K31/4166 , C08L1/284
摘要： A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa∙s, measured as a 2 wt.-% solution in water at 20°C, is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa»s and optionally one or more adjuvants.
摘要翻译：可替代地，固体分散体可以通过混合和挤出至少一种活性成分来制备，具有至多2:33下的粘度和任选的一种或多种佐剂的至少一种纤维素醚。

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