专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2014137779A1 NOVEL ESTERIFIED CELLULOSE ETHERS OF VERY HIGH MOLECULAR WEIGHT 审中-公开
标题翻译：非常高分子量的新型蛋白质纤维素
公开(公告)号：WO2014137779A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/019275
申请日：2014-02-28
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： PETERMANN, Oliver , BRACKHAGEN, Meinolf , SPREHE, Matthias
IPC分类号： A61K9/28 , C08B11/20 , C08B13/00
CPC分类号： C08B13/00 , A61K9/146 , A61K9/2866 , A61K9/4816 , C08B11/20 , C08L1/32
摘要： Esterified cellulose ethers which comprise (i) groups of the formula -C(O) - R - COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula -C(O) - R - COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa.s, measured as a 10 wt% solution of the esterified cellulose ether in acetone at 20°C, and a weight average molecular weight M w of at least 220,000 Dalton, or which have a viscosity of up 100 mPa.s, measured as a 10 wt% solution of the esterified cellulose ether in acetone at 20°C, and a weight average molecular weight M w of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.
摘要翻译：酯化纤维素醚，其包含（i）式-C（O）-R-COOA基团或（ii）脂族一价酰基和式-C（O）-R COOA基团的组合，其中R为二价脂族或芳族烃基，A为氢或阳离子，其粘度为50mPa.s，以20wt％的酯化纤维素醚在丙酮中的10wt％溶液测量，其重均分子量测量的粘度为100mPa.s的重量Mw至少为220,000道尔顿，其粘度为20wt％的酯化纤维素醚在丙酮中的10wt％溶液，重均分子量Mw为至少310000 道尔顿可用于制备包含药物的固体分散体。

2. 发明申请

WO2014031418A1 PARTIALLY CROSS-LINKED ESTERIFIED CELLULOSE ETHERS 审中-公开
标题翻译：部分交联的蛋白质酯
公开(公告)号：WO2014031418A1
公开(公告)日：2014-02-27
申请号：PCT/US2013/055037
申请日：2013-08-15
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： BRACKHAGEN, Meinolf , GRASMAN, Nicholas, S. , LI, Yongfu , MEUNIER, David, M. , PETERMANN, Oliver , SPREHE, Matthias
IPC分类号： C08B11/20 , A61K9/28 , C08B13/00
CPC分类号： C08B13/00 , A61K9/10 , A61K9/146 , A61K9/2866 , C08B11/20
摘要： A partially cross-linked esterified cellulose ether having A) groups of the formula -C(O) - R - COOA or a combination of aliphatic monovalent acyl groups and groups of the formula -C(O) - R - COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and B) having a molecular weight distribution such that [Wf(>100k) - Wf(>100k)XL] / Wf(>100k)XL is at least 0.20, wherein Wf(>100k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>100k)XL is the weight fraction that exceeds 100,000 g/mol of the methylated esterified cellulose ether is useful as enteric polymer for pharmaceutical dosage forms.
摘要翻译：具有A）基团的式-C（O）-R-COOA或脂族一价酰基和式-C（O）-R-COOA基团的组合的部分交联的酯化纤维素醚，其中R是二价脂族或芳族烃基，A是氢或阳离子，B）具有分子量分布使得[Wf（> 100k）-Wf（> 100k）XL] / Wf（> 100k）XL为至少0.20 其中Wf（> 100k）是超过100,000g / mol的酯化纤维素醚的总重量分数，Wf（> 100k）XL是甲基化酯化纤维素醚超过100,000g / mol的重量分数，可用作肠溶性聚合物用于药物剂型。

3. 发明申请

WO2013154981A1 MELT-EXTRUDED COMPOSITION COMPRISING A CELLULOSE ETHER 审中-公开
标题翻译：包含纤维素醚的熔融挤出组合物
公开(公告)号：WO2013154981A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/035594
申请日：2013-04-08
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： GRASMAN, Nicholas, S. , ROGERS, True, L. , PETERMANN, Oliver , BRACKHAGEN, Meinolf , ADDEN, Roland
IPC分类号： C08B11/193 , A61K9/50 , C08L1/28
CPC分类号： A61K47/38 , A61K9/1652 , A61K9/2095 , A61K31/192 , B29C47/004 , B29C47/0066 , B29C2793/009 , B29K2001/08 , B29K2105/0035 , C08B11/193 , C08L1/28 , C08L1/284
摘要： A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [ s23/s26 - 0.2*MS(hydroxyalkyl) ] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.
摘要翻译：一种熔融挤出的聚合物组合物，其包含a）至少一种纤维素醚，b）一种或多种活性成分和c）一种或多种任选的添加剂，其中所述至少一种纤维素醚具有0.05至0.55的MS（羟烷基）和羟基脱水葡萄糖单元的基团被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.32以下，其中s23是脱水葡萄糖单元的摩尔分数，其中只有2位和3位的两个羟基，脱水葡萄糖单元的位置被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位上的两个羟基仅被甲基取代。

4. 发明申请

WO2013081836A1 BUILDING COMPOSITION COMPRISING CELLULOSE ETHER 审中-公开
标题翻译：包含纤维素醚的建筑组合物
公开(公告)号：WO2013081836A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/065140
申请日：2012-11-15
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： KIESEWETTER, Rene , GROTE, Grit , BRACKHAGEN, Meinolf , KNARR, Matthias , ADDEN, Roland
IPC分类号： C04B24/38 , C04B28/02 , C04B28/04 , C04B40/00 , C08B11/193
CPC分类号： C04B24/383 , B28B11/04 , B28B11/042 , C04B16/02 , C04B18/24 , C04B28/02 , C04B28/04 , C04B40/0028 , C08B11/193 , C04B14/06 , C04B24/04 , C04B2103/0027 , C04B2103/302
摘要： Cellulose ethers, wherein at least a part of the hydroxyl groups of the cellulose backbone are substituted by methoxy groups and hydroxyalkoxy groups, and optionally alkoxy groups being different from methoxy groups, having an unconventional distribution of methoxy substituents at the 2-, 3- and 6-positions of the anhydroglucose units are described. Such cellulose ethers exhibit significantly higher thermoreversible gel strengths than any known hydroxyalkyl methyl celluloses of comparable viscosity and kind and level of substitution rendering them useful as additives for building compositions such as cement based tile adhesives. In particular, such cellulose ethers can be used to improve the attainable adhesion strength after heat storage conditioning and the temporal setting characteristics of a building composition.
摘要翻译：纤维素醚，其中纤维素骨架的至少一部分羟基被甲氧基和羟基烷氧基取代，以及任选的不同于甲氧基的烷氧基，其具有在2-，3-和及其上的非常规分布的甲氧基取代基描述了脱水葡萄糖单元的6-位。这种纤维素醚比任何已知的具有相似的粘度和种类和取代度的任何已知的羟烷基甲基纤维素显示出显着更高的热可逆凝胶强度，使得它们可用作建筑组合物如水泥基瓷砖粘合剂的添加剂。特别地，这种纤维素醚可以用于改善储热调节后的可达到的粘合强度和建筑组合物的时间凝固特性。

5. 发明申请

WO2018075420A1 EFFICIENT PROCESS OF PREPARING AN ESTERIFIED CELLULOSE ETHER 审中-公开
标题翻译：制备酯化纤维素醚的有效方法
公开(公告)号：WO2018075420A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/056836
申请日：2017-10-17
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： BRACKHAGEN, Meinolf , PETERMANN, Oliver , KELLING, Rene
IPC分类号： C08B13/00
摘要： An esterified cellulose ether is produced in a highly efficient manner in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride, wherein the process comprises the steps of a) preparing a reaction mixture comprising the cellulose ether, the aliphatic monocarboxylic acid anhydride and the aliphatic carboxylic acid such that the molar ratio of aliphatic carboxylic acid to anhydroglucose units of cellulose ether is up to 9.0 : 1 and heating the reaction mixture to a temperature of from 60°C to 110°C prior to, during or after mixing the components of the reaction mixture, and b) keeping the reaction mixture at least 15 minutes at the temperature of from 60°C to 110°C before adding dicarboxylic acid anhydride to the reaction mixture.
摘要翻译：在纤维素醚与脂族一元羧酸酐和二元羧酸酐反应的方法中，以高效的方式生产酯化纤维素醚，其中该方法包括以下步骤：a）制备包含纤维素醚，脂族单羧酸酐和脂族羧酸的反应混合物，使得纤维素醚的脂族羧酸与葡糖酐单元的摩尔比达到9.0:1，并将反应混合物加热至60℃的温度; 在混合反应混合物的组分之前，过程中或之后，将混合物冷却至110℃，和b）在将二羧酸酐加入反应中之前，在60℃至110℃的温度下保持反应混合物至少15分钟混合物

6. 发明申请

WO2016196152A1 CELLULOSE ETHER POWDERS 审中-公开
标题翻译：纤维素粉末
公开(公告)号：WO2016196152A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034219
申请日：2016-05-26
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： ADDEN, Roland , CHATTERJEE, Tirtha , KNARR, Matthias , BRACKHAGEN, Meinolf
IPC分类号： C08B11/02 , C08J3/12
CPC分类号： C08B11/20 , B01J2/04 , C08B11/02 , C08J3/122 , C08J3/14 , C08J2301/26
摘要： Provided is a method of making methylcellulose-type ether in powder form, said method comprising (a) providing a solution of said methylcellulose-type ether in water, and (b) then separating said methylcellulose-type ether from said water to produce dried methylcellulose-type ether, with the proviso that either (i) step (b) produces said methylcellulose-type ether in powder form, or (ii) after step (b), said method additionally comprises a step (c) of subjecting said dried methylcellulose-type ether to mechanical stress to produce said methylcellulose-type ether in powder form.
摘要翻译：提供了一种制备粉末形式的甲基纤维素型醚的方法，所述方法包括（a）提供所述甲基纤维素型醚在水中的溶液，和（b）然后从所述水中分离出所述甲基纤维素型醚以产生干燥的甲基纤维素型乙醚，条件是（i）步骤（b）产生粉末形式的甲基纤维素型醚，或（ii）在步骤（b）之后，所述方法另外包括步骤（c），使所述干燥的甲基纤维素型醚至机械应力，以产生粉末形式的所述甲基纤维素型醚。

7. 发明申请

WO2014014753A1 COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A CELLULOSE ETHER OF VERY LOW VISCOSITY 审中-公开
标题翻译：包含有机液体稀释剂的组合物和非常低粘度的纤维素醚
公开(公告)号：WO2014014753A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050216
申请日：2013-07-12
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： BRACKHAGEN, Meinolf , GRASMAN, Nicholas, S. , HALL, Mark, J. , GUILLAUDEU, Steven, J. , SCHMITT, Robert, L. , KNARR, Matthias
IPC分类号： C08L1/28 , A61K9/08 , A61K47/38 , A61K9/28 , A61K9/16
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/2866 , A61K31/343 , A61K31/4166 , C08L1/284
摘要： A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa∙s, measured as a 2 wt.-% solution in water at 20°C, is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa»s and optionally one or more adjuvants.
摘要翻译：包含有机液体稀释剂和至少一种具有高达2.33mPa.s的非离子纤维素醚的非离子纤维素醚的液体组合物，其在20℃下以2重量％的水溶液测量，在延伸的时间段。液体组合物可用于通过喷雾干燥制备包含至少一种纤维素醚中的至少一种活性成分的固体分散体。或者，可以通过共混和挤出至少一种活性成分，至少一种粘度高达2.33mPa·s的纤维素醚和任选的一种或多种佐剂来制备固体分散体。

8. 发明申请

WO2013154980A1 COMPOSITION COMPRISING AN ORGANIC DILUENT AND A CELLULOSE ETHER 审中-公开
标题翻译：包含有机稀释剂和纤维素醚的组合物
公开(公告)号：WO2013154980A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/035592
申请日：2013-04-08
申请人： DOW GLOBAL TECHNOLOGIES LLC
发明人： ADDEN, Roland , SAMMLER, Robert, L. , BRACKHAGEN, Meinolf , GRASMAN, Nicholas, S. , PETERMANN, Oliver , GUILLAUDEU, Steven, J.
IPC分类号： C09D101/28 , A61K9/08 , A61K47/38 , C08L1/28 , C08B11/20 , C08B11/193 , A61J3/10 , A61J3/07 , A61J3/06 , A61K9/50 , A61K9/48 , A61K9/28 , A61K9/14
CPC分类号： A61K47/38 , A61K9/08 , A61K9/16 , A61K9/1617 , A61K9/1652 , A61K31/343 , A61K31/4166 , A61K47/10 , C08B11/193 , C08B11/20 , C08L1/28 , C08L1/284 , C09D101/28 , C09D101/284
摘要： A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.
摘要翻译：液体组合物包含有机稀释剂和至少一种具有通过1-4键连接并具有甲基，羟基烷基和任选的不同于甲基作为取代基的烷基的脱水葡萄糖单元的纤维素醚，使得脱水葡萄糖单元的羟基被甲基，使得s23 / s26为0.29以下，其中s23是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位上的两个羟基仅被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。液体组合物可用于制备活性成分在纤维素醚中的固体分散体。

9. 发明申请

WO2012173838A1 FOOD COMPOSITION COMPRISING A CELLULOSE ETHER 审中-公开
标题翻译：包含纤维素醚的食品组合物
公开(公告)号：WO2012173838A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/041008
申请日：2012-06-06
申请人： DOW GLOBAL TECHNOLOGIES LLC , HUEBNER, Britta , MOHLER, Carol Elaine , BRACKHAGEN, Meinolf , ADDEN, Roland , SAMMLER, Robert L. , MOORE, Johnathan D. , KNARR, Matthias
发明人： HUEBNER, Britta , MOHLER, Carol Elaine , BRACKHAGEN, Meinolf , ADDEN, Roland , SAMMLER, Robert L. , MOORE, Johnathan D. , KNARR, Matthias
IPC分类号： C08B11/20 , C08L1/28 , C08L89/00 , A23L1/0534
CPC分类号： A23L11/07 , A23L29/219 , A23L29/262 , C08B11/193 , C08B11/20 , C08L1/28
摘要： Cellulose ethers are described herein which are useful in food compositions. In these cellulose ethers the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the cellulose ether has a DS(methyl) of from 1.65 to 2.20, an MS(hydroxyalkyl) of from 0.10 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [ s23/s26 - 0.2*MS(hydroxyalkyl) ] is 0.35 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
摘要翻译：本文描述了可用于食品组合物的纤维素醚。在这些纤维素醚中，醚取代基是甲基，羟烷基和任选的不同于甲基的烷基，纤维素醚的DS（甲基）为1.65〜2.20，MS（羟烷基）为0.10〜1.00，和脱水葡萄糖单元的羟基被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.35以下，其中s23是脱水葡萄糖单元的摩尔分数，其中只有2-和3中的两个羟基脱水葡萄糖单元的位置被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位中的两个羟基仅被甲基取代。

10. 发明申请

WO2012051035A1 NOVEL CELLULOSE ETHERS AND THEIR USE 审中-公开
标题翻译：新颖的纤维素及其使用
公开(公告)号：WO2012051035A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/055050
申请日：2011-10-06
申请人： DOW GLOBAL TECHNOLOGIES LLC , ADDEN, Roland , BRACKHAGEN, Meinolf , KNARR, Matthias , ZHAO, Jin
发明人： ADDEN, Roland , BRACKHAGEN, Meinolf , KNARR, Matthias , ZHAO, Jin
IPC分类号： C08B11/193 , A61J3/07 , A61K9/48 , C08L1/28
CPC分类号： C08B11/02 , A61J3/077 , A61K9/4816 , A61K9/4866 , A61K47/38 , C08B11/193 , C08L1/284
摘要： Cellulose ethers are described herein which are useful in capsules or in coatings for dosage forms. In these cellulose ethers the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [ s23/s26 - 0.2*MS(hydroxyalkyl) ] is 0.35 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
摘要翻译：本文描述了纤维素醚，其可用于胶囊或用于剂型的包衣。在这些纤维素醚中，醚取代基是甲基，羟基烷基和任选的不同于甲基的烷基，纤维素醚具有0.05至1.00的MS（羟基烷基），脱水葡萄糖单元的羟基被甲基取代，使得 [s23 / s26-0.2 * MS（羟烷基）]为0.35以下，其中s23为脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位上的两个羟基仅被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位中的两个羟基仅被甲基取代。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式