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1. 发明申请

WO2004067727A8 MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL 审中-公开
标题翻译：混合和匹配TC蛋白进行病虫害防治
公开(公告)号：WO2004067727A8
公开(公告)日：2005-08-18
申请号：PCT/US2004000394
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC , HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C , MEADE THOMAS
发明人： HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C , MEADE THOMAS
IPC分类号： A01N37/46 , A01N63/02 , C07K14/195 , C07K14/24 , C12N15/82 , A01H5/00 , C12N5/10
CPC分类号： C07K14/195 , A01N37/46 , A01N63/02 , C07K14/24 , C12N15/8286 , Y02A40/162
摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a "stand-alone" TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein "potentiators" derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin. This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterologous TC proteins are also disclosed herein.
摘要翻译：本发明涉及令人惊讶的发现，即可从Xenorhabdus，光杆状芽孢杆菌和类芽孢杆菌中获得的毒素复合物（TC）蛋白可彼此互换使用。在本发明的特别优选的实施方案中，“独立的”TC蛋白（例如来自光杆状病毒，Xenorhabdus或类芽孢杆菌属）的毒性通过一种或多种衍生自一种或多种来源于源生物的TC蛋白“增效剂” 毒素来自的不同属。如本领域技术人员将认识到本公开的益处，这具有广泛的含义并扩大了各种类型的TC蛋白现在将被识别具有的效用范围。其中最重要的优点是本领域技术人员现在将能够使用单组增效剂来增强独立的致病杆菌蛋白毒素以及独立的光杆状菌蛋白毒素的活性。这减少了转基因植物需要表达的基因数量和转化事件，以实现对更广谱目标害虫的有效控制。本文还公开了异源TC蛋白的某些优选组合。

2. 发明申请

WO2004067727A2 MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL 审中-公开
标题翻译：混合和匹配TC蛋白进行病虫害防治
公开(公告)号：WO2004067727A2
公开(公告)日：2004-08-12
申请号：PCT/US2004000394
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC , HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C
发明人： HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C , MEADE THOMAS
IPC分类号： A01N37/46 , A01N63/02 , C07K14/195 , C07K14/24 , C12N15/82 , C12N
CPC分类号： C07K14/195 , A01N37/46 , A01N63/02 , C07K14/24 , C12N15/8286 , Y02A40/162
摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibucillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a "stand-alone" TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein "potentiators" derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will new be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand alone Photorlzabdus protein toxin. (As one skilled in the art knows, Xenorhabdus toxin proteins tend to be more desirable for controlling lepidopterans while Photorhabdus toxin proteins tend to be more desirable for controlling coleopterans.) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterolugous TC proteins are also disclosed herein. Other objects, advantages, and features of the subject invention will be apparent to cue skilled in the art having the benefit of the subject disclosure.
摘要翻译：本发明涉及令人惊奇的发现，可以从Xenorhabdus，Photorhabdus和Paenibucillus获得的毒素复合物（TC）蛋白质彼此互换使用。在本发明的特别优选的实施方案中，“独立”TC蛋白（例如，来自Photorhabdus，Xenorhabdus或Paenibacillus的例如）的毒性由一种或多种衍生自以下的源生物体的TC蛋白“增强剂”增强来源于毒素的不同属。本领域技术人员将会认识到本公开的益处，这具有广泛的含义，并且扩展了新认证的各种类型的TC蛋白质具有的效用范围。最重要的优点之一是，本领域技术人员现在将能够使用单组增效剂来增强独立的Xenorhabdus蛋白毒素的活性以及独立的Photorlzabdus蛋白毒素。（如本领域技术人员所知，Xenorhabdus毒素蛋白质倾向于更有利于控制鳞翅目，而Photorhabdus毒素蛋白质倾向于更有利于控制鞘翅目）。这减少了需要表达的基因数量和转化事件一个转基因植物，以实现更广泛的目标害虫的有效控制。杂种TC蛋白的某些优选组合也在本文中公开。本发明的其它目的，优点和特征对本领域的技术人员而言是显而易见的。

3. 发明申请

WO2004067750A3 XENORHABDUS TC PROTEINS AND GENES FOR PEST CONTROL 审中-公开
标题翻译： XENORHABDUS TC蛋白和基因用于虫害控制
公开(公告)号：WO2004067750A3
公开(公告)日：2004-10-07
申请号：PCT/US2004000314
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC , BINTRIM SCOTT B , MITCHELL JON C , LARRINUA IGNACIO M , APEL-BIRKHOLD PATRICIA C , GREEN SUSAN B , SCHAFER BARRY W , BEVAN SCOTT A , YOUNG SCOTT A , GUO LINING
发明人： BINTRIM SCOTT B , MITCHELL JON C , LARRINUA IGNACIO M , APEL-BIRKHOLD PATRICIA C , GREEN SUSAN B , SCHAFER BARRY W , BEVAN SCOTT A , YOUNG SCOTT A , GUO LINING
IPC分类号： C12N5/02 , C12N15/82 , C07K14/24
CPC分类号： C12N15/8286 , Y02A40/162
摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.
摘要翻译：本发明涉及新的Xenorhabdus毒素复合物（TC）蛋白质和编码这些蛋白质的基因。更具体地说，本发明涉及可从Xenorhabdus菌株Xwi获得的TC基因和蛋白质。本发明还提供可从Xwi菌株获得的外切壳多糖酶。该外切壳多糖酶可用于使用本领域已知的方法来控制昆虫。

4. 发明申请

WO2004002223A3 PESTICIDALLY ACTIVE PROTEINS AND POLYNUCLEOTIDES OBTAINABLE FROM PAENIBACILLUS SPECIES 审中-公开
标题翻译：杀虫活性物质获得的农药活性蛋白和多核苷酸
公开(公告)号：WO2004002223A3
公开(公告)日：2004-11-04
申请号：PCT/US0320082
申请日：2003-06-27
申请人： DOW AGROSCIENCES LLC
发明人： BINTRIM SCOTT B , BEVAN SCOTT A , ZHU BAOLONG , MERLO DONALD J
IPC分类号： C12N15/09 , A01N63/00 , C07K14/195 , C07K14/32 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P19/34 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/01 , C07K14/00 , C07H21/04 , G01N33/554 , G01N33/569
CPC分类号： C12P19/34 , C07K14/195 , C12P21/02 , C12Q1/689 , C12Q2600/142
摘要： The subject invention provides unique biological alternatives for pest control. More specifically, the present invention relates to novel pesticidal proteins, novel sources of pesticidal proteins, polynucleotides that encode such toxins, and to methods of using these toxins to control insects and other plant pests. The subject invention relates to the surprising discovery that Paenibacillus species, and proteins therefrom, have toxicity to lepidopterans. There have been no known reports of a Paenibacillus species, strain, or protein having toxicity to lepidopterans. This is also the first known example of a Paenibacillus Cry protein that is toxic to lepidopterans. Furthermore, this is the first known report of Paenibacillus having toxin complex (TC)-like proteins. The DAS1529 isolate disclosed here is also the first known example of a natural bacterium that produces both a Cry toxin and TC proteins. The subject invention also relates to new classes of Cry and TC proteins that are pesticidally active.
摘要翻译：本发明提供了用于害虫防治的独特生物学替代物。更具体地说，本发明涉及新的杀虫蛋白质，新型杀虫蛋白质来源，编码这些毒素的多核苷酸，以及使用这些毒素来控制昆虫和其他植物害虫的方法。本发明涉及令人惊讶的发现，类芽孢杆菌属和来自其的蛋白质对鳞翅目昆虫具有毒性。还没有关于对鳞翅目昆虫有毒性的类芽孢杆菌菌种，菌株或蛋白质的已知报道。这也是第一个已知的对鳞翅目昆虫有毒的类芽孢杆菌Cry蛋白的例子。此外，这是类芽孢杆菌属具有毒素复合物（TC）样蛋白质的第一个已知报道。这里公开的DAS1529分离株也是产生Cry毒素和TC蛋白质的天然细菌的第一个已知例子。本发明还涉及具有杀虫活性的新类别的Cry和TC蛋白。

5. 发明专利

CA2514041A1 MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL 未知
公开(公告)号：CA2514041A1
公开(公告)日：2004-08-12
申请号：CA2514041
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC
发明人： SCHLEPER AMANDA D , BEVAN SCOTT A , MERLO DONALD J , HEY TIMOTHY D , APEL-BIRKHOLD PATRICIA C , ZHU BAOLONG , MEADE THOMAS , MITCHELL JON C , LI ZE SHENG , NI WEITING , BINTRIM SCOTT B
IPC分类号： A01N37/46 , A01N63/02 , C07K14/195 , C07K14/24 , C12N15/82 , A01H5/00 , C12N5/10
摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin. (As one skilled in the art knows, Xenorhabdus toxin proteins tend to be more desirable for controlling lepidopterans while Photorhabdus toxin proteins tend to be more desirable for controlling coleopterans.) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterologous TC proteins are also disclosed herein. Other objects, advantages, and features of the subject invention will be apparent to one skilled in the art having the benefit of the subject disclosure.

6. 发明专利

AU2017272160A1 Production of omega-3 long-chain polyunsaturated fatty acids in oilseed crops by a Thraustochytrid PUFA synthase 未知
公开(公告)号：AU2017272160A1
公开(公告)日：2017-12-21
申请号：AU2017272160
申请日：2017-12-05
申请人： DOW AGROSCIENCES LLC , DSM IP ASSETS BV
发明人： WALSH TERENCE A , GACHOTTE DANIEL J , LARSEN CORY M , BEVAN SCOTT A , MERLO P ANN OWENS , METZ JAMES G , ZIRKLE ROSS
IPC分类号： A01H5/00 , A23D9/00 , A23L33/00 , C12N15/82
摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. 5 The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

7. 发明专利

AU2014354631A1 Production of omega-3 long-chain polyunsaturated fatty acids in oilseed crops by a Thraustochytrid PUFA synthase 未知
公开(公告)号：AU2014354631A1
公开(公告)日：2016-05-19
申请号：AU2014354631
申请日：2014-11-26
申请人： DSM IP ASSETS BV , DOW AGROSCIENCES LLC
发明人： WALSH TERENCE A , GACHOTTE DANIEL J , LARSEN CORY M , BEVAN SCOTT A , MERLO P ANN OWENS , METZ JAMES G , ZIRKLE ROSS
IPC分类号： A01H5/00 , A23D9/00 , A23L33/00 , C12N15/82
摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

8. 发明专利

AU2003247650A1 PESTICIDALLY ACTIVE PROTEINS AND POLYNUCLEOTIDES OBTAINABLE FROM PAENIBACILLUS SPECIES 未知
公开(公告)号：AU2003247650A1
公开(公告)日：2004-01-19
申请号：AU2003247650
申请日：2003-06-27
申请人： DOW AGROSCIENCES LLC
发明人： BEVAN SCOTT A , ZHU BAOLONG , MERLO DONALD J , BINTRIM SCOTT B
IPC分类号： C12N15/09 , A01N63/00 , C07K14/195 , C07K14/32 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P19/34 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/01
摘要： The subject invention provides unique biological alternatives for pest control. More specifically, the present invention relates to novel pesticidal proteins, polynucleotides that encode such toxins, and to methods of toxins to control insects and other plant pests. The subject invention relates to the surprising discovery that Paenibacillus species, and proteins therefrom, have toxicity to lepidopterans. There have been no known reports of a Paenibacillus species, strain, or protein having toxicity to lepidopterans. This is also the first known example of a Paenibacillus Cry protein that is toxic to lepidopterans. Furthermore, this is the first known report of Paenibacillus having TC-like proteins. The DAS 1529 isolate disclosed here is also the first known example of a natural bacterium that produces both a Cry toxin and toxin complex (TC) proteins. The subject invention also relates to new classes of Cry and TC proteins that are pesticidally active.

9. 发明公开

EP3073817A4 PRODUCTION OF OMEGA-3 LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN OILSEED CROPS BY A THRAUSTOCHYTRID PUFA SYNTHASE 审中-公开
标题翻译： HERSTELLUNG VON LANGKETTIGEN MEHRFACH UNGESETTEN OMTIA-3-FETTSÄURENinÖLSAATPFLANZENDURCH EINE THRAUSTOCHYTRID PUFA-SYNTHASE
公开(公告)号：EP3073817A4
公开(公告)日：2017-06-21
申请号：EP14866690
申请日：2014-11-26
申请人： DOW AGROSCIENCES LLC , DSM IP ASSETS BV
发明人： WALSH TERENCE A , GACHOTTE DANIEL J , LARSEN CORY M , BEVAN SCOTT A , MERLO P ANN OWENS , METZ JAMES G , ZIRKLE ROSS
IPC分类号： A01H5/00 , A23D9/00 , A23K20/158 , A23L33/00 , C11B1/00 , C11B1/04 , C11B1/10 , C12N9/10 , C12N9/12 , C12N15/82
CPC分类号： C12N9/1029 , A23D9/00 , A23K20/158 , C11B1/00 , C11B1/04 , C11B1/10 , C12N9/1288 , C12N15/82 , C12N15/8247 , C12Y203/01085
摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.
摘要翻译：本公开涉及用多不饱和脂肪酸（PUFA）合酶系统遗传修饰的重组宿主生物和允许和/或改善宿主生物体中PUFAs产生的一种或多种辅助蛋白。本公开还涉及制造和使用此类生物体的方法以及从这些生物体获得的产品。

10. 发明公开

EP1532165A4 PESTICIDALLY ACTIVE PROTEINS AND POLYNUCLEOTIDES OBTAINABLE FROM PAENIBACILLUS SPECIES 有权
标题翻译：农药活性蛋白和多核苷酸从PAENIBAZILLUS物种可能取得胜利
公开(公告)号：EP1532165A4
公开(公告)日：2006-05-17
申请号：EP03762046
申请日：2003-06-27
申请人： DOW AGROSCIENCES LLC
发明人： BINTRIM SCOTT B , BEVAN SCOTT A , ZHU BAOLONG , MERLO DONALD J
IPC分类号： C12N15/09 , A01N63/00 , C07K14/195 , C07K14/32 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P19/34 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/01 , C07K14/00 , C07H21/04 , G01N33/554 , G01N33/569
CPC分类号： C12P19/34 , C07K14/195 , C12P21/02 , C12Q1/689 , C12Q2600/142

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