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1. 发明申请

WO2006099151A2 SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION 审中-公开
标题翻译：用于处理用于传感器校准的分析仪传感器数据的系统和方法
公开(公告)号：WO2006099151A2
公开(公告)日：2006-09-21
申请号：PCT/US2006008616
申请日：2006-03-10
申请人： DEXCOM INC , GOODE PAUL V , BRAUKER JAMES H , ULLAS APURV
发明人： GOODE PAUL V , BRAUKER JAMES H , ULLAS APURV
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B2560/0223
摘要： Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.
摘要翻译：公开了用于处理传感器分析物数据的系统和方法，包括启动校准，更新校准，评估参考和传感器分析物数据的临床可接受性，以及评估传感器校准的质量。可以使用一个或多个匹配的传感器和参考分析物数据对的校准集来校准传感器。在分析物传感器插入之前进行台式测试产生的参考数据可用于提供传感器数据的初始校准。植入用户的短期连续分析物传感器的参考数据可用于初始校准或更新来自长期连续分析物传感器的传感器数据。

2. 发明申请

WO2007120442A3 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A3
公开(公告)日：2008-11-06
申请号：PCT/US2007007612
申请日：2007-03-27
申请人： DEXCOM INC , SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
发明人： SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

3. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

4. 发明申请

WO2006127694A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2006127694A3
公开(公告)日：2007-04-12
申请号：PCT/US2006019889
申请日：2006-05-23
申请人： DEXCOM INC , BRAUKER JAMES H , SIMPSON PETER , BOOCK ROBERT , RIXMAN MONICA
发明人： BRAUKER JAMES H , SIMPSON PETER , BOOCK ROBERT , RIXMAN MONICA
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device. The sensor (34) can incorporate a working electrode (38) and at least one additional electrode (30), and can further incorporate a sensing mechanism (36) comprising a small structure as adapted for insertion under the host's skin.
摘要翻译：本发明一般涉及与可植入装置一起使用的生物界面膜，例如用于检测生物样品中分析物浓度的装置。更具体地，本发明涉及新颖的生物接触膜，包括这些膜的装置和可植入装置，在可植入装置上或周围形成生物接触膜的方法，以及使用可植入分析物检测来监测生物流体样品中的葡萄糖水平的方法设备。传感器（34）可以包括工作电极（38）和至少一个附加电极（30），并且还可以包括感测机构（36），该感测机构包括适于插入主机皮肤下方的小结构。

5. 发明申请

WO2005057168A3 CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：连续分析仪传感器的校准技术
公开(公告)号：WO2005057168A3
公开(公告)日：2007-03-22
申请号：PCT/US2004040476
申请日：2004-12-03
申请人： DEXCOM INC , KAMATH APURV ULLAS , SIMPSON PETER C , BRAUKER JAMES H , GOODE JR PAUL V
发明人： KAMATH APURV ULLAS , SIMPSON PETER C , BRAUKER JAMES H , GOODE JR PAUL V
IPC分类号： A61B5/05 , A61B5/00 , G01N20060101
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.
摘要翻译：本文公开了用于校准连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用一个或多个电极来测量另外的分析物。这样的测量可以提供用于校准传感器的基线或灵敏度测量。此外，可以使用基线和/或灵敏度测量来触发诸如数字数字滤波或暂停显示数据的事件。

6. 发明申请

WO03011354A3 MEMBRANE FOR USE WITH IMPLANTABLE DEVICES 审中-公开
标题翻译：膜与可植入器件的使用
公开(公告)号：WO03011354A3
公开(公告)日：2003-08-14
申请号：PCT/US0223902
申请日：2002-07-26
申请人： DEXCOM INC , BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A
发明人： BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A
IPC分类号： G01N27/327 , A61B5/145 , A61B5/1473 , A61L31/10 , A61L31/14 , C12M1/34 , C12M1/40 , C12Q1/26 , C12Q1/54 , G01N27/416 , A61L27/44
CPC分类号： A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
摘要： The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer and instead forms a foreign body response (FBR) layer including: an innermost FBR layer (40) composed generally of macrophages and foreign body giant cells (41) that forms over the entire surface (48a) of the membrane (48); an intermediate FBR layer (42) composed primarily of fibroblasts (43) and fibrous matrix (44); and an outermost FBR layer (46) is loose connective granular tissue containing new blood vessels (45); wherein the innermost layer (40) is resistant to cellular attachment and is impermeable to cells and wherein the outermost layer (46) supports tissue attachment and interferes with barrier cell layer formation. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
摘要翻译：本发明提供了一种用于与可植入装置一起使用的生物界面膜，该生物界面膜干扰阻挡细胞层的形成，并形成异物反应（FBR）层，其包括：最内层的FBR层（40），其通常由巨噬细胞和异物在膜（48）的整个表面（48a）上形成的巨细胞（41）; 主要由成纤维细胞（43）和纤维基质（44）组成的中间FBR层（42）; 最外面的FBR层（46）是含有新血管的松散结缔组织颗粒组织（45）; 其中最内层（40）抵抗细胞附着并且对细胞是不可渗透的，并且其中最外层（46）支持组织附着并干扰阻挡细胞层形成。此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

7. 发明申请

WO2005012873A3 ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
标题翻译：电化学传感器电极系统
公开(公告)号：WO2005012873A3
公开(公告)日：2006-04-13
申请号：PCT/US2004024178
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
发明人： SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
IPC分类号： G01N20060101 , G01N27/26 , G01N27/416 , G01N27/327
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode (16a) for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode (36) configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode (36) advantageously improves oxygen availability to the enzyme (38) and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode (36) advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括分析物测量电极（16a），用于测量分析物或与分析物的酶反应产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极（36）。通过辅助电极（36）产生的氧有利地提高了对酶（38）和/或对电极的氧可用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。辅助电极（36）的干扰修饰有利地使它们在分析物测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

8. 发明申请

WO2005057175A3 SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：连续分析传感器的信号处理
公开(公告)号：WO2005057175A3
公开(公告)日：2005-09-01
申请号：PCT/US2004041095
申请日：2004-12-08
申请人： DEXCOM INC , BRAUKER JAMES H , CARR-BRENDEL VICTORIA , GOODE JR PAUL V , KAMATH APURV , THROWER JAMES , XAVIER BEN
发明人： BRAUKER JAMES H , CARR-BRENDEL VICTORIA , GOODE JR PAUL V , KAMATH APURV , THROWER JAMES , XAVIER BEN
IPC分类号： A61B5/00 , A61B5/05 , G01N20060101
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/14503 , A61B5/1451 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/7275 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61M5/1723 , Y02A90/22 , Y02A90/26
摘要： Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk. The methods can be employed in a medical device including a continuous analyte sensor (10) that provides an output signal indicative of a concentration of an analyte, a receiver to which the signal is sent (12), and an input module (14) that receives the signal.
摘要翻译：用于动态和智能地估计来自连续分析物传感器的分析物数据的系统和方法，包括接收数据流，选择多个算法中的一个，以及使用选择的算法估计分析物值。估计可用于补偿时间滞后，将传感器数据与相应的参考数据相匹配，警告即将出现的临床风险，更换错误的传感器数据信号，并提供更及时的分析信息，鼓励积极行为并抢占临床风险。该方法可用于医疗装置中，该医疗装置包括提供指示分析物浓度的输出信号的连续分析物传感器（10），发送信号的接收器（12）和输入模块（14）接收信号。

9. 发明申请

WO2005082436A9 INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR 审中-公开
标题翻译：用于连续葡萄糖传感器的集成传送装置
公开(公告)号：WO2005082436A9
公开(公告)日：2006-11-16
申请号：PCT/US2005006301
申请日：2005-02-24
申请人： DEXCOM INC , BRAUKER JAMES H , TAPSAK MARK A , SAINT SEAN T , KAMATH APURV U , NEALE PAUL V , SIMPSON PETER C , MENSINGER MICHAEL ROBERT , MARKOVIC DUBRAVKA
发明人： BRAUKER JAMES H , TAPSAK MARK A , SAINT SEAN T , KAMATH APURV U , NEALE PAUL V , SIMPSON PETER C , MENSINGER MICHAEL ROBERT , MARKOVIC DUBRAVKA
IPC分类号： A61M1/00 , A61B5/00 , A61M31/00
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/3468 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor (12), including a receiver (14), a medicament delivery device (16), and optionally a single point glucose monitor 18 are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译：提供了用于集成包括接收器（14），药物输送装置（16）和任选的单点葡萄糖监测器18的连续葡萄糖传感器（12）的系统和方法。手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。

10. 发明申请

WO2005079257A2 BIOINTERFACE WITH MACRO- AND MICRO- ARCHITECTURE 审中-公开
标题翻译：具有宏观和微观结构的生物界
公开(公告)号：WO2005079257A2
公开(公告)日：2005-09-01
申请号：PCT/US2005004058
申请日：2005-02-09
申请人： DEXCOM INC , CARR-BRENDEL VICTORIA , SIMPSON PETER C , BRAUKER JAMES H
发明人： CARR-BRENDEL VICTORIA , SIMPSON PETER C , BRAUKER JAMES H
IPC分类号： A61F13/00 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture.The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the foreign body capsule. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：这里公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并结合到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观架构一起工作以管理和操纵高水平组织组织和体内异物反应的低水平细胞组织，从而增加靠近器官组织界面的新生血管形成，干扰屏障细胞层形成，并提供良好的组织锚定，同时降低运动神器，并扰乱异物胶囊的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传递或测量装置中的分析物浓度的装置，和/或其组合。

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