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    • 1. 发明申请
    • DENTAL ADHESIVE
    • 牙膏
    • WO2007045303A8
    • 2007-08-09
    • PCT/EP2006008612
    • 2006-09-04
    • DENTSPLY DE TREY GMBHKLEE JOACHIM ELEHMANN UWE
    • KLEE JOACHIM ELEHMANN UWE
    • A61K6/00A61K6/083
    • A61K6/0029A61K6/0023C08L33/26C08L43/02
    • A one-part self-etching, self-priming dental adhesive having a pH of at most 2, which comprises an aqueous mixture containing (i) one or more polymerizable monomers optionally containing an acidic group, (ii) optionally one or more organic or inorganic acids, (iii) a polymerization initiator, and (iv) a thermal Polymerisation inhibitor of the following formula (I): wherein R' 1 represents a hydrogen atom, or a saturated hydrocarbon group having 1 to 18 carbon atoms. R' 2 , which may be the same or different if more than one R' 2 is present, independently represent a saturated hydrocarbon group having 1 to 18 carbon atoms, and c represents an integer of from 1 to 4.
    • 一种具有pH至多为2的一部分自蚀刻自吸牙科粘合剂,其包含含有(i)一种或多种任选含有酸性基团的可聚合单体的水性混合物,(ii)任选的一种或多种有机或 无机酸,(iii)聚合引发剂,和(iv)下式(I)的热聚合抑制剂:其中R'1表示氢原子或具有1〜 18个碳原子。 R“2”可以相同或不同,如果存在多于一个R'2,独立地表示具有1至18个碳原子的饱和烃基,c 表示1〜4的整数。
    • 2. 发明申请
    • A POYMERIZABLE PHOSPHORIC ACID ESTER DERIVATIVE AND A DENTAL COMPOSITION EMPLOYING IT.
    • 可食用的磷酸酯衍生物和使用它的牙科组合物。
    • WO2004078100A3
    • 2004-10-28
    • PCT/EP2004002289
    • 2004-03-05
    • DENTSPLY DE TREY GMBHKLEE JOACHIM ELEHMANN UWEWALZ UWELIU HUAIBING
    • KLEE JOACHIM ELEHMANN UWEWALZ UWELIU HUAIBING
    • A61K6/00A61K6/08A61K6/083C07F9/09C08F30/02
    • A61K6/083A61K6/0023C07F9/091C07F9/093C08F30/02C08L43/02C08L33/00
    • The present invention provides a polymerizable phosphoric acid ester derivative having the following formula (A): wherein Z is COOR1, COSR1, CON(R1)2, CONR1 R2, or CONHR1, R1 and R2 independently are a hydrogen atom, a substituted or unsubstituted C1 to C18 alkyl group optionally substituted by a C3 to C8 cycloalkyl group, a substituted or unsubstituted C3 to C8 cycloalkyl group, a substituted or unsubstituted C4 to C,18 aryl or heteroaryl group, a substituted or unsubstituted C5 to C18 alkylaryl or alkylheteroaryl group, or a substituted or unsubstituted C7 to C30 aralkyl group, whereby two R1 residues may form together with the N-atom to which they are bonded a 5- to 7-membered heterocyclic ring which may contain beside said N-atom a further nitrogen atom or an oxygen atom, and whereby the substituted groups may be substituted by 1 to 5 C1 to C5 alkyl group(s); a is an integer of from 1 to 10, preferably 1 to 5; b is an integer of from 1 to 10, preferably 1 to 5; and R represents an organic residue containing a + b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said carbon atoms linking a phosphate or 2-(oxa-ethyl)acryl derivative group.
    • 本发明提供具有下式(A)的聚合性磷酸酯衍生物:其中Z为COOR1,COSR1,CON(R1)2,CONR1R2或CONHR1,R1和R2分别为氢原子,取代或未取代的 取代或未取代的C3至C8环烷基,取代或未取代的C4至C18芳基或杂芳基,取代或未取代的C5至C18烷基芳基或烷基杂芳基的C1至C18烷基 或取代或未取代的C7至C30芳烷基,其中两个R 1残基可以与它们所键合的N-原子一起形成5-7元杂环,其可以在所述N-原子旁边包含另外的氮原子 或氧原子,由此取代基可被1至5个C 1至C 5烷基取代; a为1〜10的整数,优选为1〜5; b为1〜10的整数,优选为1〜5; R表示含有选自伯和仲脂族碳原子,仲脂环族碳原子和芳族碳原子的+ b个碳原子的有机残基,所述碳原子各自连接磷酸酯或2-(氧杂 - 乙基)丙烯酰基衍生物基团 。
    • 3. 发明申请
    • DENTAL ADHESIVE COMPOSITION
    • 牙膏组合物
    • WO2009027005A2
    • 2009-03-05
    • PCT/EP2008006404
    • 2008-08-04
    • DENTSPLY DETREY GMBHKLEE JOACHIM ELEHMANN UWE
    • KLEE JOACHIM ELEHMANN UWE
    • A61K6/00A61K6/083
    • A61K6/0023A61K6/0067C08L33/00
    • A polymerizable dental adhesive composition, which comprises (i) 10 to 90 percent by weight based on the total weight of the composition of a mixture of hydrolysis-stable polymerizable monomers of formula (I): R(A)m(B)n (I), wherein R is a single bond or a m+n valent organic group having 1 to 20 carbon atoms and optionally 1 to 5 atoms selected from the group of nitrogen, oxygen and sulfur atoms; independently represents a moiety of formula (II), wherein L is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14aryl group or a group of formula (III), wherein R' is a hydrogen atom, a C1-6alkyl group, a C3-8 cycloalkyl group, or a C6-14 aryl group; X is O, S, NH or NR" wherein R" is a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group; a is O or 1; M is a group of formula (IV), wherein Y is O, S, NH or NR'" wherein R"' is a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group; b is an integer of from O to 3; c is O or 1; d is an integer of from O to 3; provided that when b is O, then Y cannot be O or S; x is O or i; y is O or i; provided that x and y cannot be both 1, and provided that x cannot be 1 when L or a group of formula (III) is a hydrogen atom, and provided that when x is O then a is also O, and provided that when y is 0 then b is greater than 0 or c is 0; B independently represents a group having antimicrobial activity or an acidic group; m is an integer of from 1 to 5; n is an integer of 0 to 3; and m+n is at least 2; (ii) a water-soluble organic solvent and (iii) an initiator and a stabilizer; wherein the portion of antimicrobial monomers of formula (I) wherein n is greater than 0 and at least one B is a group having antimicrobial activity is at least 0.01 percent by weight based on the total weight of the mixture, and wherein the portion of acidic monomers of formula (I) wherein n is greater than 0 and at least one B is an acidic group is at least 0.1 percent by weight based on the total weight of the mixture.
    • 一种可聚合牙科粘合剂组合物,其包含(i)基于组合物总重量的10至90重量%的式(I)的水解稳定的可聚合单体的混合物:R(A)m(B)n( I),其中R是单键或具有1至20个碳原子和任选地1至5个选自氮,氧和硫原子的原子的m + n价有机基团; 独立地表示式(II)的部分,其中L是氢原子,C 1-6烷基,C 3-8环烷基,C 6-14芳基或式(III)的基团,其中R'是 氢原子,C 1-6烷基,C 3-8环烷基或C 6-14芳基; X是O,S,NH或NR“,其中R”是C 1-6烷基,C 3-8环烷基,C 6-14芳基; a是O或1; M是式(IV)的基团,其中Y是O,S,NH或NR'“,其中R”'是C 1-6烷基,C 3-8环烷基,C 6-14芳基; b为0〜3的整数; c为O或1; d为0〜3的整数; 条件是当b为O时,Y不能为O或S; x是O或i; y是O或i; 条件是x和y不能都是1,并且当L或式(III)的基团是氢原子时x不能为1,并且条件是当x是O时,a也是O,并且如果y 是0,那么b大于0或c是0; B独立地表示具有抗微生物活性或酸性基团的基团; m为1〜5的整数, n为0〜3的整数, m + n为2以上。 (ii)水溶性有机溶剂和(iii)引发剂和稳定剂; 其中n大于0且至少一个B是具有抗微生物活性的基团的式(I)的抗微生物单体部分相对于混合物的总重量为至少0.01重量%,并且其中酸性部分 基于混合物的总重量,其中n大于0且至少一个B为酸性基团的式(I)单体为至少0.1重量%。
    • 10. 发明申请
    • MICROSYSTEM INJECTOR FOR A GAS-PHASE CHROMATOGRAPH
    • 用于气相色谱的微型系统技术注射器
    • WO2007012445A2
    • 2007-02-01
    • PCT/EP2006007278
    • 2006-07-24
    • SLS MICRO TECHNOLOGY GMBHLEHMANN UWE
    • LEHMANN UWE
    • G01N30/20
    • G01N30/20G01N30/6095G01N2030/204G01N2030/207G01N2030/407
    • The invention relates to a microsystem injector for a gas-phase chromatograph, comprising: a first and a second fluid guiding block, an actuator for moving the first and second fluid guiding blocks between a first and a second injector position, a sample inlet, a first outlet for guiding the sample material in the first injector position, a carrier gas inlet, and a second outlet for guiding the carrier gas in the first injector position into a first separating column that can be connected to the second outlet. The sample inlet in the second injector position is connected to a first sample store in order to supply the gaseous sample material thereto, and the first sample store in the first injector position is connected to the second outlet, such that the sample material stored in the first sample store in the first injector position is supplied towards the second outlet by rinsing the first sample store with carrier gas. The inventive injector enables a chromatographic separating column to be loaded in a more flexible manner, by providing a fifth opening for supply or removing the carrier gas or the sample material into or out of the injector.
    • 微系统技术喷射器的气相色谱仪,其包括:第一和第二流体传导阻滞,用于移动第一和第二Injektorstellung,样本入口端口,第一出口端口,用于在所述第一Injektorstellung,载气导入口排出的样品材料,之间的第一和第二流体传导块的致动器的 第二出口端口,用于在可连接的排出载气中的第一Injektorstellung到第二出口的第一分离柱,其中所述样品入口端口是在连接到第一样本贮存器,并将该气体样品材料,并在第一Injektorstellung第一样本贮存器与所述第二Injektorstellung 所述第二出口连接,使得存储在所述第一Injektorstellung存储样品材料的第一样品通过冲洗与第二AUSL的载体气体的第一样品存储 assöffnung被提供:本发明使多个可变加载具有这种喷射器中的色谱分离柱通过第五端口,用于供给或载气或样品材料的排出进或出的设置在喷射器。