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1. 发明申请

WO2004078100A3 A POYMERIZABLE PHOSPHORIC ACID ESTER DERIVATIVE AND A DENTAL COMPOSITION EMPLOYING IT. 审中-公开
标题翻译：可食用的磷酸酯衍生物和使用它的牙科组合物。
公开(公告)号：WO2004078100A3
公开(公告)日：2004-10-28
申请号：PCT/EP2004002289
申请日：2004-03-05
申请人： DENTSPLY DE TREY GMBH , KLEE JOACHIM E , LEHMANN UWE , WALZ UWE , LIU HUAIBING
发明人： KLEE JOACHIM E , LEHMANN UWE , WALZ UWE , LIU HUAIBING
IPC分类号： A61K6/00 , A61K6/08 , A61K6/083 , C07F9/09 , C08F30/02
CPC分类号： A61K6/083 , A61K6/0023 , C07F9/091 , C07F9/093 , C08F30/02 , C08L43/02 , C08L33/00
摘要： The present invention provides a polymerizable phosphoric acid ester derivative having the following formula (A): wherein Z is COOR1, COSR1, CON(R1)2, CONR1 R2, or CONHR1, R1 and R2 independently are a hydrogen atom, a substituted or unsubstituted C1 to C18 alkyl group optionally substituted by a C3 to C8 cycloalkyl group, a substituted or unsubstituted C3 to C8 cycloalkyl group, a substituted or unsubstituted C4 to C,18 aryl or heteroaryl group, a substituted or unsubstituted C5 to C18 alkylaryl or alkylheteroaryl group, or a substituted or unsubstituted C7 to C30 aralkyl group, whereby two R1 residues may form together with the N-atom to which they are bonded a 5- to 7-membered heterocyclic ring which may contain beside said N-atom a further nitrogen atom or an oxygen atom, and whereby the substituted groups may be substituted by 1 to 5 C1 to C5 alkyl group(s); a is an integer of from 1 to 10, preferably 1 to 5; b is an integer of from 1 to 10, preferably 1 to 5; and R represents an organic residue containing a + b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said carbon atoms linking a phosphate or 2-(oxa-ethyl)acryl derivative group.
摘要翻译：本发明提供具有下式（A）的聚合性磷酸酯衍生物：其中Z为COOR1，COSR1，CON（R1）2，CONR1R2或CONHR1，R1和R2分别为氢原子，取代或未取代的取代或未取代的C3至C8环烷基，取代或未取代的C4至C18芳基或杂芳基，取代或未取代的C5至C18烷基芳基或烷基杂芳基的C1至C18烷基或取代或未取代的C7至C30芳烷基，其中两个R 1残基可以与它们所键合的N-原子一起形成5-7元杂环，其可以在所述N-原子旁边包含另外的氮原子或氧原子，由此取代基可被1至5个C 1至C 5烷基取代; a为1〜10的整数，优选为1〜5; b为1〜10的整数，优选为1〜5; R表示含有选自伯和仲脂族碳原子，仲脂环族碳原子和芳族碳原子的+ b个碳原子的有机残基，所述碳原子各自连接磷酸酯或2-（氧杂 - 乙基）丙烯酰基衍生物基团。

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