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    • 3. 发明申请
    • DENTAL ADHESIVE
    • 牙膏
    • WO2007045303A8
    • 2007-08-09
    • PCT/EP2006008612
    • 2006-09-04
    • DENTSPLY DE TREY GMBHKLEE JOACHIM ELEHMANN UWE
    • KLEE JOACHIM ELEHMANN UWE
    • A61K6/00A61K6/083
    • A61K6/0029A61K6/0023C08L33/26C08L43/02
    • A one-part self-etching, self-priming dental adhesive having a pH of at most 2, which comprises an aqueous mixture containing (i) one or more polymerizable monomers optionally containing an acidic group, (ii) optionally one or more organic or inorganic acids, (iii) a polymerization initiator, and (iv) a thermal Polymerisation inhibitor of the following formula (I): wherein R' 1 represents a hydrogen atom, or a saturated hydrocarbon group having 1 to 18 carbon atoms. R' 2 , which may be the same or different if more than one R' 2 is present, independently represent a saturated hydrocarbon group having 1 to 18 carbon atoms, and c represents an integer of from 1 to 4.
    • 一种具有pH至多为2的一部分自蚀刻自吸牙科粘合剂,其包含含有(i)一种或多种任选含有酸性基团的可聚合单体的水性混合物,(ii)任选的一种或多种有机或 无机酸,(iii)聚合引发剂,和(iv)下式(I)的热聚合抑制剂:其中R'1表示氢原子或具有1〜 18个碳原子。 R“2”可以相同或不同,如果存在多于一个R'2,独立地表示具有1至18个碳原子的饱和烃基,c 表示1〜4的整数。
    • 4. 发明申请
    • A POYMERIZABLE PHOSPHORIC ACID ESTER DERIVATIVE AND A DENTAL COMPOSITION EMPLOYING IT.
    • 可食用的磷酸酯衍生物和使用它的牙科组合物。
    • WO2004078100A3
    • 2004-10-28
    • PCT/EP2004002289
    • 2004-03-05
    • DENTSPLY DE TREY GMBHKLEE JOACHIM ELEHMANN UWEWALZ UWELIU HUAIBING
    • KLEE JOACHIM ELEHMANN UWEWALZ UWELIU HUAIBING
    • A61K6/00A61K6/08A61K6/083C07F9/09C08F30/02
    • A61K6/083A61K6/0023C07F9/091C07F9/093C08F30/02C08L43/02C08L33/00
    • The present invention provides a polymerizable phosphoric acid ester derivative having the following formula (A): wherein Z is COOR1, COSR1, CON(R1)2, CONR1 R2, or CONHR1, R1 and R2 independently are a hydrogen atom, a substituted or unsubstituted C1 to C18 alkyl group optionally substituted by a C3 to C8 cycloalkyl group, a substituted or unsubstituted C3 to C8 cycloalkyl group, a substituted or unsubstituted C4 to C,18 aryl or heteroaryl group, a substituted or unsubstituted C5 to C18 alkylaryl or alkylheteroaryl group, or a substituted or unsubstituted C7 to C30 aralkyl group, whereby two R1 residues may form together with the N-atom to which they are bonded a 5- to 7-membered heterocyclic ring which may contain beside said N-atom a further nitrogen atom or an oxygen atom, and whereby the substituted groups may be substituted by 1 to 5 C1 to C5 alkyl group(s); a is an integer of from 1 to 10, preferably 1 to 5; b is an integer of from 1 to 10, preferably 1 to 5; and R represents an organic residue containing a + b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said carbon atoms linking a phosphate or 2-(oxa-ethyl)acryl derivative group.
    • 本发明提供具有下式(A)的聚合性磷酸酯衍生物:其中Z为COOR1,COSR1,CON(R1)2,CONR1R2或CONHR1,R1和R2分别为氢原子,取代或未取代的 取代或未取代的C3至C8环烷基,取代或未取代的C4至C18芳基或杂芳基,取代或未取代的C5至C18烷基芳基或烷基杂芳基的C1至C18烷基 或取代或未取代的C7至C30芳烷基,其中两个R 1残基可以与它们所键合的N-原子一起形成5-7元杂环,其可以在所述N-原子旁边包含另外的氮原子 或氧原子,由此取代基可被1至5个C 1至C 5烷基取代; a为1〜10的整数,优选为1〜5; b为1〜10的整数,优选为1〜5; R表示含有选自伯和仲脂族碳原子,仲脂环族碳原子和芳族碳原子的+ b个碳原子的有机残基,所述碳原子各自连接磷酸酯或2-(氧杂 - 乙基)丙烯酰基衍生物基团 。