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1. 发明申请

WO1998019604A1 BLOOD FLOW METER AND METHOD OF USE 审中-公开
标题翻译：血液流量计及其使用方法
公开(公告)号：WO1998019604A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020038
申请日：1997-11-07
申请人： DATA SCIENCES INTERNATIONAL, INC.
发明人： DATA SCIENCES INTERNATIONAL, INC. , DOTEN, Gregory, P. , BROCKWAY, Brian, P.
IPC分类号： A61B08/06
CPC分类号： A61B8/06 , A61B5/0031 , A61B8/12 , A61B2560/0209
摘要： A strobed blood flow meter provides periodic measurements of blood flow velocity or volumetric blood flow over a cardiac cycle at reduced average power consumption, which is advantageous for reducing battery size, and extending device battery life, such as in an implantable application. Continuous wave Doppler, pulsed Doppler, laser Doppler, transit time, electromagnetic flow, and thermal dilution techniques are included. Strobing provides higher level excitation during active periods, which improves signal-to-noise ratio, and provides a low power standby mode during an idle time between active periods. The invention may be used for chronic or acute applications. Doppler or other signals may be telemetered from an implanted portion of the flow meter for further signal processing to extract velocity or volumetric flow. Alternatively, such signal processing is also implanted, such that the velocity signal can be telemetered to a remote monitor.
摘要翻译：选通的血液流量计提供了在减少的平均功率消耗下在心动周期上的血流速度或体积血流量的周期性测量，这有利于减少电池尺寸并延长装置电池寿命，例如在可植入应用中。包括连续波多普勒，脉冲多普勒，激光多普勒，运输时间，电磁流量和热稀释技术。 Strobing在活动期间提供更高的电平激励，这提高了信噪比，并且在活动周期之间的空闲时间期间提供了低功率待机模式。本发明可用于慢性或急性应用。多普勒或其他信号可以从流量计的植入部分遥测，用于进一步的信号处理以提取速度或体积流量。或者，也植入这样的信号处理，使得速度信号可以被遥测到远程监视器。

2. 发明申请

WO2003030581A2 TELEMETRY OF ANALOG AND DIGITAL DATA 审中-公开
标题翻译：模拟和数字数据的演示
公开(公告)号：WO2003030581A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/028771
申请日：2002-09-10
申请人： DATA SCIENCES INTERNATIONAL, INC , BORNHOFT, Reid , BROCKWAY, Brian, P. , KUNZ, Matt , LICHTSCHEIDL, Gregg , LINDSTEDT, Brock , MILLS, Perry, A.
发明人： BORNHOFT, Reid , BROCKWAY, Brian, P. , KUNZ, Matt , LICHTSCHEIDL, Gregg , LINDSTEDT, Brock , MILLS, Perry, A.
IPC分类号： H04Q9/00
CPC分类号： H04L25/493 , A61B5/07 , G08C19/24 , H04B14/026 , H04L25/4902
摘要： A system and method involve transceiving successive first and second synchronization signals defining endpoints of a frame. A digital signal is transceived by a modulating time interval between portions of the first and second synchronization signals. A first data pulse is transceived during the frame. A relative position in the frame of the first data pulse represents a first analog signal.
摘要翻译：系统和方法涉及收发定义帧的端点的连续的第一和第二同步信号。数字信号通过第一和第二同步信号的部分之间的调制时间间隔收发。在帧期间收发第一个数据脉冲。第一数据脉冲的帧中的相对位置表示第一模拟信号。

3. 发明申请

WO1997011637A1 RESPIRATION MONITORING SYSTEM BASED ON SENSED BLOOD PRESSURE 审中-公开
标题翻译：基于感觉血压的呼吸监测系统
公开(公告)号：WO1997011637A1
公开(公告)日：1997-04-03
申请号：PCT/US1996014968
申请日：1996-09-18
申请人： DATA SCIENCES INTERNATIONAL, INC.
发明人： DATA SCIENCES INTERNATIONAL, INC. , BROCKWAY, Brian, P. , BROCKWAY, Robert, V. , FUNDAKOWSKI, Richard, A.
IPC分类号： A61B05/021
CPC分类号： A61B5/0816 , A61B5/021 , A61B5/02108 , A61B5/7239 , G06F19/00
摘要： A system and method obtains physiologic parameter information of an animal or human, such as respiratory rate, from a blood pressure signal from an implanted blood pressure sensor (11) in the animal or human (10, 12, 14). Specifically, the blood pressure signal is externally signal processed to develop an amplitude versus time waveform. A sequence of selected blood pressure features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected blood pressure features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.
摘要翻译：系统和方法根据来自动物或人类的植入式血压传感器（11）的血压信号，获得动物或人类的生理参数信息，如呼吸频率（10,12,14）。具体地说，将血压信号从外部进行信号处理，以产生振幅对时间波形。从所开发的振幅对时间波形中提取从所选择的时间间隔内的幅度对时间波形的各个心脏周期导出的选定血压特征的序列。将数学模型拟合到所选择的血压特征的提取序列以产生拟合的数学模型。从拟合数学模型计算生理参数信息。

4. 发明授权

EP0417171B1 A DEVICE FOR CHRONIC MEASUREMENT OF INTERNAL BODY PRESSURE 有权转让
标题翻译：安排心身压力的持续测量。
公开(公告)号：EP0417171B1
公开(公告)日：1995-08-02
申请号：EP89906622.9
申请日：1989-05-17
申请人： Data Sciences International, Inc.
发明人： BROCKWAY, Brian, P. , MILLS, Perry, A. , MILLER, Jonathan, T.
IPC分类号： A61B5/00
CPC分类号： G01L19/141 , A61B5/0031 , A61B5/0215 , A61B5/03 , A61B5/6882 , G01L19/0061 , G01L19/0084 , G01L19/147 , H01L2224/48091 , H01L2924/16152 , Y10S128/903 , H01L2924/00014
摘要： Measurement of a physiological pressure is accomplished by placement of a pressure transmitting catheter (20) within a blood vessel or other structure within which pressure is to be measured. The catheter (20) is blood-compatible, capable of withstanding handling during distribution and implantation, and provides adequate pressure transmission frequency response in a variety of applications. The catheter (20), which includes a hollow tube filled with a low viscosity fluid (29) and having a plug (30) of a gel-like material at its distal end (22), transmits the pressure signal to a solid-state transducer (16) which is typically connected to amplifying electronics and an implantable radio-transmitter (18) capable of relaying the pressure information from within the body to a radio receiver external to the body.

5. 发明公开

EP0417171A1 A DEVICE FOR CHRONIC MEASUREMENT OF INTERNAL BODY PRESSURE 有权转让
标题翻译：安排心身压力的持续测量。
公开(公告)号：EP0417171A1
公开(公告)日：1991-03-20
申请号：EP89906622.0
申请日：1989-05-17
申请人： Data Sciences International, Inc.
发明人： BROCKWAY, Brian, P. , MILLS, Perry, A. , MILLER, Jonathan, T.
IPC分类号： A61B5 , G01L9
CPC分类号： G01L19/141 , A61B5/0031 , A61B5/0215 , A61B5/03 , A61B5/6882 , G01L19/0061 , G01L19/0084 , G01L19/147 , H01L2224/48091 , H01L2924/16152 , Y10S128/903 , H01L2924/00014
摘要： On mesure la pression physiologique en plaçant, à l'intérieur d'un vaisseau sanguin ou d'une autre partie du corps dont on veut mesurer la pression interne, un cathéter transmettant la pression (20). Ledit cathéter (20) est compatible avec le sang, il résiste aux manipulations que comportent le transport et l'implantation et il fournit des réponses-fréquences de transmission de pression parfaitement satifaisantes dans divers modes d'application. Ledit cathéter (20), qui comprend un tube creux rempli de fluide à faible viscosité (29) et qui est doté, en son extrémité distale (22), d'un bouchon (30) d'une matière du type gel, transmet le signal de pression à un capteur semiconducteur (16), qui est en général relié à un système électronique d'amplification et à un radioémetteur (18) implantable, qui transmet les données relatives à la pression depuis l'intérieur du corps jusqu'à un récepteur radio situé à l'extérieur du corps.

6. 发明公开

EP1115329A2 IMPLANTABLE SENSOR WITH WIRELESS COMMUNICATION 有权
标题翻译：具有无线通信植入的传感器
公开(公告)号：EP1115329A2
公开(公告)日：2001-07-18
申请号：EP99946771.5
申请日：1999-09-07
申请人： Data Sciences International, Inc.
发明人： BROCKWAY, Brian, P. , MILLS, Perry, Alton , ZWIERS, Lynn, M.
IPC分类号： A61B5/00 , A61B5/0215
CPC分类号： A61B5/6882 , A61B5/0028 , A61B5/0031 , A61B5/0215 , A61N1/37205
摘要： An implantable sensor device (105), such as a pressure monitor, is implanted in the left ventricle (LV) (135), in other heart chambers, or elsewhere, from which it wirelessly communicates pressure information to a remote communication device (140). The sensor device can be implanted using a placement catheter (600), an endoscope, or a laparoscope. The device can be secured entirely within the LV or heart wall, such as by using a corkscrew (312A), a helical anchor, a harpoon (312B), a threaded member, a hook, a barb, a fastener, a suture, or a mesh (312C) or coating for receiving fibrous tissue growth. The implantable sensor device (105) provides less invasive chronic measurements of left ventricular blood pressure or other physical parameters. The wireless communication techniques include radio-telemetry, inductive coupling, passive transponders, and using the body as a conductor (referred to as 'intracorporeal conductive communication' or a 'personal area network'). Data from the receiver is downloadable into a computer for analysis or display.

7. 发明公开

EP1011451A1 BLOOD FLOW METER AND METHOD OF USE 失效
标题翻译：血流量装置
公开(公告)号：EP1011451A1
公开(公告)日：2000-06-28
申请号：EP97946496.3
申请日：1997-11-07
申请人： Data Sciences International, Inc.
发明人： DOTEN, Gregory, P. , BROCKWAY, Brian, P.
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/0031 , A61B8/12 , A61B2560/0209
摘要： A strobed blood flow meter provides periodic measurements of blood flow velocity or volumetric blood flow over a cardiac cycle at reduced average power consumption, which is advantageous for reducing battery size, and extending device battery life, such as in an implantable application. Continuous wave Doppler, pulsed Doppler, laser Doppler, transit time, electromagnetic flow, and thermal dilution techniques are included. Strobing provides higher level excitation during active periods, which improves signal-to-noise ratio, and provides a low power standby mode during an idle time between active periods. The invention may be used for chronic or acute applications. Doppler or other signals may be telemetered from an implanted portion of the flow meter for further signal processing to extract velocity or volumetric flow. Alternatively, such signal processing is also implanted, such that the velocity signal can be telemetered to a remote monitor.

8. 发明公开

EP1022983A1 CATHETER WITH PRESSURE TRANSDUCER NEXT TO THE DISTAL END 有权
标题翻译：与相邻的远端导管布置推进器
公开(公告)号：EP1022983A1
公开(公告)日：2000-08-02
申请号：EP98952131.5
申请日：1998-10-07
申请人： Data Sciences International, Inc.
发明人： BROCKWAY, Brian, P. , MILLS, Perry, Alton , MOENCH, Mel, Murray
IPC分类号： A61B5/0215 , A61B5/03
CPC分类号： A61B5/0215 , A61B5/031 , A61M2025/0003
摘要： A device measures pressures in animals and humans and includes a pressure transmission catheter (22) filled with a pressure transmitting medium (26) and implantable in an area having a physiological pressure. A transducer (30) communicates with the pressure transmitting medium (26) to provide a pressure signal representing variations in the physiologic pressure on electrical wires (34). A connecting catheter (36) carries the electrical wires (34) to signal processing and telemetry circuitry (38), which transmits a telemetry signal representing the pressure signal to a receiver external to the animal or human. A housing (44) holds the signal processing and telemetry circuitry (38), but the transducer (30) is remote from the housing (44). The device performs measuring of venous pressure, pulmonary pressure, bladder pressure, or intracranial pressure without significant head pressure artifact and with a sufficient dynamic response. One embodiment of the catheter (22) includes a multi-durometer stem.

9. 发明公开

EP0957757A1 RESPIRATION MONITORING SYSTEM BASED ON SENSED BLOOD PRESSURE 失效
标题翻译：安排监测呼吸血液压力信号的方式
公开(公告)号：EP0957757A1
公开(公告)日：1999-11-24
申请号：EP96935847.0
申请日：1996-09-18
申请人： Data Sciences International, Inc.
发明人： BROCKWAY, Brian, P. , BROCKWAY, Robert, V. , FUNDAKOWSKI, Richard, A.
IPC分类号： A61B5
CPC分类号： A61B5/0816 , A61B5/021 , A61B5/02108 , A61B5/7239 , G06F19/00
摘要： A system and method obtains physiologic parameter information of an animal or human, such as respiratory rate, from a blood pressure signal from an implanted blood pressure sensor in the animal or human. Specifically, the blood pressure signal is externally signal processed to develop an amplitude versus time waveform. A sequence of selected blood pressure features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected blood pressure features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.

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