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1. 发明专利

AU5383998A Biocompatible medical devices with polyurethane surface 未知
公开(公告)号：AU5383998A
公开(公告)日：1998-07-03
申请号：AU5383998
申请日：1997-12-12
申请人： DATA SCIENCES INTERNATIONAL INC
发明人： DELMAIN GREGORY J
IPC分类号： A61M25/00 , A61F2/84 , A61L29/00 , A61L29/06 , A61L33/00 , A61L33/06 , C08J7/02
摘要： A system for improving the biocompatibility of medical devices present within a patient's body. In one embodiment, the present subject matter reduces the thrombogenicity of polyurethane materials in contact with the blood of a patient. In one embodiment, the medical device has a polymeric wall and a coating of polyurethane, said coating of polyurethane having the same chemical composition throughout the thickness and displaying an antithrombogenic effect when inserted into a patient's body in contact with blood for a period of at least twenty-four hours. The present subject matter relates to the manufacture and treatment of polymeric materials that may be inserted as medical devices, accessories, implants or replacements into animal bodies, such as the human body.

2. 发明专利

AU2004247041B2 Reduced-noise plethysmograph 未知
公开(公告)号：AU2004247041B2
公开(公告)日：2009-10-01
申请号：AU2004247041
申请日：2004-05-26
申请人： DATA SCIENCES INTERNATIONAL INC
发明人： LOMASK JOSEPH
IPC分类号： A61B5/08
摘要： The accuracy of measurements of changes in air volumes within a plethysmograph is improved by addition of a manifold to provide a common source of exterior air to the plethysmograph test and reference chamber. The preferred plethysmograph includes test and reference chambers divided by a common separator wall, pneumotachs in communication with the chambers, and a differential pressure transducer having a first inlet in communication with the test chamber and a second inlet in communication with the reference chamber. The manifold includes an exterior air inlet and a passageway extending between the two pneumotachs and the air inlet. The passageway may be in the form of separate tubes or conduits, or a common housing covering the pneumotachs. Preferably, the distances from the exterior air inlets to the two pneumotachs are approximately the same.

3. 发明专利

AU9790098A Catheter with pressure transducer next to the distal end 未知
公开(公告)号：AU9790098A
公开(公告)日：1999-05-03
申请号：AU9790098
申请日：1998-10-07
申请人： DATA SCIENCES INTERNATIONAL INC
发明人： BROCKWAY BRIAN P , MILLS PERRY ALTON , MOENCH MEL MURRAY
IPC分类号： A61B5/0215 , A61B5/03
摘要： A device measures pressures in animals and humans and includes a pressure transmission catheter (PTC) filled with a pressure transmitting medium and implantable in an area in having a physiological pressure. A transducer communicates with the pressure transmitting medium to provide a pressure signal representing variations in the physiologic pressure on electrical wires. A connecting catheter carries the electrical wires to signal processing and telemetry circuitry, which transmits a telemetry signal representing the pressure signal to a receiver external to the animal or human. A housing holds the signal processing and telemetry circuitry, but the transducer is remote from the housing. The device is particularly useful in measuring venous pressure, pulmonary pressure, bladder pressure, or intracranial pressure without significant head pressure artifact and with a sufficient dynamic response. One embodiment of the PTC includes a multi-durometer stem.

4. 发明专利

AU7363296A Respiration monitoring system based on sensed blood pressure 未知
公开(公告)号：AU7363296A
公开(公告)日：1997-04-17
申请号：AU7363296
申请日：1996-09-18
申请人： DATA SCIENCES INTERNATIONAL INC
发明人： BROCKWAY BRIAN P , BROCKWAY ROBERT V , FUNDAKOWSKI RICHARD A
IPC分类号： A61B5/021 , A61B5/08
摘要： A system and method obtains physiologic parameter information of an animal or human, such as respiratory rate, from a blood pressure signal from an implanted blood pressure sensor in the animal or human. Specifically, the blood pressure signal is externally signal processed to develop an amplitude versus time waveform. A sequence of selected blood pressure features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected blood pressure features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.

5. 发明专利

AU5165398A Blood flow meter and method of use 未知
公开(公告)号：AU5165398A
公开(公告)日：1998-05-29
申请号：AU5165398
申请日：1997-11-07
申请人： DATA SCIENCES INTERNATIONAL INC
发明人： DOTEN GREGORY P , BROCKWAY BRIAN P
IPC分类号： G01F1/00 , A61B5/00 , A61B8/06 , G01F1/58 , G01F1/66 , G01F1/68
摘要： A strobed blood flow meter provides periodic measurements of blood flow velocity or volumetric blood flow over a cardiac cycle at reduced average power consumption, which is advantageous for reducing battery size, and extending device battery life, such as in an implantable application. Continuous wave Doppler, pulsed Doppler, laser Doppler, transit time, electromagnetic flow, and thermal dilution techniques are included. Strobing provides higher level excitation during active periods, which improves signal-to-noise ratio, and provides a low power standby mode during an idle time between active periods. The invention may be used for chronic or acute applications. Doppler or other signals may be telemetered from an implanted portion of the flow meter for further signal processing to extract velocity or volumetric flow. Alternatively, such signal processing is also implanted, such that the velocity signal can be telemetered to an remote monitor.

6. 发明申请

WO1998019604A1 BLOOD FLOW METER AND METHOD OF USE 审中-公开
标题翻译：血液流量计及其使用方法
公开(公告)号：WO1998019604A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020038
申请日：1997-11-07
申请人： DATA SCIENCES INTERNATIONAL, INC.
发明人： DATA SCIENCES INTERNATIONAL, INC. , DOTEN, Gregory, P. , BROCKWAY, Brian, P.
IPC分类号： A61B08/06
CPC分类号： A61B8/06 , A61B5/0031 , A61B8/12 , A61B2560/0209
摘要： A strobed blood flow meter provides periodic measurements of blood flow velocity or volumetric blood flow over a cardiac cycle at reduced average power consumption, which is advantageous for reducing battery size, and extending device battery life, such as in an implantable application. Continuous wave Doppler, pulsed Doppler, laser Doppler, transit time, electromagnetic flow, and thermal dilution techniques are included. Strobing provides higher level excitation during active periods, which improves signal-to-noise ratio, and provides a low power standby mode during an idle time between active periods. The invention may be used for chronic or acute applications. Doppler or other signals may be telemetered from an implanted portion of the flow meter for further signal processing to extract velocity or volumetric flow. Alternatively, such signal processing is also implanted, such that the velocity signal can be telemetered to a remote monitor.
摘要翻译：选通的血液流量计提供了在减少的平均功率消耗下在心动周期上的血流速度或体积血流量的周期性测量，这有利于减少电池尺寸并延长装置电池寿命，例如在可植入应用中。包括连续波多普勒，脉冲多普勒，激光多普勒，运输时间，电磁流量和热稀释技术。 Strobing在活动期间提供更高的电平激励，这提高了信噪比，并且在活动周期之间的空闲时间期间提供了低功率待机模式。本发明可用于慢性或急性应用。多普勒或其他信号可以从流量计的植入部分遥测，用于进一步的信号处理以提取速度或体积流量。或者，也植入这样的信号处理，使得速度信号可以被遥测到远程监视器。

7. 发明申请

WO2021216508A1 SYSTEMS AND METHODS FOR TESTING ONE OR MORE SMOKING ARTICLES 审中-公开
公开(公告)号：WO2021216508A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028098
申请日：2021-04-20
申请人： DATA SCIENCES INTERNATIONAL INC.
发明人： BENJAMIN, Aaron , VAN HEE, Justin R. , AARDAHL, Craig V.
IPC分类号： A24F40/80 , A24F47/00 , A24C5/34
摘要： This specification generally discloses a system and method configured to generate vapor samples from one or more smoking articles (e.g., cigarette, tobacco product, e-cigarette, or nicotine vapor product), in which such vapor sample may optionally be used for testing purposes. The system may be configured in a manner that reduces the likelihood of exposing particular mechanical components to the smoking article vapor, which may in turn reduce effects of fouling or corroding such components of the system over a period time.

8. 发明申请

WO2002065894A3 ENDOCARDIAL PRESSURE MEASUREMENT 审中-公开
公开(公告)号：WO2002065894A3
公开(公告)日：2002-08-29
申请号：PCT/US2002/004648
申请日：2002-02-19
申请人： DATA SCIENCES INTERNATIONAL, INC.
发明人： BROCKWAY, Brian , DOTEN, Gregory , HOLTZ, Michael , KALM, Michael, L. , KUEHN, Scott , LAMBERT, Scott , LICHTSCHEIDL, Gregg , MILLS, Perry , MOSESOV, Oleg , NICOLOFF, Demetre, M. , ODDEN, Karen , PARK, Soon , QUINN, Christopher , STOFER, Alyse , TAYLOR, Jeff , VANHEE, Justin , ZWIERS, Lynn
IPC分类号： A61B05/00
摘要： Endocardial pressure measurement devices, systems and methods for effective treatment of congestive heart failure and its underlying causes, in addition to other clinical applications. A representative device includes an implantable pressure measuring system including a pressure transducer (31) and a fluid filled catheter (34), the catheter having a proximal portion (34A) and a distal portion (34B). The proximal portion (34a) is connected to the pressure transducer (31) and the distal portion (34b) has an opening (36) with a barrier (26). The proximal portion (34a) is relatively crush-resistant and the distal portion (34b) is relatively flexible.

9. 发明申请

WO1998025654A1 BIOCOMPATIBLE MEDICAL DEVICES WITH POLYURETHANE SURFACE 审中-公开
标题翻译：具有聚氨酯表面的生物成分医疗器械
公开(公告)号：WO1998025654A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023229
申请日：1997-12-12
申请人： DATA SCIENCES INTERNATIONAL, INC. , DELMAIN, Gregory, J.
发明人： DATA SCIENCES INTERNATIONAL, INC.
IPC分类号： A61L29/00
CPC分类号： C08J7/02 , A61L29/06 , A61L33/068 , C08J2375/04 , C08L75/04
摘要： The present invention provides a method for improving the biocompatibility of devices, especially medical devices which are invasively present within a patient's body and the improved medical device. The present invention particularly reduces the thrombogenicity of polyurethane materials in contact with the blood of a living patient. The method comprises providing a biocompatible medical device having polymeric polyurethane components thereon, exposing the polyurethane components of the medical device to polar solvents for said polymeric components while the polar solvents are in the vapor phase, and allowing said vapor phase exposure to continue for a sufficient amount of time as to reduce at least some irregular or sharp features on the surface of the polymeric component. The invention describes a method of improving a medical device having at least one polymeric component, the process comprising the steps of providing a vapor phase comprising a solvent for said polymer component, and exposing said polymeric component to said vapor phase. The process comprises taking a polyurethane component having a surface with a topography (e.g., roughness, grooves, wave patterns, sharp edge features, deviations from planarity and the like), and exposing the polyurethane component to said vapor phase to increase planarity in said topography. This is done without chemical reaction with the polymer component, and because of the control of the amount of solvent which can contact the polymer, the potential for damage to the polymeric component is reduced. In particular, the vapor phase treatment will reduce the dimensions of extrusion markings on the exterior surface of the polyurethane with minimum potential for damage to the structure of the polyurethane, even where the polyurethane is present as thin walls (e.g., less than 0.0762 mm).
摘要翻译：本发明提供一种用于改善设备，特别是侵入地存在于患者体内的医疗设备和改进的医疗设备的生物相容性的方法。本发明特别降低与活体患者的血液接触的聚氨酯材料的血栓形成。该方法包括在其上提供具有聚合物聚氨酯组分的生物相容性医疗装置，将所述医疗装置的聚氨酯组分暴露于所述聚合物组分的极性溶剂，同时极性溶剂处于气相中，并允许所述气相暴露持续足够的用于减少聚合物组分表面上至少一些不规则或尖锐特征的时间量。本发明描述了改进具有至少一种聚合物组分的医疗装置的方法，所述方法包括以下步骤：提供包含所述聚合物组分的溶剂并将所述聚合物组分暴露于所述气相的气相。该方法包括使具有表面的聚氨酯组分（例如，粗糙度，凹槽，波形图，尖锐边缘特征，与平面性等的偏差），以及将聚氨酯组分暴露于所述气相以增加所述形貌中的平面度。这完成了与聚合物组分的化学反应，并且由于可以控制可以与聚合物接触的溶剂的量，所以降低了对聚合物组分的损害的可能性。特别地，气相处理将减小聚氨酯外表面上的挤出标记的尺寸，即使在聚氨酯以薄壁（例如，小于0.0762mm）存在聚氨酯的结构的情况下，也可能损坏聚氨酯的结构，。

10. 发明申请

WO1997011637A1 RESPIRATION MONITORING SYSTEM BASED ON SENSED BLOOD PRESSURE 审中-公开
标题翻译：基于感觉血压的呼吸监测系统
公开(公告)号：WO1997011637A1
公开(公告)日：1997-04-03
申请号：PCT/US1996014968
申请日：1996-09-18
申请人： DATA SCIENCES INTERNATIONAL, INC.
发明人： DATA SCIENCES INTERNATIONAL, INC. , BROCKWAY, Brian, P. , BROCKWAY, Robert, V. , FUNDAKOWSKI, Richard, A.
IPC分类号： A61B05/021
CPC分类号： A61B5/0816 , A61B5/021 , A61B5/02108 , A61B5/7239 , G06F19/00
摘要： A system and method obtains physiologic parameter information of an animal or human, such as respiratory rate, from a blood pressure signal from an implanted blood pressure sensor (11) in the animal or human (10, 12, 14). Specifically, the blood pressure signal is externally signal processed to develop an amplitude versus time waveform. A sequence of selected blood pressure features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected blood pressure features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.
摘要翻译：系统和方法根据来自动物或人类的植入式血压传感器（11）的血压信号，获得动物或人类的生理参数信息，如呼吸频率（10,12,14）。具体地说，将血压信号从外部进行信号处理，以产生振幅对时间波形。从所开发的振幅对时间波形中提取从所选择的时间间隔内的幅度对时间波形的各个心脏周期导出的选定血压特征的序列。将数学模型拟合到所选择的血压特征的提取序列以产生拟合的数学模型。从拟合数学模型计算生理参数信息。

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