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1. 发明申请

WO2009097527A1 MINIMALLY INVASIVE PHYSIOLOGIC PARAMETER RECORDER AND INTRODUCER SYSTEM 审中-公开
标题翻译：微生物生理参数记录仪和引导系统
公开(公告)号：WO2009097527A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032640
申请日：2009-01-30
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian P. , MILLS, Perry A.
发明人： BROCKWAY, Brian P. , MILLS, Perry A.
IPC分类号： A61N1/375 , A61B5/00
CPC分类号： A61B5/686 , A61B5/0031 , A61B5/042 , A61B5/0422 , A61B5/076 , A61B5/7232 , A61B2560/0219 , A61B2560/063 , A61B2560/066 , A61B2562/0209 , A61B2562/164 , A61B2562/18 , A61N1/0504 , A61N1/37229 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： An implantable monitoring device includes a flexible lead body that includes at least one sensing element. The device also includes a rigid main body connected to the flexible lead body at an attachment point. The rigid main body is generally centered about a longitudinal axis defined by the flexible lead body when the lead body is unflexed. The device further includes a measurement circuit, which is housed within the rigid main body and electrically coupled to the at least one sensing element of the flexible lead body and at least another sensing element on an outside surface of the rigid main body. The measurement circuit is configured to measure a potential difference between the at least one sensing element of the flexible lead body and the at least another sensing element of the main body.
摘要翻译：可植入监测装置包括一个包括至少一个传感元件的柔性引线体。该装置还包括在附接点处连接到柔性引线主体的刚性主体。当铅体未折叠时，刚性主体通常由柔性引线体限定的纵向轴线对准。该装置还包括测量电路，其被容纳在刚性主体内并电耦合到柔性引线本体的至少一个感测元件和至少另一感测元件在刚性主体的外表面上。测量电路被配置为测量柔性引线体的至少一个感测元件与主体的至少另一感测元件之间的电位差。

2. 发明申请

WO2006089246A2 IMPEDANCE BASED SENSOR FOR MONITORING LEAKAGE IN AAA STENT GRAFT 审中-公开
标题翻译：基于阻尼的传感器，用于监测AAA级钢筋中的泄漏
公开(公告)号：WO2006089246A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005880
申请日：2006-02-16
申请人： TRANSOMA MEDICAL INC , BROCKWAY BRIAN P , MILLS PERRY A
发明人： BROCKWAY BRIAN P , MILLS PERRY A
IPC分类号： A61B5/05
CPC分类号： A61B5/053
摘要： Embodiment of the invention provide a technique for detecting endoleakage of an abdominal aortic aneurism (AAA) stent graft on a relatively frequent basis at home or the clinic without the safety risks and/or costs associated with current approaches. In one embodiment, an apparatus for detecting leakage in an AAA graft comprises: an electrode array having a plurality of electrodes distributed over and coupled with a surface of the AAA graft; and an electrical circuit configured to generate a stimulus voltage or current to be applied between sets of the plurality of electrodes of the electrode array and measure an impedance between the sets of the plurality of electrodes. The sets of electrodes for measuring the impedance are same as or different from the sets of electrodes for applying the stimulus voltage or current. A leakage is detected by a decrease in the impedance measured by the electrical circuit.
摘要翻译：本发明的实施例提供了一种用于在家庭或临床上相对频繁地检测腹主动脉瘤（AAA）支架移植物的内漏的技术，而没有与当前方法相关的安全风险和/或成本。在一个实施例中，用于检测AAA移植物中的泄漏的装置包括：电极阵列，其具有分布在所述AAA移植物的表面上并与所述AAA移植物的表面耦合的多个电极; 以及电路，其被配置为产生施加在所述电极阵列的所述多个电极的组之间的刺激电压或电流，并且测量所述多个电极的所述组之间的阻抗。用于测量阻抗的电极组与用于施加刺激电压或电流的电极组相同或不同。通过由电路测量的阻抗的降低来检测泄漏。

3. 发明申请

WO2005104779A2 IMPLANTABLE MEDICAL DEVICES AND RELATED METHODS 审中-公开
标题翻译：可植入医疗器械及相关方法
公开(公告)号：WO2005104779A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014625
申请日：2005-04-27
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian, P. , MILLS, Perry, A. , FOSTER, Arthur, J. , LAMBERT, Scott , SHERWOOD, Kathy, Lynn
发明人： BROCKWAY, Brian, P. , MILLS, Perry, A. , FOSTER, Arthur, J. , LAMBERT, Scott , SHERWOOD, Kathy, Lynn
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/0402 , A61N1/00 , A61N1/05 , A61N1/372 , A61N1/375 , A61N1/378
CPC分类号： A61N1/3727 , A61B5/0006 , A61B5/0031 , A61B5/0215 , A61B5/0402 , A61B5/413 , A61N1/05 , A61N1/37276 , A61N1/375 , A61N1/3752 , A61N1/3756 , A61N1/3785 , A61N1/3787
摘要： Implantable medical devices and associated methods are disclosed. In one implementation, the implantable medical device comprises a conductive housing and a remote electrode that is mechanically coupled to the conductive housing by a lead body. An amplifier is electrically connected to the remote electrode and the conductive housing for providing a signal representative of a voltage difference between the remote electrode and the conductive housing. In some methods in accordance with the present invention, the implantable medical device is implanted in an implant site overlaying one half of a rib cage of a human body. The implantable medical device produces a signal representative of the voltage difference between the remote electrode and the conductive housing and the signal is transmitted to a receiver located outside the human body.
摘要翻译：公开了可植入医疗装置和相关方法。在一个实施方案中，可植入医疗装置包括导电壳体和远程电极，其通过引线体机械耦合到导电壳体。放大器电连接到远程电极和导电壳体，用于提供表示远程电极和导电壳体之间的电压差的信号。在根据本发明的一些方法中，将植入式医疗装置植入覆盖人体肋骨的一半的植入部位。可植入医疗装置产生表示远程电极和导电外壳之间的电压差的信号，并且信号被传送到位于人体外部的接收器。

4. 发明申请

WO2007098228A3 SYSTEM AND METHOD OF MONITORING PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：监测生理信号的系统和方法
公开(公告)号：WO2007098228A3
公开(公告)日：2008-03-27
申请号：PCT/US2007004556
申请日：2007-02-20
申请人： TRANSOMA MEDICAL INC , BROCKWAY BRIAN P , KOVTUN VLADIMIR , RICCI CARLOS , ARNOLD JOHN , JASPERSON KEITH , SHERWOOD KATHY L , MAZAR SCOTT T
发明人： BROCKWAY BRIAN P , KOVTUN VLADIMIR , RICCI CARLOS , ARNOLD JOHN , JASPERSON KEITH , SHERWOOD KATHY L , MAZAR SCOTT T
IPC分类号： A61B5/0464
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/7275 , A61N1/3702
摘要： A physiological signal monitoring and analysis system including an implantable medical device and a signal processor. The implantable medical device is configured to monitor and record sample segments of at least one physiological signal of a patient at time separated recording intervals over a time period. The signal processor configured to measure values of at least one selected characteristic of the at least one physiological signal from the recorded sample segments, to determine trend information representing a trend in the at least one selected characteristic based on the measured values, and to assess a risk of a physiological event to the patient based on the trend information.
摘要翻译：一种生理信号监测和分析系统，包括可植入医疗装置和信号处理器。可植入医疗装置被配置为在一段时间内以分开的时间间隔监视和记录患者的至少一个生理信号的样本片段。所述信号处理器被配置为测量来自记录的采样段的至少一个生理信号的至少一个所选特征的值，以基于所述测量值确定表示所述至少一个所选特征中的趋势的趋势信息，并且评估根据趋势信息向患者发生生理事件的风险。

5. 发明申请

WO2009018580A1 PERIODIC SAMPLING OF CARDIAC SIGNALS USING AN IMPLANTABLE MONITORING DEVICE 审中-公开
标题翻译：使用可移植监控设备对心脏信号进行周期性采样
公开(公告)号：WO2009018580A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/072135
申请日：2008-08-04
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian P. , BELALCAZAR, Andres
发明人： BROCKWAY, Brian P. , BELALCAZAR, Andres
IPC分类号： A61B5/0432 , A61B5/046 , A61N1/37
CPC分类号： A61B5/046 , A61B5/0031 , A61N1/395
摘要： In a method of diagnosing an atrial fibrillation or atrial flutter condition, a monitoring device implanted in a subject acquires strips of a subcutaneous ECG signal of a predetermined length. The strips are acquired at regular, periodic intervals, and the timing of when the strips are acquired is not triggered by analysis of the subcutaneous ECG signal by the monitoring device. The acquired subcutaneous ECG strips are stored in memory of the implanted monitoring device, and transmitted from the implanted monitoring device for receipt by an external analysis system. In the external analysis system, the received subcutaneous ECG strips are processed to generate information for an assessment of an atrial fibrillation or atrial flutter burden for the subject.
摘要翻译：在诊断房颤或心房扑动状态的方法中，植入对象的监测装置获取预定长度的皮下ECG信号的条带。以规则的周期性间隔获取条带，并且获取条带的时间不是通过监测装置对皮下ECG信号的分析来触发的。获取的皮下ECG条带存储在植入的监测装置的存储器中，并从植入的监测装置传输，以便由外部分析系统接收。在外部分析系统中，接收的皮下ECG条带被处理以产生用于评估受试者的房颤或心房扑动负担的信息。

6. 发明申请

WO2005086753A3 VASCULAR BLOOD PRESSURE MONITORING SYSTEM WITH TRANSDERMAL CATHETER AND TELEMETRY CAPABILITY 审中-公开
标题翻译：血管导管血管压力监测系统及电导率
公开(公告)号：WO2005086753A3
公开(公告)日：2006-07-27
申请号：PCT/US2005007312
申请日：2005-03-07
申请人： TRANSOMA MEDICAL INC , BROCKWAY BRIAN P , MILLS PERRY A
发明人： BROCKWAY BRIAN P , MILLS PERRY A
IPC分类号： A61B5/0215 , A61B5/00 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/411
摘要： Systems and methods for monitoring intravascular pressure of a patient. The system includes a pressure sensor and catheter assembly (100) having a pressure sensor portion (130) and a transdermal catheter portion (110). The transdermal catheter portion (110) has a fluid filled lumen (112) and a distal barrier (116) to maintain patency. A transmitter unit (200) may be connected to the pressure sensor portion (130) via a lead (300). The transmitter unit (200) transmits pressure data to a remote receiver unit (400) that may communicate (directly or indirectly) with a cable management device, a data acquisition device, a monitoring instrument,, a computer, a modem, a telecommunication line, a network, etc. In addition, the system may include means to correct for pressure variations due to any difference in elevation between the sensor assembly and the heart.
摘要翻译：监测患者血管内压力的系统和方法。该系统包括具有压力传感器部分（130）和透皮导管部分（110）的压力传感器和导管组件（100）。透皮导管部分（110）具有流体填充腔（112）和远侧屏障（116）以保持通畅。发射器单元（200）可以经由引线（300）连接到压力传感器部分（130）。发射机单元（200）将压力数据发送到可以与电缆管理设备，数据采集设备，监视仪器，计算机，调制解调器，电信线路（直接或间接）通信的远程接收机单元400 ，网络等。此外，系统可以包括用于校正由于传感器组件和心脏之间的任何高度差异而导致的压力变化的装置。

7. 发明申请

WO2005104779A3 IMPLANTABLE MEDICAL DEVICES AND RELATED METHODS 审中-公开
标题翻译：可植入医疗器械及相关方法
公开(公告)号：WO2005104779A3
公开(公告)日：2006-05-18
申请号：PCT/US2005014625
申请日：2005-04-27
申请人： TRANSOMA MEDICAL INC , BROCKWAY BRIAN P , MILLS PERRY A , FOSTER ARTHUR J , LAMBERT SCOTT , SHERWOOD KATHY LYNN
发明人： BROCKWAY BRIAN P , MILLS PERRY A , FOSTER ARTHUR J , LAMBERT SCOTT , SHERWOOD KATHY LYNN
IPC分类号： A61N1/372 , A61B5/00 , A61B5/0215 , A61B5/0402 , A61N1/00 , A61N1/05 , A61N1/375 , A61N1/378
CPC分类号： A61N1/3727 , A61B5/0006 , A61B5/0031 , A61B5/0215 , A61B5/0402 , A61B5/413 , A61N1/05 , A61N1/37276 , A61N1/375 , A61N1/3752 , A61N1/3756 , A61N1/3785 , A61N1/3787
摘要： Implantable medical devices and associated methods are disclosed. In one implementation, the implantable medical device comprises a conductive housing and a remote electrode that is mechanically coupled to the conductive housing by a lead body. An amplifier is electrically connected to the remote electrode and the conductive housing for providing a signal representative of a voltage difference between the remote electrode and the conductive housing. In some methods in accordance with the present invention, the implantable medical device is implanted in an implant site overlaying one half of a rib cage of a human body. The implantable medical device produces a signal representative of the voltage difference between the remote electrode and the conductive housing and the signal is transmitted to a receiver located outside the human body.
摘要翻译：公开了可植入医疗装置和相关方法。在一个实施方案中，可植入医疗装置包括导电壳体和远程电极，其通过引线体机械耦合到导电壳体。放大器电连接到远程电极和导电壳体，用于提供表示远程电极和导电壳体之间的电压差的信号。在根据本发明的一些方法中，将植入式医疗装置植入覆盖人体肋骨的一半的植入部位。可植入医疗装置产生表示远程电极和导电外壳之间的电压差的信号，并且信号被传送到位于人体外部的接收器。

8. 发明申请

WO2005051838A2 FEEDBACK CONTROL OF VENTRICULAR ASSIST DEVICES 审中-公开
标题翻译：心室辅助装置的反馈控制
公开(公告)号：WO2005051838A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/039274
申请日：2004-11-19
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian, P.
发明人： BROCKWAY, Brian, P.
IPC分类号： B81C
CPC分类号： A61M1/1086 , A61M1/101 , A61M1/122 , A61M1/127 , A61M2205/3334 , A61M2205/8243
摘要： Various devices, systems and methods for providing effective, long term and reliable use of pressure feedback in VADs. Exemplary embodiments are described which provide for direct LV pressure measurement, non-invasive calibration techniques to detect ventricular collapse and recalibrate the feedback mechanism, improved pressure sensor designs with reduced drift, and barometric pressure correction schemes. These devices and methods may be used alone or in combination with each other, and may also be combined with other feedback mechanisms.
摘要翻译：用于在VAD中提供有效，长期和可靠使用压力反馈的各种设备，系统和方法。描述了提供直接LV压力测量，非侵入性校准技术以检测心室塌陷并重新校准反馈机制的示例性实施例，改进的减小漂移的压力传感器设计和大气压力校正方案。这些装置和方法可以单独使用或者彼此组合使用，并且还可以与其他反馈机制组合使用。

9. 发明申请

WO2007098228A2 SYSTEM AND METHOD OF MONITORING PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：监测生理信号的系统和方法
公开(公告)号：WO2007098228A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/004556
申请日：2007-02-20
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian, P. , KOVTUN, Vladimir , RICCI, Carlos , ARNOLD, John , JASPERSON, Keith , SHERWOOD, Kathy, L. , MAZAR, Scott, T.
发明人： BROCKWAY, Brian, P. , KOVTUN, Vladimir , RICCI, Carlos , ARNOLD, John , JASPERSON, Keith , SHERWOOD, Kathy, L. , MAZAR, Scott, T.
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/7275 , A61N1/3702 , G06F19/00
摘要： A physiological signal monitoring and analysis system including an implantable medical device and a signal processor. The implantable medical device is configured to monitor and record sample segments of at least one physiological signal of a patient at time separated recording intervals over a time period. The signal processor configured to measure values of at least one selected characteristic of the at least one physiological signal from the recorded sample segments, to determine trend information representing a trend in the at least one selected characteristic based on the measured values, and to assess a risk of a physiological event to the patient based on the trend information.
摘要翻译：一种生理信号监测和分析系统，包括可植入医疗装置和信号处理器。可植入医疗装置被配置为在一段时间内以分开的时间间隔监视和记录患者的至少一个生理信号的样本片段。所述信号处理器被配置为测量来自记录的采样段的至少一个生理信号的至少一个所选特征的值，以基于所述测量值确定表示所述至少一个所选特征中的趋势的趋势信息，并且评估根据趋势信息向患者发生生理事件的风险。

10. 发明申请

WO2006089246A3 IMPEDANCE BASED SENSOR FOR MONITORING LEAKAGE IN AAA STENT GRAFT 审中-公开
公开(公告)号：WO2006089246A3
公开(公告)日：2006-08-24
申请号：PCT/US2006/005880
申请日：2006-02-16
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian, P. , MILLS, Perry, A.
发明人： BROCKWAY, Brian, P. , MILLS, Perry, A.
IPC分类号： A61B5/05
摘要： Embodiment of the invention provide a technique for detecting endoleakage of an abdominal aortic aneurism (AAA) stent graft on a relatively frequent basis at home or the clinic without the safety risks and/or costs associated with current approaches. In one embodiment, an apparatus for detecting leakage in an AAA graft comprises: an electrode array having a plurality of electrodes distributed over and coupled with a surface of the AAA graft; and an electrical circuit configured to generate a stimulus voltage or current to be applied between sets of the plurality of electrodes of the electrode array and measure an impedance between the sets of the plurality of electrodes. The sets of electrodes for measuring the impedance are same as or different from the sets of electrodes for applying the stimulus voltage or current. A leakage is detected by a decrease in the impedance measured by the electrical circuit.

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