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1. 发明授权

US08114382B2 Myelin detection using benzofuran derivatives 有权
标题翻译：使用苯并呋喃衍生物的髓磷脂检测
公开(公告)号：US08114382B2
公开(公告)日：2012-02-14
申请号：US12211854
申请日：2008-09-17
申请人： Cristina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Cristina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K49/00
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

2. 发明申请

US20110305635A9 MYELIN DETECTION USING BENZOFURAN DERIVATIVES 有权
标题翻译：使用苯唑嘌呤衍生物进行MYELIN检测
公开(公告)号：US20110305635A9
公开(公告)日：2011-12-15
申请号：US12211854
申请日：2008-09-17
申请人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K51/04
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

3. 发明申请

US20100068140A1 MYELIN DETECTION USING BENZOFURAN DERIVATIVES 有权
标题翻译：使用苯唑嘌呤衍生物进行MYELIN检测
公开(公告)号：US20100068140A1
公开(公告)日：2010-03-18
申请号：US12211854
申请日：2008-09-17
申请人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K51/04
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

4. 发明授权

US08144410B2 Multimodal optical imaging 有权
标题翻译：多模光学成像
公开(公告)号：US08144410B2
公开(公告)日：2012-03-27
申请号：US12263673
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B5/22 , A61B1/06
CPC分类号： G02B5/189 , G02B5/20 , G02B5/201 , G02B7/006 , G02B26/008 , G02B26/0875
摘要： Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.
摘要翻译：公开了多模光学成像。可能的设备包括在实时图像采集期间能够旋转动作的过滤器组件。公开了包括这样的过滤器组件的系统，其可拆卸或集成在系统中。还公开了使用多个光源（例如白光和荧光）捕获图像目标的各种技术。

5. 发明申请

US20100111353A1 MULTIMODAL OPTICAL IMAGING 有权
标题翻译：多模光学成像
公开(公告)号：US20100111353A1
公开(公告)日：2010-05-06
申请号：US12263677
申请日：2008-11-03
申请人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Siavash Yazdanfar , Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G06K9/00
CPC分类号： G02B26/008 , G02B7/006 , G02B21/16 , G02B21/361 , G02B23/2407
摘要： Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.
摘要翻译：本文提供了用于多模光学成像的装置，系统和方法。这些装置包括能够在实时图像采集期间旋转动作的过滤器组件。这些系统包括可拆卸或集成在系统中的过滤组件。这些方法包括使用诸如白光和荧光灯的多个光源捕获图像目标的技术。

6. 发明授权

US07692160B2 Method and system of optical imaging for target detection in a scattering medium 失效
标题翻译：散射介质中目标检测的光学成像方法与系统
公开(公告)号：US07692160B2
公开(公告)日：2010-04-06
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P. M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： G01J1/58
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译：提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像的散射介质。

7. 发明申请

US20080296482A1 METHOD AND SYSTEM OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 失效
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20080296482A1
公开(公告)日：2008-12-04
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： H01J40/14
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译：提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像的散射介质。

8. 发明申请

US20080238338A1 Method and system for providing scalable and configurable illumination 审中-公开
标题翻译：用于提供可扩展和可配置照明的方法和系统
公开(公告)号：US20080238338A1
公开(公告)日：2008-10-02
申请号：US11731613
申请日：2007-03-30
申请人： Stephen Andrew Latham , Robert William Tait , Stephen Johnson Lomnes , Duncan Spalding Pratt , Carl Stephen Lester
发明人： Stephen Andrew Latham , Robert William Tait , Stephen Johnson Lomnes , Duncan Spalding Pratt , Carl Stephen Lester
IPC分类号： H05B37/02 , F21V21/00 , F21V9/00
CPC分类号： A61B5/0059 , F21W2131/205 , F21Y2115/10
摘要： A modular, scalable and configurable incoherent light source is provided. The light source includes an array of lighting modules supported on a frame that focuses emitted radiation from the modules at a region of interest. The geometry and physical configuration of the support structures, including the frame, may accommodate various energy intensities at various distances. The modules may be made up of multiple LEDs or other individual light sources, may be of different or the same wavelength, and may be individually controllable for the ultimate lighting application. The light source may be used in medical imaging applications.
摘要翻译：提供了模块化，可扩展和可配置的非相干光源。光源包括支撑在框架上的照明模块阵列，其将来自模块的发射的辐射聚焦在感兴趣的区域。支撑结构（包括框架）的几何形状和物理结构可适应各种距离的各种能量强度。模块可以由多个LED或其他单独的光源组成，可以具有不同或相同的波长，并且可以单独地控制以用于终极照明应用。光源可用于医学成像应用。

9. 发明申请

US20090236541A1 System and Methods for Optical Imaging 审中-公开
标题翻译：光学成像系统与方法
公开(公告)号：US20090236541A1
公开(公告)日：2009-09-24
申请号：US12054214
申请日：2008-03-24
申请人： Stephen Johnson Lomnes , Michael Cooper , Anup Sood , Siavash Yazdanfar , Kathleen Bove
发明人： Stephen Johnson Lomnes , Michael Cooper , Anup Sood , Siavash Yazdanfar , Kathleen Bove
IPC分类号： G01T1/00
CPC分类号： A61B1/05 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084
摘要： The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display. The image processing engine may receive the reflectance image data and the fluorescence image data and generate a merged image in which the fluorescence image data is superimposed on the reflectance image data. The display may be used by a surgeon, for example, to more effectively visualize the surgical site during surgery.
摘要翻译：本发明涉及成像方法和系统。所述系统可以包括被配置为产生第一波长范围的光的白光源，被配置为产生用于激发荧光物质的一个或多个波长的光的激发源，被配置为获取表示反射的白光的反射率图像数据的第一检测器以及第二检测器，被配置为获取表示来自所述受试者的荧光发射的荧光图像数据。由激发光源产生的一个或多个波长中的至少一个在白光源的第一波长范围内。荧光物质可以是例如在手术之前或手术期间注射到患者体内的荧光染料。该系统还可以包括图像处理引擎和显示器。图像处理引擎可以接收反射图像数据和荧光图像数据，并生成其中荧光图像数据叠加在反射率图像数据上的合并图像。外科医生可以使用显示器，例如在手术期间更有效地使外科手术部位可视化。

10. 发明授权

US07502174B2 System and method for imaging 失效
标题翻译：成像系统和方法
公开(公告)号：US07502174B2
公开(公告)日：2009-03-10
申请号：US11563002
申请日：2006-11-23
申请人： Vernon Thomas Jensen , Stephen Johnson Lomnes
发明人： Vernon Thomas Jensen , Stephen Johnson Lomnes
IPC分类号： G02B15/14 , G03B29/00
CPC分类号： H04N5/2251 , A61B6/04 , A61B6/08 , A61B6/4405 , A61B6/4441 , A61B6/4488 , A61B6/485 , A61B6/488 , H04N5/232 , H04N5/32
摘要： A system provides a multi-axis translation and orientation capability for optical imaging. The system includes an optical imaging apparatus providing a signal representing a digitized image, and a mechanical frame. The frame includes a first set of articulations capable of independently translating the optical imaging apparatus in multiple linear directions. The system also includes a second set of articulations formed as joints providing at least three independent degrees of rotation of the optical imaging apparatus. The system also provides an opening configured to permit the frame to be postured about a patient such that an isocenter corresponds to a region of interest of the patient, and includes an illumination source attached to the frame and configured to direct illumination towards the isocenter. The system also comprises a camera system co-located with the illumination source and having a focal plane at the isocenter.
摘要翻译：系统为光学成像提供了多轴平移和定位能力。该系统包括提供表示数字化图像的信号的光学成像设备和机械框架。该框架包括能够在多个线性方向上独立地平移光学成像装置的第一组关节。该系统还包括形成为提供光学成像装置的至少三个独立旋转角度的关节的第二组关节。该系统还提供一个开口，该开口被配置为允许框架围绕患者姿态使得等角点对应于患者的感兴趣区域，并且包括附接到框架并被配置为将照明指向等角点的照明源。该系统还包括与照明源共同位置并且在等角点处具有焦平面的相机系统。

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