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1. 发明申请

US20110054567A1 METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE SHIFTING 有权
标题翻译：使用脉冲移位在多通道神经网络系统中避免频率锁定的方法
公开(公告)号：US20110054567A1
公开(公告)日：2011-03-03
申请号：US12550213
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/36021 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04004 , A61B5/0488 , A61B5/1118 , A61B5/112 , A61B5/4812 , A61B5/4836 , A61M5/1723 , A61N1/0529 , A61N1/08 , A61N1/306 , A61N1/36025 , A61N1/36031 , A61N1/36034 , A61N1/3605 , A61N1/3606 , A61N1/36062 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36171 , A61N1/36178
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.
摘要翻译：提供了一种用于治疗患者的方法和神经刺激系统。多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。可以预测脉冲电波形内可能在时间上重叠的一组刺激脉冲。相应脉冲电波形中的刺激脉冲以防止可能重叠的脉冲组重叠的方式在时间上移位，同时防止定时通道之间的频率锁定。

2. 发明申请

US20110054568A1 METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT 有权
标题翻译：使用脉冲放置在多通道神经元系统中避免频率锁定的方法
公开(公告)号：US20110054568A1
公开(公告)日：2011-03-03
申请号：US12550237
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36082
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.
摘要翻译：提供了一种用于治疗患者的方法和神经刺激系统。多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定在定时通道之间。

3. 发明授权

US08543200B2 Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement 有权
标题翻译：使用脉冲放置避免频率锁定在多通道神经刺激系统中的方法
公开(公告)号：US08543200B2
公开(公告)日：2013-09-24
申请号：US12550237
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36082
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.
摘要翻译：提供了一种用于治疗患者的方法和神经刺激系统。多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定在定时通道之间。

4. 发明授权

US09724513B2 Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse shifting 有权
公开(公告)号：US09724513B2
公开(公告)日：2017-08-08
申请号：US12550213
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36021 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04004 , A61B5/0488 , A61B5/1118 , A61B5/112 , A61B5/4812 , A61B5/4836 , A61M5/1723 , A61N1/0529 , A61N1/08 , A61N1/306 , A61N1/36025 , A61N1/36031 , A61N1/36034 , A61N1/3605 , A61N1/3606 , A61N1/36062 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36171 , A61N1/36178
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.

5. 发明申请

US20100125315A1 IMPLANTABLE MEDICAL DEVICE THAT USES ELECTRICAL CURRENT STEERING BY MEANS OF OUTPUT IMPEDANCE MODULATION 有权
标题翻译：通过输出阻抗调制方式使用电流转向的可植入医疗器械
公开(公告)号：US20100125315A1
公开(公告)日：2010-05-20
申请号：US12606065
申请日：2009-10-26
申请人： Jordi Parramon , David K.L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
发明人： Jordi Parramon , David K.L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/36157 , A61N1/36185
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动分别与一个或多个电路径相关联。

6. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

7. 发明申请

US20100023090A1 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION 有权
标题翻译：用于避免，反向和管理神经病学接受电子刺激的系统和方法
公开(公告)号：US20100023090A1
公开(公告)日：2010-01-28
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/08
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

8. 发明申请

US20100268298A1 DEEP BRAIN STIMULATION CURRENT STEERING WITH SPLIT ELECTRODES 有权
标题翻译：深层脑刺激电流转向与分离电极
公开(公告)号：US20100268298A1
公开(公告)日：2010-10-21
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.
摘要翻译：用于脑刺激的装置包括具有纵向表面，近端，远端和引线主体的引线。该装置还包括沿引线的远端附近的铅的纵向表面设置的多个电极。所述多个电极包括第一组分段电极，所述第一组分段电极包括沿着所述引线在第一纵向位置处围绕所述引线的圆周设置的至少两个分段电极; 以及第二组分段电极，其包括在沿着引线的第二纵向位置处围绕引线的圆周设置的至少两个分段电极。该装置还包括一个或多个导体，其将所有第一组分段电极组的所有分段电极电耦合在一起。

9. 发明申请

US20100057177A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
公开(公告)号：US20100057177A1
公开(公告)日：2010-03-04
申请号：US12204114
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61N1/0553 , A61N1/36017 , A61N1/36185
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

10. 发明申请

US20100057165A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
标题翻译：用于通过电流转向增加医疗 - 行走和护理 - 灵活性的平台上的多个可调中央阴茎
公开(公告)号：US20100057165A1
公开(公告)日：2010-03-04
申请号：US12204170
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.
摘要翻译：提供神经刺激桨引导，神经刺激方法和神经刺激系统。神经刺激桨引线承载包括至少四列电极的多个电极，所述至少四列电极具有小于内电极柱和相邻外电极柱之间的间隔的两个内电极柱之间的间隔。内电极柱也可以与外电极柱纵向偏移。方法和神经刺激系统在电极之间引导电流以修改邻近脊髓组织产生的内侧 - 外侧电场。

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