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1. 发明申请

US20100268298A1 DEEP BRAIN STIMULATION CURRENT STEERING WITH SPLIT ELECTRODES 有权
标题翻译：深层脑刺激电流转向与分离电极
公开(公告)号：US20100268298A1
公开(公告)日：2010-10-21
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.
摘要翻译：用于脑刺激的装置包括具有纵向表面，近端，远端和引线主体的引线。该装置还包括沿引线的远端附近的铅的纵向表面设置的多个电极。所述多个电极包括第一组分段电极，所述第一组分段电极包括沿着所述引线在第一纵向位置处围绕所述引线的圆周设置的至少两个分段电极; 以及第二组分段电极，其包括在沿着引线的第二纵向位置处围绕引线的圆周设置的至少两个分段电极。该装置还包括一个或多个导体，其将所有第一组分段电极组的所有分段电极电耦合在一起。

2. 发明授权

US08473061B2 Deep brain stimulation current steering with split electrodes 有权
公开(公告)号：US08473061B2
公开(公告)日：2013-06-25
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K. L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K. L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.

3. 发明申请

US20100228325A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 有权
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：US20100228325A1
公开(公告)日：2010-09-09
申请号：US12782589
申请日：2010-05-18
申请人： Michael A. Moffitt , David K.L. Peterson
发明人： Michael A. Moffitt , David K.L. Peterson
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

4. 发明申请

US20080294226A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 有权
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：US20080294226A1
公开(公告)日：2008-11-27
申请号：US11752895
申请日：2007-05-23
申请人： Michael A. Moffitt , David K.L. Peterson
发明人： Michael A. Moffitt , David K.L. Peterson
IPC分类号： A61N1/32
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调节预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调理预脉冲具有相对较短的持续时间（例如，小于200μA）。

5. 发明申请

US20120290038A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 审中-公开
公开(公告)号：US20120290038A1
公开(公告)日：2012-11-15
申请号：US13470158
申请日：2012-05-11
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

6. 发明申请

US20120290040A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
公开(公告)号：US20120290040A1
公开(公告)日：2012-11-15
申请号：US13470328
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

7. 发明申请

US20120290039A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
标题翻译：神经系统中刺激安全限制的管理
公开(公告)号：US20120290039A1
公开(公告)日：2012-11-15
申请号：US13470326
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
摘要翻译：用于管理刺激安全限值的神经刺激系统。系统确定每个电极处的组织电荷注入度量，将该度量与硬停止电荷限制进行比较，并且根据比较来防止神经刺激器将刺激能量递送至组织区域。硬停止极限可以是用户可编程的，或者可以响应于电极特性的检测而被自动修改。该系统可以定量地向使用者通知注入到组织中的注入电荷的值。电极可以组织成不同的组，在这种情况下，系统可以在每个电极组中独立地直接控制组织电荷。如果提供电流转向，则系统可以沿着一个方向沿着组织区域移位电刺激能量，同时防止每个电极处的电荷注入值达到或超过硬停止充电极限。

8. 发明授权

US09855432B2 System and method for providing fluid real-time visualization of region of tissue activation 有权
公开(公告)号：US09855432B2
公开(公告)日：2018-01-02
申请号：US13244415
申请日：2011-09-24
申请人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
发明人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/36135 , A61N1/36185
摘要： A system for a tissue stimulator coupled to an array of electrodes. The system comprises a user-controlled input device configured for generating control signals, and at least one processor configured for generating a plurality of stimulation parameter sets in response to the control signals that, when applied to the electrodes, will shift electrical current between electrodes to modify a region of tissue activation. The processor(s) is further configured for computing an estimate of the region of tissue activation, and for generating display signals capable of prompting a monitor to display an animated graphical representation of the computed estimate of the region of tissue activation.

9. 发明申请

US20120109257A1 SYSTEM AND METHOD FOR PROVIDING FLUID REAL-TIME VISUALIZATION OF REGION OF TISSUE ACTIVATION 有权
标题翻译：用于提供组织活化区域的流体实时可视化的系统和方法
公开(公告)号：US20120109257A1
公开(公告)日：2012-05-03
申请号：US13244415
申请日：2011-09-24
申请人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
发明人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/36135 , A61N1/36185
摘要： A system for a tissue stimulator coupled to an array of electrodes. The system comprises a user-controlled input device configured for generating control signals, and at least one processor configured for generating a plurality of stimulation parameter sets in response to the control signals that, when applied to the electrodes, will shift electrical current between electrodes to modify a region of tissue activation. The processor(s) is further configured for computing an estimate of the region of tissue activation, and for generating display signals capable of prompting a monitor to display an animated graphical representation of the computed estimate of the region of tissue activation.
摘要翻译：一种耦合到电极阵列的组织刺激器的系统。该系统包括被配置为产生控制信号的用户控制的输入装置，以及至少一个处理器，被配置为响应于控制信号产生多个刺激参数集合，当被施加到电极时将使电极之间的电流移位到修改组织激活的区域。处理器还被配置用于计算组织激活区域的估计，并且用于产生能够促使监视器显示所计算的组织激活区域的估计的动画图形表示的显示信号。

10. 发明授权

US09192760B2 Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权
标题翻译：用于确定神经刺激导联的相对位置和取向的装置和方法
公开(公告)号：US09192760B2
公开(公告)日：2015-11-24
申请号：US12856905
申请日：2010-08-16
申请人： Kerry Bradley , James R. Thacker , Michael A. Moffitt
发明人： Kerry Bradley , James R. Thacker , Michael A. Moffitt
IPC分类号： A61N1/00 , A61N1/08 , A61N1/05 , A61B5/053
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551 , A61N1/3605 , A61N1/37247
摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.
摘要翻译：一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅基于第一和第二单极阻抗的第二电极和双极性阻抗。

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