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1. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

2. 发明授权

US08131358B2 System and method for maintaining a distribution of currents in an electrode array using independent voltage sources 有权
标题翻译：用于使用独立电压源维持电极阵列中的电流分布的系统和方法
公开(公告)号：US08131358B2
公开(公告)日：2012-03-06
申请号：US12508290
申请日：2009-07-23
申请人： Michael Moffitt , David K. L. Peterson
发明人： Michael Moffitt , David K. L. Peterson
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/0551
摘要： In one technique, a desired electrical current distribution on at least three active electrodes is selected. An electrical energy perturbation is generated on at least one electrode. A current-to-voltage relationship at each active electrode is estimated based on the energy perturbation. The current-to-voltage relationship for each active electrode takes into account current flow through other active electrodes. The voltage distribution necessary to achieve the desired current distribution is determined based on the estimated current-to-voltage relationship. Voltage-regulated energy is conveyed between the electrodes and tissue in accordance with the determined electrical voltage distribution. In another technique, an electrical energy perturbation on at least one of the electrodes is generated. Network resistances for each of at least three active electrodes are computed in response to the energy perturbation. The network resistances represent the resistances between the electrodes and common node to which the electrodes are connected.
摘要翻译：在一种技术中，选择在至少三个有效电极上的期望的电流分布。在至少一个电极上产生电能扰动。基于能量扰动来估计每个有源电极处的电流 - 电压关系。每个有源电极的电流 - 电压关系考虑到通过其他有源电极的电流。基于估计的电流 - 电压关系确定实现所需电流分布所需的电压分布。电压调节能量根据确定的电压分布在电极和组织之间传送。在另一技术中，产生至少一个电极上的电能扰动。响应于能量扰动计算至少三个有效电极中的每一个的网络电阻。网络电阻表示电极与电极连接的公共节点之间的电阻。

3. 发明申请

US20120004707A1 USE OF STIMULATION PULSE SHAPE TO CONTROL NEURAL RECRUITMENT ORDER AND CLINICAL EFFECT 审中-公开
标题翻译：刺激脉冲形状的使用来控制神经激励和临床效果
公开(公告)号：US20120004707A1
公开(公告)日：2012-01-05
申请号：US13231493
申请日：2011-09-13
申请人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
发明人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/36146 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36036 , A61N1/36046 , A61N1/3605 , A61N1/3606 , A61N1/36135 , A61N1/37247 , A61N1/378 , A61N1/3787 , A61N1/3906
摘要： A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.
摘要翻译：提供了一种用于向患者提供治疗的方法，电组织刺激系统和程序员。电极被放置在患者的组织（例如，脊髓组织）的附近，电刺激能量根据定义的波形从电极传送到组织，并且限定波形的脉冲形状被修改，从而改变从电极传递到组织的电刺激能量。可以通过选择多种不同的脉冲形状类型之一或通过调整脉冲形状的时间常数来修改脉冲形状。

4. 发明申请

US20110009919A1 METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
标题翻译：使用噪声共振方法来提高实际和有效的传输
公开(公告)号：US20110009919A1
公开(公告)日：2011-01-13
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.
摘要翻译：提供了向患者提供治疗的方法。在一种方法中，患者具有应用亚阈值生物电刺激的神经元。该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。在另一种方法中，患者具有应用超临界生物电刺激的神经元。该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。

5. 发明申请

US20100057164A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
公开(公告)号：US20100057164A1
公开(公告)日：2010-03-04
申请号：US12204154
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

6. 发明申请

US20100023070A1 SYSTEM AND METHOD FOR MAINTAINING A DISTRIBUTION OF CURRENTS IN AN ELECTRODE ARRAY USING INDEPENDENT VOLTAGE SOURCES 有权
标题翻译：使用独立电压源在电极阵列中维持电流分配的系统和方法
公开(公告)号：US20100023070A1
公开(公告)日：2010-01-28
申请号：US12508290
申请日：2009-07-23
申请人： Michael Moffitt , David K.L. Peterson
发明人： Michael Moffitt , David K.L. Peterson
IPC分类号： A61N1/08
CPC分类号： A61N1/36071 , A61N1/0551
摘要： In one technique, a desired electrical current distribution on at least three active electrodes is selected. An electrical energy perturbation is generated on at least one electrode. A current-to-voltage relationship at each active electrode is estimated based on the energy perturbation. The current-to-voltage relationship for each active electrode takes into account current flow through other active electrodes. The voltage distribution necessary to achieve the desired current distribution is determined based on the estimated current-to-voltage relationship. Voltage-regulated energy is conveyed between the electrodes and tissue in accordance with the determined electrical voltage distribution. In another technique, an electrical energy perturbation on at least one of the electrodes is generated. Network resistances for each of at least three active electrodes are computed in response to the energy perturbation. The network resistances represent the resistances between the electrodes and common node to which the electrodes are connected.
摘要翻译：在一种技术中，选择在至少三个有效电极上的期望的电流分布。在至少一个电极上产生电能扰动。基于能量扰动来估计每个有源电极处的电流 - 电压关系。每个有源电极的电流 - 电压关系考虑到通过其他有源电极的电流。基于估计的电流 - 电压关系确定实现所需电流分布所需的电压分布。电压调节能量根据确定的电压分布在电极和组织之间传送。在另一技术中，产生至少一个电极上的电能扰动。响应于能量扰动计算至少三个有效电极中的每一个的网络电阻。网络电阻表示电极与电极连接的公共节点之间的电阻。

7. 发明申请

US20100010566A1 SYSTEM AND METHOD FOR CONVERTING TISSUE STIMULATION PROGRAMS IN A FORMAT USABLE BY AN ELECTRICAL CURRENT STEERING NAVIGATOR 有权
标题翻译：用于电流转向导管可用的格式转换组织刺激方案的系统和方法
公开(公告)号：US20100010566A1
公开(公告)日：2010-01-14
申请号：US12501282
申请日：2009-07-10
申请人： James R. Thacker , Michael Moffitt , Kerry Bradley , David K.L. Peterson
发明人： James R. Thacker , Michael Moffitt , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/08 , A61N1/34
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36146 , A61N1/3615 , A61N1/36167 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.
摘要翻译：提供了一种用于编程控制器的方法，计算机介质和系统。控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。

8. 发明授权

US09737703B2 Method to enhance afferent and efferent transmission using noise resonance 有权
公开(公告)号：US09737703B2
公开(公告)日：2017-08-22
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.

9. 发明授权

US09724513B2 Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse shifting 有权
公开(公告)号：US09724513B2
公开(公告)日：2017-08-08
申请号：US12550213
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36021 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04004 , A61B5/0488 , A61B5/1118 , A61B5/112 , A61B5/4812 , A61B5/4836 , A61M5/1723 , A61N1/0529 , A61N1/08 , A61N1/306 , A61N1/36025 , A61N1/36031 , A61N1/36034 , A61N1/3605 , A61N1/3606 , A61N1/36062 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36171 , A61N1/36178
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.

10. 发明授权

US09238138B2 Use of stimulation pulse shape to control neural recruitment order and clinical effect 有权
标题翻译：使用刺激脉冲形状来控制神经的招募顺序和临床效果
公开(公告)号：US09238138B2
公开(公告)日：2016-01-19
申请号：US13231493
申请日：2011-09-13
申请人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
发明人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
IPC分类号： A61N1/36 , A61N1/372 , A61N1/378 , A61N1/39
CPC分类号： A61N1/36146 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36036 , A61N1/36046 , A61N1/3605 , A61N1/3606 , A61N1/36135 , A61N1/37247 , A61N1/378 , A61N1/3787 , A61N1/3906
摘要： A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.
摘要翻译：提供了一种用于向患者提供治疗的方法，电组织刺激系统和程序员。电极被放置在患者的组织（例如，脊髓组织）的附近，电刺激能量根据定义的波形从电极传送到组织，并且限定波形的脉冲形状被修改，从而改变从电极传递到组织的电刺激能量。可以通过选择多种不同的脉冲形状类型中的一种或通过调整脉冲形状的时间常数来修改脉冲形状。

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