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1. 发明申请

WO2011081973A1 LABEL-FREE METHODS RELATED TO HERG POTASSIUM ION CHANNELS 审中-公开
标题翻译：与烟草离子通道相关的无标记方法
公开(公告)号：WO2011081973A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060688
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan
发明人： FANG, Ye , SUN, Haiyan
IPC分类号： G01N33/68 , G01N33/94
CPC分类号： G01N33/6872 , G01N2500/10
摘要： Disclosed are methods to classify human ether-à-go-go related gene (hERG) ion channel modulators using label-free biosensors. Disclosed is the use of label-free resonant waveguide grating (RWG) biosensors to reveal the patterns of the DMR signals of hERG modulators across three types of cell lines (a native cell line endogenously expressing hERG, a native cell line without hERG and its engineered cell line stably expressed hERG), as well as the corresponding modulation index of the modulators molecules against a hERG activator acting on a panel of markers/cells, particularly the known hERG activator mallotoxin DMR signals in the two hERG expressing cell lines.
摘要翻译：公开了使用无标记生物传感器分类人类醚转运相关基因（hERG）离子通道调节剂的方法。公开了使用无标记谐振波导光栅（RWG）生物传感器来显示三种类型的细胞系（内源性表达hERG的天然细胞系，没有hERG的天然细胞系及其工程设计的）的hERG调节剂的DMR信号的模式细胞系稳定表达hERG），以及调节剂分子对作用于一组标志物/细胞的hERG激活剂的相应调节指数，特别是两种hERG表达细胞系中已知的hERG活化剂mallotoxin DMR信号。

2. 发明申请

WO2012012278A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX 审中-公开
标题翻译：治疗与GPR35和/或GPR35-HERG复合物相关的病理学条件的组合物和方法
公开(公告)号：WO2012012278A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044124
申请日：2011-07-15
申请人： CORNING INCORPORATED , DENG, Huayun , FANG, Ye , HE, Mingqian , HU, Haibei , NIU, Weijun , SUN, Haiyan
发明人： DENG, Huayun , FANG, Ye , HE, Mingqian , HU, Haibei , NIU, Weijun , SUN, Haiyan
IPC分类号： A61K31/44 , C07D307/68 , C12Q1/02 , A61K31/341 , C07D495/04 , A61K31/381 , C07D333/40 , C07D409/04 , C07C229/56 , A61K31/196 , C07C229/58 , C07D213/74 , C07D307/66 , C07D333/36 , C07D207/34 , A61K31/40 , C07C255/42 , A61K31/277 , C40B30/06 , A61P29/00 , A61P3/10 , A61P9/06 , A61P3/00 , A61P9/00 , A61P35/00 , A61P3/06 , A61P3/04 , A61P9/10 , A61P9/12 , G01N21/64
CPC分类号： C07D207/34 , C07C229/56 , C07C229/58 , C07C255/34 , C07D213/74 , C07D307/52 , C07D307/66 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/36 , C07D333/38
摘要： Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject.
摘要翻译：公开了用于预防和/或治疗与GPR35和/或GPR35-hERG信号传导复合物病理生理学相关的疾病的组合物和方法。例如，公开了用于预防和/或治疗受试者与病理生理学上与GPR35相关的疾病的化合物。

3. 发明申请

WO2011081968A1 PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译： PI3K调节剂，RHO激酶调节剂及其鉴定和使用方法
公开(公告)号：WO2011081968A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060648
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
发明人： FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
IPC分类号： G01N33/543 , C12Q1/48
CPC分类号： G01N33/5041 , G01N33/54373 , G01N2333/91215
摘要： Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.
摘要翻译：公开了使用无标记细胞测定来表征PI3K抑制剂和Rho激酶抑制剂的方法。还公开了表征细胞是否具有失去PI3K途径的方法。

4. 发明公开

EP2519827A1 LABEL-FREE METHODS RELATED TO HERG POTASSIUM ION CHANNELS 审中-公开
标题翻译： MARK free方法均与HERG钾离子通道连接
公开(公告)号：EP2519827A1
公开(公告)日：2012-11-07
申请号：EP10795587.4
申请日：2010-12-16
申请人： Corning Incorporated
发明人： FANG, Ye , SUN, Haiyan
IPC分类号： G01N33/68 , G01N33/94
CPC分类号： G01N33/6872 , G01N2500/10
摘要： Disclosed are methods to classify human ether-à-go-go related gene (hERG) ion channel modulators using label-free biosensors. Disclosed is the use of label-free resonant waveguide grating (RWG) biosensors to reveal the patterns of the DMR signals of hERG modulators across three types of cell lines (a native cell line endogenously expressing hERG, a native cell line without hERG and its engineered cell line stably expressed hERG), as well as the corresponding modulation index of the modulators molecules against a hERG activator acting on a panel of markers/cells, particularly the known hERG activator mallotoxin DMR signals in the two hERG expressing cell lines.

5. 发明申请

WO2011123424A1 SCREENING METHODS FOR MITOCHONDRIA KATP MODULATORS USING CELL LINES 审中-公开
标题翻译：使用细胞线的MITOCHONDRIA KATP调制器的筛选方法
公开(公告)号：WO2011123424A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030284
申请日：2011-03-29
申请人： CORNING INCORPORATED , FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N21/553 , G01N21/7703 , G01N33/48714 , G01N33/54373 , Y02A50/60 , Y02A90/26
摘要： Disclosed are compositions and methods related to modulation of K ATP channels and methods of treating liver disorders by modulating K ATP and mito-K ATP channels.
摘要翻译：公开了与调节KATP通道有关的组合物和方法以及通过调节KATP和mito-KATP通道治疗肝脏疾病的方法。

6. 发明申请

WO2011081971A2 EGFR/VEGFR DUAL MODULATORS AND METHODS OF USING 审中-公开
标题翻译： EGFR / VEGFR双重调节剂及其使用方法
公开(公告)号：WO2011081971A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060663
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/381 , A61P35/00
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

7. 发明申请

WO2011081970A2 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF 审中-公开
标题翻译：分子相关的hERG离子通道及其用途
公开(公告)号：WO2011081970A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060655
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/341 , A61P9/06 , A61P35/00 , G01N33/48
CPC分类号： A61K31/341 , G01N33/6872 , G01N2500/10 , G01N2800/52
摘要： Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R 1 , R 2 , R 3 , R 6 , R 5 , and R 4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
摘要翻译：公开了具有结构式（I，II）的化合物或其可药用的销售，溶剂化物，包合物或前药，其中R 1， R 3，R 6，R 5和R 4如本文所定义。这些化合物可用作调节hERG离子通道的治疗剂，并用于改善hERG相关心脏复极障碍的预防和治疗。

8. 发明申请

WO2010065372A1 LIVER CELL TOXICITY ASSAY 审中-公开
标题翻译：肝细胞毒性测定
公开(公告)号：WO2010065372A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/065527
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50 , G01N33/543 , C12Q1/02
CPC分类号： G01N33/5067 , C12N2503/00 , C12Q1/025 , G01N33/5014 , G01N33/54373
摘要： The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.
摘要翻译：本公开提供了表征候选分子对本文定义的肝细胞的毒性的方法; 在本文定义的生物传感器上培养代谢活性肝细胞的方法; 和如本文所定义的生物传感器肝脏培养系统。

9. 发明公开

EP2595975A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX 审中-公开
标题翻译：组合物和方法用于治疗与GPR35和/或GPR35-hERG复合物有关的病理症状
公开(公告)号：EP2595975A2
公开(公告)日：2013-05-29
申请号：EP11736244.2
申请日：2011-07-15
申请人： Corning Incorporated
发明人： DENG, Huayun , FANG, Ye , HE, Mingqian , HU, Haibei , NIU, Weijun , SUN, Haiyan
IPC分类号： C07D307/68 , C12Q1/02 , A61K31/341 , C07D495/04 , A61K31/381 , C07D333/40 , C07D409/04 , C07C229/56 , A61K31/196 , C07C229/58 , C07D213/74 , C07D307/66 , C07D333/36 , C07D207/34 , A61K31/40 , C07C255/42 , A61K31/277 , C40B30/06 , A61P29/00
CPC分类号： C07D207/34 , C07C229/56 , C07C229/58 , C07C255/34 , C07D213/74 , C07D307/52 , C07D307/66 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/36 , C07D333/38
摘要： Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject. The compounds having a formula (I), (II) or (III):

10. 发明公开

EP2519824A1 PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译： PI3K调节剂，Rho激酶调制器和方法鉴定和使用
公开(公告)号：EP2519824A1
公开(公告)日：2012-11-07
申请号：EP10801312.9
申请日：2010-12-16
申请人： Corning Incorporated
发明人： FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
IPC分类号： G01N33/543 , C12Q1/48
CPC分类号： G01N33/5041 , G01N33/54373 , G01N2333/91215
摘要： Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.

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