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1. 发明授权

US5498549A Sensors and methods for sensing 失效
标题翻译：传感器和传感方法
公开(公告)号：US5498549A
公开(公告)日：1996-03-12
申请号：US373855
申请日：1995-01-18
申请人： Colleen C. Nagel , James G. Bentsen , Masao Yafuso , Alan R. Katritzky , John L. Dektar , Cary A. Kipke
发明人： Colleen C. Nagel , James G. Bentsen , Masao Yafuso , Alan R. Katritzky , John L. Dektar , Cary A. Kipke
IPC分类号： A61B5/00 , C07F7/08 , C08G77/38 , G01N21/62 , G01N21/64 , G01N21/77 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1455 , A61B5/1459 , C07F7/0849 , C08G77/38 , G01N21/6428 , G01N31/225 , G01N2021/6434 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , Y10S436/80 , Y10S436/805 , Y10T436/255
摘要： A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one or which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
摘要翻译：公开了一种用于测量介质中分析物浓度的传感器。在一个实施例中，传感器包括感测元件，其包括基体材料，并共价键合到一个或多个单体指示器部件，每个单体指示器部件能够响应于暴露于激励信号而提供给定波长的第一发射信号。感测元件能够响应于暴露于激励信号而提供具有比第一发射信号更长的波长的第二发射信号，第二发射信号由感测元件中产生的准分子组分由单体指示剂组分，并且取决于介质中分析物的浓度比第一发射信号或信号更大程度。在另一个实施例中，传感器包括感测元件，其包括两个或更多个不同的单体成分至少一个或者是能够响应于暴露于第一激发信号而提供第一发射信号的单体指示剂成分。响应于暴露于第二激励信号，感测元件能够提供第二发射信号。该第二发射信号由由单体组分产生的激元复合体提供。该第二发射信号优选地取决于介质中分析物的浓度。激励组件被定位并适于将激励信号提供给感测元件。检测器组件被定位并适于检测第二发射信号。优选地，处理器组件被定位并适于在确定介质中分析物的浓度时分析第二发射信号。

2. 发明授权

US5409666A Sensors and methods for sensing 失效
标题翻译：传感器和传感方法
公开(公告)号：US5409666A
公开(公告)日：1995-04-25
申请号：US137289
申请日：1993-10-14
申请人： Colleen C. Nagel , James G. Bentsen , John L. Dektar , Cary A. Kipke , Masao Yafuso , Alan R. Katritzky
发明人： Colleen C. Nagel , James G. Bentsen , John L. Dektar , Cary A. Kipke , Masao Yafuso , Alan R. Katritzky
IPC分类号： A61B5/00 , C07F7/08 , C08G77/38 , G01N21/62 , G01N21/64 , G01N21/77 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1455 , A61B5/1459 , C07F7/0849 , C08G77/38 , G01N21/6428 , G01N31/225 , G01N2021/6434 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , Y10S436/80 , Y10S436/805 , Y10T436/255
摘要： A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one of which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
摘要翻译：公开了一种用于测量介质中分析物浓度的传感器。在一个实施例中，传感器包括感测元件，其包括基体材料，并共价键合到一个或多个单体指示器部件，每个单体指示器部件能够响应于暴露于激励信号而提供给定波长的第一发射信号。感测元件能够响应于暴露于激励信号而提供具有比第一发射信号更长的波长的第二发射信号，第二发射信号由感测元件中产生的准分子组分由单体指示剂组分，并且取决于介质中分析物的浓度比第一发射信号或信号更大程度。在另一个实施例中，传感器包括感测元件，其包括两个或更多个不同的单体组分，其中至少一个单体组分是能够响应于暴露于第一激发信号而提供第一发射信号的单体指示剂组分。响应于暴露于第二激励信号，感测元件能够提供第二发射信号。该第二发射信号由由单体组分产生的激元复合体提供。该第二发射信号优选地取决于介质中分析物的浓度。激励组件被定位并适于将激励信号提供给感测元件。检测器组件被定位并适于检测第二发射信号。优选地，处理器组件被定位并适于在确定介质中分析物的浓度时分析第二发射信号。

3. 发明授权

US5958782A Cation-sensing composite structure and compounds for use therein 失效
标题翻译：阳离子检测复合结构和其中使用的化合物
公开(公告)号：US5958782A
公开(公告)日：1999-09-28
申请号：US810969
申请日：1997-02-27
申请人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
发明人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
IPC分类号： G01N21/64 , C07D498/18 , C09B23/10 , G01N31/22 , G01N33/20 , G01N33/487
CPC分类号： C07D498/18 , C09B23/102 , G01N31/22 , G01N31/221
摘要： A fluorescent ionophoric compound is disclosed that includes a complexing moiety, such as a cryptand or crown-ether portion, and a fluorescing moiety such as a coumarin portion. The coumarin portion may be substituted at the 3-position with an electron withdrawing or polarizable group such as a substituted aromatic group or a substituted heterocyclic group having a heteroatom in at least one of its alpha positions. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.
摘要翻译：公开了一种荧光离子化合物，其包括络合部分，例如穴状或冠醚部分，以及荧光部分如香豆素部分。香豆素部分可以在3位被吸电子或可极化基团取代，例如取代的芳基或在其α位中的至少一个具有杂原子的取代的杂环基。具有良好的光稳定性的化合物可以通过方便的共价连接点并入阳离子感应复合结构中。

4. 发明授权

US5508509A Sensing elements and methods for uniformly making individual sensing elements 失效
标题翻译：用于均匀地制作各个感应元件的感测元件和方法
公开(公告)号：US5508509A
公开(公告)日：1996-04-16
申请号：US159799
申请日：1993-11-30
申请人： Masao Yafuso , Ronnie L. Pratt , Kathryn R. Bretscher , Kenneth B. Wood , John L. Dektar , James G. Bentsen
发明人： Masao Yafuso , Ronnie L. Pratt , Kathryn R. Bretscher , Kenneth B. Wood , John L. Dektar , James G. Bentsen
IPC分类号： G01N31/22 , G01N33/49 , G01N33/52 , G01N33/84 , G01N33/50
CPC分类号： G01N33/52 , G01N31/223 , G01N33/84 , Y10T436/207497
摘要： Sensing elements, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g. blood, and methods for making such sensing elements are disclosed. In one embodiment, the method comprises continuously placing a sensing composition precursor in contact with a continuous web, forming a continuous sensing composition from the precursor, and applying a continuous opaque film to the sensing composition. A plurality of individual sensing elements are formed from this composite structure. These sensing elements, which each have very similar sensing characteristics, are placed in a sensor fixture for use.
摘要翻译：感测元件，可用于感测介质中气体（例如二氧化碳）的浓度，例如二氧化碳。血液和制造这种感测元件的方法被公开。在一个实施方案中，该方法包括将感测组合物前体连续地放置成与连续纤维网接触，从前体形成连续感测组合物，以及向感测组合物施加连续的不透明膜。从该复合结构形成多个单独的感测元件。这些感测元件（每个具有非常相似的感测特性）被放置在传感器夹具中以供使用。

5. 发明授权

US5474743A Cation-sensing composite structure and compounds for use therein 失效
标题翻译：阳离子检测复合结构和其中使用的化合物
公开(公告)号：US5474743A
公开(公告)日：1995-12-12
申请号：US140257
申请日：1993-10-21
申请人： John E. Trend , Cary A. Kipke , Mitchell A. Rossman , Masao Yafuso , Sanjay L. Patil
发明人： John E. Trend , Cary A. Kipke , Mitchell A. Rossman , Masao Yafuso , Sanjay L. Patil
IPC分类号： G01N31/22 , C07C43/23 , C07C45/51 , C07C45/60 , C07C47/575 , C07D498/18 , G01N21/64 , G01N21/78 , G01N33/84 , C07D419/02 , G01N21/77
CPC分类号： C07D498/18 , C07C43/23 , C07C45/513 , C07C45/60 , C07C47/575 , G01N33/84
摘要： A fluorescent ionophoric compound comprises a cryptand portion and a coumarin portion substituted at the 3-position with an electron withdrawing or polarizable group. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures useful in biological and environmental testing, which can be used with conventional glass optics, by means of convenient points of covalent attachment.
摘要翻译：荧光离子化合物包括穴位部分和在3位被吸电子或可极化基团取代的香豆素部分。具有良好光稳定性的化合物可以并入用于生物和环境测试的阳离子感测复合结构中，其可以通过共价连接的方便点与常规玻璃光学元件一起使用。

6. 发明授权

US5081041A Ionic component sensor and method for making and using same 失效
标题翻译：离子元件传感器及其制造和使用方法
公开(公告)号：US5081041A
公开(公告)日：1992-01-14
申请号：US503838
申请日：1990-04-03
申请人： Masao Yafuso , Evan A. Thompson , John L. Dektar , James F. Fagan , Sanjay L. Patil
发明人： Masao Yafuso , Evan A. Thompson , John L. Dektar , James F. Fagan , Sanjay L. Patil
IPC分类号： G01N31/22 , G01N21/80 , G01N33/84
CPC分类号： G01N33/84 , G01N21/80 , G01N2021/6434 , G01N21/6428
摘要： A composition of matter useful in a sensor for sensing the concentration of an ionic component in a medium is disclosed. This composition comprises a first material which includes a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a first matrix material which is permeable to the ionic component; and a second material which includes a second matrix material which is permeable to the ionic component, and an opaque agent in an amount sufficient to render the second material effectively opaque. The first material matrix and the second matrix material are covalently bonded together. Sensing apparatus including such composition of matter and methods for making and using such composition of matter are also disclosed.

7. 发明授权

US5075127A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US5075127A
公开(公告)日：1991-12-24
申请号：US492550
申请日：1990-03-12
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/81 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1459 , G01N21/6428 , G01N31/223 , G01N2021/6434 , G01N2021/772 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

8. 发明授权

US4954318A Optical sensor 失效
标题翻译：光学传感器
公开(公告)号：US4954318A
公开(公告)日：1990-09-04
申请号：US91432
申请日：1987-08-31
申请人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
发明人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , G01N2021/772
摘要： An apparatus for measuring the concentration of a component in a medium comprising:an optical sensor including at least one optical indicator for providing an optical signal which varies in response to the presence of a component in a medium;an optical signal fiber capable of transmitting the optical signal from the optical sensor; anda supply reservoir associated with the optical sensor and acting to provide additional optical indicator to the optical sensor.
摘要翻译：一种用于测量介质中的组分的浓度的装置，包括：光学传感器，包括至少一个光学指示器，用于提供响应于介质中组分的存在而变化的光学信号; 能够从光学传感器发送光信号的光信号光纤; 以及与所述光学传感器相关联并用于向所述光学传感器提供附加光学指示器的供应储存器。

9. 发明授权

US5284775A Gas sensing element and method for making same 失效
标题翻译：气体传感元件及其制造方法
公开(公告)号：US5284775A
公开(公告)日：1994-02-08
申请号：US949771
申请日：1992-09-21
申请人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
发明人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
IPC分类号： G01N21/64 , G01N21/77 , G01N21/78 , G01N31/22 , G01N33/49 , G01N33/50
CPC分类号： G01N21/783 , G01N31/223 , Y10T436/204998
摘要： Sensing composition precursors and sensing compositions, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g., blood, are disclosed. In one embodiment, the sensing composition precursor comprises a dispersed aqueous liquid including a sensing component dissolved therein, a polymer precursor, and a hydrophilic dispersing agent selected from hydroxyalkyl celluloses and mixtures thereof in an amount effective to facilitate maintaining the dispersed aqueous liquid.
摘要翻译：公开了感测组合物前体和感测组合物，其可用于感测介质（例如血液）中的二氧化碳气体的浓度。在一个实施方案中，感测组合物前体包含分散的水性液体，其包含溶解于其中的感测组分，聚合物前体和选自羟烷基纤维素及其混合物的亲水性分散剂，其量有助于维持分散的水性液体。

10. 发明授权

US4919891A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US4919891A
公开(公告)日：1990-04-24
申请号：US49844
申请日：1987-05-15
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/643 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N21/80 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

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