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1. 发明申请

US20110251484A1 Molecular imaging using radioluminescent nanoparticles 有权
标题翻译：使用放射性发光纳米粒子的分子成像
公开(公告)号：US20110251484A1
公开(公告)日：2011-10-13
申请号：US13066190
申请日：2011-04-08
申请人： Colin M. Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
发明人： Colin M. Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
IPC分类号： A61B6/00
CPC分类号： A61B6/4057 , A61B6/032 , A61B6/425 , A61B6/508
摘要： Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.
摘要翻译：注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。检测和处理光学光以确定探针的空间分布。放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜或注射放射性药物。光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

2. 发明授权

US09456794B2 Molecular imaging using radioluminescent nanoparticles 有权
标题翻译：使用放射性发光纳米粒子的分子成像
公开(公告)号：US09456794B2
公开(公告)日：2016-10-04
申请号：US13066190
申请日：2011-04-08
申请人： Colin M Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
发明人： Colin M Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/4057 , A61B6/032 , A61B6/425 , A61B6/508
摘要： Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.
摘要翻译：注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。检测和处理光学光以确定探针的空间分布。放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜或注射放射性药物。光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

3. 发明申请

US20110250128A1 Method for tissue characterization based on beta radiation and coincident Cherenkov radiation of a radiotracer 审中-公开
标题翻译：基于β辐射的组织表征方法和放射性示踪剂的符合Cherenkov辐射的方法
公开(公告)号：US20110250128A1
公开(公告)日：2011-10-13
申请号：US13066351
申请日：2011-04-12
申请人： Colin M Carpenter , Lei Xing , Conroy Ghin Chee Sun , Guillem Pratx
发明人： Colin M Carpenter , Lei Xing , Conroy Ghin Chee Sun , Guillem Pratx
IPC分类号： A61K51/00 , C12Q1/02
CPC分类号： A61K51/04
摘要： A method of characterizing a tissue sample is provided that includes injecting a tissue sample with radiotracers, where the radiotracers include beta-emitter radio tracers, the beta-emitter radio tracers emit beta particles according to a decay of the beta-emitter radio tracers, and measuring the beta particles or Cherenkov radiation from the beta particles in the tissue sample, and determining a condition of the radio tracers in the tissue sample according to the measured beta particles or the measured Cherenkov radiation, where the determined condition includes a depth and/or a concentration of the radiotracers in the tissue sample.
摘要翻译：提供了表征组织样本的方法，其包括用放射性示踪剂注射组织样本，其中放射性示踪剂包括β-发射体无线电示踪剂，β-发射体无线电示踪剂根据β-发射体无线电示踪剂的衰变发射β粒子，以及测量来自组织样本中的β粒子的β粒子或切伦科夫辐射，以及根据测量的β粒子或所测量的切伦科夫辐射来确定组织样本中的无线电示踪剂的状态，其中所确定的条件包括深度和/或组织样品中放射性示踪剂的浓度。

4. 发明申请

US20140242600A1 IMAGING THE HETEROGENEOUS UPTAKE OF RADIOLABELED MOLECULES IN SINGLE LIVING CELLS 审中-公开
标题翻译：在单生动物细胞中成像放射性分子的异质摄取
公开(公告)号：US20140242600A1
公开(公告)日：2014-08-28
申请号：US13492606
申请日：2012-06-08
申请人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
发明人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
IPC分类号： G01N33/50
CPC分类号： G01N21/6458
摘要： A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of radiolabeled molecules inside, bound to, or surrounding the cells, is recorded on an imaging device. Fluorescence microscopy of the same cells with other types of molecules of interest that are labeled with different fluorophores can be conducted concurrently and the biological activity of the labeled molecules can be correlated.
摘要翻译：放射性显微镜系统和用于在活细胞培养和组织切片中成像放射性标记分子的分布的方法。将细胞生长并与闪烁体板上的放射性标记的分子一起孵育，或者在孵育后将闪烁体板放置在与细胞相邻的位置。在成像装置上记录由放射性标记的分子内部，结合或围绕细胞的衰变产生的闪烁光。可以同时进行用不同荧光团标记的其他类型感兴趣的分子的相同细胞的荧光显微镜检查，并且标记分子的生物学活性可以相关。

5. 发明授权

US09227085B2 Including fiducial markers in radiation therapy planning to facilitate real-time position monitoring during treatment delivery 有权
公开(公告)号：US09227085B2
公开(公告)日：2016-01-05
申请号：US12932666
申请日：2011-03-02
申请人： Yunzhi Ma , Paul J. Keall , Lei Xing
发明人： Yunzhi Ma , Paul J. Keall , Lei Xing
IPC分类号： G21K1/02 , A61N5/10 , A61B19/00
CPC分类号： A61N5/1031 , A61B2090/3966 , A61N5/1036 , A61N5/1037 , A61N5/1045 , A61N5/1047 , A61N5/1077 , A61N2005/1035 , A61N2005/1061
摘要： An inverse planning method that is capable of controlling the appearance of the implanted fiducial(s) in segmented IMRT fields for cine MV or combined MV/kV image-guided IMRT is provided. The method for radiation treatment includes computing a radiation treatment plan and delivering beams to a target in accordance with the radiation treatment plan, where computing the radiation treatment plan includes introducing a penalty in an inverse planning objective function optimization calculation to discourage or avoid blockage of one or more fiducials in optimized multi-leaf collimator (MLC) apertures.

6. 发明授权

US08498465B2 Accurate determination of the shape and localization of metallic object(s) in X-ray CT imaging 失效
标题翻译：准确测定X射线CT成像中金属物体的形状和定位
公开(公告)号：US08498465B2
公开(公告)日：2013-07-30
申请号：US12924327
申请日：2010-09-23
申请人： Lei Xing , Jing Wang
发明人： Lei Xing , Jing Wang
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/30052
摘要： A binary image reconstruction method is provided to identify metal objects in a computer tomography (CT) image. The method includes providing a suitably programmed computer, providing a CT image, where the CT image includes intensity data, and the suitably programmed computer is used to determine a first range of attenuation coefficient values and a second range of attenuation coefficient values in the intensity data, where when a difference between the first range of attenuation coefficient values and the second range of attenuation coefficient values is less than a pre-determined gradient threshold value, a boundary of a metal object in the CT image is determined.
摘要翻译：提供二值图像重建方法来识别计算机断层摄影（CT）图像中的金属物体。该方法包括提供适当编程的计算机，提供CT图像，其中CT图像包括强度数据，并且适当编程的计算机用于确定强度数据中的衰减系数值的第一范围和衰减系数值的第二范围其中，当第一衰减系数值范围和第二衰减系数值范围之间的差小于预定梯度阈值时，确定CT图像中的金属物体的边界。

7. 发明授权

US08121368B2 3D real-time tracking of human anatomy using combined kV and MV imaging 有权
标题翻译：使用组合的kV和MV成像对人体解剖结构的3D实时跟踪
公开(公告)号：US08121368B2
公开(公告)日：2012-02-21
申请号：US12291829
申请日：2008-11-12
申请人： Rodney D. Wiersma , Lei Xing , Weihua Mao
发明人： Rodney D. Wiersma , Lei Xing , Weihua Mao
IPC分类号： G06K9/00
CPC分类号： G06T7/251 , G06T2207/10081 , G06T2207/10116 , G06T2207/30096 , G06T2207/30204
摘要： A medical imaging-based system and method uses both kV and MV images captured during a treatment period for organ motion tracking. 3D geometric locations of internal features are computationally tracked as a function of time from internal features, such as natural biological features or implanted fiducials, which are computationally extracted from the captured kV and MV images. A partial information method allows 3D tracking to be maintained in the event that imaging information is temporarily not available.
摘要翻译：基于医学成像的系统和方法使用在治疗期间捕获的用于器官运动跟踪的kV和MV图像。内部特征的3D几何位置作为时间的函数从内部特征（例如自然生物特征或植入的基准）计算地跟踪，其从捕获的kV和MV图像计算地提取。如果成像信息暂时不可用，则部分信息方法允许维护3D跟踪。

8. 发明授权

US06697452B2 Verification method of monitor units and fluence map in intensity modulated radiation therapy 有权
标题翻译：强度调制放射治疗监测单位和能量密度图的验证方法
公开(公告)号：US06697452B2
公开(公告)日：2004-02-24
申请号：US10077825
申请日：2002-02-15
申请人： Lei Xing
发明人： Lei Xing
IPC分类号： A61N510
CPC分类号： A61N5/1031 , A61N5/1042 , Y10S378/901
摘要： A general computer-implemented method and computer program for an independent MU or dose and fluence calculation of an intensity modulated photon field in intensity modulated radiation therapy (IMRT) is provided. The present invention provides for the verification MU or dose calculation in high dose regions or low dose regions. In general, the dose at an arbitrary spatial point is expressed as a summation of the contributions from all the beamlets in a treatment field, each modulated by a dynamic modulation factor. The verification of a low dose region is based on using the inverted field of the low dose region. The advantage of the present invention that it is an independent method and therefore generally applicable and useful irrespective of the type of leaf sequence algorithm and delivery machines. It provides an automated computer-implemented method or program that generalizes and simplifies dose verification in IMRT.
摘要翻译：提供了一种用于强度调制放射治疗（IMRT）中的强度调制光子场的独立MU或剂量和注量计算的通用计算机实现的方法和计算机程序。本发明提供了在高剂量区域或低剂量区域中的验证MU或剂量计算。通常，在任意空间点处的剂量被表示为处理场中所有子束的贡献的总和，每个子束由动态调制因子调制。低剂量区域的验证是基于使用低剂量区域的反转场。本发明的优点是它是一种独立的方法，因此无论叶序算法和递送机器的类型是多么适用和有用的。它提供了一种自动计算机实现的方法或程序，可以概括和简化IMRT中的剂量验证。

9. 发明授权

US09270159B2 EMI filter using active damping with frequency dependant impedance 有权
标题翻译： EMI滤波器采用具有频率相关阻抗的主动阻尼
公开(公告)号：US09270159B2
公开(公告)日：2016-02-23
申请号：US13568578
申请日：2012-08-07
申请人： Miaosen Shen , Ming Li , Lei Xing
发明人： Miaosen Shen , Ming Li , Lei Xing
IPC分类号： H02M1/12
CPC分类号： H02M1/12 , H02M2001/123
摘要： A circuit for providing damping in an electromagnetic interference (EMI) filter with an inductor-capacitor (LC) circuit, includes at least one capacitor connected to receive a common-mode current from the LC circuit; a current sensor that senses the common-mode current; a linear amplifier that amplifies the sensed common-mode current; and a power amplifier that receives the amplified sensed common-mode current and outputs a voltage which creates a damping impedance for frequencies of the common-mode current less than a threshold frequency and absorbs the common-mode current for frequencies greater than the threshold frequency.
摘要翻译：用于在具有电感器 - 电容器（LC）电路的电磁干扰（EMI）滤波器中提供阻尼的电路包括至少一个连接以接收来自LC电路的共模电流的电容器; 感测共模电流的电流传感器; 放大感测的共模电流的线性放大器; 以及功率放大器，其接收放大的感测到的共模电流并且输出产生小于阈值频率的共模电流的频率的阻尼阻抗的电压，并且对于大于阈值频率的频率吸收共模电流。

10. 发明申请

US20140043871A1 EMI FILTER USING ACTIVE DAMPING WITH FREQUENCY DEPENDANT IMPEDANCE 有权
标题翻译： EMI滤波器使用具有频率相关阻抗的主动阻尼
公开(公告)号：US20140043871A1
公开(公告)日：2014-02-13
申请号：US13568578
申请日：2012-08-07
申请人： Miaosen Shen , Ming Li , Lei Xing
发明人： Miaosen Shen , Ming Li , Lei Xing
IPC分类号： H02M1/12
CPC分类号： H02M1/12 , H02M2001/123
摘要： A circuit for providing damping in an electromagnetic interference (EMI) filter with an inductor-capacitor (LC) circuit, includes at least one capacitor connected to receive a common-mode current from the LC circuit; a current sensor that senses the common-mode current; a linear amplifier that amplifies the sensed common-mode current; and a power amplifier that receives the amplified sensed common-mode current and outputs a voltage which creates a damping impedance for frequencies of the common-mode current less than a threshold frequency and absorbs the common-mode current for frequencies greater than the threshold frequency.
摘要翻译：用于在具有电感器 - 电容器（LC）电路的电磁干扰（EMI）滤波器中提供阻尼的电路包括至少一个连接以接收来自LC电路的共模电流的电容器; 感测共模电流的电流传感器; 放大感测的共模电流的线性放大器; 以及功率放大器，其接收放大的感测到的共模电流并且输出产生小于阈值频率的共模电流的频率的阻尼阻抗的电压，并且对于大于阈值频率的频率吸收共模电流。

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