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1. 发明申请

US20100240136A1 APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES 有权
公开(公告)号：US20100240136A1
公开(公告)日：2010-09-23
申请号：US12785257
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

2. 发明授权

US07977106B2 Method for assaying coagulation in fluid samples 有权
公开(公告)号：US07977106B2
公开(公告)日：2011-07-12
申请号：US12785191
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

3. 发明授权

US07923256B2 Method for assaying coagulation in fluid samples 有权
标题翻译：测定流体样品中凝血的方法
公开(公告)号：US07923256B2
公开(公告)日：2011-04-12
申请号：US12785257
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

4. 发明申请

US20100240067A1 APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES 有权
标题翻译：用于测定流体样品中凝集的装置和方法
公开(公告)号：US20100240067A1
公开(公告)日：2010-09-23
申请号：US12785191
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/573
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

5. 发明授权

US06750053B1 Apparatus and method for assaying coagulation in fluid samples 有权
标题翻译：用于测定流体样品中凝血的装置和方法
公开(公告)号：US06750053B1
公开(公告)日：2004-06-15
申请号：US09712209
申请日：2000-11-15
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andy Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andy Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： C12M134
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

6. 发明授权

US07736901B2 Apparatus and method for assaying coagulation in fluid samples 有权
标题翻译：用于测定流体样品中凝血的装置和方法
公开(公告)号：US07736901B2
公开(公告)日：2010-06-15
申请号：US10807290
申请日：2004-03-24
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrezej Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrezej Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/48
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

7. 发明授权

US06438498B1 System, method and computer implemented process for assaying coagulation in fluid samples 有权
标题翻译：系统，方法和计算机实现流体样品凝固测定方法
公开(公告)号：US06438498B1
公开(公告)日：2002-08-20
申请号：US09528238
申请日：2000-03-17
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andy Maczuszenko , Imants R. Lauks
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andy Maczuszenko , Imants R. Lauks
IPC分类号： G01N3100
CPC分类号： B01L3/5027 , B01L3/502746 , B01L2200/0605 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N11/04 , G01N33/4905
摘要： A sample analyzing system includes at least one sensor located at least partially within a sample retaining area. In addition, the sensor has at least one edge defining a sample detection location. This sample detection location defines an area within which the sensor is capable of detecting a presence or an absence of the sample. The system analyzes sample data by first introducing the sample into the sample retaining area and then mixing a reagent with the sample to commence formation of a reagent product. After mixing and upon detecting the absence of the sample from the sample detection location by the at least one sensor, an edge of the sample is moved past an edge of the at least one sensor and into the sample detection location. Then, upon detecting the presence of the sample in the sample detection location by the at least one sensor, the edge of the sample is moved past the edge of the at least one sensor and out of the sample detection location. Additionally, between oscillations, data may be collected by one or more sensors. By repeating these steps, an accumulation of material on or about the at least one sensor may be prevented.
摘要翻译：样品分析系统包括至少部分地位于样品保留区域内的至少一个传感器。另外，传感器具有至少一个限定样本检测位置的边缘。该样本检测位置定义了传感器能够检测样品存在或不存在的区域。该系统通过首先将样品引入样品保留区域，然后将试剂与样品混合以开始形成试剂产物来分析样品数据。在混合之后并且当通过至少一个传感器检测到来自样品检测位置的样品的不存在时，样品的边缘移动经过至少一个传感器的边缘并进入样品检测位置。然后，当通过至少一个传感器检测样品检测位置中的样品的存在时，样品的边缘移动经过至少一个传感器的边缘并且离开样品检测位置。此外，在振荡之间，可以由一个或多个传感器收集数据。通过重复这些步骤，可以防止材料在该至少一个传感器上或周围的积聚。

8. 外观设计

USD639956S1 Blood analysis system 有权
标题翻译：血液分析系统
公开(公告)号：USD639956S1
公开(公告)日：2011-06-14
申请号：US29341416
申请日：2009-08-05
申请人： David Francis McGregor Bain , Dmitry Elman , Mark Andrew Fritz , Imants R. Lauks , Andrzej Maczuszenko
设计人： David Francis McGregor Bain , Dmitry Elman , Mark Andrew Fritz , Imants R. Lauks , Andrzej Maczuszenko

9. 发明申请

US20090065368A1 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 有权
标题翻译：用于分析测量和免疫测定的装置和方法
公开(公告)号：US20090065368A1
公开(公告)日：2009-03-12
申请号：US12165925
申请日：2008-07-01
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/327 , G01N27/40
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

10. 发明授权

US07419821B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US07419821B2
公开(公告)日：2008-09-02
申请号：US10087730
申请日：2002-03-05
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其它基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术，疗养院，重症监护病房和非医疗环境中的使用。

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