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1. 发明申请

US20090065368A1 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 有权
标题翻译：用于分析测量和免疫测定的装置和方法
公开(公告)号：US20090065368A1
公开(公告)日：2009-03-12
申请号：US12165925
申请日：2008-07-01
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/327 , G01N27/40
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

2. 发明授权

US07419821B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US07419821B2
公开(公告)日：2008-09-02
申请号：US10087730
申请日：2002-03-05
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其它基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术，疗养院，重症监护病房和非医疗环境中的使用。

3. 发明申请

US20120305409A1 Apparatus and Methods for Analyte Measurement and Immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US20120305409A1
公开(公告)日：2012-12-06
申请号：US13495224
申请日：2012-06-13
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/26
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在说导管。包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

4. 发明申请

US20110290669A1 Apparatus and Methods for Analyte Measurement and Immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US20110290669A1
公开(公告)日：2011-12-01
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： G01N27/327 , G01N27/40 , G01N33/50 , G01N27/28
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

5. 发明授权

US08017382B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08017382B2
公开(公告)日：2011-09-13
申请号：US12165925
申请日：2008-07-01
申请人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants R. Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其它基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术，疗养院，重症监护病房和非医疗环境中的使用。

6. 发明授权

US08679827B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08679827B2
公开(公告)日：2014-03-25
申请号：US13495224
申请日：2012-06-13
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在说导管。包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

7. 发明授权

US08222024B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08222024B2
公开(公告)日：2012-07-17
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

8. 发明授权

US09050595B2 Assay devices with integrated sample dilution and dilution verification and methods of using same 有权
标题翻译：具有集成样品稀释和稀释验证的测定装置及其使用方法
公开(公告)号：US09050595B2
公开(公告)日：2015-06-09
申请号：US13308968
申请日：2011-12-01
申请人： Cary James Miller , Graham Davis , Michael Zelin
发明人： Cary James Miller , Graham Davis , Michael Zelin
IPC分类号： B01L3/00 , G01N33/543 , B01F11/00
CPC分类号： G01N33/54373 , B01F11/0071 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/045 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/126 , B01L2400/0481 , B01L2400/0672 , G01N21/25 , G01N21/78 , G01N27/02 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N27/49 , G01N33/54366 , G01N33/76
摘要： The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.
摘要翻译：本发明是用于通过各种测定法快速测定液体样品中分析物的装置和方法，其包括结合用于形成用于分析的稀释样品的样品稀释特征的免疫测定。该装置和方法还包括用于验证稀释样品的稀释程度的稀释验证特征。优选地，这些装置能够用于提供的护理点诊断领域。

9. 发明申请

US20120142026A1 Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same 有权
标题翻译：具有集成样品稀释和稀释验证的测定装置及其使用方法
公开(公告)号：US20120142026A1
公开(公告)日：2012-06-07
申请号：US13308968
申请日：2011-12-01
申请人： Cary James Miller , Graham Davis , Michael Zelin
发明人： Cary James Miller , Graham Davis , Michael Zelin
IPC分类号： G01N33/53 , G01N27/26 , G01N21/64 , G01N21/75 , C12M1/40
CPC分类号： G01N33/54373 , B01F11/0071 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/045 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/126 , B01L2400/0481 , B01L2400/0672 , G01N21/25 , G01N21/78 , G01N27/02 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N27/49 , G01N33/54366 , G01N33/76
摘要： The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.
摘要翻译：本发明是用于通过各种测定法快速测定液体样品中分析物的装置和方法，其包括结合用于形成用于分析的稀释样品的样品稀释特征的免疫测定。该装置和方法还包括用于验证稀释样品的稀释程度的稀释验证特征。优选地，这些装置能够用于提供的护理点诊断领域。

10. 发明授权

US08168439B2 Method for measuring an analyte in blood 有权
标题翻译：测量血液中分析物的方法
公开(公告)号：US08168439B2
公开(公告)日：2012-05-01
申请号：US12708445
申请日：2010-02-18
申请人： Cary James Miller , John Lewis Emerson Campbell
发明人： Cary James Miller , John Lewis Emerson Campbell
IPC分类号： G01N21/75
CPC分类号： G01N33/5438 , Y10S436/807
摘要： An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the region of the first immunosensor, anda second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein that is in the sample and that is not the target analyte.
摘要翻译：一种具有降低的干扰的电化学免疫传感器系统，包括：第一免疫传感器，其基于在固定化抗体，靶分析物和标记抗体之间形成夹心而产生电化学信号，其中信号的一部分来自非特异性结合的第一免疫传感器区域中的标记抗体，以及第二免疫传感器，其作为免疫参考传感器，并产生与非特异性结合程度相同或可预测相关的信号，其发生在第一免疫传感器，并且在固定的抗体和在样品中的内源或外源蛋白质之间具有免疫复合物，而不是靶分析物。

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