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1. 发明申请

US20080096794A1 Peptide Mixture From Peptides Having A Molecular Weight Of from 1000 To 5000 Dalton 审中-公开
标题翻译：具有分子量为1000至5000道尔顿的肽的肽混合物
公开(公告)号：US20080096794A1
公开(公告)日：2008-04-24
申请号：US11660595
申请日：2005-08-12
申请人： Gunther Boehm , Christopher Beermann , Bernd Stahl , Gilda Georgi , Joachim Schmitt , Nadine Bock , Sorge Kelm
发明人： Gunther Boehm , Christopher Beermann , Bernd Stahl , Gilda Georgi , Joachim Schmitt , Nadine Bock , Sorge Kelm
IPC分类号： A61K38/00 , A23C9/00 , A23J3/08 , A61P43/00 , C07K16/00 , A23J3/10 , A23L1/305
CPC分类号： A23J3/346 , A23J3/344 , A23L33/18 , A23L33/40 , A61K35/20 , A61K36/06 , A61K36/31 , A61K36/48 , A61K36/88 , A61K38/168 , A61K38/1709 , A61K2300/00
摘要： The invention relates to the use of a peptide mixture comprising peptides with a molecular weight from 1000 to 5000 Daltons for the prevention and/or treatment of tumour diseases, of diseases which are associated with a development disorder of the immune system, of diseases of the immune system, of autoimmune reactions, of allergies and of inflammation in man, a protein component which contains such a peptide mixture and a formula food containing this peptide mixture. The peptides are preferably obtained from non-human proteins suitable for nutritional purposes, in particular by the enzymatic or hydrolytic cleavage of these proteins.
摘要翻译：本发明涉及包含分子量为1000至5000道尔顿的肽的肽混合物在预防和/或治疗与免疫系统发育障碍相关的疾病的肿瘤疾病中的用途，免疫系统，自身免疫反应，过敏和人类炎症，含有这种肽混合物的蛋白质组分和含有该肽混合物的配方食品。肽优选地从适合于营养目的的非人蛋白质获得，特别是通过这些蛋白质的酶促或水解切割。

2. 发明授权

US08729123B2 Nutrition containing fat blend 有权
标题翻译：营养含脂肪混合物
公开(公告)号：US08729123B2
公开(公告)日：2014-05-20
申请号：US13251399
申请日：2011-10-03
申请人： Bernd Stahl , Gunther Boehm , Christopher Beermann , Johan Garssen
发明人： Bernd Stahl , Gunther Boehm , Christopher Beermann , Johan Garssen
IPC分类号： A61K31/22 , A61K31/20
CPC分类号： A61K31/202 , A23L33/12 , A23L33/22 , A23L33/40 , A23V2002/00 , A23V2250/187 , A23V2250/1868 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/0644 , A23V2250/1642
摘要： The invention relates to the use of long chain polyunsaturated fatty acids for the manufacture of a nutritional composition for feeding infants of a mother who suffered from a metabolic disorder during pregnancy and to a corresponding composition. Said composition comprises a n-3 polyunsaturated fatty acid fraction containing at least 0.1 wt % docosahexaenoic acid (DHA) based on total weight of the lipid, at least 0.01 wt % n-3 docosapentaenoic acid (DPAn-3) based on total weight of the lipid, and at least 0.01 wt. % eicosapentaenoic acid (EPA) based on total weight of the lipid, wherein the sum of DHA, DPAn-3 and EPA is below 1 wt. % of total lipid.
摘要翻译：本发明涉及长链多不饱和脂肪酸用于制造用于喂养怀孕期间代谢紊乱的母亲的婴儿的营养组合物和相应组合物的用途。所述组合物包含n-3多不饱和脂肪酸级分，其含有基于脂质总重量的至少0.1重量％二十二碳六烯酸（DHA），至少0.01重量％的n-3二十二碳五烯酸（DPAn-3），基于脂质和至少0.01重量％基于脂质总重量的二十碳五烯酸（EPA），其中DHA，DPAn-3和EPA的总和低于1wt。总脂质的百分比。

3. 发明申请

US20080125346A1 Infant Formula 审中-公开
标题翻译：婴幼儿配方奶粉
公开(公告)号：US20080125346A1
公开(公告)日：2008-05-29
申请号：US11573939
申请日：2005-08-22
申请人： Christopher Beermann , Gunther Boehm , Bernd Stahl
发明人： Christopher Beermann , Gunther Boehm , Bernd Stahl
IPC分类号： A61K38/00 , A61P37/08 , A61P1/12 , A61P17/00 , A61P29/00
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (NpxN); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.
摘要翻译：本发明涉及含有蛋白质，脂肪和碳水化合物的营养组合物; 和a。选自核酸，核酸衍生物，核苷酸，多磷酸核苷，多核苷酸，核苷，核糖，脱氧核糖和二核苷酸多磷酸的核苷酸成分（Np×N）。和b。分子量在200至20.000道尔顿之间的非蛋白质带负电的聚糖或糖缀合物组分。目前的营养组合物特别适用于喂养婴儿，因为它模仿人乳的保护作用，特别是针对过敏和感染。

4. 发明申请

US20080269330A1 Nutrition Containing Fat Blend 有权
标题翻译：营养含脂肪混合
公开(公告)号：US20080269330A1
公开(公告)日：2008-10-30
申请号：US11666990
申请日：2005-11-11
申请人： Bernd Stahl , Gunther Boehm , Christopher Beermann , Johan Garssen
发明人： Bernd Stahl , Gunther Boehm , Christopher Beermann , Johan Garssen
IPC分类号： A61K31/202 , A61P3/02
CPC分类号： A61K31/202 , A23L33/12 , A23L33/22 , A23L33/40 , A23V2002/00 , A23V2250/187 , A23V2250/1868 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/0644 , A23V2250/1642
摘要： The invention relates to the use of long chain polyunsaturated fatty acids for the manufacture of a nutritional composition for feeding infants of a mother who suffered from a metabolic disorder during pregnancy and to a corresponding composition. Said composition comprises a n-3 polyunsaturated fatty acid fraction containing at least 0.1 wt docosahexaenoic acid (DHA) based on total weight of the lipid, at least 0.01 wt % n-3 docosapentaenoic acid (DPAn-3) based on total weight of the lipid, and at least 0.01 wt. % eicosapentaenoic acid (EPA) based on total weight of the lipid, wherein the sum of DHA, DPAn-3 and EPA is below 1 wt. % of total lipid.
摘要翻译：本发明涉及长链多不饱和脂肪酸用于制造用于喂养怀孕期间代谢紊乱的母亲的婴儿的营养组合物和相应组合物的用途。所述组合物包含n-3多不饱和脂肪酸级分，其含有至少0.1重量％的二十二碳六烯酸（DHA），基于脂质的总重量，至少0.01重量％的n-3二十二碳烯酸（DPAn-3），基于脂质，和至少0.01重量％基于脂质总重量的二十碳五烯酸（EPA），其中DHA，DPAn-3和EPA的总和低于1wt。总脂质的百分比。

5. 发明申请

US20070054877A1 Antiadhesive carbohydrates 有权
标题翻译：防粘碳水化合物
公开(公告)号：US20070054877A1
公开(公告)日：2007-03-08
申请号：US11511500
申请日：2006-08-29
申请人： Bernd Stahl , Gunther Boehm
发明人： Bernd Stahl , Gunther Boehm
IPC分类号： A61K31/715
CPC分类号： A61K31/7012 , A23L5/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A23L33/125 , A61K31/702 , A61K31/715
摘要： Provided is a pharmaceutical or dietetic product, which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, in particular mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100% of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and C5 atom.
摘要翻译：提供了一种药物或饮食产品，其用于减少和/或阻断致病物质和生物体对真核细胞特别是哺乳动物细胞的粘附。所述制剂包含至少一种在其一个端部具有糖醛酸单元的碳水化合物。本发明的碳原子数为10〜100％的末端糖醛酸单元具有特别位于C 4〜C 5原子之间的双键。

6. 发明申请

US20060105990A1 Antiadhesive carbohydrates 失效
标题翻译：防粘碳水化合物
公开(公告)号：US20060105990A1
公开(公告)日：2006-05-18
申请号：US11313674
申请日：2005-12-22
申请人： Bernd Stahl , Gunther Boehm
发明人： Bernd Stahl , Gunther Boehm
IPC分类号： A61K31/715
CPC分类号： A61K31/7012 , A23L5/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A23L33/125 , A61K31/702 , A61K31/715
摘要： Provided is a pharmaceutical or dietetic product, which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, in particular mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100% of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and C5 atom.
摘要翻译：提供了一种药物或饮食产品，其用于减少和/或阻断致病物质和生物体对真核细胞特别是哺乳动物细胞的粘附。所述制剂包含至少一种在其一个端部具有糖醛酸单元的碳水化合物。本发明的碳原子数为10〜100％的末端糖醛酸单元具有特别位于C 4〜C 5原子之间的双键。

7. 发明申请

US20120195975A1 IMMUNE STIMULATORY INFANT NUTRITION 有权
标题翻译：免疫刺激性哺乳动物营养
公开(公告)号：US20120195975A1
公开(公告)日：2012-08-02
申请号：US13360508
申请日：2012-01-27
申请人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
发明人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
IPC分类号： A61K38/16 , A61K33/30 , A61P17/00 , A61P37/08 , A61P29/00 , A61P1/12
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition comprising fat, protein, carbohydrate, whey and casein is provided. The composition has a weight ratio of casein to whey between 1:1 to 1:2.4 and comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids selected from docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. Methods of treatment by administering the composition are also provided.
摘要翻译：提供了包含脂肪，蛋白质，碳水化合物，乳清和酪蛋白的营养或药物组合物。该组合物的酪蛋白与乳清的重量比在1:1至1:2.4之间，包括：a）每100克蛋白质至少3克精氨酸; b）至少10wt。％亚油酸基于总脂肪酸; c）至少1wt。基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。基于选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸的总脂肪酸的％; e）5至25wt。至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为每100克组合物干重2至100。还提供了施用该组合物的治疗方法。

8. 发明授权

US07919479B2 Antiadhesive carbohydrates 有权
标题翻译：防粘碳水化合物
公开(公告)号：US07919479B2
公开(公告)日：2011-04-05
申请号：US11511500
申请日：2006-08-29
申请人： Bernd Stahl , Gunther Boehm
发明人： Bernd Stahl , Gunther Boehm
IPC分类号： A61K31/702 , A61K31/733 , A61K31/732
CPC分类号： A61K31/7012 , A23L5/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A23L33/125 , A61K31/702 , A61K31/715
摘要： Provided is a pharmaceutical or dietetic product, which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, in particular mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100% of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and C5 atom.
摘要翻译：提供了一种药物或饮食产品，其用于减少和/或阻断致病物质和生物体对真核细胞特别是哺乳动物细胞的粘附。所述制剂包含至少一种在其一个端部具有糖醛酸单元的碳水化合物。本发明的碳原子数为10〜100％的末端糖醛酸单元具有特别位于C4和C5原子之间的双键。

9. 发明授权

US07498318B1 Food for diabetics 失效
标题翻译：糖尿病食物
公开(公告)号：US07498318B1
公开(公告)日：2009-03-03
申请号：US10129095
申请日：2000-11-10
申请人： Bernd Stahl , Michael Kliem , Sandra Farwer , Gunther Sawatzki , Gunther Boehm
发明人： Bernd Stahl , Michael Kliem , Sandra Farwer , Gunther Sawatzki , Gunther Boehm
IPC分类号： A61K31/718
CPC分类号： C12Y204/01019 , A23L5/00 , A23L29/30 , A23L33/125 , A23L33/20 , A23L33/21 , C12P19/14 , C12P19/18 , C12Y204/01024
摘要： Provided is a carbohydrate mixture comprising at least one modified carbohydrate from a base body and a carbohydrate residue coupled therewith. The base body concerned is either a digestible glucose-containing carbohydrate in the form of a digestible glucan or a non-digestible reserve carbohydrate, skeletal carbohydrate or a low-molecular component thereof. By coupling the base body with a carbohydrate residue, the glucose release from the inventive carbohydrate mixture is reduced by at least 10%, determined in an in-vivo digestion system on the basis of pancreatine and compared with a carbohydrate mixture containing the same amount by weight of non-modified carbohydrates. By means of the inventive carbohydrate mixture, the postprandial blood glucose concentration after eating can be moderated. The glucose can thus be metabolized by diabetics in spite of the existing lack of insulin. The inventive carbohydrate mixtures can be used in food for diabetics and in pharmaceuticals.
摘要翻译：提供了包含至少一种来自碱体的修饰的碳水化合物和与其偶联的碳水化合物残基的碳水化合物混合物。所涉及的基体是可消化葡萄糖或不可消化的储备碳水化合物，骨骼碳水化合物或其低分子组分形式的可消化的含葡萄糖的碳水化合物。通过将基体与碳水化合物残基偶联，将本发明的碳水化合物混合物的葡萄糖释放量减少至少10％，在基于胰腺的体内消化系统中测定，并与含有相同量的碳水化合物混合物非改性碳水化合物的重量。通过本发明的碳水化合物混合物，饮食后餐后血糖浓度可以缓和。糖可以由糖尿病代谢，尽管目前缺乏胰岛素。本发明的碳水化合物混合物可用于糖尿病患者和药物中。

10. 发明授权

US09084433B2 Intestinal barrier integrity 有权
标题翻译：肠屏障完整性
公开(公告)号：US09084433B2
公开(公告)日：2015-07-21
申请号：US13594147
申请日：2012-08-24
申请人： Eric Alexander Franciscus Van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
发明人： Eric Alexander Franciscus Van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
IPC分类号： A61K31/733 , A61P1/00 , A61P1/12 , A61P37/08 , A23L1/29 , A23L1/30
CPC分类号： A23L29/04 , A23L29/30 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/702 , A23V2200/32 , A23V2200/304 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/28 , A23V2250/5062
摘要： The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), and at least two distinct oligosaccharides.
摘要翻译：本发明涉及通过向哺乳动物施用包含二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和花生四烯酸（ARA）以及至少两种不同的低聚糖的组合物来刺激哺乳动物的屏障完整性的方法。

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