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1. 发明授权

US5686477A 5-(arloxymethyl)oxazolines 失效
标题翻译： 5-（芳氧基甲基）恶唑啉
公开(公告)号：US5686477A
公开(公告)日：1997-11-11
申请号：US556797
申请日：1995-11-02
申请人： Christian Jarry , Isabelle Forfar , Jean-Jacques Bosc , Pierre Renard , Elizabeth Scalbert , Beatrice Guardiola
发明人： Christian Jarry , Isabelle Forfar , Jean-Jacques Bosc , Pierre Renard , Elizabeth Scalbert , Beatrice Guardiola
IPC分类号： A61K31/42 , A61K31/421 , A61K31/44 , A61P9/12 , A61P43/00 , C07D263/28 , C07D413/12 , C07D263/00 , A01N43/76 , C07D263/06
CPC分类号： C07D413/12 , C07D263/28
摘要： The invention relates to compounds of formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are selected, each independently of the other, from hydrogen and an alkyl radical, A is selected from the radicals: ##STR2## wherein: R.sub.3 represents a radical selected from halogen, alkyl, alkoxy, amino, 2-acetyl, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, trifluoromethyl and cyano, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are selected, each independently of the others, from hydrogen, a halogen, an alkyl, alkoxy, amino, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, cyano and a trifluoromethyl radical, R.sub.9 represents the nitro radical, with the proviso that A cannot represent a grouping selected from: dihalophenyl, trihalophenyl, 4-methylphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-tert-butylphenyl and 3-(dimethylamino)phenyl, optical isomers thereof in pure form or in the form of a mixture, and pharmaceutically acceptable addition salts thereof with an acid or base, it being understood that: the terms "alkyl" and "alkoxy" represent straight-chained or branched radicals having from 1 to 6 carbon atoms. The compounds of the invention and the pharmaceutical compositions comprising them are proving to be useful in the treatment of disorders associated with I.sub.1 -receptors.
摘要翻译：本发明涉及式（I）化合物：其中：R 1和R 2各自独立地选自氢和烷基，A选自以下基团：其中：R3表示选自卤素，烷基，烷氧基，氨基，2-乙酰基，烷基氨基，二烷基氨基，羧基，烷氧基羰基，三氟甲基和氰基的基团，R4，R5， R6，R7和R8各自独立地选自氢，卤素，烷基，烷氧基，氨基，烷基氨基，二烷基氨基，羧基，烷氧基羰基，氰基和三氟甲基，R9表示硝基，条件是 A不能代表选自二卤代苯基，三卤代苯基，4-甲基苯基，4-氯苯基，4-甲氧基苯基，4-叔丁基苯基和3-（二甲基氨基）苯基的基团，其纯的形式或其形式为混合物及其药学上可接受的加成盐与酸或碱反应要求：术语“烷基”和“烷氧基”表示具有1至6个碳原子的直链或支链基团。证明本发明的化合物和包含它们的药物组合物可用于治疗与I1受体相关的病症。

2. 发明授权

US5849781A Tricyclic amides 失效
公开(公告)号：US5849781A
公开(公告)日：1998-12-15
申请号：US942177
申请日：1997-10-01
申请人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
发明人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
IPC分类号： A61K31/16 , A61K31/165 , A61K31/17 , A61K31/38 , A61K31/381 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C231/14 , C07C233/06 , C07C233/23 , C07C233/25 , C07C233/32 , C07C233/54 , C07C233/58 , C07C233/60 , C07C273/18 , C07C275/26 , C07C327/42 , C07D209/90 , C07D307/92 , C07D333/74 , A61K31/34 , A61K31/40 , C07D209/56 , C07D307/77
CPC分类号： C07D307/92 , C07C233/06 , C07C233/23 , C07C233/58 , C07C233/60 , C07D209/90 , C07D333/74 , C07C2101/02 , C07C2101/04 , C07C2103/24 , C07C2103/26 , C07C2103/28
摘要： The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.

3. 发明授权

US5712312A Tricyclic amides 失效
标题翻译：三环酰胺
公开(公告)号：US5712312A
公开(公告)日：1998-01-27
申请号：US631196
申请日：1996-04-12
申请人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
发明人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
IPC分类号： A61K31/16 , A61K31/165 , A61K31/17 , A61K31/38 , A61K31/381 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C231/14 , C07C233/06 , C07C233/23 , C07C233/25 , C07C233/32 , C07C233/54 , C07C233/58 , C07C233/60 , C07C273/18 , C07C275/26 , C07C327/42 , C07D209/90 , C07D307/92 , C07D333/74
CPC分类号： C07D307/92 , C07C233/06 , C07C233/23 , C07C233/58 , C07C233/60 , C07D209/90 , C07D333/74 , C07C2101/02 , C07C2101/04 , C07C2103/24 , C07C2103/26 , C07C2103/28
摘要： The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
摘要翻译：本发明涉及选自这些式（I）的化合物：其中R 7，R 8，Y，n和A如说明书中所定义的其中R 1，R 2，的褪黑激素系统。

4. 发明授权

US5519023A New aminoalkylchromones, processes for the preparation thereof 失效
标题翻译：新氨基烷基色酮，其制备方法
公开(公告)号：US5519023A
公开(公告)日：1996-05-21
申请号：US94564
申请日：1993-07-02
申请人： Marc Payard , Genevieve Baziard-Mouysset , Gilbert De Saqui-Sannes , Beatrice Guardiola , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Marc Payard , Genevieve Baziard-Mouysset , Gilbert De Saqui-Sannes , Beatrice Guardiola , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/35 , A61K31/352 , A61K31/357 , A61K31/40 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/505 , A61K31/535 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D311/22 , C07D317/58 , C07D405/06 , C07D405/12 , C07D407/12 , C07D521/00 , C07D405/14
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D311/22 , C07D405/06 , C07D405/12 , C07D407/12
摘要： The invention relates to compounds of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and Z are as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base and medicaments containing the same, useful in the treatment and prevention of stress, anxiety, and related ailments.
摘要翻译：本发明涉及通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和Z如说明书中所定义，其光学异构体及其加成盐与药学上可接受的酸或碱和含有它们的药物，可用于治疗和预防压力，焦虑和相关疾病。

5. 发明授权

US5432173A 1-amidooctahydropyrido[2,1,-C][1,4]oxazine compounds 失效
标题翻译： 1-氨基八氢吡啶并[2,1，-C] [1,4]恶嗪化合物
公开(公告)号：US5432173A
公开(公告)日：1995-07-11
申请号：US135807
申请日：1993-10-13
申请人： Henri P. Husson , Jean C. Quirion , Martine Bonin , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人： Henri P. Husson , Jean C. Quirion , Martine Bonin , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号： A61K31/535 , A61P25/00 , A61P25/18 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention relates to the compounds of general formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and A are as defined in the description.their isomers, diastereoisomers, and enantiomers as well as their addition salts with a pharmaceutically acceptable inorganic or organic acid, andmedicinal products containing the same which are usable for the treatment of psycho-behavioral disorders.
摘要翻译：本发明涉及通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5和A如说明书中所定义。它们的异构体，非对映异构体和对映异构体以及它们与药学上可接受的无机或有机酸的加成盐，以及含有它们的可用于治疗精神行为障碍的药物。

6. 发明授权

US5196434A Heterocycle-substituted alkylamines compounds 失效
标题翻译：杂环取代的烷基胺化合物
公开(公告)号：US5196434A
公开(公告)日：1993-03-23
申请号：US765959
申请日：1991-09-26
申请人： Thierry Taverne , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人： Thierry Taverne , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P9/12 , A61P25/04 , A61P25/18 , A61P25/20 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/056
CPC分类号： C07D277/68 , C07D265/36 , C07D279/16 , C07D417/12
摘要： Compound of general formula (I): ##STR1## where R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description.Medicinal products.
摘要翻译：通式（I）的化合物：其中R 1，R 2，R 3，n，X和A在说明书中定义。药用产品。

7. 发明授权

US5919814A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US5919814A
公开(公告)日：1999-07-06
申请号：US66235
申请日：1998-04-24
申请人： Gerald Guillaumet , Isabelle Charton , Ahmed Mamai , Pierre Renard , Bruno Pfeiffer , Philippe Delagrange , Beatrice Guardiola
发明人： Gerald Guillaumet , Isabelle Charton , Ahmed Mamai , Pierre Renard , Bruno Pfeiffer , Philippe Delagrange , Beatrice Guardiola
IPC分类号： A61K31/335 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/38 , A61K31/382 , A61P3/04 , A61P3/08 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/28 , A61P43/00 , C07D311/04 , C07D311/64 , C07D319/18 , C07D327/06 , C07D335/06 , C07D355/04
CPC分类号： C07D335/06 , C07D311/64 , C07D319/18 , C07D327/06
摘要： The invention relates to compound of general formula (I): ##STR1## wherein: Z represents O or CH.sub.2n is from 0 to 4R, X and Y are as defined in the description, andA represents ##STR2## wherein R.sup.1, R.sup.2, R.sup.6, R.sup.7 and T' are as defined in the description,and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
摘要翻译：本发明涉及通式（I）的化合物：其中：Z表示O或CH 2 n为0至4 R，X和Y如说明书中所定义，A表示其中R1，R2，R6，R7和T '如说明书中所定义，含有该药物的药物可用于治疗或预防褪黑激素障碍。

8. 发明授权

US5397783A 3-aminochroman spiro compounds 失效
公开(公告)号：US5397783A
公开(公告)日：1995-03-14
申请号：US174205
申请日：1993-12-27
申请人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
发明人： Gerald Guillaumet , Tchao Podona , Gerard Adam , Beatrice Guardiola , Pierre Renard
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00 , C07D471/10 , A61K31/44
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.

9. 发明授权

US5322843A Benzoxazolinonyl and benzothiazolinonyl ethyl morpholinoacetamides 失效
标题翻译：苯并恶唑啉酮和苯并噻唑啉基乙基吗啉代乙酰胺
公开(公告)号：US5322843A
公开(公告)日：1994-06-21
申请号：US54720
申请日：1993-04-28
申请人： Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人： Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号： C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要： Compounds of general formula (I): ##STR1## wherein R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
摘要翻译：通式（I）的化合物：其中R，X，A，B和p在说明书中定义。可用于治疗包含其的睡眠障碍的药用产品。

10. 发明授权

US5240919A Benzthiazolinonyl-substituted alkylamides 失效
标题翻译：苯并噻唑基取代的烷基亚胺
公开(公告)号：US5240919A
公开(公告)日：1993-08-31
申请号：US848373
申请日：1992-03-09
申请人： Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人： Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号： C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要： Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
摘要翻译：通式（I）的化合物：其中R，X，A，B和p在说明书中定义。可用于治疗包含其的睡眠障碍的药用产品。

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