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    • 1. 发明授权
    • 5-(arloxymethyl)oxazolines
    • 5-(芳氧基甲基)恶唑啉
    • US5686477A
    • 1997-11-11
    • US556797
    • 1995-11-02
    • Christian JarryIsabelle ForfarJean-Jacques BoscPierre RenardElizabeth ScalbertBeatrice Guardiola
    • Christian JarryIsabelle ForfarJean-Jacques BoscPierre RenardElizabeth ScalbertBeatrice Guardiola
    • A61K31/42A61K31/421A61K31/44A61P9/12A61P43/00C07D263/28C07D413/12C07D263/00A01N43/76C07D263/06
    • C07D413/12C07D263/28
    • The invention relates to compounds of formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are selected, each independently of the other, from hydrogen and an alkyl radical, A is selected from the radicals: ##STR2## wherein: R.sub.3 represents a radical selected from halogen, alkyl, alkoxy, amino, 2-acetyl, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, trifluoromethyl and cyano, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are selected, each independently of the others, from hydrogen, a halogen, an alkyl, alkoxy, amino, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, cyano and a trifluoromethyl radical, R.sub.9 represents the nitro radical, with the proviso that A cannot represent a grouping selected from: dihalophenyl, trihalophenyl, 4-methylphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-tert-butylphenyl and 3-(dimethylamino)phenyl, optical isomers thereof in pure form or in the form of a mixture, and pharmaceutically acceptable addition salts thereof with an acid or base, it being understood that: the terms "alkyl" and "alkoxy" represent straight-chained or branched radicals having from 1 to 6 carbon atoms. The compounds of the invention and the pharmaceutical compositions comprising them are proving to be useful in the treatment of disorders associated with I.sub.1 -receptors.
    • 本发明涉及式(I)化合物:其中:R 1和R 2各自独立地选自氢和烷基,A选自以下基团: 其中:R3表示选自卤素,烷基,烷氧基,氨基,2-乙酰基,烷基氨基,二烷基氨基,羧基,烷氧基羰基,三氟甲基和氰基的基团,R4,R5, R6,R7和R8各自独立地选自氢,卤素,烷基,烷氧基,氨基,烷基氨基,二烷基氨基,羧基,烷氧基羰基,氰基和三氟甲基,R9表示硝基,条件是 A不能代表选自二卤代苯基,三卤代苯基,4-甲基苯基,4-氯苯基,4-甲氧基苯基,4-叔丁基苯基和3-(二甲基氨基)苯基的基团,其纯的形式或其形式为 混合物及其药学上可接受的加成盐与酸或碱反应 要求:术语“烷基”和“烷氧基”表示具有1至6个碳原子的直链或支链基团。 证明本发明的化合物和包含它们的药物组合物可用于治疗与I1受体相关的病症。