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1. 发明申请

US20100211328A1 Method for detecting the impacts of interfering effects on experimental data 审中-公开
标题翻译：检测干扰效应对实验数据的影响的方法
公开(公告)号：US20100211328A1
公开(公告)日：2010-08-19
申请号：US12656444
申请日：2010-01-29
申请人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
发明人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
IPC分类号： G01N21/62 , G06F19/00
CPC分类号： G01N21/6445 , G01N2201/1215
摘要： The invention provides a method for identifying the impacts of interfering effects on experimental data. In particular, a method is described for identifying the impacts of unwanted auto-fluorescence, fluorescence quenching, and deterioration of a fluorescent sample under study on the collected experimental data. The data are analyzed whether or not said data fulfill certain criteria with respect to a threshold which is indicative for said interfering effect.
摘要翻译：本发明提供了一种识别干扰效应对实验数据的影响的方法。特别地，描述了一种用于识别不期望的自动荧光，荧光猝灭和正在研究的荧光样品的劣化对所收集的实验数据的影响的方法。分析数据是否所述数据是否符合指示所述干扰效应的阈值的某些标准。

2. 发明申请

US20080270073A1 Method for detecting the impacts of interfering effects on experimental data 审中-公开
标题翻译：检测干扰效应对实验数据的影响的方法
公开(公告)号：US20080270073A1
公开(公告)日：2008-10-30
申请号：US12068644
申请日：2008-02-08
申请人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
发明人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
IPC分类号： G06F17/18
CPC分类号： G01N21/6445 , G01N2201/1215
摘要： The invention provides a method for identifying the impacts of interfering effects on experimental data. In particular, a method is described for identifying the impacts of unwanted auto-fluorescence, fluorescence quenching, and deterioration of a fluorescent sample under study on the collected experimental data. The data are analyzed whether or not said data fulfill certain criteria with respect to a threshold which is indicative for said interfering effect.
摘要翻译：本发明提供了一种识别干扰效应对实验数据的影响的方法。特别地，描述了一种用于识别不期望的自动荧光，荧光猝灭和正在研究的荧光样品的劣化对所收集的实验数据的影响的方法。分析数据是否所述数据是否符合指示所述干扰效应的阈值的某些标准。

3. 发明授权

US09759659B2 Method for detecting the impacts of interfering effects on experimental data 有权
公开(公告)号：US09759659B2
公开(公告)日：2017-09-12
申请号：US13044787
申请日：2011-03-10
申请人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
发明人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
IPC分类号： G06F17/18 , G01N21/64
CPC分类号： G01N21/6445 , G01N2201/1215
摘要： A method for identifying the impact on data, such as experimental data, of interfering effects, such as unwanted auto-fluorescence, fluorescence quenching, and fluorescent-sample deterioration, whether or not the data fulfill certain criteria with respect to a threshold indicative of the interfering effects.

4. 发明申请

US20110218767A1 Method for Detecting The Impacts of Interfering Effects on Experimental Data 有权
标题翻译：检测干扰效应对实验数据影响的方法
公开(公告)号：US20110218767A1
公开(公告)日：2011-09-08
申请号：US13044787
申请日：2011-03-10
申请人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
发明人： Christian Eggeling , Kaupo Palo , Nicolas Fay , Maciej Hoffman-Wecker , Pierre Ilouga
IPC分类号： G06F17/18
CPC分类号： G01N21/6445 , G01N2201/1215
摘要： The invention provides a method for identifying the impacts of interfering effects on experimental data. In particular, a method is described for identifying the impacts of unwanted auto-fluorescence, fluorescence quenching, and deterioration of a fluorescent sample under study on the collected experimental data. The data are analyzed whether or not said data fulfill certain criteria with respect to a threshold which is indicative for said interfering effect.
摘要翻译：本发明提供了一种识别干扰效应对实验数据的影响的方法。特别地，描述了一种用于识别不期望的自动荧光，荧光猝灭和正在研究的荧光样品的劣化对所收集的实验数据的影响的方法。分析数据是否所述数据是否符合指示所述干扰效应的阈值的某些标准。

5. 发明授权

US07345759B2 Method and device for the measurement of chemical and/or biological samples 有权
标题翻译：用于测量化学和/或生物样品的方法和装置
公开(公告)号：US07345759B2
公开(公告)日：2008-03-18
申请号：US10380192
申请日：2001-08-22
申请人： Rolf Guenther , Leif Brand , Christian Eggeling , Karsten Gall , Claus Seidel
发明人： Rolf Guenther , Leif Brand , Christian Eggeling , Karsten Gall , Claus Seidel
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A device for the measurement of chemical and/or biological samples, in particular by means of luminescence spectroscopy, comprises an irradiation unit, a sample receiver, at least one optical unit and a detector unit. The color marker in the sample, which contains at least one color marker, is stimulated by irradiation into producing luminescence and gives off light. The light emitted by the color markers is detected by detectors in the detector unit. According to the invention, the measurement results may be improved by the irradiation unit generating pulsed irradiation. The irradiation unit is thus preferably controlled by a control unit in such a way that the irradiation pulses impinge on the sample in a temporal sequence.
摘要翻译：用于测量化学和/或生物样品，特别是通过发光光谱测量的装置包括照射单元，样品接收器，至少一个光学单元和检测器单元。包含至少一种颜色标记的样品中的颜色标记物被照射刺激以产生发光并发光。由颜色标记发出的光由检测器单元中的检测器检测。根据本发明，可以通过产生脉冲照射的照射单元改善测量结果。因此，照射单元优选地由控制单元控制，使得照射脉冲以时间顺序照射在样品上。

6. 发明申请

US20110160083A1 HIGH SPATIAL RESOLUTION IMAGING OF A STRUCTURE OF INTEREST IN A SPECIMEN 有权
标题翻译：一个样本中利益结构的高空间分辨率成像
公开(公告)号：US20110160083A1
公开(公告)日：2011-06-30
申请号：US13013359
申请日：2011-01-25
申请人： Stefan Hell , Christian Eggeling , Alexander Egner , Jonas Fölling , Andreas Schönle , Mariano Bossi
发明人： Stefan Hell , Christian Eggeling , Alexander Egner , Jonas Fölling , Andreas Schönle , Mariano Bossi
IPC分类号： C40B30/04 , C40B30/10
CPC分类号： G01N21/6458 , G01N21/6428 , G02B21/16 , G02B21/367 , G02B27/58
摘要： For imaging of a structure, the structure is marked with a substance which can be converted by a switching signal from a first into a second state, and which provides an optical measurement signal in one of its states, only. The switching signal is applied such that at least 10% of the molecules of the substance being in the measurement signal providing state are at a distance from their closest neighbors, which is greater than the spatial resolution limit of imaging the specimen onto a sensor array, which in turn is greater than an average distance between the molecules of the substance. From an intensity distribution of the measurement signal recorded with the sensor array, the position is only determined for those molecules of the substance which are at a distance from their closest neighboring molecules in the measurement signal providing state, which is greater than the spatial resolution limit.
摘要翻译：对于结构的成像，结构用可以通过开关信号从第一状态转换为第二状态并且仅在其状态之一提供光学测量信号的物质标记。施加开关信号，使得处于测量信号提供状态的物质的至少10％的分子距离它们最近的邻近物一个距离，其大于将样本成像到传感器阵列上的空间分辨率极限，其又大于物质分子之间的平均距离。根据记录有传感器阵列的测量信号的强度分布，该位置仅对于在测量信号提供状态中离它们最近的相邻分子一定距离的物质的那些分子确定，其大于空间分辨率极限。

7. 发明授权

US07719679B2 Method and device for optically measuring a sample 失效
标题翻译：用于光学测量样品的方法和装置
公开(公告)号：US07719679B2
公开(公告)日：2010-05-18
申请号：US11955793
申请日：2007-12-13
申请人： Stefan Hell , Christian Eggeling , Gerald Donnert
发明人： Stefan Hell , Christian Eggeling , Gerald Donnert
IPC分类号： G01N21/64
CPC分类号： G01N21/6458
摘要： The inventive method for optically measuring a sample consists in temporarily repeatedly transmitting an electromagnetic signal (2) to the sample in such a way that a substance contained in the sample is transferred from a first electronic state (1) into a second electronic state (3), wherein at least one part of said substance in the second state (3) emits photons which are used for carrying out the optical measurement of the sample, the signal (2) is transmitted to the same sample area at a certain repetition interval and said repetition interval of the signal (2) is adjusted with a lifetime of the second state (3) of the substance having an order of magnitude of 1 ns on a value of at least 0.1 μs which is optimized with respect to photon yield from the substance.
摘要翻译：用于光学测量样品的本发明的方法在于将样品中包含的物质从第一电子状态（1）转移到第二电子状态（3）的方式临时重复地将电磁信号（2）发送到样品），其中在第二状态（3）中的所述物质的至少一部分发射用于进行样品的光学测量的光子，所述信号（2）以一定的重复间隔传输到相同的样品区域，所述信号（2）的所述重复间隔在具有1ns量级的物质的第二状态（3）的寿命的至少0.1μs的值上被调整，所述寿命针对来自物质。

8. 发明申请

US20120135459A1 NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES 有权
标题翻译：新型荧光罗丹明作为标示和成像技术的可光化荧光染料
公开(公告)号：US20120135459A1
公开(公告)日：2012-05-31
申请号：US13380148
申请日：2009-06-26
申请人： Stefan W. Hell , Vladimir N. Belov , Gyuzel Mitronova , Mariano Bossi , Gael Moneron , Christian A. Wurm , Stefan Jakobs , Christian Eggeling , Jakob Bierwagen , Lars Meyer
发明人： Stefan W. Hell , Vladimir N. Belov , Gyuzel Mitronova , Mariano Bossi , Gael Moneron , Christian A. Wurm , Stefan Jakobs , Christian Eggeling , Jakob Bierwagen , Lars Meyer
IPC分类号： G01N21/64 , C07K17/02 , C07H21/04 , C07D493/10
CPC分类号： C07D311/82 , A61K49/0041 , A61K49/0058 , C07K1/13 , C09B11/24 , G01N33/582
摘要： The present invention relates to novel fluorinated 3,6-diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and fluorescence correlation spectroscopy. The claimed compounds are also useful as molecular probes in various spectroscopic applications.
摘要翻译：本发明涉及衍生自基本结构式（I）的新型氟化3,6-二氨基呫吨化合物及其作为光稳定荧光染料的用途。用于免疫染色和光谱和微观应用，特别是在常规显微镜，受激发射耗尽（STED）可逆饱和光学线性荧光转换（RESOLFT）显微镜和荧光相关光谱学中。所要求保护的化合物也可用作各种光谱应用中的分子探针。

9. 发明申请

US20120100559A1 NOVEL HYDROPHILIC AND LIPOPHILIC RHODAMINES FOR LABELLING AND IMAGING 有权
标题翻译：用于标签和成像的新型水解和液体罗丹明
公开(公告)号：US20120100559A1
公开(公告)日：2012-04-26
申请号：US13266775
申请日：2010-04-26
申请人： Stefan Hell , Vladimir N. Belov , Kirill Kolmakov , Volker Westphal , Marcel Lauterbach , Stefan Jakobs , Christian Wurm , Christian Eggeling , Christian Ringemann
发明人： Stefan Hell , Vladimir N. Belov , Kirill Kolmakov , Volker Westphal , Marcel Lauterbach , Stefan Jakobs , Christian Wurm , Christian Eggeling , Christian Ringemann
IPC分类号： G01N33/567 , C07D491/22 , C07H21/00 , C12Q1/02 , C07H1/00
CPC分类号： C07D491/22 , C09B11/24 , G01N33/582
摘要： The invention relates to novel and improved photostable rhodamine dyes of the general structural formulae I or II and their uses as fluorescent markers, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional and stimulated emission depletion (STED) microscopy and fluorescence correlation spectroscopy. The partially deuterated analogues are useful as molecular mass distribution tags in mass spectroscopic applications. wherein R1=an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group; R2═H, an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group, or an unsubstituted or substituted aryl group or heteroaryl group, or any combination of such groups; X═CH2, C═O, C═NORa, C═NNRaNRb, CH(ORa), O, S, SO, SO2, or any other derivatives of these groups, with Ra and Rb independently being H or an organic residue, in particular an unsubstituted or substituted (cyclo) alkyl group or heterocycloalkyl group, an unsubstituted or substituted aryl group or heteroaryl group; Z=a negatively charged group with 1, 2, 3, 4 or 5 charges per anion.
摘要翻译：本发明涉及通用结构式I或II的新型和改进的光稳定罗丹明染料及其作为荧光标记物的用途。用于免疫染色和光谱和微观应用，特别是在常规和受激发射耗尽（STED）显微镜和荧光相关光谱学中。部分氘代类似物可用作质谱分析应用中的分子量分布标签。其中R1 =未取代或取代的烷基，包括环烷基或杂环烷基; R 2 = H，未取代或取代的烷基，包括环烷基或杂环烷基，或未取代或取代的芳基或杂芳基，或这些基团的任何组合; X = CH 2，C = O，C = NOR a，C = NR N R a R b，CH（OR a），O，S，SO，SO 2或这些基团的任何其它衍生物，其中Ra和Rb独立地为H或有机残基特别是未取代或取代的（环）烷基或杂环烷基，未取代或取代的芳基或杂芳基; Z =带负电荷的基团，每个阴离子具有1,2,3,4或5个电荷。

10. 发明申请

US20070047287A1 Method and apparatus for storing a three-dimensional arrangement of data bits in a solid-state body 审中-公开
标题翻译：用于在固体中存储数据位的三维排列的方法和装置
公开(公告)号：US20070047287A1
公开(公告)日：2007-03-01
申请号：US11510194
申请日：2006-08-25
申请人： Stefan Hell , Stefan Jakobs , Martin Andresen , Andre-C Stiel , Christian Eggeling
发明人： Stefan Hell , Stefan Jakobs , Martin Andresen , Andre-C Stiel , Christian Eggeling
IPC分类号： G11C11/00
CPC分类号： G11B7/0045 , B82Y10/00 , G11B7/244 , G11B7/246 , G11B2007/0009 , G11B2007/24624
摘要： A method which serves for writing a three-dimensional arrangement of data bits to a solid-state body comprises the steps of selecting a protein having fluorescence properties that can be altered by means of an optical write signal; providing the solid-state body made from the protein, the protein being present in the solid-state body in crystalline form; setting a spatial distribution which corresponds to the three-dimensional arrangement of data bits of the fluorescence properties of the protein of the solid-state body by means of the optical write signal.
摘要翻译：用于将数据位的三维排列写入固态体的方法包括以下步骤：选择具有可通过光写入信号改变的荧光特性的蛋白质; 提供由蛋白质制成的固态体，该蛋白质以结晶形式存在于固态体中; 通过光写入信号设置与固体物质的蛋白质的荧光特性的数据位的三维排列相对应的空间分布。

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