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1. 发明申请

US20080088839A1 Method and Device for Optically Measuring a Sample 失效
标题翻译：用于光学测量样品的方法和装置
公开(公告)号：US20080088839A1
公开(公告)日：2008-04-17
申请号：US11955793
申请日：2007-12-13
申请人： Stefan Hell , Christian Eggeling , Gerald Donnert
发明人： Stefan Hell , Christian Eggeling , Gerald Donnert
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G01N21/6458
摘要： The inventive method for optically measuring a sample consists in temporarily repeatedly transmitting an electromagnetic signal (2) to the sample in such a way that a substance contained in the sample is transferred from a first electronic state (1) into a second electronic state (3), wherein at least one part of said substance in the second state (3) emits photons which are used for carrying out the optical measurement of the sample, the signal (2) is transmitted to the same sample area at a certain repetition interval and said repetition interval of the signal (2) is adjusted with a lifetime of the second state (3) of the substance having an order of magnitude of 1 ns on a value of at least 0.1 μs which is optimized with respect to photon yield from the substance.
摘要翻译：用于光学测量样品的本发明的方法在于将样品中包含的物质从第一电子状态（1）转移到第二电子状态（3）的方式临时重复地将电磁信号（2）发送到样品），其中在第二状态（3）中的所述物质的至少一部分发射用于进行样品的光学测量的光子，所述信号（2）以一定的重复间隔传输到相同的样品区域，所述信号（2）的所述重复间隔在具有1ns量级的物质的第二状态（3）的寿命的情况下调整为至少0.1μA的值，其相对于来自物质。

2. 发明授权

US07719679B2 Method and device for optically measuring a sample 失效
标题翻译：用于光学测量样品的方法和装置
公开(公告)号：US07719679B2
公开(公告)日：2010-05-18
申请号：US11955793
申请日：2007-12-13
申请人： Stefan Hell , Christian Eggeling , Gerald Donnert
发明人： Stefan Hell , Christian Eggeling , Gerald Donnert
IPC分类号： G01N21/64
CPC分类号： G01N21/6458
摘要： The inventive method for optically measuring a sample consists in temporarily repeatedly transmitting an electromagnetic signal (2) to the sample in such a way that a substance contained in the sample is transferred from a first electronic state (1) into a second electronic state (3), wherein at least one part of said substance in the second state (3) emits photons which are used for carrying out the optical measurement of the sample, the signal (2) is transmitted to the same sample area at a certain repetition interval and said repetition interval of the signal (2) is adjusted with a lifetime of the second state (3) of the substance having an order of magnitude of 1 ns on a value of at least 0.1 μs which is optimized with respect to photon yield from the substance.
摘要翻译：用于光学测量样品的本发明的方法在于将样品中包含的物质从第一电子状态（1）转移到第二电子状态（3）的方式临时重复地将电磁信号（2）发送到样品），其中在第二状态（3）中的所述物质的至少一部分发射用于进行样品的光学测量的光子，所述信号（2）以一定的重复间隔传输到相同的样品区域，所述信号（2）的所述重复间隔在具有1ns量级的物质的第二状态（3）的寿命的至少0.1μs的值上被调整，所述寿命针对来自物质。

3. 发明申请

US20140220588A1 FLUORESCENT DYES WITH PHOSPHORYLATED HYDROXYMETHYL GROUPS AND THEIR USE IN LIGHT MICROSCOPY AND IMAGING TECHNIQUES 有权
标题翻译：荧光染料与羟基甲基纤维素组合及其在光学显微镜和成像技术中的应用
公开(公告)号：US20140220588A1
公开(公告)日：2014-08-07
申请号：US13702252
申请日：2011-10-18
申请人： Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Bueckers , Katrin Willig
发明人： Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Bueckers , Katrin Willig
IPC分类号： G01N33/52
CPC分类号： G01N33/52 , C09B11/24 , C09B57/02 , C09B57/10 , G01N33/533 , G01N33/582 , G01N2458/00
摘要： The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. The fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae I-III: wherein W=OP(O) Y1Y2 or P(O) Y1Y2, where Y1 and Y2 independently denote any of the following residues: OH, O(−), ORa and ORb, NHRa and NHRb, NRaRb and NRcRd, ORa and NHRb, ORa and NRbRc, NHRa and NRbRc; and any salt thereof.
摘要翻译：本发明涉及具有磷酸化羟甲基的新型荧光染料，其制备方法以及其在成像技术中的应用。荧光染料是具有以下通式I-III之一的香豆素，罗丹明或BODIPY染料：其中W = OP（O）Y1Y2或P（O）Y1Y2，其中Y1和Y2独立地表示以下任何残基：OH ，O（ - ），ORa和ORb，NHRa和NHRb，NRaRb和NRcRd，ORa和NHRb，ORa和NRbRc，NHRa和NRbRc; 及其任何盐。

4. 发明授权

US09164086B2 Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques 有权
标题翻译：具有磷酸化羟甲基的荧光染料及其在光学显微镜和成像技术中的应用
公开(公告)号：US09164086B2
公开(公告)日：2015-10-20
申请号：US13702252
申请日：2011-10-18
申请人： Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Wildanger , Katrin Willig
发明人： Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Wildanger , Katrin Willig
IPC分类号： C09B57/02 , G01N33/52 , C09B11/24 , C09B57/10 , G01N33/58 , G01N33/533
CPC分类号： G01N33/52 , C09B11/24 , C09B57/02 , C09B57/10 , G01N33/533 , G01N33/582 , G01N2458/00
摘要： The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. The fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae I-III: wherein W=OP(O)Y1Y2 or P(O)Y1Y2, where Y1 and Y2 independently denote any of the following residues: OH, O(−), ORa and ORb, NHRa and NHRb, NRaRb and NRcRd, ORa and NHRb, ORa and NRbRc, NHRa and NRbRc; and any salt thereof.
摘要翻译：本发明涉及具有磷酸化羟甲基的新型荧光染料，其制备方法以及其在成像技术中的应用。荧光染料是具有以下通式I-III之一的香豆素，罗丹明或BODIPY染料：其中W = OP（O）Y1Y2或P（O）Y1Y2，其中Y1和Y2独立地表示以下任何残基：OH ，O（ - ），ORa和ORb，NHRa和NHRb，NRaRb和NRcRd，ORa和NHRb，ORa和NRbRc，NHRa和NRbRc; 及其任何盐。

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