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1. 发明授权

US4983584A Therapeutic and prophylactic agents for peptic ulcers 失效
标题翻译：消化性溃疡的治疗和预防剂
公开(公告)号：US4983584A
公开(公告)日：1991-01-08
申请号：US124139
申请日：1987-11-23
申请人： Chikara Fukaya , Hitoshi Yasuda , Toshiaki Akira , Masakazu Iwai , Kanemichi Okano , Kazumasa Yokoyama
发明人： Chikara Fukaya , Hitoshi Yasuda , Toshiaki Akira , Masakazu Iwai , Kanemichi Okano , Kazumasa Yokoyama
IPC分类号： A61K31/045 , A61K31/075 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/70 , C07C47/192 , C07C47/198 , C07C49/11 , C07C49/172 , C07C49/175 , C07C49/497 , C07C49/517
CPC分类号： A61K31/7004 , A61K31/045 , A61K31/075 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/70 , C07C47/192 , C07C47/198 , C07C49/11 , C07C49/172 , C07C49/175 , C07C49/497 , C07C49/517 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers comprising as an effective ingredient a cyclohexane derivative represented by general formula (I): ##STR1## wherein A represents a group shown by formula, >CH.sub.2, ##STR2## wherein X represents ethynylene, vinylene or ethylene, Y represents oxo or a hydroxy group; R.sup.1, R.sup.3, R.sup.4 and R.sup.5 each represents a hydrogen atom or alkyl; R.sup.2 represents a hydrogen atom, alkyl or a group shown by --OR.sup.8 ;R.sup.6 represents a hydrogen atom, oxo or a group shown by --OR.sup.8 ; and R.sup.7 represents a hydrogen atom or a group shown by --OR.sup.8, wherein R.sup.8 represents a hydrogen atom or an organic residue.

2. 发明授权

US5053498A Therapeutic and prophylactic agents for peptic ulcer 失效
标题翻译： PEPTIC ULCER的治疗和预防药物
公开(公告)号：US5053498A
公开(公告)日：1991-10-01
申请号：US421917
申请日：1989-10-16
申请人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
发明人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
IPC分类号： A61K31/12 , A61K31/70 , A61K36/54 , C07C49/242 , C07C49/255 , C07C49/647 , C07C49/743 , C07H15/18 , C07H15/203 , C07H15/207
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07H15/18 , C07H15/203 , C07C2101/16 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or .dbd.O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.5 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A);.dbd.C.dbd.CH--COR.sub.8 (A)or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5, R.sub.4 represents OR.sub.7 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or and a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

3. 发明授权

US4888417A Therapeutic and prophylactic agents for peptic ulcer 失效
标题翻译：消化性溃疡的治疗和预防剂
公开(公告)号：US4888417A
公开(公告)日：1989-12-19
申请号：US867169
申请日：1986-05-27
申请人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
发明人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
IPC分类号： A61K31/12 , A61K31/70 , A61K36/54 , C07C49/242 , C07C49/255 , C07C49/647 , C07C49/743 , C07H15/18 , C07H15/203 , C07H15/207
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07H15/18 , C07H15/203 , C07C2101/16 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A):.dbd.C.dbd.CH--COR.sub.8 (A) or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5 ; R.sub.4 represents OR.sub.7 and the bond between the carbon atoms to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
摘要翻译：含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R4代表-OR7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R1和R3都表示氢，R2表示-OR5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，则R 1表示= O，R 2表示氢，R 3表示 -OR 6和X所连接的碳原子和与R 4连接的碳原子之间的键是双键，或其药学上可接受的盐或通式（II）的化合物：（ II）其中R 11表示氢或有机残基，R 12，R 13和R 14各自表示有机残基或其药学上可接受的盐。通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。

4. 发明授权

US4983723A Cycloalkane derivatives 失效
标题翻译：环烷烃衍生物
公开(公告)号：US4983723A
公开(公告)日：1991-01-08
申请号：US129217
申请日：1987-12-07
申请人： Hitoshi Yasuda , Chikara Fukaya , Kanemichi Okano , Kazumasa Yokoyama
发明人： Hitoshi Yasuda , Chikara Fukaya , Kanemichi Okano , Kazumasa Yokoyama
IPC分类号： A61K31/12 , C07C35/06 , C07C35/17 , C07C45/29 , C07C45/68 , C07C49/21 , C07C49/707 , C07C49/713 , A61K31/00 , C07C13/00
CPC分类号： C07C49/21 , C07C35/06 , C07C35/17 , C07C403/08 , C07C403/16 , C07C45/298 , C07C45/68 , C07C2101/14 , C07C2101/16 , Y10S514/927
摘要： A cycloalkane derivative represented by the formula (I): ##STR1## wherein A, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Z, and n are as defined in the specification. The compounds of formula (I) exhibit activities against peptic ulcers and are useful as therapeutic and prophylactic agents for peptic ulcers.
摘要翻译：由式（I）表示的环烷烃衍生物：其中A，R2，R3，R4，R5，R6，R7，Z和n如说明书中所定义。式（I）化合物显示针对消化性溃疡的活性，并且可用作消化性溃疡的治疗和预防剂。

5. 发明授权

US4916130A Platelet agglutination-inhibiting agent 失效
标题翻译：血小板凝集抑制剂
公开(公告)号：US4916130A
公开(公告)日：1990-04-10
申请号：US241447
申请日：1988-09-08
申请人： Masakazu Iwai , Chikara Fukaya , Kazumasa Yokoyama
发明人： Masakazu Iwai , Chikara Fukaya , Kazumasa Yokoyama
IPC分类号： A61K31/16
CPC分类号： A61K31/16
摘要： An antithrombotic composition containing an amide derivative which is obtained by binding a sulfur-containing amine to an unsaturated fatty acid having 4 to 13 carbon atoms through an amide bond and which exerts a high platelet agglutination-inhibiting effect.

6. 发明授权

US4933329A Bis-S-alkylbenzene derivatives 失效
标题翻译：双-S-烷基苯衍生物
公开(公告)号：US4933329A
公开(公告)日：1990-06-12
申请号：US280402
申请日：1988-12-06
申请人： Youichiro Naito , Yasunari Yamaura , Masanori Sugiura , Chikara Fukaya , Kazumasa Yokoyama
发明人： Youichiro Naito , Yasunari Yamaura , Masanori Sugiura , Chikara Fukaya , Kazumasa Yokoyama
IPC分类号： A61K31/10 , A61K31/22 , A61K31/27 , A61K31/325 , A61K31/495 , A61K31/66 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P19/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/20 , C07D295/08 , C07D295/096 , C07F9/09 , C07F9/12
CPC分类号： C07D295/096 , A61K31/10 , C07C323/00 , C07C323/20 , C07F9/12 , Y10S514/826
摘要： Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various diseases, including allergic diseases such as asthma, inflammation, myocardial infarction, nephritis, scabies and gout.

7. 发明授权

US4604385A Perfluoro-1-azatricyclic amine compounds useful as oxygen carriers in artificial blood and infusion fluids 失效
公开(公告)号：US4604385A
公开(公告)日：1986-08-05
申请号：US751851
申请日：1985-07-05
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , A61K31/395 , A61K31/55
CPC分类号： A61K9/0026 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , Y10S514/832 , Y10S514/833
摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

8. 发明授权

US4599343A Perfluoroindolizines and emulsions thereof useful as blood substitutes 失效
标题翻译：全氟吲哚及其乳液可用作血液代用品
公开(公告)号：US4599343A
公开(公告)日：1986-07-08
申请号：US670969
申请日：1984-11-13
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08 , A61K31/40
CPC分类号： A61K9/0026 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08
摘要： A perfluorobicyclo compound of the general formula: ##STR1## wherein either or both of Ring A and Ring B may optionally be substituted with lower perfluoroalkyl group(s) and m and n each represent 3 or 4.
摘要翻译：一种具有下列通式的全氟二环化合物：其中环A和环B中的任一个或两者可以任选地被低级全氟烷基取代，m和n各自表示3或4。

9. 发明授权

US4596810A Emulsions of perfluoro octahydro quinolizines useful as blood substitutes 失效
标题翻译：用作血液代用品的全氟八氢喹嗪的乳液
公开(公告)号：US4596810A
公开(公告)日：1986-06-24
申请号：US670970
申请日：1984-11-13
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08 , C07D455/00 , A61K31/435
CPC分类号： A61K9/0026 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08
摘要： A perfluorobicyclo compound of the general formula: ##STR1## wherein either or both of Ring A and Ring B may optionally be substituted with lower perfluoroalkyl group(s) and m and n each represent 3 or 4.
摘要翻译：一种具有下列通式的全氟二环化合物：其中环A和环B中的任一个或两者可以任选地被低级全氟烷基取代，m和n各自表示3或4。

10. 发明授权

US4535085A Perfluorotricyclic amines as oxygen carriers 失效
标题翻译：全氟三环胺作为氧载体
公开(公告)号：US4535085A
公开(公告)日：1985-08-13
申请号：US480131
申请日：1983-03-29
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： C07D209/58 , C07D209/72 , C07D221/22 , A61K31/445 , A61K31/40 , C07D221/16
CPC分类号： C07D209/58 , C07D209/72 , C07D221/22
摘要： A perfluorotricyclic amine compound which is usable as an oxygen carrier in an artificial blood, represented by the general formula ##STR1## wherein R denotes a perfluoroalkyl group having 1-4 carbon atoms; the ring A denotes a five- or six-membered ring, the ring B denotes a five-, six- or seven-membered ring, the ring C denotes a five- or six-membered ring any one of the rings A, B and C optionary being substituted by one or more lower perfluoroalkyl group in addition to the above-mentioned substituent R; and further f, g, h, i, j and k denote integers appropriately selected to construct the above-mentioned size of rings A, B, and C; is prepared by reacting the corresponding perhydrotricyclic amine with fluorine.
摘要翻译：一种全氟三环胺化合物，其可用作人造血液中的氧载体，由通式表示，其中R表示具有1-4个碳原子的全氟烷基; 环A表示五元或六元环，环B表示五元，六元或七元环，环C表示环A，B和除了上述取代基R外，C选自被一个或多个低级全氟烷基取代; 并且f，g，h，i，j和k表示适当选择以构成环A，B和C的上述尺寸的整数; 通过使相应的全氢三环胺与氟反应来制备。

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