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1. 发明授权

US4983584A Therapeutic and prophylactic agents for peptic ulcers 失效
标题翻译：消化性溃疡的治疗和预防剂
公开(公告)号：US4983584A
公开(公告)日：1991-01-08
申请号：US124139
申请日：1987-11-23
申请人： Chikara Fukaya , Hitoshi Yasuda , Toshiaki Akira , Masakazu Iwai , Kanemichi Okano , Kazumasa Yokoyama
发明人： Chikara Fukaya , Hitoshi Yasuda , Toshiaki Akira , Masakazu Iwai , Kanemichi Okano , Kazumasa Yokoyama
IPC分类号： A61K31/045 , A61K31/075 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/70 , C07C47/192 , C07C47/198 , C07C49/11 , C07C49/172 , C07C49/175 , C07C49/497 , C07C49/517
CPC分类号： A61K31/7004 , A61K31/045 , A61K31/075 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/70 , C07C47/192 , C07C47/198 , C07C49/11 , C07C49/172 , C07C49/175 , C07C49/497 , C07C49/517 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers comprising as an effective ingredient a cyclohexane derivative represented by general formula (I): ##STR1## wherein A represents a group shown by formula, >CH.sub.2, ##STR2## wherein X represents ethynylene, vinylene or ethylene, Y represents oxo or a hydroxy group; R.sup.1, R.sup.3, R.sup.4 and R.sup.5 each represents a hydrogen atom or alkyl; R.sup.2 represents a hydrogen atom, alkyl or a group shown by --OR.sup.8 ;R.sup.6 represents a hydrogen atom, oxo or a group shown by --OR.sup.8 ; and R.sup.7 represents a hydrogen atom or a group shown by --OR.sup.8, wherein R.sup.8 represents a hydrogen atom or an organic residue.

2. 发明授权

US4888417A Therapeutic and prophylactic agents for peptic ulcer 失效
标题翻译：消化性溃疡的治疗和预防剂
公开(公告)号：US4888417A
公开(公告)日：1989-12-19
申请号：US867169
申请日：1986-05-27
申请人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
发明人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
IPC分类号： A61K31/12 , A61K31/70 , A61K36/54 , C07C49/242 , C07C49/255 , C07C49/647 , C07C49/743 , C07H15/18 , C07H15/203 , C07H15/207
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07H15/18 , C07H15/203 , C07C2101/16 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A):.dbd.C.dbd.CH--COR.sub.8 (A) or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5 ; R.sub.4 represents OR.sub.7 and the bond between the carbon atoms to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
摘要翻译：含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R4代表-OR7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R1和R3都表示氢，R2表示-OR5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，则R 1表示= O，R 2表示氢，R 3表示 -OR 6和X所连接的碳原子和与R 4连接的碳原子之间的键是双键，或其药学上可接受的盐或通式（II）的化合物：（ II）其中R 11表示氢或有机残基，R 12，R 13和R 14各自表示有机残基或其药学上可接受的盐。通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。

3. 发明授权

US4748157A Composition for gastrointestinal ulcers 失效
标题翻译：胃肠溃疡的成分
公开(公告)号：US4748157A
公开(公告)日：1988-05-31
申请号：US827209
申请日：1986-02-04
申请人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
发明人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
IPC分类号： A61K38/00 , C07K16/18 , A61K37/00 , C07G7/00
CPC分类号： C07K16/18 , A61K38/00 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/929 , Y10S530/866
摘要： Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other group. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.
摘要翻译：通过人IgG的酶消化可获得的人IgG的Fab或Fc片段被还原剂还原，以切断其中二硫键的链间，然后封闭由可能含有其它基团的烷基形成的SH自由基。所得到的烷基化Fab和Fc片段通过口服或肠胃外给药显示对胃肠溃疡的治疗和预防作用。

4. 发明授权

US4186253A Perfusate for preserving organ to be transplanted and preserving method 失效
标题翻译：用于保存器官的移植和保存方法
公开(公告)号：US4186253A
公开(公告)日：1980-01-29
申请号：US950071
申请日：1978-10-10
申请人： Kazumasa Yokoyama , Masakazu Iwai , Hiroyuki Okamoto , Noboru Yamada
发明人： Kazumasa Yokoyama , Masakazu Iwai , Hiroyuki Okamoto , Noboru Yamada
IPC分类号： A01N1/00 , A01N1/02 , C12B3/00 , A61K31/025
CPC分类号： A01N1/02 , A01N1/0226
摘要： An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.
摘要翻译：通过使用通过将通过增加钾离子修饰的林格氏溶液混合至8-20meq / l而制成的灌注液，可以通过灌注相当长的时间来有效地保存要移植的器官，例如肾脏，稳定的全氟化碳化合物乳液和白蛋白，使得全氟化碳化合物的浓度为7.5至12.5％（W / V），而白蛋白的浓度为基于灌注液的1-8％（W / V）。

5. 发明授权

US4916130A Platelet agglutination-inhibiting agent 失效
标题翻译：血小板凝集抑制剂
公开(公告)号：US4916130A
公开(公告)日：1990-04-10
申请号：US241447
申请日：1988-09-08
申请人： Masakazu Iwai , Chikara Fukaya , Kazumasa Yokoyama
发明人： Masakazu Iwai , Chikara Fukaya , Kazumasa Yokoyama
IPC分类号： A61K31/16
CPC分类号： A61K31/16
摘要： An antithrombotic composition containing an amide derivative which is obtained by binding a sulfur-containing amine to an unsaturated fatty acid having 4 to 13 carbon atoms through an amide bond and which exerts a high platelet agglutination-inhibiting effect.

6. 发明授权

US4849404A Therapeutic and prophylactic agent for gastrointestinal ulcers 失效
标题翻译：胃肠溃疡的治疗和预防剂
公开(公告)号：US4849404A
公开(公告)日：1989-07-18
申请号：US163732
申请日：1988-03-03
申请人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
发明人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
IPC分类号： A61K38/00 , C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/929 , Y10S530/866
摘要： Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other groups. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.

7. 发明授权

US5264681A Ceramic heater 失效
标题翻译：陶瓷加热器
公开(公告)号：US5264681A
公开(公告)日：1993-11-23
申请号：US832315
申请日：1992-02-07
申请人： Shunkichi Nozaki , Yasuhiko Suzuki , Kazuho Tatematsu , Masakazu Iwai , Kiminori Horiki
发明人： Shunkichi Nozaki , Yasuhiko Suzuki , Kazuho Tatematsu , Masakazu Iwai , Kiminori Horiki
IPC分类号： F23Q7/22 , H05B3/12 , H05B3/28 , H05B3/44 , H05B3/10 , H05B3/50
CPC分类号： H05B3/283 , F23Q7/22 , H05B3/12
摘要： The invention relates to a ceramic heater for use, e.g., as a glow plug for a diesel engine or as an igniter for an oil or gas burner. The ceramic heater has a nonoxide ceramic body having a heating part and a supporting part and a heating resistor embedded in the heating part of the ceramic body. The material of the heating resistor is W, WC, tungsten alloy or a metal nitride such as TiN or TaN. According to the invention the heating part of the ceramic body is formed of aluminum nitride ceramic, which is high in heat conductivity and resistant to oxidation at high temperatures, at least in a core region in contact with the heating resistor, and the supporting part is formed of silicon nitride ceramic which is low in heat conductivity at least in a surface region. The ceramic body is made by uniting a heating part entirely formed of aluminum nitride ceramic and a supporting part entirely formed of silicon nitride ceramic with interposal of a joint part which is formed of mixed ceramic of aluminum nitride and silicon nitride with a gradient of the proportion of aluminum nitride to silicon nitride, or by thoroughly covering a core formed of aluminum nitride ceramic with silicon nitride ceramic.
摘要翻译：本发明涉及一种陶瓷加热器，其用于例如用作柴油发动机的电热塞或用作油或燃气燃烧器的点火器。陶瓷加热器具有非氧化物陶瓷体，其具有加热部分和支撑部分以及嵌入陶瓷体的加热部分中的加热电阻器。加热电阻体的材料为W，WC，钨合金或TiN，TaN等金属氮化物。根据本发明，陶瓷体的加热部分由氮化铝陶瓷形成，该氮化铝陶瓷至少在与加热电阻器接触的芯区域中具有高导热性和耐高温氧化性，并且支撑部分是由至少在表面区域中导热性低的氮化硅陶瓷形成。陶瓷体通过将由氮化铝陶瓷完全形成的加热部分和由氮化硅陶瓷整体形成的支撑部分结合在一起，该接合部分由氮化铝和氮化硅的混合陶瓷形成的接合部分以比例的梯度的氮化铝到氮化硅，或者通过用氮化硅陶瓷充分覆盖由氮化铝陶瓷形成的芯。

8. 发明授权

US5053498A Therapeutic and prophylactic agents for peptic ulcer 失效
标题翻译： PEPTIC ULCER的治疗和预防药物
公开(公告)号：US5053498A
公开(公告)日：1991-10-01
申请号：US421917
申请日：1989-10-16
申请人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
发明人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
IPC分类号： A61K31/12 , A61K31/70 , A61K36/54 , C07C49/242 , C07C49/255 , C07C49/647 , C07C49/743 , C07H15/18 , C07H15/203 , C07H15/207
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07H15/18 , C07H15/203 , C07C2101/16 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or .dbd.O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.5 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A);.dbd.C.dbd.CH--COR.sub.8 (A)or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5, R.sub.4 represents OR.sub.7 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or and a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

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