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1. 发明授权

US4613605A Perfluoro-1-azatricyclic amines as blood substitutes 失效
标题翻译：全氟-1-氮杂环胺作为血液代用品
公开(公告)号：US4613605A
公开(公告)日：1986-09-23
申请号：US751948
申请日：1985-07-05
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , A61K31/445 , C07D453/00
CPC分类号： A61K9/0026 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , Y10S514/832 , Y10S514/833
摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

2. 发明授权

US4605786A Perfluoro ether compound containing perfluorocycloalkyl moiety 失效
标题翻译：含全氟环烷基部分的全氟醚化合物
公开(公告)号：US4605786A
公开(公告)日：1986-08-12
申请号：US563436
申请日：1983-12-20
申请人： Kazumasa Yokoyama , Yoshihisa Inoue , Taizo Ono , Chikara Fukaya , Yoshio Arakawa , Youichiro Naito , Koichi Yamauchi , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Yoshihisa Inoue , Taizo Ono , Chikara Fukaya , Yoshio Arakawa , Youichiro Naito , Koichi Yamauchi , Tadakazu Suyama
IPC分类号： C07C41/00 , C07C43/12 , C07C43/192 , C07C43/313 , C07C67/00 , C25B3/02 , C25B3/08
CPC分类号： C07C43/123 , C07C43/192 , C07C43/313 , Y10S514/832
摘要： A perfluoroether compound having the following formula is useful as a thermostable, inert solvent and inter alia as an oxygen carrier in an artificial blood or infusion fluid. ##STR1## wherein Rf.sub.1 and Rf.sub.2 are different from each other and are selected from the group of a C.sub.1 or C.sub.3 perfluoroalkyl group which may be interrupted by an oxygen atom, and a C.sub.5 -C.sub.7 perfluorocycloalkyl group, and n and n' are zero or an integer of 1; one of Rf.sub.1 and Rf.sub.2 being the C.sub.5 -C.sub.7 perfluorocycloalkyl group and the total number of carbon atoms being 9-11 inclusive.
摘要翻译：具有下式的全氟醚化合物可用作热稳定的惰性溶剂，尤其用作人造血液或输注液中的氧载体。其中Rf1和Rf2彼此不同，并且选自可被氧原子中断的C1或C3全氟烷基和C5-C7全氟环烷基，n和n'为零或整数1; Rf1和Rf2之一是C5-C7全氟环烷基，碳原子总数为9-11（含）。

3. 发明授权

US4591593A Perfluoro compound and emulsion thereof 失效
标题翻译：全氟化合物及其乳液
公开(公告)号：US4591593A
公开(公告)日：1986-05-27
申请号：US442416
申请日：1982-11-17
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Isuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Isuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
IPC分类号： A01N1/02 , A61K9/00 , C07D209/30 , C07D209/44 , C07D209/52 , C07D215/18 , C07D217/22 , C07D221/04 , C25B3/08 , A61K31/47 , A61K31/40 , C07D209/10
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , C07D209/30 , C07D209/44 , C07D209/52 , C07D215/18 , C07D217/22 , C07D221/04 , C25B3/08
摘要： A novel compound of the formula, ##STR1## wherein R denotes a lower perfluoroalkyl group l is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.
摘要翻译：式（1）的新化合物，其中R表示低级全氟烷基1为3或4的整数，n + m为2或3的整数，条件是n可以为0，并且环中的至少一个为环 A和环B可以被通过使相应的全氢化合物与氟反应制备的低级全氟烷基取代，可用作能够在水性乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内脏。

4. 发明授权

US4530926A Perfluorotricyclic amines as oxygen carriers 失效
标题翻译：全氟三环胺作为氧载体
公开(公告)号：US4530926A
公开(公告)日：1985-07-23
申请号：US505324
申请日：1983-06-17
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A01N1/02 , C07D455/03 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , A61K31/55 , A61K31/40 , A61K31/445 , C07D455/06
CPC分类号： C07D455/00 , A01N1/021 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： A novel compound of the formula, ##STR1## wherein k, j, l and m are zero or an integer of from 1 to 3, and n is an integer of from 1 to 3, the rings A, B and C being optionally substituted with at least one trifluoromethyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.
摘要翻译：式（I）的新颖化合物，其中k，j，l和m为0或1〜3的整数，n为1〜3的整数，环A，B，C 任选地被至少一个三氟甲基取代，其通过使相应的全氢化合物与氟反应制备，可用作能够在水乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内脏。

5. 发明授权

US4433360A Tubular ceramic capacitor 失效
标题翻译：管状陶瓷电容器
公开(公告)号：US4433360A
公开(公告)日：1984-02-21
申请号：US313963
申请日：1981-10-22
申请人： Kikuo Wakino , Yoshio Arakawa
发明人： Kikuo Wakino , Yoshio Arakawa
IPC分类号： H01G4/228 , H01G4/12 , H01G4/248 , H01G4/28 , H01G1/01 , H01G1/153
CPC分类号： H01G4/228
摘要： A tubular ceramic capacitor in which a lead terminal for leading out an internal electrode is formed of a Dumet wire, the internal electrode and an external electrode are plated to be formed at the inner and outer surfaces of a tubular ceramic dielectric except for both end faces thereof respectively, the lead terminal of the Dumet wire having a diameter substantially equal to a diameter of an inner bore of the dielectric where the internal electrode is formed and being inserted into the bore substantially throughout the whole length thereof so as to be fixedly soldered, and a metallic cap terminal having an inner diameter substantially equal to an outer diameter of the dielectric and a lead wire projecting from the outer surface of the closed end of the cap terminal, is fitted onto the dielectric in relation of contacting with the external electrode, thereby reducing an amount of solder used for mounting the lead terminal, thus making it possible to prevent the internal electrode from peeling off.
摘要翻译：一种管状陶瓷电容器，其中用于引出内部电极的引线端子由Dumet线形成，内部电极和外部电极被电镀以形成在管状陶瓷电介质的内外表面，除了两个端面 Dumet线的引线端子的直径基本上等于形成有内部电极的电介质的内孔的直径，并且基本上在其整个长度上插入孔中以便被固定地焊接，并且与绝缘体的外径大致相等的内径的金属盖端子和从盖端子的封闭端的外表面突出的引线与外部电极接触地嵌合在电介质上，从而减少用于安装引线端子的焊料的量，从而可以防止内部电极剥离。

6. 发明授权

US07511144B2 Reverse hydroxamic acid derivatives 有权
标题翻译：反向异羟肟酸衍生物
公开(公告)号：US07511144B2
公开(公告)日：2009-03-31
申请号：US10488530
申请日：2002-09-05
申请人： Masanao Shimano , Noriyuki Kamei , Tomohiro Tanaka , Tatsuhiro Harada , Makoto Haino , Akihiko Okuyama , Yoshio Arakawa , Yoshiko Murakami
发明人： Masanao Shimano , Noriyuki Kamei , Tomohiro Tanaka , Tatsuhiro Harada , Makoto Haino , Akihiko Okuyama , Yoshio Arakawa , Yoshiko Murakami
IPC分类号： C07D215/38 , C07D215/44
CPC分类号： C07D409/12 , C07C317/28 , C07C2601/14 , C07D207/20 , C07D211/70 , C07D213/30 , C07D213/42 , C07D215/14 , C07D277/14 , C07D317/72 , C07D319/06 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Ar1 is an arylene or the like; Ar2 is an optionally substituted aryl, a heteroaryl or the like; R1 is a hydrogen atom, an alkyl or the like; R2a is a substituted cycloaryl, a heterocycloaryl or the like) and a general formula (I): (wherein A, Ar1, Ar2, and R1 are the same as defined above and R2 is an hydrogen atom, R2a or the like) and salts thereof, which have TNF-α converting enzyme (TACE) inhibitory activity.
摘要翻译：具有由通式（Ia）表示的具体结构的反式异羟肟酸衍生物：其中A为氢原子等; Ar 1为亚芳基等; Ar 2为任选取代的芳基，杂芳基等; R 1为氢原子，烷基等; R 2a是取代的环芳基，杂环芳基等）和通式（I）：（其中A，Ar1，Ar2和R1与上述相同，R2是氢原子，R 2a等）及其盐，其具有TNF-α转化酶（TACE）抑制活性。

7. 发明授权

US4713459A Perfluoro compounds 失效
标题翻译：全氟化合物
公开(公告)号：US4713459A
公开(公告)日：1987-12-15
申请号：US830094
申请日：1986-02-18
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
IPC分类号： A01N1/02 , A61K9/00 , C07D209/30 , C07D209/44 , C07D209/52 , C07D215/18 , C07D217/22 , C07D221/04 , C25B3/08 , A61K31/47 , A61K31/40 , C07D209/10
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , C07D209/30 , C07D209/44 , C07D209/52 , C07D215/18 , C07D217/22 , C07D221/04 , C25B3/08
摘要： A novel compound of the formula, ##STR1## wherein R denotes a lower perfluoroalkyl group, l is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

8. 发明授权

US4654337A Perfluoro-1-azatricyclic amine compounds useful as blood substitutes or in infusion fluids 失效
标题翻译：全氟-1-氮杂环胺化合物可用作血液代用品或输注液
公开(公告)号：US4654337A
公开(公告)日：1987-03-31
申请号：US751880
申请日：1985-07-05
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , C07D223/00 , A61K31/435
CPC分类号： A61K9/0026 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , Y10S514/832 , Y10S514/833
摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

9. 发明授权

US4591599A Perfluoropyrrolizines and emulsions thereof useful as blood substitutes 失效
标题翻译：全氟吡咯嗪及其乳剂可用作血液代用品
公开(公告)号：US4591599A
公开(公告)日：1986-05-27
申请号：US670971
申请日：1984-11-13
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08 , C07D487/06 , A61K31/40
CPC分类号： A61K9/0026 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08
摘要： A perfluorobicyclo compound of the general formula: ##STR1## wherein either or both of Ring A and Ring B may optionally be substituted with lower perfluoroalkyl group (s) and m and n each represent 3 or 4.
摘要翻译：一种具有下列通式的全氟二环化合物：其中环A和环B中的任一个或两者可以任选地被低级全氟烷基取代，m和n各自表示3或4。

10. 发明授权

US4425347A Perfluorobicyclo compound emulsion preparation 失效
标题翻译：全氟双环化合物乳液制剂
公开(公告)号：US4425347A
公开(公告)日：1984-01-10
申请号：US454105
申请日：1982-12-28
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A01N1/02 , A61K9/10 , A61K31/435 , A61P7/08 , B01F17/14 , C07D455/02
CPC分类号： C07D455/02 , A01N1/021 , A61K31/435 , Y10S514/832
摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: ##STR1## wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.
摘要翻译：一种全氟双环化合物乳液制剂，其具有含有下列通式的全氟二环化合物的氧承载能力：其中R表示全氟甲基或全氟乙基，作为携氧组分。

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