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1. 发明授权

US09272137B2 Transdermal methods and systems for the delivery of anti-migraine compounds 有权
公开(公告)号：US09272137B2
公开(公告)日：2016-03-01
申请号：US13105562
申请日：2011-05-11
申请人： Carter R. Anderson , Russell L. Morris , Terri B. Sebree
发明人： Carter R. Anderson , Russell L. Morris , Terri B. Sebree
IPC分类号： A61N1/30
CPC分类号： A61K9/7038 , A61K31/4045 , A61N1/30
摘要： Iontophoretic patches for the delivery of anti-migraine compounds and methods of using the patches are described.

2. 发明授权

US08475837B2 Abuse potential reduction in abusable substance dosage form 有权
公开(公告)号：US08475837B2
公开(公告)日：2013-07-02
申请号：US12952516
申请日：2010-11-23
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61K9/70
CPC分类号： A62D3/33 , A61J1/00 , A61J1/14 , A61K9/7084 , A61K31/445 , A62D3/00 , A62D2101/26 , B09B3/0075 , B09B2220/14 , B65D25/14
摘要： The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.

3. 发明授权

US08239018B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US08239018B2
公开(公告)日：2012-08-07
申请号：US12868123
申请日：2010-08-25
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.
摘要翻译：用于经皮给药活性治疗物种的离子电渗疗法装置的电极组件具有包含优先吸收（氧化或还原）水的连接导电基材的基层，涂覆在第一上层的牺牲材料基底层的第一部分，其中牺牲材料优先地消耗到基底层的连接导电基底材料。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，第二上层由保留在其间的基层材料的窄暴露的连接区连接。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层将被完全消耗，之后是基底层的暴露的连接区域的连接导电基底材料，其切断基底层，从而破坏器件中的电路连续性失效活动。可以提供视觉指示器，允许佩戴者监视连接区域的反应状态。

4. 发明申请

US20110245755A1 Sacrificial Electrode Design and Delivery Species Suitable for Prolonged Iontophoresis Application Periods 有权
标题翻译：牺牲电极设计和交付物种适用于延长离子渗透应用期
公开(公告)号：US20110245755A1
公开(公告)日：2011-10-06
申请号：US12597941
申请日：2009-08-31
申请人： Kathleen A. Eischen , Carter R. Anderson , Russell L. Morris
发明人： Kathleen A. Eischen , Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation is disclosed that includes a readily oxidizable metal-based sacrificial anode in the form of a generally planar layer having a connecting area that has a width that is sufficient to insure complete consumption of the oxidizable metal wherein the anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions, and a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.
摘要翻译：公开了一种用于从盐制剂中延长递送带正电荷的药物物质的可穿戴离子电渗装置，其包括易于氧化的金属基牺牲阳极，其形式为大致平坦的层，其具有连接区域，该连接区域的宽度足以确保完全消耗可氧化金属，其中阳极被配置为在皮肤安全条件下具有至少6小时的最小使用寿命;以及药物递送凝胶垫，其与所述阳极电接触以容纳含有带正电荷的药物配制用于透皮给药的盐形式的物种。

5. 发明申请

US20090062720A1 Transdermal Methods and Systems for the Delivery of Corticosteroid Compounds 有权
标题翻译：用于皮质类固醇化合物递送的透皮方法和系统
公开(公告)号：US20090062720A1
公开(公告)日：2009-03-05
申请号：US12199051
申请日：2008-08-27
申请人： Carter R. Anderson , Russell L. Morris , Robert Cohen , William V. Fowler
发明人： Carter R. Anderson , Russell L. Morris , Robert Cohen , William V. Fowler
IPC分类号： A61N1/30 , A61K9/70
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/044
摘要： An integrated iontophoresis skin-worn patch and method for delivering a therapeutically effective amount of a corticosteroid drug compound in a systemically-safe and skin-safe manner for site-specific treatment of inflammation pain is disclosed.
摘要翻译：公开了一种用于以系统安全和皮肤安全的方式递送治疗有效量的皮质类固醇药物化合物的综合离子电渗皮肤磨损贴片和方法，用于炎症疼痛的特异性治疗。

6. 发明授权

US07856263B2 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权
标题翻译：用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统
公开(公告)号：US07856263B2
公开(公告)日：2010-12-21
申请号：US11112196
申请日：2005-04-22
申请人： Carter R. Anderson , Walter L. Sembrowich , Russell L. Morris , Robert Cohen
发明人： Carter R. Anderson , Walter L. Sembrowich , Russell L. Morris , Robert Cohen
IPC分类号： A61N1/30 , A61M31/00 , A61F13/00 , A61K9/70
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译：一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量，供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括从由外部信号激活的传感器和开关组成的组中选择的控制元件。

7. 发明授权

US07844327B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US07844327B2
公开(公告)日：2010-11-30
申请号：US10545761
申请日：2003-10-02
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.
摘要翻译：用于经皮给药活性治疗物种的离子电渗装置的电极组件具有包括优先吸收（氧化或还原）于水的连接导电基材的基层，涂覆在第一上层的牺牲材料基底层的第一部分，其中牺牲材料优先地消耗到基底层的连接导电基底材料。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，第二上层由保留在其间的基层材料的窄暴露的连接区连接。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层将被完全消耗，之后是基底层的暴露的连接区域的连接导电基底材料，其切断基底层，从而破坏器件中的电路连续性失效活动。可以提供视觉指示器，允许佩戴者监视连接区域的反应状态。

8. 发明授权

US07031769B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US07031769B2
公开(公告)日：2006-04-18
申请号：US10371532
申请日：2003-02-21
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30 , A61N1/00 , A61N1/04 , A61N1/05 , A61M31/00
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species includes a base layer of conductive material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the conductive material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, a narrow exposed linking area of the base layer material remaining therebetween. The exposed linking area of the base layer extends across the base layer. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be followed by the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity in the device.
摘要翻译：用于经皮给药活性治疗物种的离子电渗疗法装置的电极组件包括优先被消耗（氧化或减少）水的导电材料的基底层，涂覆在第一部分上的第一牺牲材料上层其中牺牲材料优先地消耗到基层的导电材料的基层。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，基层材料残留在其间的窄暴露的连接区域。基底层的暴露的连接区域延伸穿过基底层。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层之后将是基底层的暴露的连接区域，从而破坏器件的电路连续性。

9. 发明授权

US07016723B2 Rate adjustable drug delivery system 有权
公开(公告)号：US07016723B2
公开(公告)日：2006-03-21
申请号：US10162473
申请日：2002-06-03
申请人： Russell L. Morris , Carter R. Anderson
发明人： Russell L. Morris , Carter R. Anderson
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A transdermal iontophoretic therapeutic agent delivery system which is provided with a plurality of self-contained serially connected galvanic sources.

10. 发明授权

US06653014B2 Power sources for iontophoretic drug delivery systems 有权
公开(公告)号：US06653014B2
公开(公告)日：2003-11-25
申请号：US09867949
申请日：2001-05-30
申请人： Carter R. Anderson , Clayton J. Anderson , Lori A. Grace , Russell L. Morris
发明人： Carter R. Anderson , Clayton J. Anderson , Lori A. Grace , Russell L. Morris
IPC分类号： H01M228
CPC分类号： A61N1/30 , H01M6/12 , H01M6/26 , H01M6/30 , H01M6/40 , H01M6/50 , H01M6/5016 , H01M16/00
摘要： The capacity of an electro-chemical power source having an initial amount of an oxidizable material and an initial amount of a reducible material, is adjusted to a target capacity by altering the initial amount of one or both of the oxidizable material and the reducible material available to participate in the source by a technique selected from the group consisting of adding, removing and isolating a known fraction of the initial amount from the power source.

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