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1. 发明授权

US06653014B2 Power sources for iontophoretic drug delivery systems 有权
公开(公告)号：US06653014B2
公开(公告)日：2003-11-25
申请号：US09867949
申请日：2001-05-30
申请人： Carter R. Anderson , Clayton J. Anderson , Lori A. Grace , Russell L. Morris
发明人： Carter R. Anderson , Clayton J. Anderson , Lori A. Grace , Russell L. Morris
IPC分类号： H01M228
CPC分类号： A61N1/30 , H01M6/12 , H01M6/26 , H01M6/30 , H01M6/40 , H01M6/50 , H01M6/5016 , H01M16/00
摘要： The capacity of an electro-chemical power source having an initial amount of an oxidizable material and an initial amount of a reducible material, is adjusted to a target capacity by altering the initial amount of one or both of the oxidizable material and the reducible material available to participate in the source by a technique selected from the group consisting of adding, removing and isolating a known fraction of the initial amount from the power source.

2. 发明授权

US06745071B1 Iontophoretic drug delivery system 有权
标题翻译：离子电渗药物输送系统
公开(公告)号：US06745071B1
公开(公告)日：2004-06-01
申请号：US10371851
申请日：2003-02-21
申请人： Carter R. Anderson , Russell L. Morris , Clayton J. Anderson , Lori A. Grace
发明人： Carter R. Anderson , Russell L. Morris , Clayton J. Anderson , Lori A. Grace
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： A reliable, self-contained iontophoretic drug delivery system is disclosed which enjoys a long stable shelf life and which is easy for the user to activate and employ. This system includes a wearable iontophoretic device that is prepackaged as a complete self-contained unit which includes the active species or drug to be administered and counter ions. The system includes a provision for isolating moisture sources from the electrodes and from the power source during storage and provides a simple, user-friendly mechanism to connect the drug to be administered and counter ion reservoirs to the electrodes and the device to the skin of a user in order to activate the device circuit. All elements of the device are contained in a single outer package.
摘要翻译：公开了一种可靠，独立的离子电渗药物输送系统，其具有长的稳定的保质期，并且易于使用者活化和使用。该系统包括可佩戴的离子电渗疗法装置，其预先包装为完整的独立单元，其包括要施用的活性物质或药物和抗衡离子。该系统包括用于在储存期间从电极和电源隔离水分源的设置，并且提供简单的，用户友好的机制，用于将要施用的药物和反离子储存器连接到电极和装置到皮肤的用户为了激活设备电路。设备的所有元素都包含在一个外包装中。

3. 发明授权

US07031768B2 Controlled dosage drug delivery 有权
公开(公告)号：US07031768B2
公开(公告)日：2006-04-18
申请号：US10166157
申请日：2002-06-10
申请人： Carter R. Anderson , Clayton J. Anderson , Walter L. Sembrowich , Russell L. Morris
发明人： Carter R. Anderson , Clayton J. Anderson , Walter L. Sembrowich , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0448
摘要： A planar disposable transdermal iontophoretic delivery system is disclosed which includes amounts of an oxidizable species and a reducible species connected by a common conductor forming a galvanic battery for serving as the sole source of power and control for the system, an amount of a therapeutic agent is provided to be driven through the skin of a patient solely through the use of the galvanic battery. The galvanic battery is provided with a lot-tested coulombic capacity rating to predict dosage.

4. 发明授权

US07856263B2 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权
标题翻译：用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统
公开(公告)号：US07856263B2
公开(公告)日：2010-12-21
申请号：US11112196
申请日：2005-04-22
申请人： Carter R. Anderson , Walter L. Sembrowich , Russell L. Morris , Robert Cohen
发明人： Carter R. Anderson , Walter L. Sembrowich , Russell L. Morris , Robert Cohen
IPC分类号： A61N1/30 , A61M31/00 , A61F13/00 , A61K9/70
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译：一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量，供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括从由外部信号激活的传感器和开关组成的组中选择的控制元件。

5. 发明授权

US07844327B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US07844327B2
公开(公告)日：2010-11-30
申请号：US10545761
申请日：2003-10-02
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.
摘要翻译：用于经皮给药活性治疗物种的离子电渗装置的电极组件具有包括优先吸收（氧化或还原）于水的连接导电基材的基层，涂覆在第一上层的牺牲材料基底层的第一部分，其中牺牲材料优先地消耗到基底层的连接导电基底材料。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，第二上层由保留在其间的基层材料的窄暴露的连接区连接。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层将被完全消耗，之后是基底层的暴露的连接区域的连接导电基底材料，其切断基底层，从而破坏器件中的电路连续性失效活动。可以提供视觉指示器，允许佩戴者监视连接区域的反应状态。

6. 发明授权

US07031769B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US07031769B2
公开(公告)日：2006-04-18
申请号：US10371532
申请日：2003-02-21
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30 , A61N1/00 , A61N1/04 , A61N1/05 , A61M31/00
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species includes a base layer of conductive material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the conductive material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, a narrow exposed linking area of the base layer material remaining therebetween. The exposed linking area of the base layer extends across the base layer. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be followed by the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity in the device.
摘要翻译：用于经皮给药活性治疗物种的离子电渗疗法装置的电极组件包括优先被消耗（氧化或减少）水的导电材料的基底层，涂覆在第一部分上的第一牺牲材料上层其中牺牲材料优先地消耗到基层的导电材料的基层。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，基层材料残留在其间的窄暴露的连接区域。基底层的暴露的连接区域延伸穿过基底层。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层之后将是基底层的暴露的连接区域，从而破坏器件的电路连续性。

7. 发明授权

US07016723B2 Rate adjustable drug delivery system 有权
公开(公告)号：US07016723B2
公开(公告)日：2006-03-21
申请号：US10162473
申请日：2002-06-03
申请人： Russell L. Morris , Carter R. Anderson
发明人： Russell L. Morris , Carter R. Anderson
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A transdermal iontophoretic therapeutic agent delivery system which is provided with a plurality of self-contained serially connected galvanic sources.

8. 发明授权

US09272137B2 Transdermal methods and systems for the delivery of anti-migraine compounds 有权
公开(公告)号：US09272137B2
公开(公告)日：2016-03-01
申请号：US13105562
申请日：2011-05-11
申请人： Carter R. Anderson , Russell L. Morris , Terri B. Sebree
发明人： Carter R. Anderson , Russell L. Morris , Terri B. Sebree
IPC分类号： A61N1/30
CPC分类号： A61K9/7038 , A61K31/4045 , A61N1/30
摘要： Iontophoretic patches for the delivery of anti-migraine compounds and methods of using the patches are described.

9. 发明授权

US08475837B2 Abuse potential reduction in abusable substance dosage form 有权
公开(公告)号：US08475837B2
公开(公告)日：2013-07-02
申请号：US12952516
申请日：2010-11-23
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61K9/70
CPC分类号： A62D3/33 , A61J1/00 , A61J1/14 , A61K9/7084 , A61K31/445 , A62D3/00 , A62D2101/26 , B09B3/0075 , B09B2220/14 , B65D25/14
摘要： The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.

10. 发明授权

US08239018B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US08239018B2
公开(公告)日：2012-08-07
申请号：US12868123
申请日：2010-08-25
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.
摘要翻译：用于经皮给药活性治疗物种的离子电渗疗法装置的电极组件具有包含优先吸收（氧化或还原）水的连接导电基材的基层，涂覆在第一上层的牺牲材料基底层的第一部分，其中牺牲材料优先地消耗到基底层的连接导电基底材料。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，第二上层由保留在其间的基层材料的窄暴露的连接区连接。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层将被完全消耗，之后是基底层的暴露的连接区域的连接导电基底材料，其切断基底层，从而破坏器件中的电路连续性失效活动。可以提供视觉指示器，允许佩戴者监视连接区域的反应状态。

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