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1. 发明专利

JP2014185333A Near infrared dye-binding hyaluronic acid derivative and contrast medium for optical imaging having the same 有权
标题翻译：近红外线粘合剂的羟基丙酸衍生物和对比剂中间体进行光学成像
公开(公告)号：JP2014185333A
公开(公告)日：2014-10-02
申请号：JP2014031227
申请日：2014-02-21
申请人： Kyoto Univ , 国立大学法人京都大学 , Canon Inc , キヤノン株式会社
发明人： MIKI YASUTSUGU , INOUE TATSUHIRO , KOBAYASHI YASUTO , NAKANO KATSUYA , OE KOICHI , YAMAUCHI FUMIO , YANO TETSUYA , MINAMI MASATO
IPC分类号： C08B37/08 , A61K49/00
CPC分类号： A61K49/221 , A61K47/50 , A61K47/51 , A61K47/55 , A61K47/56 , A61K47/61 , C08B37/0072
摘要： PROBLEM TO BE SOLVED: To provide a compound high in accumulation property in tumor, high in optical acoustic signal intensity generated from tumor and high in ICG content even when time has passed after administration.SOLUTION: There is provided a hyaluronic acid derivative which polyethylene glycol and an ICG derivative are bound.
摘要翻译：要解决的问题：为了提供肿瘤中积聚性高的化合物，由肿瘤产生的光学信号强度高，ICG含量高，即使给药后经过了时间。提供了一种透明质酸衍生物，其是聚乙二醇并且ICG衍生物被绑定。

2. 发明专利

JP2014001371A Polymer, contrast agent for nuclear magnetic resonance analysis or magnetic resonance imaging using said polymer, compound, and method of nuclear magnetic resonance analysis and method of magnetic resonance imaging using said polymer 有权
标题翻译：聚合物，使用固体聚合物，化合物和核磁共振分析方法的核磁共振分析或磁共振成像的对比剂和使用合成聚合物的磁共振成像方法
公开(公告)号：JP2014001371A
公开(公告)日：2014-01-09
申请号：JP2013103159
申请日：2013-05-15
申请人： Kyoto Univ , 国立大学法人京都大学 , Canon Inc , キヤノン株式会社
发明人： KONDO TERUYUKI , YAMADA HISATSUGU , HASEGAWA YOSHINORI , KIMURA TAKU , AOYAMA YASUHIRO , TOCHIO TOSHIHITO , SHIRAKAWA MASAHIRO , SUGIHARA AYANORI , MATSUDA TETSUYA , SANTO SHINSUKE , MINAMI MASATO , YAMAUCHI FUMIO , YANO TETSUYA , TSUZUKI EIJU
IPC分类号： C08F20/36 , A61B5/055 , A61K49/00 , C07B59/00 , C07F9/09 , C08F4/40 , C08F8/00 , C08F20/38 , C08F20/60 , C08G63/06 , C08G63/685 , C08G63/688 , C08G63/692 , C08G69/36 , C08G69/42 , G01N24/12 , G01R33/28
CPC分类号： A61K49/126 , A61K49/12 , C08F30/02
摘要： PROBLEM TO BE SOLVED: To provide a substance with high selectivity and high sensitivity as a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging.SOLUTION: When a polymer is used that has, in a side chain thereof, a sequence of aH-C-N,H-N-C, orH-C-C bond, which is a structure labeled with stable isotopesC andN, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.
摘要翻译：要解决的问题：提供具有高选择性和高灵敏度的物质作为用作核磁共振分析方法的造影剂的物质或磁共振成像方法。解决方案：当使用具有其侧链，H-CN，HNC或H-CC键的序列，其是用稳定同位素C和N标记的结构，可以增加一个分子中这样的序列的丰度，因此，高选择性和更高的灵敏度当用作造影剂时可以获得。

3. 发明专利

JP2009079046A Compound, diagnostic agent, method of nuclear magnetic resonance analysis, method of nuclear magnetic resonance-imaging, method of mass analysis and method of mass analysis-imaging 有权
标题翻译：化合物，诊断试剂，核磁共振分析方法，核磁共振成像方法，质量分析方法和质量分析成像方法
公开(公告)号：JP2009079046A
公开(公告)日：2009-04-16
申请号：JP2008228439
申请日：2008-09-05
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： YOSHIMURA KIMIHIRO , YAMAUCHI FUMIO , HISAIE KATSUAKI , YANO TETSUYA , SHIRAKAWA MASAHIRO , AOYAMA YASUHIRO
IPC分类号： C07C215/40 , A61B5/055 , A61K49/00 , C07C219/06 , C07F9/09 , G01N24/12 , G01N27/62 , G01R33/28 , G01R33/465
CPC分类号： C07C215/40 , A61K49/10 , C07B2200/05 , C07C219/06 , C07F9/091 , C07F9/106 , G01N24/08 , G01R33/4608 , G01R33/5601 , G01R33/5605
摘要： PROBLEM TO BE SOLVED: To produce (1) a labeling compound for a selected substance in a living body by using a stable isotope atom, not using a radioactive isotope having a fear of being irradiated or a limitation in handling time, and to make (2) the labeling compound capable of being measured in a good sensitivity by being separated from the substituted compounds of the stable isotope atom presenting in the nature, of the selected substance in the living body. SOLUTION: This substance in the living body, choline is used as a diagnostic agent by substituting all of the nitrogen atoms in its quaternary ammonium group and the whole of the carbon atoms of methyl groups bonded with the nitrogen atoms by the isotopes 15 N and 13 C for labeling, respectively. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：（1）通过使用稳定的同位素原子制造（1）活体中所选择的物质的标记化合物，不使用具有被照射的放射性同位素或处理时间的限制，以及使（2）能够通过与活体中所选择的物质的天然存在的稳定同位素原子的取代化合物分离而以良好的灵敏度测定的标记化合物。解决方案：通过将其季铵基中的所有氮原子和与氮原子键合的甲基的全部碳原子用同位素代替，将生物体中的该物质胆碱用作诊断剂，分别标记SP> 15 N和 13 C。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2009077710A Substrate probe, method for detecting enzyme-activity by multi-dimensional nuclear magnetic resonance method and enzyme-activity imaging method 有权
标题翻译：基底探针，通过多维核磁共振方法和酶活性成像方法检测酶活性的方法
公开(公告)号：JP2009077710A
公开(公告)日：2009-04-16
申请号：JP2008228433
申请日：2008-09-05
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： YAMAUCHI FUMIO , YANO TETSUYA , YOSHIMURA KIMIHIRO , HISAIE KATSUAKI , SHIRAKAWA MASAHIRO , AOYAMA YASUHIRO , SANTO SHINSUKE
IPC分类号： C12Q1/00 , C07K7/06 , C12Q1/37 , C12Q1/54 , G01N24/12 , G01R33/465 , G01R33/48
CPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/34 , G01N24/088 , G01R33/281 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/5601 , Y02P20/582
摘要： PROBLEM TO BE SOLVED: To provide a substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi-dimensional nuclear magnetic resonance method to use the probe. SOLUTION: Multi-dimensional nuclear magnetic resonance measurement is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing an enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, and the group is present specifically to the enzyme recognition site, thereby detecting the presence of the substrate probe and the enzyme activity. The enzyme activity is imaged by a multi-dimensional magnetic resonance imaging method. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够以高精度检测酶活性的底物探针和通过多维核磁共振法检测酶活性的方法来使用探针。解决方案：通过使用用于通过多维核磁共振法测量酶活性的底物探针进行多维核磁共振测量，其特征在于含有选择性识别的酶识别位点作为至少一个结构单元的活性酶，连接具有核自旋和不同共振频率的至少三个核磁共振活性核的基团，并且该基团特异性地存在于酶识别位点，从而检测底物探针的存在和酶活性。通过多维磁共振成像方法对酶活性进行成像。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2010083860A Polymer nanoparticle and contrast agent for optical molecular imaging 审中-公开
标题翻译：聚合物纳米材料和对比剂用于光学分子成像
公开(公告)号：JP2010083860A
公开(公告)日：2010-04-15
申请号：JP2009044222
申请日：2009-02-26
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： ITO SHINSABURO , NITAHARA SATOSHI , AOKI HIROYUKI , MINAMI MASATO , TOMITA YOSHINORI , YANO TETSUYA , YOSHIMURA KIMIHIRO
IPC分类号： A61K49/00 , A61K9/51 , A61K47/34 , G01N21/78
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0036 , A61K49/0093 , C09B23/083 , C09B23/086 , C09B67/0097 , C09B69/10 , C09B69/105
摘要： PROBLEM TO BE SOLVED: To provide polymer nanoparticles excellent in FRET (fluorescent resonance energy transfer) efficiency and dispersibility, and a contrast agent for optical molecular imaging using the same.
SOLUTION: The polymer nanoparticles each having a fluorescent dye dispersed in the matrix of a fluorescent polymer are characterized in that the surface of the nanoparticles is protected by a surfactant, and fluorescence is emitted via FRET between the fluorescent polymer and the fluorescent dye, and also provided is a contrast agent for optical molecular imaging using the polymer nanoparticles.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供FRET（荧光共振能量转移）效率和分散性优异的聚合物纳米颗粒，以及使用其的光学分子成像造影剂。解决方案：各自具有分散在荧光聚合物基质中的荧光染料的聚合物纳米粒子的特征在于纳米颗粒的表面被表面活性剂保护，荧光聚合物和荧光染料之间通过FRET发射荧光并且还提供了使用聚合物纳米颗粒的光学分子成像的造影剂。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2009280567A Multisite phosphorylated peptide (protein) recognizing compound, and detection method using the same 有权
标题翻译：多肽磷酸酯（蛋白质）识别化合物及其检测方法
公开(公告)号：JP2009280567A
公开(公告)日：2009-12-03
申请号：JP2009046253
申请日：2009-02-27
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： HAMACHI ITARU , OJIDA AKIO , SAKAMOTO TAKASHI , INOUE MASAAKI , YAMAUCHI FUMIO , YANO TETSUYA , YOSHIMURA KIMIHIRO
IPC分类号： C07D213/38 , A61K49/00 , A61K51/00 , A61P25/28 , C07F3/06 , C07F5/02 , C07K14/47 , G01N21/78 , G01N33/68
CPC分类号： C07F5/022 , C07D207/335 , C07D401/14 , G01N33/6842 , Y10T436/16 , Y10T436/163333
摘要： PROBLEM TO BE SOLVED: To provide a compound specifically detecting an overphosphorylated τ-protein observed in the brain affected by Alzheimer's disease, and to provide in vitro and in vivo diagnostic methods for Alzheimer's disease using the above compound. SOLUTION: By bringing a metal complex compound having two dipicolylamine (Dpa) moieties and a spacer including a chromophoric or luminescent functional group or atomic group into contact with a multisite-phosphorylated peptide or protein, the compound recognizes the distance between phosphate groups and specifically binds to the peptide or the protein, and a multisite-phosphorylated peptide or protein or a kinase activity is optically detected by measuring the thus induced luminescent change, or a multisite-phosphorylated peptide or protein or kinase activity is imaged by an optical imaging method applicable to the luminescent change. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供特异性检测在受阿尔茨海默病影响的脑中观察到的过磷酸化τ-蛋白的化合物，并使用上述化合物提供体外和体内的阿尔茨海默病诊断方法。解决方案：通过使具有两个二苯基胺（Dpa）部分的金属络合物和包含发色官能团或发光官能团或原子团的间隔基与多位点磷酸化肽或蛋白质接触，化合物识别磷酸基团之间的距离并且特异性地结合肽或蛋白质，并且通过测量由此诱导的发光变化来光学检测多位点磷酸化的肽或蛋白质或激酶活性，或者通过光学成像对多位点磷酸化肽或蛋白质或激酶活性进行成像适用于发光变化的方法。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009235372A Dendrimer particle, mri contrast medium, and production method for dendrimer particle 有权
标题翻译： DENDRIMER颗粒，MRI对比剂中和用于DENDRIMER颗粒的生产方法
公开(公告)号：JP2009235372A
公开(公告)日：2009-10-15
申请号：JP2008230241
申请日：2008-09-08
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： ITO SHINSABURO , NITAHARA SATOSHI , AOKI HIROYUKI , YOSHIMURA KIMIHIRO , TSUZUKI EIJU , YANO TETSUYA , TOMITA YOSHINORI
IPC分类号： C08F20/22 , A61K49/00 , C08F4/40
CPC分类号： C08G83/003 , A61K49/124 , C08G73/028 , C08L101/04
摘要： PROBLEM TO BE SOLVED: To provide an F-MRI contrast medium of high contrast sensitivity with a size controlled severely, a dendrimer particle, and a production method therefor. SOLUTION: This dendrimer particle has a unit containing a fluorine atom in a plurality of branch terminals of an aliphatic branched polymer (dendrimer) of high regularity. The dendrimer particle is produced using an atom transfer radical polymerization method or the like. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有严格控制的大小对比度灵敏度的F-MRI造影剂，树枝状大分子颗粒及其制备方法。解决方案：该树枝状聚合物颗粒在具有高规则性的脂肪族支链聚合物（树枝状大分子）的多个分支末端中具有含有氟原子的单元。使用原子转移自由基聚合法等制造树枝状大分子粒子。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009221187A Compound, method for producing the same, metal complex compound, method for producing the same and mri contrast agent 有权
标题翻译：化合物，其生产方法，金属复合化合物，其制备方法和MRI对比剂
公开(公告)号：JP2009221187A
公开(公告)日：2009-10-01
申请号：JP2008306627
申请日：2008-12-01
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： KONDO TERUYUKI , TSUJITA HIROSHI , SIDDIQUE ZAINUL ABEDIN , MATSUKI SHINGO , MIURA DAIKI , TOCHIO TAKEHITO , MATSUDA TETSUYA , NARASAKI MICHIKO , TSUZUKI EIJU , HISAIE KATSUAKI , TOMITA YOSHINORI , YOSHIMURA KIMIHIRO , YANO TETSUYA
IPC分类号： C07D405/14 , A61K49/00 , C07B53/00 , C07B61/00 , C07F5/00
CPC分类号： C07F5/003 , A61K49/106 , C07D255/02 , C07D257/02 , C07D259/00 , C07D405/14
摘要： PROBLEM TO BE SOLVED: To provide a metal complex compound having excellent T1-reducing effect and an MRI contrast agent produced by using the compound. SOLUTION: A core having a cyclic structure represented by (-N-(CH 2 ) n -) k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound having a specific structure for producing a metal complex compound exhibiting a T1-reducing effect, and the resulting compound is coordinated to a metal ion exhibiting a T1-reducing effect to obtain a metal complex compound useful as an effective component of an MRI contrast agent. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有优异的T1减少效果的金属络合物和使用该化合物制备的MRI造影剂。＆lt; P＆gt;解决方案：具有由（-N-（CH 2）2）x - 表示的环状结构的核结合到在核心中的所有氮原子处具有特定支化结构的树枝状大分子侧链，以产生具有特定结构的化合物，用于制备显示T1还原作用的金属络合物，并将所得化合物与显示出获得可用作MRI造影剂的有效成分的金属络合物的T1减少效果。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2009078141A Nuclear magnetic resonance measuring method 有权
标题翻译：核磁共振测量方法
公开(公告)号：JP2009078141A
公开(公告)日：2009-04-16
申请号：JP2008229687
申请日：2008-09-08
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： HISAIE KATSUAKI , YOSHIMURA KIMIHIRO , YAMAUCHI FUMIO , YANO TETSUYA , SHIRAKAWA MASAHIRO , AOYAMA YASUHIRO
IPC分类号： A61B5/055 , G01N24/08
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： PROBLEM TO BE SOLVED: To provide a method for observing behavior, distribution, and concentration in a living body due to metabolism etc., of probe agent while suppressing influence on a living body, by MRS.
SOLUTION: The nuclear magnetic resonance signal measuring method includes: a process for imparting an isotope-labeled compound, in which at least two nuclei which have each different nuclear magnetic resonance frequency and are bonded to each other are isotope-labeled at a higher ratio than a natural isotope abundance ratio, to a measurement sample; and a process for observing a nuclear magnetic resonance signal of a first nucleus derived from the isotope-labeled compound in the measurement sample by using a pulse sequence which can observe a nuclear magnetic resonance signal via magnetization transfer from the first nucleus to a second nucleus, from the second nucleus to a third nucleus, from the third nucleus to the second nucleus, and from the second nucleus to the first nucleus based on spin-spin coupling between three nuclei including at least two isotope-labeled nuclei, bonded to each other, and having each different nuclear magnetic resonance frequency in the isotope-labeled compound imparted to the measurement sample.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过MRS来抑制由于代谢等引起的生物体的行为，分布和浓度的方法，同时抑制对生物体的影响。解决方案：核磁共振信号测量方法包括：赋予同位素标记化合物的方法，其中至少两个具有不同核磁共振频率的核并且彼此结合的核在同位素标记比天然同位素丰度比更高的比例; 以及通过使用能够通过从第一核到第二核的磁化转移观察核磁共振信号的脉冲序列来观测来自测定样品中的同位素标记化合物的第一核的核磁共振信号的方法，基于彼此结合的包含至少两个同位素标记的核的三个核之间的自旋 - 自旋耦合，从第二核到第三核，从第三核到第二核，从第二核到第一核，并且在赋予测量样品的同位素标记化合物中具有各自不同的核磁共振频率。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2014031363A Particle and photoacoustic contrast agent having the particle 有权
标题翻译：颗粒和具有颗粒的光电对比剂
公开(公告)号：JP2014031363A
公开(公告)日：2014-02-20
申请号：JP2013041919
申请日：2013-03-04
申请人： Canon Inc , キヤノン株式会社
发明人： TABATA YASUHIKO , YAMAUCHI SACHIKO , KISHI MAYUKO , MINAMI MASATO , YAMAGATA MIKA , YUASA SATOSHI , YANO TETSUYA
IPC分类号： A61K49/00 , A61B8/00
CPC分类号： A61K49/00 , A61K49/0021 , A61K49/0093
摘要： PROBLEM TO BE SOLVED: To solve the problem in which an iron oxide particle constituting a Resovist (trademark) absorbs a small quantity of light in a near infrared region and emits a weak photoacoustic signal.SOLUTION: According to a particle having catechols and iron atoms, the particle having a ratio of the number of moles of the catechols to the number of moles of the iron atoms of 270/10,000 or more, light absorption in the near infrared region increases and a strong photoacoustic signal can be transmitted.
摘要翻译：要解决的问题：为了解决构成Resovist（商标）的氧化铁颗粒吸收近红外区域的少量光并发出弱光声信号的问题。解决方案：根据具有儿茶酚和铁原子的颗粒，具有邻苯二酚的摩尔数与铁原子摩尔数的比例为270 / 10,000以上的颗粒，近红外区域的光吸收增加，并且可以透射强的光声信号。

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