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    • 9. 发明专利
    • Nuclear magnetic resonance measuring method
    • 核磁共振测量方法
    • JP2009078141A
    • 2009-04-16
    • JP2008229687
    • 2008-09-08
    • Canon IncKyoto Univキヤノン株式会社国立大学法人京都大学
    • HISAIE KATSUAKIYOSHIMURA KIMIHIROYAMAUCHI FUMIOYANO TETSUYASHIRAKAWA MASAHIROAOYAMA YASUHIRO
    • A61B5/055G01N24/08
    • G01R33/485G01R33/4608G01R33/4633G01R33/4833G01R33/5605G01R33/5607
    • PROBLEM TO BE SOLVED: To provide a method for observing behavior, distribution, and concentration in a living body due to metabolism etc., of probe agent while suppressing influence on a living body, by MRS.
      SOLUTION: The nuclear magnetic resonance signal measuring method includes: a process for imparting an isotope-labeled compound, in which at least two nuclei which have each different nuclear magnetic resonance frequency and are bonded to each other are isotope-labeled at a higher ratio than a natural isotope abundance ratio, to a measurement sample; and a process for observing a nuclear magnetic resonance signal of a first nucleus derived from the isotope-labeled compound in the measurement sample by using a pulse sequence which can observe a nuclear magnetic resonance signal via magnetization transfer from the first nucleus to a second nucleus, from the second nucleus to a third nucleus, from the third nucleus to the second nucleus, and from the second nucleus to the first nucleus based on spin-spin coupling between three nuclei including at least two isotope-labeled nuclei, bonded to each other, and having each different nuclear magnetic resonance frequency in the isotope-labeled compound imparted to the measurement sample.
      COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供一种用于通过MRS来抑制由于代谢等引起的生物体的行为,分布和浓度的方法,同时抑制对生物体的影响。 解决方案:核磁共振信号测量方法包括:赋予同位素标记化合物的方法,其中至少两个具有不同核磁共振频率的核并且彼此结合的核在同位素标记 比天然同位素丰度比更高的比例; 以及通过使用能够通过从第一核到第二核的磁化转移观察核磁共振信号的脉冲序列来观测来自测定样品中的同位素标记化合物的第一核的核磁共振信号的方法, 基于彼此结合的包含至少两个同位素标记的核的三个核之间的自旋 - 自旋耦合,从第二核到第三核,从第三核到第二核,从第二核到第一核, 并且在赋予测量样品的同位素标记化合物中具有各自不同的核磁共振频率。 版权所有(C)2009,JPO&INPIT