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1. 发明专利

JP2009078141A Nuclear magnetic resonance measuring method 有权
标题翻译：核磁共振测量方法
公开(公告)号：JP2009078141A
公开(公告)日：2009-04-16
申请号：JP2008229687
申请日：2008-09-08
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： HISAIE KATSUAKI , YOSHIMURA KIMIHIRO , YAMAUCHI FUMIO , YANO TETSUYA , SHIRAKAWA MASAHIRO , AOYAMA YASUHIRO
IPC分类号： A61B5/055 , G01N24/08
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： PROBLEM TO BE SOLVED: To provide a method for observing behavior, distribution, and concentration in a living body due to metabolism etc., of probe agent while suppressing influence on a living body, by MRS.
SOLUTION: The nuclear magnetic resonance signal measuring method includes: a process for imparting an isotope-labeled compound, in which at least two nuclei which have each different nuclear magnetic resonance frequency and are bonded to each other are isotope-labeled at a higher ratio than a natural isotope abundance ratio, to a measurement sample; and a process for observing a nuclear magnetic resonance signal of a first nucleus derived from the isotope-labeled compound in the measurement sample by using a pulse sequence which can observe a nuclear magnetic resonance signal via magnetization transfer from the first nucleus to a second nucleus, from the second nucleus to a third nucleus, from the third nucleus to the second nucleus, and from the second nucleus to the first nucleus based on spin-spin coupling between three nuclei including at least two isotope-labeled nuclei, bonded to each other, and having each different nuclear magnetic resonance frequency in the isotope-labeled compound imparted to the measurement sample.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过MRS来抑制由于代谢等引起的生物体的行为，分布和浓度的方法，同时抑制对生物体的影响。解决方案：核磁共振信号测量方法包括：赋予同位素标记化合物的方法，其中至少两个具有不同核磁共振频率的核并且彼此结合的核在同位素标记比天然同位素丰度比更高的比例; 以及通过使用能够通过从第一核到第二核的磁化转移观察核磁共振信号的脉冲序列来观测来自测定样品中的同位素标记化合物的第一核的核磁共振信号的方法，基于彼此结合的包含至少两个同位素标记的核的三个核之间的自旋 - 自旋耦合，从第二核到第三核，从第三核到第二核，从第二核到第一核，并且在赋予测量样品的同位素标记化合物中具有各自不同的核磁共振频率。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2014001371A Polymer, contrast agent for nuclear magnetic resonance analysis or magnetic resonance imaging using said polymer, compound, and method of nuclear magnetic resonance analysis and method of magnetic resonance imaging using said polymer 有权
标题翻译：聚合物，使用固体聚合物，化合物和核磁共振分析方法的核磁共振分析或磁共振成像的对比剂和使用合成聚合物的磁共振成像方法
公开(公告)号：JP2014001371A
公开(公告)日：2014-01-09
申请号：JP2013103159
申请日：2013-05-15
申请人： Kyoto Univ , 国立大学法人京都大学 , Canon Inc , キヤノン株式会社
发明人： KONDO TERUYUKI , YAMADA HISATSUGU , HASEGAWA YOSHINORI , KIMURA TAKU , AOYAMA YASUHIRO , TOCHIO TOSHIHITO , SHIRAKAWA MASAHIRO , SUGIHARA AYANORI , MATSUDA TETSUYA , SANTO SHINSUKE , MINAMI MASATO , YAMAUCHI FUMIO , YANO TETSUYA , TSUZUKI EIJU
IPC分类号： C08F20/36 , A61B5/055 , A61K49/00 , C07B59/00 , C07F9/09 , C08F4/40 , C08F8/00 , C08F20/38 , C08F20/60 , C08G63/06 , C08G63/685 , C08G63/688 , C08G63/692 , C08G69/36 , C08G69/42 , G01N24/12 , G01R33/28
CPC分类号： A61K49/126 , A61K49/12 , C08F30/02
摘要： PROBLEM TO BE SOLVED: To provide a substance with high selectivity and high sensitivity as a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging.SOLUTION: When a polymer is used that has, in a side chain thereof, a sequence of aH-C-N,H-N-C, orH-C-C bond, which is a structure labeled with stable isotopesC andN, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.
摘要翻译：要解决的问题：提供具有高选择性和高灵敏度的物质作为用作核磁共振分析方法的造影剂的物质或磁共振成像方法。解决方案：当使用具有其侧链，H-CN，HNC或H-CC键的序列，其是用稳定同位素C和N标记的结构，可以增加一个分子中这样的序列的丰度，因此，高选择性和更高的灵敏度当用作造影剂时可以获得。

3. 发明专利

JP2009079046A Compound, diagnostic agent, method of nuclear magnetic resonance analysis, method of nuclear magnetic resonance-imaging, method of mass analysis and method of mass analysis-imaging 有权
标题翻译：化合物，诊断试剂，核磁共振分析方法，核磁共振成像方法，质量分析方法和质量分析成像方法
公开(公告)号：JP2009079046A
公开(公告)日：2009-04-16
申请号：JP2008228439
申请日：2008-09-05
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： YOSHIMURA KIMIHIRO , YAMAUCHI FUMIO , HISAIE KATSUAKI , YANO TETSUYA , SHIRAKAWA MASAHIRO , AOYAMA YASUHIRO
IPC分类号： C07C215/40 , A61B5/055 , A61K49/00 , C07C219/06 , C07F9/09 , G01N24/12 , G01N27/62 , G01R33/28 , G01R33/465
CPC分类号： C07C215/40 , A61K49/10 , C07B2200/05 , C07C219/06 , C07F9/091 , C07F9/106 , G01N24/08 , G01R33/4608 , G01R33/5601 , G01R33/5605
摘要： PROBLEM TO BE SOLVED: To produce (1) a labeling compound for a selected substance in a living body by using a stable isotope atom, not using a radioactive isotope having a fear of being irradiated or a limitation in handling time, and to make (2) the labeling compound capable of being measured in a good sensitivity by being separated from the substituted compounds of the stable isotope atom presenting in the nature, of the selected substance in the living body. SOLUTION: This substance in the living body, choline is used as a diagnostic agent by substituting all of the nitrogen atoms in its quaternary ammonium group and the whole of the carbon atoms of methyl groups bonded with the nitrogen atoms by the isotopes 15 N and 13 C for labeling, respectively. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：（1）通过使用稳定的同位素原子制造（1）活体中所选择的物质的标记化合物，不使用具有被照射的放射性同位素或处理时间的限制，以及使（2）能够通过与活体中所选择的物质的天然存在的稳定同位素原子的取代化合物分离而以良好的灵敏度测定的标记化合物。解决方案：通过将其季铵基中的所有氮原子和与氮原子键合的甲基的全部碳原子用同位素代替，将生物体中的该物质胆碱用作诊断剂，分别标记SP> 15 N和 13 C。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2009077710A Substrate probe, method for detecting enzyme-activity by multi-dimensional nuclear magnetic resonance method and enzyme-activity imaging method 有权
标题翻译：基底探针，通过多维核磁共振方法和酶活性成像方法检测酶活性的方法
公开(公告)号：JP2009077710A
公开(公告)日：2009-04-16
申请号：JP2008228433
申请日：2008-09-05
申请人： Canon Inc , Kyoto Univ , キヤノン株式会社 , 国立大学法人京都大学
发明人： YAMAUCHI FUMIO , YANO TETSUYA , YOSHIMURA KIMIHIRO , HISAIE KATSUAKI , SHIRAKAWA MASAHIRO , AOYAMA YASUHIRO , SANTO SHINSUKE
IPC分类号： C12Q1/00 , C07K7/06 , C12Q1/37 , C12Q1/54 , G01N24/12 , G01R33/465 , G01R33/48
CPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/34 , G01N24/088 , G01R33/281 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/5601 , Y02P20/582
摘要： PROBLEM TO BE SOLVED: To provide a substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi-dimensional nuclear magnetic resonance method to use the probe. SOLUTION: Multi-dimensional nuclear magnetic resonance measurement is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing an enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, and the group is present specifically to the enzyme recognition site, thereby detecting the presence of the substrate probe and the enzyme activity. The enzyme activity is imaged by a multi-dimensional magnetic resonance imaging method. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够以高精度检测酶活性的底物探针和通过多维核磁共振法检测酶活性的方法来使用探针。解决方案：通过使用用于通过多维核磁共振法测量酶活性的底物探针进行多维核磁共振测量，其特征在于含有选择性识别的酶识别位点作为至少一个结构单元的活性酶，连接具有核自旋和不同共振频率的至少三个核磁共振活性核的基团，并且该基团特异性地存在于酶识别位点，从而检测底物探针的存在和酶活性。通过多维磁共振成像方法对酶活性进行成像。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2011180570A Fluorescence microscope device 有权
标题翻译：荧光显微镜装置
公开(公告)号：JP2011180570A
公开(公告)日：2011-09-15
申请号：JP2010109527
申请日：2010-05-11
申请人： Jeol Ltd , Kyoto Univ , 国立大学法人京都大学 , 日本電子株式会社
发明人： SHIRAKAWA MASAHIRO , HARADA YOSHISHIGE , YOKOTA HIROAKI , YOSHINARI YOSUKE , TSUJI SEIGO
IPC分类号： G02B21/06 , G01N21/64
摘要： PROBLEM TO BE SOLVED: To provide a fluorescence microscope device achieving selective visual field-observation of aimed fluorescence.
SOLUTION: The fluorescence microscope device includes: an optical microscope 3 which irradiates a sample 16 including a phosphor 1 whose fluorescence intensity is varied by magnetic resonance with exciting light to observe the fluorescence of the phosphor 1; a high-frequency magnetic field generation part 5 which irradiates the sample 16 with high-frequency magnetic field for generating electron spin magnetic resonance; a modulation part 7 which generates a modulation signal for modulating the high-frequency magnetic field; a detector 9 which detects light intensity on a surface of the sample observed by the optical microscope 3 in each of a plurality of pixels at each sampling time while modulating the high-frequency magnetic field; and a processing unit 10 which extracts an object pixel in which time-sequential variation of the light intensity correlates with the modulation signal from the plurality of pixels.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供实现目标荧光的选择性视场观察的荧光显微镜装置。解决方案：荧光显微镜装置包括：光学显微镜3，其照射包括荧光体1的样品16，荧光体1的荧光强度通过磁共振用激发光改变以观察荧光体1的荧光; 用于产生电子自旋磁共振的高频磁场照射样本16的高频磁场产生部分5; 生成用于调制高频磁场的调制信号的调制部7; 检测器9，其在调制高频磁场的同时，在每个采样时间检测由多个像素中的每个中的光学显微镜3观察到的样品的表面上的光强度; 以及处理单元10，其提取其中光强度的时间顺序变化与来自多个像素的调制信号相关的对象像素。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2007232596A Magnetic resonance force microscope 审中-公开
标题翻译：磁共振力显微镜
公开(公告)号：JP2007232596A
公开(公告)日：2007-09-13
申请号：JP2006055443
申请日：2006-03-01
申请人： Jeol Ltd , Kyoto Univ , Yokohama City Univ , 公立大学法人横浜市立大学 , 国立大学法人京都大学 , 日本電子株式会社
发明人： TSUJI SEIGO , YOSHINARI YOSUKE , SHIRAKAWA MASAHIRO , FURUKUBO TETSURO
IPC分类号： G01B7/34 , G01Q60/50 , G01Q60/52 , G01Q60/54
CPC分类号： G01Q60/08 , G01Q60/52
摘要： PROBLEM TO BE SOLVED: To provide a magnetic resonance force microscope capable of still more deepening the understanding of an MRI image. SOLUTION: A high frequency magnetic field producing device 31 is constituted so as to control the spin of a sample 21 (specimen) in a state that a cantilever 23 is self-excited in the high frequency magnetic field uniformly produced in the whole of the sample 21 by a cantilever self-exciting loop part and a frequency demodulator 26 measures the resonance frequency of the cantilever from the detection signal of a cantilever displacement measuring instrument 29 based on magnetic resonance force and also measure the resonance frequency shift of the cantilever and controls the scanner 22 so that the DC component Δv of the shift quantity of the resonance frequency of the cantilever becomes constant to adjust the distance Z from the surface of the sample 21 to the leading end of a probe 24. The atomic force image (AFM) of the sample 21 is formed by a scanner drive power supply 25. A magnetic resonance force image (MRFM) is formed by a phase detector 34 corresponding to the AC component δv of the resonance frequency shift quantity of the cantilever in the frequency demodulator 26. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：
要解决的问题：提供一种能够进一步加深MRI图像的理解的磁共振力显微镜。
解决方案：一个高频磁场产生装置31构成为，以控制样品21（待测物）的的状态下，悬臂23是自激的高频磁场在整个均匀地产生的旋通过悬臂自励环路部分的样本21的频率，频率解调器26基于磁共振力从悬臂位移测量仪29的检测信号测量悬臂的共振频率，并测量悬臂的共振频移并控制扫描仪22，以使悬臂的共振频率的移位量的直流分量ΔV变得恒定，从样品21的表面调整的距离Z为探头24的原子力图像的前端（样品21的AFM）由扫描仪驱动电源25.一种磁共振图像力（MRFM）形成由对应于AC分量相位检测器34上形成（C）2007，JPO＆INPIT：在频解调器26，
COPYRIGHT悬臂的谐振频率偏移量v的

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