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1. 发明专利

IL294082A Engineered acid alpha-glucosidase variants 未知
公开(公告)号：IL294082A
公开(公告)日：2022-08-01
申请号：IL29408222
申请日：2022-06-19
申请人： CODEXIS INC , HALLOWS WILLIAM CASEY , BOTHAM RACHEL CATHLEEN , ZHU YU , CHNG CHINPING , DELLAS NIKKI , HUISMAN GJALT , ALAOUI ISMAILI MOULAY HICHAM , HOMAN DAVID WILLIAM , SILVERMAN ADAM P , VROOM JONATHAN , LAO JESSICA P
发明人： ZHU YU , HALLOWS WILLIAM CASEY , BOTHAM RACHEL CATHLEEN , CHNG CHINPING , DELLAS NIKKI , HUISMAN GJALT , ALAOUI ISMAILI MOULAY HICHAM , HOMAN DAVID WILLIAM , SILVERMAN ADAM P , VROOM JONATHAN , LAO JESSICA P
IPC分类号： A61K38/00
摘要： The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.

2. 发明申请

WO2010111622A2 AMIDASES AND METHODS OF THEIR USE 审中-公开
标题翻译：其使用方法及方法
公开(公告)号：WO2010111622A2
公开(公告)日：2010-09-30
申请号：PCT/US2010028874
申请日：2010-03-26
申请人： CODEXIS INC , GOODING OWEN , JONES ROBERT J , HUISMAN GJALT , YANG JIE , CLARK LOUIS
发明人： GOODING OWEN , JONES ROBERT J , HUISMAN GJALT , YANG JIE , CLARK LOUIS
IPC分类号： C12N9/80 , C12N15/52 , C12N15/63 , C12P13/02 , C12P41/00
CPC分类号： C12N9/80 , C12P13/02 , C12P13/04 , C12P41/007
摘要： The disclosure relates to engineered amidase polypeptides and processes of using the polypeptides for chiral resolution of amino acid amide compounds. The disclosure further relates to the polynucleotides that encode the engineered amidase polypeptides and related vectors, host cells, and methods for making the engineered amidase polypeptides.
摘要翻译：本公开涉及工程化的酰胺酶多肽和使用该多肽用于手性拆分氨基酸酰胺化合物的方法。本公开还涉及编码工程化的酰胺酶多肽和相关载体的多核苷酸，宿主细胞和用于制备工程化的酰胺酶多肽的方法。

3. 发明申请

WO2010075574A3 ENONE REDUCTASES 审中-公开
标题翻译：降低成本
公开(公告)号：WO2010075574A3
公开(公告)日：2011-02-24
申请号：PCT/US2009069515
申请日：2009-12-23
申请人： CODEXIS INC , SAVILE CHRISTOPHER , MITCHELL VESNA , ZHANG XIYUN , HUISMAN GJALT
发明人： SAVILE CHRISTOPHER , MITCHELL VESNA , ZHANG XIYUN , HUISMAN GJALT
IPC分类号： C12N9/02 , C12N15/53
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
摘要翻译：本公开涉及具有改进性质的工程化烯酮还原酶多肽，编码工程改造多肽的多核苷酸，相关载体，宿主细胞和用于制备工程化烯酮还原酶多肽的方法。本公开还提供了使用工程化烯酮还原酶多肽进行化学转化的方法。

4. 发明申请

WO2009029554A3 IMPROVED KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE 审中-公开
标题翻译：改进的（R）-3-羟基乙醇的立体选择性生产的糖热解聚合物
公开(公告)号：WO2009029554A3
公开(公告)日：2009-07-02
申请号：PCT/US2008074135
申请日：2008-08-24
申请人： CODEXIS INC , LIANG JACK , JENNE STEPHANE J , MUNDORFF EMILY , VOLADRI RAMA , LALONDE JAMES , HUISMAN GJALT
发明人： LIANG JACK , JENNE STEPHANE J , MUNDORFF EMILY , VOLADRI RAMA , LALONDE JAMES , HUISMAN GJALT
IPC分类号： C12P17/16
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成手性化合物的方法。

5. 发明申请

WO0168803A3 ENZYMES, PATHWAYS AND ORGANISMS FOR MAKING A POLYMERIZABLE MONOMER BY WHOLE CELL BIOPROCESS 审中-公开
标题翻译：通过全细胞生物学制备可聚合单体的酶，途径和有机物
公开(公告)号：WO0168803A3
公开(公告)日：2002-04-04
申请号：PCT/US0106941
申请日：2001-02-28
申请人： MAXYGEN INC , SELIFONOV SERGEY A , HUISMAN GJALT
发明人： SELIFONOV SERGEY A , HUISMAN GJALT
IPC分类号： C12N9/00 , C12N9/04 , C12N9/88 , C12P7/62 , C07H21/04 , C12N1/20 , C12N15/00 , C12P7/02 , C12P7/18
CPC分类号： C12N9/93 , C12N9/0006 , C12N9/88 , C12P7/62
摘要： Methods for producing enzymes, biochemical pathways, and whole cell bioprocesses that convert simple carbon sources into polymerizable substrates, and into polyhydroxyalkanoates (PHAs) are provided. Artificial pathways for converting itaconate to the polymerizable substrate methylene- gamma -butyrolactone via regioselective reduction of the C(1) or C(4) carbons are described. Novel enzymes for converting such polymerizable substrates to PHA are provided.
摘要翻译：提供了将简单碳源转化为可聚合底物的酶，生物化学途径和全细胞生物过程的生产方法，以及聚羟基链烷酸酯（PHA）。描述了通过C（1）或C（4）碳的区域选择性还原将衣康酸酯转化为可聚合底物亚甲基γ-丁内酯的人造途径。提供了将这种可聚合底物转化为PHA的新型酶。

6. 发明申请

WO0229079A2 ENANTIOSELECTIVE PRODUCTION OF AMINO CARBOXYLIC ACIDS 审中-公开
标题翻译：氨基羧酸的选择性生产
公开(公告)号：WO0229079A2
公开(公告)日：2002-04-11
申请号：PCT/US0131273
申请日：2001-10-04
申请人： MAXYGEN INC , RAMER SANDRA W , HUISMAN GJALT , MILLIS JIM , SHELDON ROGER , DEL CARDAYRE STEPHEN , TOBIN MATTHEW , COX ANTHONY , DAVIS S CHRISTOPHER
发明人： RAMER SANDRA W , HUISMAN GJALT , MILLIS JIM , SHELDON ROGER , DEL CARDAYRE STEPHEN , TOBIN MATTHEW , COX ANTHONY , DAVIS S CHRISTOPHER
IPC分类号： C12N9/78 , C12N9/88 , C12P13/00 , C12P13/02 , C12P13/04 , C12P41/00
CPC分类号： C12P13/04 , C12N9/88 , C12P13/02 , C12P41/006
摘要： Enantioselective or enantiospecific nitrilases and nitrile hydratases are used to produce R or S enantiomers of amides, and carboxylic acids. R-amino acids and S-amino acids are produced using such enantioselective enzymes. In addition, methods of producing and screening enantioselective nitrilases and nitrile hydratases are provided.
摘要翻译：对映选择性或对映体特异性腈水解酶和腈水合酶用于产生酰胺和羧酸的R或S对映异构体。使用这种对映选择性酶产生R-氨基酸和S-氨基酸。另外，提供了生产和筛选对映选择性腈水解酶和腈水合酶的方法。

7. 发明申请

WO0061731A3 MODIFIED STARCH METABOLISM ENZYMES AND ENCODING GENES FOR IMPROVEMENT AND OPTIMIZATION OF PLANT PHENOTYPES 审中-公开
标题翻译：改良淀粉代谢酶和编码基因改良和优化植物基因
公开(公告)号：WO0061731A3
公开(公告)日：2001-02-22
申请号：PCT/US0009840
申请日：2000-04-12
申请人： MAXYGEN INC , STEMMER WILLEM P C , SUBRAMANIAN VENKITSWARAN , RAILLARD SUN AI , HUISMAN GJALT
发明人： STEMMER WILLEM P C , SUBRAMANIAN VENKITSWARAN , RAILLARD SUN AI , HUISMAN GJALT
IPC分类号： C08B30/00 , C08L3/00 , C12N9/10 , C12N9/12 , C12N15/10 , C12N15/82 , C12P19/04 , C12P19/26 , C12N5/10 , C12N15/63 , C12P19/34
CPC分类号： C12N15/1079 , C08B30/00 , C08L3/00 , C12N9/1051 , C12N9/1241 , C12N15/8245 , C12P19/04 , C12P19/26
摘要： The invention provides methods for generating, identifying, and selecting polynucleotides encoding novel starch metabolizing enzymes (NSME), NSME-encoding polynucleotides, compositions of recombinant shuffled NSME protein, plant cells and microbes containing a shuffled NSME polynucleotide in expressible form, plants containing a shuffled NSME polynucleotide in expressible form, novel starch compositions produced by said plants and cells, uses of such plants, cells, and starch compositions.
摘要翻译：本发明提供了用于产生，鉴定和选择编码新型淀粉代谢酶（NSME），NSME编码多核苷酸，重组洗牌NSME蛋白质的组合物，植物细胞和含有可表达形式的洗牌NSME多核苷酸的微生物的多核苷酸的方法，所述植物含有洗牌可表达形式的NSME多核苷酸，由所述植物和细胞产生的新型淀粉组合物，这种植物，细胞和淀粉组合物的用途。

8. 发明申请

WO0004190A9 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION 审中-公开
标题翻译：通过重新序列重组实现全细胞和有机体的发育
公开(公告)号：WO0004190A9
公开(公告)日：2000-08-10
申请号：PCT/US9915972
申请日：1999-07-15
申请人： MAXYGEN INC , DEL CARDAYRE STEPHEN , TOBIN MATTHEW , STEMMER WILLEM P C , NESS JON E , MINSHULL JEREMY , PATTEN PHILLIP A , SUBRAMANIAN VENKITESWATAN , CASTLE LINDA A , KREBBER CLAUS M , BASS STEVE , ZHANG YING XIN , COX TONY , HUISMAN GJALT , YUAN LING , AFFHOLTER JOSEPH A
发明人： DEL CARDAYRE STEPHEN , TOBIN MATTHEW , STEMMER WILLEM P C , NESS JON E , MINSHULL JEREMY , PATTEN PHILLIP A , SUBRAMANIAN VENKITESWATAN , CASTLE LINDA A , KREBBER CLAUS M , BASS STEVE , ZHANG YING-XIN , COX TONY , HUISMAN GJALT , YUAN LING , AFFHOLTER JOSEPH A
IPC分类号： A01H5/00 , A01K67/027 , C07K14/245 , C12N15/09 , C12N15/10 , C12N15/82 , C12P17/16 , C12Q1/68 , C12N15/00
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译：本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。

9. 发明专利

ECSP22056585A VARIANTES DE ALFA-GLUCOSIDASA ÁCIDA DISEÑADAS POR INGENIERÍA 未知
公开(公告)号：ECSP22056585A
公开(公告)日：2022-11-30
申请号：ECDI202256585
申请日：2022-07-19
申请人： CODEXIS INC
发明人： ALAOUI ISMAILI MOULAY , CHNG CHINPING , HALLOWS WILLIAM , ZHU YU , VROOM JONATHAN , HUISMAN GJALT , BOTHAM RACHEL , DELLAS NIKKI , HOMAN DAVID , LAO JESSICA , SILVERMAN ADAM
IPC分类号： C12N15/56 , A61K38/47 , C12N9/26
摘要： La presente invención proporciona polipéptidos de alfa-glucosidasa ácida (GAA) diseñados por ingeniería y composiciones de los mismos. En algunas realizaciones, los polipéptidos de GAA diseñados por ingeniería se han optimizado para proporcionar expresión aumentada, estabilidad a pH neutro y actividad en lisados celulares. La invención también proporciona métodos para la utilización de las composiciones que comprenden los polipéptidos de GAA diseñados por ingeniería para fines terapéuticos y otros fines.

10. 发明专利

SG11201906880VA ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES 未知
公开(公告)号：SG11201906880VA
公开(公告)日：2019-08-27
申请号：SG11201906880V
申请日：2018-02-12
申请人： CODEXIS INC
发明人： CHNG CHINPING , HALLOWS WILLIAM , AGARD NICHOLAS , ALVIZO OSCAR , DELLAS NIKKI , HUISMAN GJALT , NICOLS JOHN
IPC分类号： A61K38/51 , A61K45/00 , A61P3/00 , A61P43/00
摘要： 0 0 025 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIP0 1 PCT 0111111010 0111 °nolo olommoillin onovoimIE (10) International Publication Number WO 2018/148633 Al (51) International Patent Classification: A61K 38/51 (2006.01) A61P 3/00 (2006.01) A61K 45/00 (2006.01) A61P 43/00 (2006.01) (21) International Application Number: PCT/US2018/017773 (22) International Filing Date: 12 February 2018 (12.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/458,232 13 February 2017 (13.02.2017) US 62/565,555 29 September 2017 (29.09.2017) US (71) Applicant: CODEXIS, INC. [US/US]; 200 Penobscot Dri- ve, Redwood City, California 94063 (US). (72) Inventors: CHNG, Chinping; 200 Penobscot Drive, Red- wood City, California 94063 (US). HALLOWS, William, Casey; 200 Penobscot Drive, Redwood City, California 94063 (US). AGARD, Nicholas, J.; 1047 Diamond St., San Francisco, California 94114 (US). ALVIZO, Oscar; 200 Penobscot Drive, Redwood City, California 94063 (US). DELLAS, Nikki; 200 Penobscot Drive, Redwood City, California 94063 (US). HUISMAN, Gjalt, W.; 200 Penobscot Drive, Redwood City, California 94063 (US). NICOLS, John, Joseph; 200 Penobscot Drive, Redwood City, California 94063 (US). (74) Agent: MACKNIGHT, Kamrin, T.; Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = (54) Title: ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES -4- Av PAL PBS - Av PAL FaSSIF -A- Av PAL FeSSIF Early -v- Av PAL FeSSIF Middle - Av PAL FeSSIF Late -o- Variant 126 PBS -o- Variant 126 FaSSIF - 6 - Variant 126 FeSSIF Early Variant 126 FeSSIF Middle - o- Variant 126 FeSSIF Late 0.00 0 2 4 6 8 10 15 20 25 30 Time (hrs) FIG. 1 (57) : The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. In some embodiments, the engi- neered PAL polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis and increased tolerance to storage at elevated temperatures. In some embodiments, the engineered PAL polypeptides contain fewer phenylalanine residues than wild-type PAL polypeptides. The present invention also provides methods for the use of the compositions comprising the engineered PAL polypeptides for therapeutic and industrial purposes. C [Continued on next page] WO 2018/148633 Al MIDEDIMOMOIDEIREEMOMMIVE110110100MEMOIS OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))

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