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1. 发明专利

IL294082A Engineered acid alpha-glucosidase variants 未知
公开(公告)号：IL294082A
公开(公告)日：2022-08-01
申请号：IL29408222
申请日：2022-06-19
申请人： CODEXIS INC , HALLOWS WILLIAM CASEY , BOTHAM RACHEL CATHLEEN , ZHU YU , CHNG CHINPING , DELLAS NIKKI , HUISMAN GJALT , ALAOUI ISMAILI MOULAY HICHAM , HOMAN DAVID WILLIAM , SILVERMAN ADAM P , VROOM JONATHAN , LAO JESSICA P
发明人： ZHU YU , HALLOWS WILLIAM CASEY , BOTHAM RACHEL CATHLEEN , CHNG CHINPING , DELLAS NIKKI , HUISMAN GJALT , ALAOUI ISMAILI MOULAY HICHAM , HOMAN DAVID WILLIAM , SILVERMAN ADAM P , VROOM JONATHAN , LAO JESSICA P
IPC分类号： A61K38/00
摘要： The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.

2. 发明专利

IL295818A Human alpha-galactosidase variants 未知
公开(公告)号：IL295818A
公开(公告)日：2022-10-01
申请号：IL29581822
申请日：2022-08-22
申请人： CODEXIS INC , HALLOWS WILLIAM CASEY , DELLAS NIKKI , ZHU YU , VIDUYA JUDY VICTORIA ANTONIO , CHNG CHINPING , SERO ANTOINETTE , BOTHAM RACHEL CATHLEEN , HOMAN DAVID WILLIAM , ALAOUI ISMAILI MOULAY HICHAM , VROOM JONATHAN , SILVERMAN ADAM P , VALLIEU KRISTEN JEAN , REDDY CHARU SHUKLA , MCCLUSKIE KERRYN
发明人： HALLOWS WILLIAM CASEY , DELLAS NIKKI , ZHU YU , VIDUYA JUDY VICTORIA ANTONIO , CHNG CHINPING , SERO ANTOINETTE , BOTHAM RACHEL CATHLEEN , HOMAN DAVID WILLIAM , ALAOUI ISMAILI MOULAY HICHAM , VROOM JONATHAN , SILVERMAN ADAM P , VALLIEU KRISTEN JEAN , REDDY CHARU SHUKLA , MCCLUSKIE KERRYN
IPC分类号： C12N15/85
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.

3. 发明专利

AU2003209565A1 COLOR CONVERSION AND STANDARDIZATION SYSTEM AND METHODS OF MAKING AND USING SAME 未知
公开(公告)号：AU2003209565A1
公开(公告)日：2003-09-04
申请号：AU2003209565
申请日：2003-02-12
申请人： SNOWDON VIC , SOROCCO DOUGLAS J , TURPIN KENNETH ALBERT , WICKES ZACHARY THOMAS , MARIN CARMEN CRISTIAN , MULLEN CHRISTOPHER PAUL , ZHU YU , VAVRUKH IRENE , JONGKIND YONAS , VANDERMEER DOBES C I
发明人： SNOWDON VIC , TURPIN KENNETH ALBERT , WICKES ZACHARY THOMAS , MARIN CARMEN CRISTIAN , MULLEN CHRISTOPHER PAUL , ZHU YU , VAVRUKH IRENE , JONGKIND YONAS , VANDERMEER DOBES C I
IPC分类号： G06F3/033 , G06F3/048 , G06F19/00 , G06Q30/06 , G06T11/00
摘要： The present invention relates, in general, to a standardized color formulation apparatus and methods of making and using same and, more particularly, to a standardized color formulation apparatus that is capable of formulating a selected color across one or more materials-i.e. the standardized color formulation apparatus is capable of formulating a selected color for any colorable product and is thus material independent.

4. 发明专利

AU2003209565A8 Color conversion and standardization system and methods of making and using same 未知
公开(公告)号：AU2003209565A8
公开(公告)日：2003-09-04
申请号：AU2003209565
申请日：2003-02-12
申请人： JONGKIND YONAS , MARIN CARMEN , MULLEN CHRISTOPHER , SNOWDON VIC , SOROCCO DOUGLAS , TURPIN KENNETH , VANDERMEER DOBES , VAVRUKH IRENE , WICKES ZACHARY , ZHU YU
发明人： JONGKIND YONAS , ZHU YU , MULLEN CHRISTOPHER PAUL , WICKES ZACHARY THOMAS , VAVRUKH IRENE , VANDERMEER DOBES C I , MARIN CARMEN CRISTIAN , SNOWDON VIC , TURPIN KENNETH ALBERT
IPC分类号： G06F3/033 , G06F3/048 , G06F19/00 , G06Q30/06 , G06T11/00 , G06F17/60
摘要： The present invention relates, in general, to a standardized color formulation apparatus and methods of making and using same and, more particularly, to a standardized color formulation apparatus that is capable of formulating a selected color across one or more materials-i.e. the standardized color formulation apparatus is capable of formulating a selected color for any colorable product and is thus material independent.

5. 发明申请

WO2008042100A3 HARMONIC PHASE TUNING FILTER FOR RF SWITCHES 审中-公开
标题翻译：用于RF开关的谐波相位调谐滤波器
公开(公告)号：WO2008042100A3
公开(公告)日：2008-08-14
申请号：PCT/US2007019990
申请日：2007-09-13
申请人： SKYWORKS SOLUTIONS INC , PRIKHODKO DIMA , TKACHENKO GENE A , CARTER RICHARD A , NABOKIN SERGEY , CHIESA JASON , SPRINKLE STEVEN C , ZHU YU , PELUSO BEVERLY A
发明人： PRIKHODKO DIMA , TKACHENKO GENE A , CARTER RICHARD A , NABOKIN SERGEY , CHIESA JASON , SPRINKLE STEVEN C , ZHU YU , PELUSO BEVERLY A
IPC分类号： H01P1/203
CPC分类号： H03H7/0115 , H03H7/1758 , H03H7/1766 , H03H7/38 , H03H7/465
摘要： According to one exemplary embodiment, a switching module includes a first harmonic phase tuning filter coupled to a first input of an RF switch The first harmonic phase tuning filter is configured to provide an output impedance that substantially matches an input impedance of the RF switch at approximately a fundamental frequency and to provide a low impedance at approximately a harmonic frequency generated by the RF switch The first harmonic phase tuning filter includes an LC circuit coupled between an output terminal of the first harmonic phase tuning filter and a ground and tuned to provide the low impedance at approximately the harmonic frequency generated by the RF switch The RF switching module further includes a second harmonic phase tuning filter coupled to a second input of the RF switch The first and second harmonic phase tuning filters can be fabricated on a single semiconductor die.
摘要翻译：根据一个示例性实施例，开关模块包括耦合到RF开关的第一输入的第一谐波相位调谐滤波器。第一谐波相位调谐滤波器被配置为提供基本上匹配RF开关的输入阻抗的输出阻抗，基本频率，并且在由RF开关产生的近似谐波频率处提供低阻抗。第一谐波相位调谐滤波器包括耦合在第一谐波相位调谐滤波器的输出端和地之间并被调谐以提供低频的LC电路大约由RF开关产生的谐波频率的阻抗RF开关模块还包括耦合到RF开关的第二输入端的二次谐波相位调谐滤波器。可以在单个半导体管芯上制造第一和第二谐波相位调谐滤波器。

7. 发明申请

WO2008042099A2 SWITCHING MODULE WITH HARMONIC PHASE TUNING FILTER 审中-公开
标题翻译：带谐波相位调谐滤波器的开关模块
公开(公告)号：WO2008042099A2
公开(公告)日：2008-04-10
申请号：PCT/US2007019984
申请日：2007-09-13
申请人： SKYWORKS SOLUTIONS INC , PRIKHODKO DIMA , TKACHENKO GENE A , CARTER RICHARD A , NABOKIN SERGEY , CHIESA JASON , SPRINKLE STEVEN C , ZHU YU , PELUSO BEVERLY A
发明人： PRIKHODKO DIMA , TKACHENKO GENE A , CARTER RICHARD A , NABOKIN SERGEY , CHIESA JASON , SPRINKLE STEVEN C , ZHU YU , PELUSO BEVERLY A
IPC分类号： H03H7/01 , H03H7/38
CPC分类号： H03H7/0115 , H03H7/1758 , H03H7/1766 , H03H7/1783 , H03H7/38 , H03H7/465
摘要： According to one exemplary embodiment, a switching module (102) includes a first harmonic phase tuning filter (106, 108) coupled to a first input (210, 212) of an RF switch (104, 204). The first harmonic phase tuning filter (106, 108) is configured to provide an output impedance that substantially matches an input impedance of the RF switch (104, 204) at approximately a fundamental frequency and to provide a high impedance at approximately a harmonic frequency generated by the RF switch (104, 204). The first harmonic phase tuning filter (106, 108) includes an LC circuit coupled between input and output terminals of the first harmonic phase tuning filter (106, 108) and tuned to provide the high impedance at approximately the harmonic frequency generated by the RF switch (104, 204). The RF switching module (102) further includes a second harmonic phase tuning filter (106, 108) coupled to a second input (210, 212) of the RF switch (104, 204). The first and second harmonic phase tuning filters (106, 108) can be fabricated on a single semiconductor die.
摘要翻译：根据一个示例性实施例，开关模块（102）包括耦合到RF开关（104,204）的第一输入（210,212）的第一谐波相位调谐滤波器（106,108）。第一谐波相位调谐滤波器（106,108）被配置为提供输出阻抗，该输出阻抗在大致基频处基本上匹配RF开关（104,204）的输入阻抗并且在近似产生的谐波频率下提供高阻抗通过RF开关（104,204）。第一谐波相位调谐滤波器（106,108）包括耦合在第一谐波相位调谐滤波器（106,108）的输入端和输出端之间的LC电路，并被调谐以提供近似由RF开关产生的谐波频率的高阻抗（104,204）。 RF开关模块（102）还包括耦合到RF开关（104,204）的第二输入（210,212）的二次谐波相位调谐滤波器（106,108）。第一和第二谐波相位调谐滤波器（106,108）可以制造在单个半导体管芯上。

8. 发明申请

WO2006065633A3 METHOD AND DEVICE FOR DIGITAL RIGHTS MANAGEMENT 审中-公开
标题翻译：用于数字权利管理的方法和设备
公开(公告)号：WO2006065633A3
公开(公告)日：2006-10-19
申请号：PCT/US2005044532
申请日：2005-12-08
申请人： MOTOROLA INC , GAO YAN , ZHU YU
发明人： GAO YAN , ZHU YU
IPC分类号： H04L9/00 , H04L9/32
CPC分类号： G06F21/10
摘要： A method (400) for Digital Rights management (DRM) of protected digital content. The method (400) performs requesting usage of protected digital content (310) to be used by an application supported by an electronics device (100) having a device identity and then reading a rights object (450) associated with and governing allowed use of the protected digital content . Next, the method (400) performs determining from the rights object (460) an identifier and at least one partial match identifier constraint. Thereafter, a decision (470) is provided for allowing (490) the use, governed by the rights object, of the protected digital content by the device (100) only when the device identity exactly matches the identifier or partially matches the identifier as stipulated by the at least one partial match identifier constraint.
摘要翻译：一种用于受保护的数字内容的数字版权管理（DRM）的方法（400）。该方法（400）执行请求使用受保护的数字内容（310）以由具有设备身份的电子设备（100）支持的应用使用，然后读取与该设备身份相关联的权限对象（450）保护数字内容。接下来，方法（400）从版权对象（460）执行标识符和至少一个部分匹配标识符约束的确定。之后，仅当设备标识完全匹配标识符或部分地匹配标识符时，才提供（490）由设备（100）允许（490）由权限对象管理的受保护数字内容的使用通过至少一个部分匹配标识符约束。

9. 发明专利

AU2021228689A1 Human alpha-galactosidase variants 未知
公开(公告)号：AU2021228689A1
公开(公告)日：2022-09-01
申请号：AU2021228689
申请日：2021-02-26
申请人： CODEXIS INC
发明人： HALLOWS WILLIAM CASEY , DELLAS NIKKI , ZHU YU , VIDUYA JUDY VICTORIA ANTONIO , CHNG CHINPING , SERO ANTOINETTE , BOTHAM RACHEL CATHLEEN , HOMAN DAVID WILLIAM , ALAOUI ISMAILI MOULAY HICHAM , VROOM JONATHAN , SILVERMAN ADAM P , VALLIEU KRISTEN JEAN , REDDY CHARU SHUKLA , MCCLUSKIE KERRYN
IPC分类号： C12N15/56 , A61K38/00 , C12N9/24 , C12N15/85
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.

10. 发明专利

PE20221266A1 VARIANTES DE ALFA-GLUCOSIDASA ACIDA DISENADAS POR INGENIERIA 未知
公开(公告)号：PE20221266A1
公开(公告)日：2022-08-16
申请号：PE2022001133
申请日：2020-12-18
申请人： CODEXIS INC
发明人： HALLOWS WILLIAM CASEY , BOTHAM RACHEL CATHLEEN , ZHU YU , CHNG CHINPING , DELLAS NIKKI , HUISMAN GJALT W , ALAOUI ISMAILI MOULAY HICHAM , HOMAN DAVID WILLIAM , SILVERMAN ADAM P , VROOM JONATHAN , LAO JESSICA P
IPC分类号： C12N15/56 , A61K38/47 , C12N9/26
摘要： La presente invencion proporciona polipeptidos de alfa-glucosidasa acida (GAA) disenados por ingenieria y composiciones de los mismos. En algunas realizaciones, los polipeptidos de GAA disenados por ingenieria se han optimizado para proporcionar expresion aumentada, estabilidad a pH neutro y actividad en lisados celulares. La invencion tambien proporciona metodos para la utilizacion de las composiciones que comprenden los polipeptidos de GAA disenados por ingenieria para fines terapeuticos y otros fines

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