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1. 发明申请

WO2008135564A3 ASSAYS 审中-公开
公开(公告)号：WO2008135564A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008055508
申请日：2008-05-05
申请人： CLONDIAG GMBH , KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALE , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明在样品中存在目标分析物。

2. 发明申请

WO2008062048A3 METHODS FOR OPTICALLY DETECTING MULTIPLE ANALYTES IN A LIQUID SAMPLE WITH A COMPRESSIBLE MICROFLUIDIC DEVICE 审中-公开
标题翻译：用可压缩微流体装置在液体样品中光学检测多种分析物的方法
公开(公告)号：WO2008062048A3
公开(公告)日：2008-07-10
申请号：PCT/EP2007062716
申请日：2007-11-22
申请人： CLONDIAG GMBH , SCHULZ TORSTEN , KAISER THOMAS , UHLIG THOMAS , MOEBIUS KLAUS PETER , VON SCHENK ZU SCHWEINSBERG ALE
发明人： SCHULZ TORSTEN , KAISER THOMAS , UHLIG THOMAS , MOEBIUS KLAUS PETER , VON SCHENK ZU SCHWEINSBERG ALE
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54386 , B01L3/5027 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/0481 , Y10T436/2575
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区域的相互作用表明样品中目标分析物的存在。

3. 发明专利

AU2008248605B2 Assays 未知
公开(公告)号：AU2008248605B2
公开(公告)日：2014-02-20
申请号：AU2008248605
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： MOBIUS KLAUS-PETER , ERMANTRAUT EUGEN , UHLIG THOMAS , TUCHSCHEERER JENS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , SCHULZ TORSTEN , KAISER THOMAS
IPC分类号： B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.

4. 发明专利

DK2089159T3 ANALYSER 未知
公开(公告)号：DK2089159T3
公开(公告)日：2013-04-22
申请号：DK08750065
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS , MOEBIUS KLAUS-PETER
IPC分类号： B01L3/00

5. 发明专利

NZ580395A Microfluidic networks for performing assays 未知
公开(公告)号：NZ580395A
公开(公告)日：2012-02-24
申请号：NZ58039508
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
摘要： Disclosed is a device for detecting an analyte, comprising: a) a cartridge having: a microfluidic channel including an inlet and a detection region in fluid communication with the inlet; b) a microfluidic flow path having an at least partially deformable wall and in fluid communication with the detection region of the channel; and c) a cap having: a sealing member configured to seal with the inlet and form a fluid circuit including the inlet, the microfluidic channel and the microfluidic flow path. Also disclosed is a method comprising: a) introducing a liquid sample into an inlet of a microfluidic channel thereby forming a contiguous liquid slug enclosed by the channel and bounded at a first end by a transport fluid, the liquid sample comprising multiple particles, b) sealing a sealing member of a cap with the inlet and thereby forming a fluid circuit such that the transport fluid provides fluid communication between the first and second ends of the liquid slug, c) forming a mixture comprising at least a portion of the liquid sample and an optical label present within the microfluidic channel by applying a differential pressure to the first and second ends of the liquid slug via the transport fluid and thereby moving the liquid slug within the fluid circuit, d) forming multiple complexes, each complex comprising one of the multiple particles and at least one of the optical labels, and e) detecting complexes present within a subset of the mixture.

6. 发明专利

AT538382T 未知
公开(公告)号：AT538382T
公开(公告)日：2012-01-15
申请号：AT07822829
申请日：2007-11-22
申请人： CLONDIAG GMBH
发明人： SCHULZ TORSTEN , KAISER THOMAS , UHLIG THOMAS , MOEBIUS KLAUS PETER , VON SCHENK ZU SCHWEINSBERG ALEXANDER
IPC分类号： G01N33/543 , B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

7. 发明专利

CA2684095C DEVICES AND METHODS FOR DETECTING ANALYTES 未知
公开(公告)号：CA2684095C
公开(公告)日：2016-12-13
申请号：CA2684095
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： G01N33/48 , B01L3/00 , G01N33/52 , G01N33/58
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.

8. 发明专利

ES2404067T3 Análisis 未知
公开(公告)号：ES2404067T3
公开(公告)日：2013-05-23
申请号：ES08750065
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
摘要： Un dispositivo para detectar un analito, que comprende: un cartucho (100) que tiene: un canal microfluídico (105) que incluye una entrada (109) y una región de detección (711) en comunicación de fluido con la entrada (109); una trayectoria del flujo microfluídico (104) que tiene una pared al menos parcialmente deformable y en comunicación de fluido con la región de detección (711) del canal (105); y un tapa (102) que tiene un elemento de estanqueidad configurado para asegurar la estanqueidad de la entrada (109) y formar un circuito de fluido que incluye la entrada (109), el canal microfluídico (105) y la trayectoria del flujo microfluídico.

9. 发明专利

ZA200907612B Assays 未知
公开(公告)号：ZA200907612B
公开(公告)日：2010-07-28
申请号：ZA200907612
申请日：2009-10-29
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L20100101

10. 发明专利

BRPI0810760A2 未知
公开(公告)号：BRPI0810760A2
公开(公告)日：2014-10-21
申请号：BRPI0810760
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , SCHWEINSBERG ALEXANDER VON SCHENK ZU , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

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