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1. 发明专利

JP2013046618A Device and process for assay using binding member 有权
标题翻译：用于使用绑定会员的测定的设备和方法
公开(公告)号：JP2013046618A
公开(公告)日：2013-03-07
申请号：JP2012214711
申请日：2012-09-27
申请人： Clondiag Gmbh , クロンデイアグ・ゲーエムベーハー
发明人： STEINMETZER KATRIN , ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS DIPL ING , ULLRICH THOMAS
IPC分类号： C12Q1/68 , C12M1/34 , C12N15/09
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a method for determining the presence of a pathogen in a biological sample using a device adapted for releasing cells, spores or viruses, the contents including target molecules such as polynucleotides.SOLUTION: There is provided the method for determining a value indicative of the presence and/or the amount of a reporter compound using the reporter compound, a first binding member being configured to bind an anchor group of a capture molecule, a second binding member for capturing the reporter compound, a target nucleic acid for forming complexes with the reporter compound and the capture molecule.
摘要翻译：要解决的问题：提供一种使用适于释放细胞，孢子或病毒的装置来确定生物样品中病原体的存在的方法，所述内容物包括目标分子例如多核苷酸。解决方案：提供了用于使用报告化合物确定指示报道化合物的存在和/或量的值的方法，第一结合成员被配置为结合捕获分子的锚定基团，第二用于捕获报告化合物的结合成员，用于与报告化合物和捕获分子形成复合物的靶核酸。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2014195453A アッセイ有权
标题翻译： ASSAY
公开(公告)号：JP2014195453A
公开(公告)日：2014-10-16
申请号：JP2014080013
申请日：2014-04-09
申请人：クロンデイアグ・ゲーエムベーハー , Clondiag Gmbh
发明人： ERMANTRAUT EUGEN , KAISER THOMAS DIPL ING , SCHULZ TORSTEN , STEINMETZER KATRIN , ULLRICH THOMAS
IPC分类号： C12M1/00 , C12Q1/68 , C12Q1/70 , G01N33/50 , G01N33/569 , G01N37/00
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要：【課題】簡易な様式で試料の分析を可能とする装置及び方法の提供。【解決手段】微小流体カートリッジにおいて、試料からの標的分子を捕捉する工程、標的分子を増幅する工程及び試料中の標的分子の存在の指標となる1つ又はそれ以上の値を検出する工程を少なくとも実施するためのシステムであり、検出システム、アクチュエータ要素及びアクチュエータ・バルブユニット、コンプレッサ、調節ユニット、及び微小流体カートリッジの少なくとも一部分を加熱及び/又は冷却するためのシステムを含む。加熱及び/又は冷却するためのシステムは、第一及び第二の加熱/冷却要素を含み少なくとも1つは柔軟に戴置されカートリッジの構造へ柔軟な適応が可能で第一の加熱/冷却要素は、カートリッジの基材の上面に配置第二の加熱要素は、中央陥凹部に有し、カートリッジの中央ウェルでの分子の光学的検出が可能となるシステム。【選択図】図1a
摘要翻译：要解决的问题：提供能够以简单的方式分析样品的装置和方法。解决方案：一种用于至少从样品捕获靶分子的步骤的系统，扩增靶分子的步骤和在微流体盒中检测指示样品中靶分子存在的一个或多个值的步骤包括：检测系统; 致动器元件和致动器和阀的单元; 压缩机调整单位以及用于加热和/或冷却至少部分微流体盒的系统。用于加热和/或冷却的系统包括第一和第二加热/冷却元件。第一和第二加热/冷却元件中的至少一个被柔性地安装并且适合于盒的结构。第一加热/冷却元件布置在盒的基板的上表面上，第二加热/冷却元件具有中心凹部，使得该系统可以对墨盒的中心孔中的分子执行光学检测。

3. 发明申请

WO2008135564A3 ASSAYS 审中-公开
公开(公告)号：WO2008135564A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008055508
申请日：2008-05-05
申请人： CLONDIAG GMBH , KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALE , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明在样品中存在目标分析物。

4. 发明申请

WO2009112594A3 ASSAYS 审中-公开
公开(公告)号：WO2009112594A3
公开(公告)日：2010-03-04
申请号：PCT/EP2009053106
申请日：2009-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： B01L3/00
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区域的相互作用表明样品中目标分析物的存在。装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

5. 发明申请

WO2009013321A3 ASSAYS 审中-公开
公开(公告)号：WO2009013321A3
公开(公告)日：2009-10-08
申请号：PCT/EP2008059670
申请日：2008-07-23
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , STEINMETZER KATRIN , ULLRICH THOMAS
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , STEINMETZER KATRIN , ULLRICH THOMAS
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
摘要翻译：一种包括刚性基板的装置，至少部分地覆盖基板的柔性盖元件，形成在基板中的适于容纳液体并适于释放一个或多个单元，孢子或病毒内容物的第一结构，所述内容包括目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，以及用于确定指示靶分子的存在和/或量的值;互连的微流体网络至少第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。

6. 发明申请

WO2008055915A3 DEVICE AND PROCESS FOR ASSAYS USING BINDING MEMBERS 审中-公开
标题翻译：使用绑定成员的设备和方法
公开(公告)号：WO2008055915A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007061953
申请日：2007-11-06
申请人： CLONDIAG GMBH , STEINMETZER KATRIN , ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS
发明人： STEINMETZER KATRIN , ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译：一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。

7. 发明申请

WO2010105802A3 ASSAY METHODS USING ARRAY OF TEST ZONES 审中-公开
标题翻译：使用测试区域的测定方法
公开(公告)号：WO2010105802A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010001650
申请日：2010-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： G01N21/64 , G01N21/27
CPC分类号： G01N21/6452 , B01L3/502715 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/088 , B01L2400/0481 , B01L2400/0694 , G01N21/274 , G01N2021/6441
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体设备的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明样品中存在目标分析物。装置的毛细管结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

8. 发明申请

WO2008034914A3 A DISPENSER DEVICE FOR AND A METHOD OF DISPENSING A SUBSTANCE ONTO A SUBSTRATE 审中-公开
标题翻译：用于分配物质的分配器装置和分配物质的方法
公开(公告)号：WO2008034914A3
公开(公告)日：2008-07-31
申请号：PCT/EP2007060129
申请日：2007-09-24
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , SCHULZ TORSTEN , FISCHER JOACHIM , WEICHERDING DANIEL , POSER SIEGFRIED , KIRST MATTHIAS
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , FISCHER JOACHIM , WEICHERDING DANIEL , POSER SIEGFRIED , KIRST MATTHIAS
IPC分类号： G01N35/10 , G01N35/00 , G01N35/02
CPC分类号： G01N35/1011 , G01N35/028 , G01N35/109 , G01N2001/4027 , G01N2035/00158 , G01N2035/1037 , G01N2035/1039
摘要： A dispenser device (100) for dispensing a substance (101) onto a substrate (102), the dispenser device (100) comprising a gripper unit (103) adapted for gripping a container (104) including the substance (101), a first motion mechanism (116, 117) adapted for moving the gripper unit (103) and the substrate (102) relative to each other within a planar region (106), and a second motion mechanism (115, 201 to 209) adapted for moving the gripper unit (103) and the substrate (102) relative to each other in a direction (108) essentially perpendicular to the planar region (106) to thereby dispense the substance (101) to a surface portion (109) of the substrate (102), wherein the first motion mechanism (115) and the second motion mechanism (116, 117) are decoupled from one another.
摘要翻译：一种用于将物质（101）分配到基底（102）上的分配器装置（100），所述分配器装置（100）包括适于夹持包括所述物质（101）的容器（104）的夹持器单元（103），第一适于在平坦区域（106）内相对于彼此移动所述夹持单元（103）和所述基板（102）的运动机构（116,117）以及适于移动所述夹持单元夹持器单元（103）和基板（102）在基本上垂直于平面区域（106）的方向（108）上相对于彼此分配，从而将物质（101）分配到基板（102）的表面部分（109）），其中所述第一运动机构（115）和所述第二运动机构（116,117）彼此分离。

9. 发明专利

AU2020203279B2 ASSAYS 未知
公开(公告)号：AU2020203279B2
公开(公告)日：2022-10-06
申请号：AU2020203279
申请日：2020-05-20
申请人： CLONDIAG GMBH
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS , STEINMETZER KATRIN
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/68
摘要： Abstract A device, comprising a reaction chamber which comprises a first binding member adapted for capturing target compounds and a second binding member adapted for capturing reporter compounds indicative of the presence and/or amount of the target compounds, wherein the first binding member comprises synthetic particles, beads or a porous matrix configured to bind complexes of a capture compound and a target compound and wherein the second binding member is a microarray of reporter specific capture compounds arranged on a surface.

10. 发明专利

AU2014200826B2 ASSAYS 未知
公开(公告)号：AU2014200826B2
公开(公告)日：2016-01-14
申请号：AU2014200826
申请日：2014-02-17
申请人： CLONDIAG GMBH
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS , STEINMETZER KATRIN
IPC分类号： C12Q1/68 , B01J19/00 , B01L3/00
摘要： Abstract A method, comprising (a) providing an amount of a reporter compound; a first binding member being configured to bind an anchor group of a capture molecule; a 5 second binding member capable of capturing the reporter compound; an amount of a target nucleic acid capable of forming complexes with the reporter compound, the forming of complexes with the reporter compound inhibiting capturing of the reporter compound by the second binding member; and an amount of capture molecules wherein each capture molecule comprises a binding portion specific to a 10 region of the target nucleic acid and an anchor group; (b) forming complexes each comprising a target nucleic acid and a capture molecule; (c) contacting the complexes with the first binding member to bind at least a subset of the complexes to the first binding member; (d) releasing at least a subset of the amount of target nucleic acid from the first binding member; (e) forming complexes of a subset of the 15 amount of reporter compound with at least a subset of the amount of target nucleic acid; (f) capturing a remaining subset of the amount of reporter compound not in complex with a target nucleic acid on the second binding member; and (g) determining a value indicative of the presence and/or amount of reporter compound captured on the second binding member.

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