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1. 发明申请

WO2008135564A3 ASSAYS 审中-公开
公开(公告)号：WO2008135564A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008055508
申请日：2008-05-05
申请人： CLONDIAG GMBH , KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALE , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明在样品中存在目标分析物。

2. 发明申请

WO2010105802A3 ASSAY METHODS USING ARRAY OF TEST ZONES 审中-公开
标题翻译：使用测试区域的测定方法
公开(公告)号：WO2010105802A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010001650
申请日：2010-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： G01N21/64 , G01N21/27
CPC分类号： G01N21/6452 , B01L3/502715 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/088 , B01L2400/0481 , B01L2400/0694 , G01N21/274 , G01N2021/6441
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体设备的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明样品中存在目标分析物。装置的毛细管结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

3. 发明申请

WO2009112594A3 ASSAYS 审中-公开
公开(公告)号：WO2009112594A3
公开(公告)日：2010-03-04
申请号：PCT/EP2009053106
申请日：2009-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： B01L3/00
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区域的相互作用表明样品中目标分析物的存在。装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

4. 发明专利

CA2946024C DEVICES AND METHODS FOR DETECTING ANALYTES 未知
公开(公告)号：CA2946024C
公开(公告)日：2020-06-02
申请号：CA2946024
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： G01N33/58 , G01N33/48 , G01N33/52
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.

5. 发明专利

AU2008248605B2 Assays 未知
公开(公告)号：AU2008248605B2
公开(公告)日：2014-02-20
申请号：AU2008248605
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： MOBIUS KLAUS-PETER , ERMANTRAUT EUGEN , UHLIG THOMAS , TUCHSCHEERER JENS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , SCHULZ TORSTEN , KAISER THOMAS
IPC分类号： B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.

6. 发明专利

DK2089159T3 ANALYSER 未知
公开(公告)号：DK2089159T3
公开(公告)日：2013-04-22
申请号：DK08750065
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS , MOEBIUS KLAUS-PETER
IPC分类号： B01L3/00

7. 发明专利

NZ580395A Microfluidic networks for performing assays 未知
公开(公告)号：NZ580395A
公开(公告)日：2012-02-24
申请号：NZ58039508
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
摘要： Disclosed is a device for detecting an analyte, comprising: a) a cartridge having: a microfluidic channel including an inlet and a detection region in fluid communication with the inlet; b) a microfluidic flow path having an at least partially deformable wall and in fluid communication with the detection region of the channel; and c) a cap having: a sealing member configured to seal with the inlet and form a fluid circuit including the inlet, the microfluidic channel and the microfluidic flow path. Also disclosed is a method comprising: a) introducing a liquid sample into an inlet of a microfluidic channel thereby forming a contiguous liquid slug enclosed by the channel and bounded at a first end by a transport fluid, the liquid sample comprising multiple particles, b) sealing a sealing member of a cap with the inlet and thereby forming a fluid circuit such that the transport fluid provides fluid communication between the first and second ends of the liquid slug, c) forming a mixture comprising at least a portion of the liquid sample and an optical label present within the microfluidic channel by applying a differential pressure to the first and second ends of the liquid slug via the transport fluid and thereby moving the liquid slug within the fluid circuit, d) forming multiple complexes, each complex comprising one of the multiple particles and at least one of the optical labels, and e) detecting complexes present within a subset of the mixture.

8. 发明专利

DE502005010814D1 VERFAHREN ZUR ORTSSPEZIFISCHEN SYNTHESE VON BIOPOLYMEREN AUF FESTEN TRÄGERN 未知
公开(公告)号：DE502005010814D1
公开(公告)日：2011-02-17
申请号：DE502005010814
申请日：2005-11-25
申请人： CLONDIAG GMBH
发明人： ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
IPC分类号： B01J19/00 , C40B40/06 , C40B50/14

9. 发明专利

HK1134917A1 ASSAYS 未知
公开(公告)号：HK1134917A1
公开(公告)日：2010-05-20
申请号：HK10101469
申请日：2010-02-09
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L20060101
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

10. 发明专利

CA2684095A1 ASSAYS 未知
公开(公告)号：CA2684095A1
公开(公告)日：2008-11-13
申请号：CA2684095
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： MOEBIUS KLAUS-PETER , KAISER THOMAS , ERMANTRAUT EUGEN , TUCHSCHEERER JENS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , UHLIG THOMAS , SCHULZ TORSTEN
IPC分类号： B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described . The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wa ll and a second wall which may or may not be flexible. Each test zone compri sing a probe compound specific for a respective target analyte. The microflu idic device is compressed to reduce the thickness of the channel, which is t he distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surf aces at the corresponding location is reduced. The interaction ateach test z one is indicative of the presence in the sample of a target analyte.

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